Abstract

Medicinal Chemistry: Lipid Pharmacology, Volume 2 focuses on the effects of drugs on lipid metabolism. This book explores the methodology in lipid chemistry by which transport and release mechanisms can be investigated very effectively by the use of drugs.
Organized into 12 chapters, this book starts with an overview of the total lipid fraction that can be isolated from tissues by any one of many solvent extraction procedures. This text then defines atherosclerosis disease and explores the studies in experimental atherosclerosis, which are designed to better understand the progression of this disease in humans. Other chapters discuss the inhibitors of cholesterol biosynthesis and examine the pathways involved in the synthesis of other classes of lipids. This book describes as well all drugs known to influence steroid metabolism in humans and other mammals. The final chapter deals with the biological activity of a substance, which is determined by several factors.
Chemists, biochemists, and pharmacologists will find this book extremely useful.