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Nucleophilic Aromatic Substitution of Hydrogen

Nucleophilic Aromatic Substitution of Hydrogen

Oleg N. Chupakhin | Valery N. Charushin | Henk C. van der Plas


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Nucleophilic aromatic substitution in carbo- and heteroaromatic systems is a subject of considerable interest to chemists. This book uniquely addresses the systematic analysis of a vast range of nucleophilic substitutions of aromatic hydrogen.

  • Nucleophilic displacement of hydrogen (the S N/H reactions) in pi-deficient aromatics, such as nitroarenes, arene-metal complexes, and the like
  • Nucleophilic displacement of hydrogen in heterocyclic substrates such as pyridines, their aza and benzo analogs, pyrylium and thiapyrylium cations, and other heterocycles
  • Mechanisms for the S N/H reactions (S N/H(AE), vicarious nucleophilic substitutions, and radical S N/H substitutions

"This is an excellent book that will prove useful for those interested in the chemistry of SN reactions." --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY