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Book Details
Abstract
This issue of Immunology and Allergy Clinics provides the latest essential updates in food allergies. Topics include the following: mechanisms of allergic sensitization to foods—bypassing immune tolerance pathways; determinants of food allergenicity; epidemiology of food allergy; prevention of food allergy through manipulating the timing of food exposure; diagnosis and management of eosinophilic esophagitis; the burden of food allergies and mental health issues; state-of-the-art and new horizons in food allergy diagnostic testing; food-induced anaphylaxis; oral tolerance; immunotherapy for food allergy; complementary and alternative medicine for food allergy; paradigm shift in management of milk and egg allergy—baked milk and egg diet.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Immunology and Allergy Clinics of North America | i | ||
| Copyright Page | ii | ||
| Table of Contents | vii | ||
| Contributors | iii | ||
| Foreword: Is Food Allergy Giving Me a Headache? | xiii | ||
| REFERENCES | xiv | ||
| Preface: Food Allergy Guidelines and Beyond | xv | ||
| REFERENCES | xix | ||
| Chapter 1. Mechanisms of Allergic Sensitization to Foods: Bypassing Immune Tolerance Pathways | 1 | ||
| ORAL TOLERANCE | 1 | ||
| ANIMAL MODELS OF FOOD ALLERGY | 3 | ||
| MECHANISM OF ACTION OF ADJUVANTS | 3 | ||
| SENSITIZATION THROUGH NONORAL ROUTES | 4 | ||
| DIRECT EFFECTS OF FOOD ALLERGENS ON THE INNATE IMMUNE SYSTEM | 5 | ||
| SUMMARY | 6 | ||
| REFERENCES | 7 | ||
| Chapter 2. Determinants of Food Allergy | 11 | ||
| WHAT IS A FOOD ALLERGEN? | 11 | ||
| STRUCTURAL FEATURES | 14 | ||
| FUNCTIONAL FEATURES | 15 | ||
| PLANT FOOD ALLERGENS | 16 | ||
| ANIMAL FOOD ALLERGENS | 17 | ||
| WHAT CAN WE LEARN FROM 3 DISPARATE EXAMPLES OF FOOD ALLERGY? | 17 | ||
| MAMMALIAN MEAT ALLERGY | 21 | ||
| SUMMARY | 26 | ||
| ACKNOWLEDGMENTS | 26 | ||
| REFERENCES | 26 | ||
| Chapter 3. The Epidemiology of IgE-Mediated Food Allergy and Anaphylaxis | 35 | ||
| METHODOLOGIES FOR MEASURING FOOD ALLERGY PREVALENCE | 36 | ||
| THE MOST RECENT PREVALENCE ESTIMATES OF IGE-MEDIATED FOOD ALLERGY | 37 | ||
| FOOD-INDUCED ANAPHYLAXIS | 38 | ||
| EPIDEMIOLOGY OF FATAL ANAPHYLAXIS | 40 | ||
| WHAT IS THE EVIDENCE FOR A RISE IN INCIDENCE OF FOOD ALLERGY? | 40 | ||
| FACTORS ASSOCIATED WITH THE PRESUME RISE IN PREVALENCE | 41 | ||
| THE ROLE OF GENETICS IN PREDISPOSITION TO FOOD ALLERGY | 41 | ||
| ROLE OF RACE AND GENDER IN FOOD ALLERGY PREDISPOSITION | 41 | ||
| MODIFIABLE ENVIRONMENTAL RISK FACTORS FOR FOOD ALLERGY DEVELOPMENT | 42 | ||
| SUMMARY | 46 | ||
| REFERENCES | 46 | ||
| Chapter 4. Can We Prevent Food Allergy by Manipulating the Timing of Food Exposure? | 51 | ||
| BIOLOGICAL RATIONALE FOR TOLERANCE DEVELOPMENT ANTENATALLY AND POSTNATALLY | 52 | ||
| FACTORS AFFECTING TOLERANCE DEVELOPMENT | 53 | ||
| EFFECT OF TIMING OF FOOD EXPOSURE: PREGNANCY AND LACTATION | 54 | ||
| EFFECT OF TIMING OF FOOD EXPOSURE: INFANCY | 56 | ||
| SUMMARY | 60 | ||
| REFERENCES | 60 | ||
| Chapter 5. Eosinophilic Esophagitis: Diagnosis and Management | 67 | ||
| DIAGNOSIS | 67 | ||
| ALLERGY EVALUATION | 71 | ||
| TREATMENT | 72 | ||
| SUMMARY AND KEY POINTS | 76 | ||
| REFERENCES | 77 | ||
| Chapter 6. Mental Health and Quality-of-Life Concerns Related to the Burden of Food Allergy | 83 | ||
| THE CHILD’S PERSPECTIVE | 84 | ||
| THE FAMILY PERSPECTIVE | 87 | ||
| FOOD ALLERGY AND BULLYING: AN EMERGING ISSUE | 89 | ||
| INTERVENTIONS THAT ATTEMPT TO IMPROVE EMOTIONAL OUTCOMES AND QOL | 90 | ||
| CONCLUSIONS AND FUTURE DIRECTIONS | 91 | ||
| SUMMARY | 92 | ||
| REFERENCES | 93 | ||
| Chapter 7. Beyond Skin Testing: State of the Art and New Horizons in Food Allergy Diagnostic Test ing | 97 | ||
| MOLECULAR DIAGNOSIS IN FOOD ALLERGY | 98 | ||
| FUNCTIONAL ASSAYS | 102 | ||
| OTHER ASSESSMENT | 103 | ||
| SUMMARY | 104 | ||
| ACKNOWLEDGMENTS | 104 | ||
| REFERENCES | 104 | ||
| Chapter 8. Oral Immunotherapy and Anti-IgE Antibody-Adjunctive Treatment for Food Allergy | 111 | ||
| FOOD OIT | 112 | ||
| TRENDS IN OIT | 122 | ||
| IGE IN PATIENTS WITH FOOD ALLERGY | 123 | ||
| ANTI-IGE MONOCLONAL ANTIBODIES | 123 | ||
| MECHANISMS OF ANTI-IGE MAB | 124 | ||
| ANTI-IGE MAB IN RUSH SUBCUTANEOUS IMMUNOTHERAPY FOR RAGWEED | 126 | ||
| ANTI-IGE IN FOOD ALLERGY | 126 | ||
| COMBINING ANTI-IGE MAB WITH OIT | 127 | ||
| OTHER IMMUNOTHERAPEUTIC APPROACHES IN FOOD ALLERGY | 129 | ||
| SUMMARY AND FUTURE DIRECTIONS IN FOOD OIT | 129 | ||
| REFERENCES | 130 | ||
| Chapter 9. Alternative and Complementary Treatment for Food Allergy | 135 | ||
| FOOD ALLERGY AND CAM | 135 | ||
| CURRENT CONCEPTS IN MECHANISMS OF ORAL TOLERANCE AND A ROLE FOR CAM | 136 | ||
| THE SCOPE OF CAM | 136 | ||
| ALTERNATIVE APPROACHES TO DIAGNOSIS OF FOOD ALLERGY | 137 | ||
| SAFETY OF CAM | 138 | ||
| HERBAL MEDICINE FOR THE TREATMENT OF FOOD ALLERGY | 138 | ||
| ALTERNATIVE IMMUNOTHERAPY | 144 | ||
| NUTRITION | 144 | ||
| PROBIOTICS AND SOY ISOFLAVONES | 145 | ||
| SUMMARY | 145 | ||
| REFERENCES | 146 | ||
| Chapter 10. Paradigm Shift in the Management of Milk and Egg Allergy: Baked Milk and Egg Diet | 151 | ||
| EFFECT OF THERMAL PROCESSING ON ANTIGENICITY AND ALLERGENICITY | 151 | ||
| THE ROLE OF THERMAL PROCESSING IN THE NATURAL HISTORY OF EGG AND MILK ALLERGY | 159 | ||
| SUMMARY | 160 | ||
| REFERENCES | 160 | ||
| Chapter 11. Food-Induced Anaphylaxis | 165 | ||
| DEFINITION | 165 | ||
| EPIDEMIOLOGY | 165 | ||
| TRIGGERS OF FIA | 167 | ||
| RISK FACTORS | 177 | ||
| PATHOGENESIS | 177 | ||
| DIAGNOSIS | 179 | ||
| TREATMENT | 183 | ||
| PREVENTION OF ANAPHYLAXIS AND FATAL ANAPHYLAXIS | 186 | ||
| FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS | 187 | ||
| SUMMARY | 188 | ||
| REFERENCES | 188 | ||
| Index | 197 |