BOOK
Pediatric Rheumatology, An Issue of Pediatric Clinics - E-Book
Ronald M. Laxer | David D. Sherry
(2012)
Additional Information
Book Details
Abstract
The Guest Editors have assembled international experts in rheumatology to present an update to pediatricians. The basics are covered, including an article on the principles of inflammation in the child and one on the approach to the child with joint inflammation. From there, specifics are presented in the following articles: Laboratory Testing in Rheumatology; Rheumatologic Emergencies in newborns, children and adolescents; Juvenile Idiopathic Arthritis; Macrophage Activation Syndrome; Systemic Lupus Erythematosus; Idiopathic Inflammatory Myopathies in Childhood; Scleroderma; Vasculitis; Kawasaki disease; Autoinflammatory diseases; Approach to the patient with non-inflammatory musculoskeletal pain; and Immune deficiency diseases with rheumatic manifestations.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Pediatric Clinics of North America | i | ||
| Copyright Page | ii | ||
| Table of Contents | vii | ||
| Contributors | v | ||
| Preface: Pediatric Rheumatology | xiii | ||
| Chapter 1. Principles of Inflammation for the Pediatrician | 225 | ||
| THE IMMUNE SYSTEM: INNATE AND ADAPTIVE IMMUNITY | 225 | ||
| INDUCTION OF THE IMMUNE RESPONSE: HOW CELLS OF THE INNATE SYSTEM RECOGNIZE NONSELF PROTEINS AND BECOME ACTIVATED | 226 | ||
| ROLE OF THE INNATE SYSTEM IN THE INITIATION OF THE INFLAMMATORY RESPONSE | 229 | ||
| ACUTE INFLAMMATION | 232 | ||
| ROLE OF THE ADAPTIVE IMMUNITY IN PERPETUATING THE INFLAMMATORY RESPONSE | 234 | ||
| REFERENCES | 241 | ||
| Chapter 2. Approach to the Child with Joint Inflammation | 245 | ||
| MONOARTHRITIS | 245 | ||
| POLYARTHRITIS | 255 | ||
| SUMMARY | 259 | ||
| REFERENCES | 260 | ||
| Chapter 3. Laboratory Testing in Pediatric Rheumatology | 263 | ||
| CBC | 263 | ||
| ACUTE PHASE REACTANTS | 265 | ||
| TESTS SPECIFIC TO RHEUMATOLOGIC DISEASES | 266 | ||
| LABORATORY TESTS FREQUENTLY USED IN RHEUMATOLOGY | 273 | ||
| GENETIC TESTS USED IN RHEUMATOLOGY | 276 | ||
| SUMMARY | 278 | ||
| REFERENCES | 278 | ||
| Chapter 4. Rheumatologic Emergencies in Newborns, Children,and Adolescents | 285 | ||
| THE FETUS OR NEONATE WITH COMPLETE HEART BLOCK | 286 | ||
| THE FEBRILE CHILD WITH PANCYTOPENIA | 287 | ||
| THE CHILD WITH RESPIRATORY DISTRESS AND RENAL FAILURE | 291 | ||
| THE CHILD WITH MULTIPLE ORGAN DYSFUNCTION WITH OR WITHOUT OBVIOUS THROMBOSIS | 293 | ||
| THE CHILD WITH PERICARDIAL TAMPONADE | 296 | ||
| REFERENCES | 297 | ||
| Chapter 5. Juvenile Idiopathic Arthritis | 301 | ||
| EPIDEMIOLOGY | 302 | ||
| CAUSE AND PATHOGENESIS | 302 | ||
| DIAGNOSIS AND CLASSIFICATION | 303 | ||
| CLINICAL MANIFESTATIONS OF JIA | 303 | ||
| OLIGOARTICULAR JIA | 303 | ||
| POLYARTICULAR JIA | 305 | ||
| sJIA | 306 | ||
| ENTHESITIS-RELATED JIA | 307 | ||
| PsJIA | 308 | ||
| COMPLICATIONS OF JIA | 308 | ||
| TREATMENT | 312 | ||
| NONPHARMACOLOGIC THERAPY | 313 | ||
| PHARMACOLOGIC THERAPY | 313 | ||
| CORTICOSTEROIDS | 314 | ||
| BIOLOGIC AGENTS | 316 | ||
| TUMOR NECROSIS FACTOR α INHIBITORS | 316 | ||
| IL INHIBITORS | 318 | ||
| T-CELL AND B-CELL TARGETED THERAPY | 319 | ||
| ADVERSE EFFECTS OF BIOLOGIC AGENTS | 320 | ||
| SUMMARY | 321 | ||
| REFERENCES | 321 | ||
| Chapter 6. Making Sense of the Cytokine Storm: A Conceptual Framework for Understanding, Diagnosing, and Treating Hemophagocytic Syndromes | 329 | ||
| OBJECTIVES | 329 | ||
| THE FINAL COMMON PATHWAY | 329 | ||
| CAUSES | 331 | ||
| DISTINGUISHING CSSs | 337 | ||
| CAUSE-BASED TREATMENT | 338 | ||
| SUMMARY | 341 | ||
| REFERENCES | 341 | ||
| Chapter 7. Systemic Lupus Erythematosus in Children and Adolescents | 345 | ||
| EPIDEMIOLOGY | 345 | ||
| CLASSIFICATION AND DIAGNOSIS OF cSLE | 346 | ||
| CLINICAL FEATURES | 346 | ||
| IS IT SLE? | 355 | ||
| COMPLICATIONS | 356 | ||
| TREATMENT | 357 | ||
| ADOLESCENT ISSUES TO CONSIDER FOR OPTIMAL DISEASE MANAGEMENT | 358 | ||
| LONG-TERM OUTLOOK | 359 | ||
| SUMMARY | 360 | ||
| REFERENCES | 360 | ||
| Chapter 8. Idiopathic Inflammatory Myopathies in Childhood: Current Concepts | 365 | ||
| CLINICAL PRESENTATION AND EVALUATION | 365 | ||
| DIFFERENTIAL DIAGNOSIS | 369 | ||
| INVESTIGATION | 371 | ||
| THERAPY | 373 | ||
| PROGNOSIS AND OUTCOME | 374 | ||
| SUMMARY | 375 | ||
| REFERENCES | 376 | ||
| Chapter 9. Pediatric Scleroderma: Systemic or Localized Forms | 381 | ||
| PEDIATRIC SCLERODERMA | 381 | ||
| SYSTEMIC SCLEROSIS | 382 | ||
| LOCALIZED SCLERODERMA | 388 | ||
| REFERENCES | 400 | ||
| Chapter 10. Pediatric Vasculitis | 407 | ||
| DIAGNOSIS | 407 | ||
| CLASSIFICATION | 408 | ||
| EPIDEMIOLOGY AND PATHOGENESIS | 408 | ||
| SUMMARY | 420 | ||
| REFERENCES | 420 | ||
| Chapter 11. Kawasaki Disease | 425 | ||
| HISTORICAL PERSPECTIVES | 425 | ||
| EPIDEMIOLOGY | 425 | ||
| CAUSE | 426 | ||
| CLINICAL, LABORATORY, AND CARDIAC FEATURES | 427 | ||
| TREATMENT | 434 | ||
| LONG-TERM | 437 | ||
| SUMMARY | 438 | ||
| REFERENCES | 438 | ||
| Chapter 12. Autoinflammatory Syndromes | 447 | ||
| THE INNATE IMMUNE SYSTEM AS IT RELATES TO THE PATHOGENESIS OF AUTOINFLAMMATORY SYNDROMES | 450 | ||
| FAMILIAL MEDITERRANEAN FEVER | 450 | ||
| HYPERIMMUNOGLOBULINEMIA D WITH PERIODIC FEVER SYNDROME | 457 | ||
| DEFICIENCY OF THE IL-1 RECEPTOR ANTAGONIST (DIRA) | 459 | ||
| DEFICIENCY OF IL-36 RECEPTOR ANTAGONIST (DITRA): FAMILIAL GENERALIZED PUSTULAR PSORIASIS | 459 | ||
| THE TNF-RECEPTOR–ASSOCIATED PERIODIC SYNDROME | 460 | ||
| THE CRYOPYRIN-ASSOCIATED PERIODIC SYNDROMES | 461 | ||
| FAMILIAL COLD AUTOINFLAMMATORY SYNDROME II RELATEDTO MUTATIONS IN THE NALP12 GENE | 463 | ||
| PYOGENIC STERILE ARTHRITIS, PYODERMA GANGRENOSUM, ACNE SYNDROME | 463 | ||
| PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, ADENITIS SYNDROME | 464 | ||
| CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS | 465 | ||
| THE OUTCOME OF PATIENTS WITH UNDIAGNOSED NONINFECTIOUS RECURRENT FEVER | 465 | ||
| SUMMARY | 465 | ||
| ACKNOWLEDGMENTS | 466 | ||
| REFERENCES | 466 | ||
| Chapter 13. Approach to the Patient with Noninflammatory Musculoskeletal Pain | 471 | ||
| BENIGN LIMB PAIN OF CHILDHOOD | 471 | ||
| MALIGNANCY | 474 | ||
| HYPERMOBILITY SYNDROMES | 476 | ||
| OVERUSE SYNDROMES (OSTEOCHONDROSES) AND SKELETAL DEFECTS | 478 | ||
| AMPLIFIED MUSCULOSKELETAL PAIN SYNDROMES | 481 | ||
| REFERENCES | 489 | ||
| Chapter 14. Immunodeficiency Diseases with Rheumatic Manifestations | 493 | ||
| PREVALENCE OF PRIMARY IMMUNODEFICIENCY DISORDERS | 493 | ||
| THE 4 MAJOR COMPARTMENTS OF THE IMMUNE SYSTEM | 494 | ||
| IMMUNODEFICIENCIES BY COMPARTMENT | 495 | ||
| OVERALL DIAGNOSTIC APPROACH TO IMMUNODEFICIENCY DISORDERS | 504 | ||
| SUMMARY | 505 | ||
| REFERENCES | 505 | ||
| Index | 509 |