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Book Details
Abstract
Dilated cardiomyopathy (DCM) is traditionally referred to as idiopathic dilated cardiomyopathy (IDC), which includes genetic forms of DCM.
The patients present with a wide range of symptoms like dyspnea, orthopnea, paroxysmal nocturnal dyspnea, arrhythmias or complications associated with DCM.
The diagnosis is based on exclusion of the various identifiable causes of systolic left ventricular dysfunction, such as ischemic cardiomyopathy, hypertensive cardiomyopathy, alcoholic cardiomyopathy, myocarditis secondary to viral or other causes, peripartum cardiomyopathy and cardiomyopathies secondary to amyloidosis, hemochromatosis, sarcoidosis, and due to drug toxicity.
The sophisticated and expensive diagnostic tests might not be feasible for a typical Indian patient. This prompts us to emphasize the need for corroborating the clinical clues with the available affordable investigative tests that also offer reasonably valid results.
The medical management of congestive heart failure is vital to the management protocol of DCM. The roles of heart transplant, cardiomyoplasty and surgical devices have to be weighed from patient to patient with a clear understanding of the etiology of the disease. The recent improvement in the prognosis of DCM presents an encouraging picture to the researchers and practitioners dedicated to the development of drugs and devices to improve the life expectancy of patients of DCM.
This clinical update module has been formulated to update the readers on the existing and emerging treatment strategies widely followed and recommended by practitioners of international repute. The essential features of the medical and surgical management have been discussed in detail. Moreover, a comprehensive discussion on the occurrence and management of DCM in pediatric patients has also been incorporated in this book. The book is an honest attempt to provide the medical practitioner with a wide knowledge platform about DCM and its clinical implications.
Table of Contents
Section Title | Page | Action | Price |
---|---|---|---|
Front Matter | Front Cover | ||
Elsevier Clinical Advisory Board:Cardiology | ic | ||
Copyright | ie | ||
About the Authors | if | ||
Contents | 1 | ||
ECAB Clinical Update Information | i | ||
Preface | vi | ||
Dilated Cardiomyopathy | 1a | ||
Definition | 2 | ||
Incidence and Prevalence | 2 | ||
Etiopathogenesis | 2 | ||
Familial and Genetic Factors | 3 | ||
Viral Myocarditis and other Cytotoxic Insults | 3 | ||
Immune Abnormalities | 4 | ||
The Role of the Sympathetic Nervous System | 4 | ||
Pathology | 5 | ||
Natural History | 5 | ||
Clinical Presentation | 6 | ||
History and Physical Examination | 6 | ||
Diagnostic Testing | 8 | ||
General Investigations | 8 | ||
Specific Investigations | 9 | ||
Chest X-ray PA and Lateral View | 9 | ||
Electrocardiogram | 10 | ||
Echocardiogram | 10 | ||
Assessment of Ventricular Dyssynchrony | 11 | ||
Metabolic Exercise Testing | 11 | ||
Coronary Angiogram | 13 | ||
Magnetic Resonance Imaging | 14 | ||
Endomyocardial Biopsy | 14 | ||
Iron Studies | 14 | ||
HIV Assay | 14 | ||
Prognosis | 14 | ||
Factors Associated with Adverse Prognosis | 15 | ||
Management of Dilated Cardiomyopathy | 15 | ||
Lifestyle Management | 16 | ||
Medical Management | 16 | ||
Lifestyle Changes | 16 | ||
Pharmacological Therapy | 17 | ||
Management of Heart Failure | 17 | ||
Mechanical Devices | 23 | ||
Intracardiac Defibrillators | 23 | ||
Cardiac Resynchronization Therapy | 23 | ||
Investigational Treatments | 25 | ||
Percutaneous Heart Valve Repair | 25 | ||
Implantable Sensors | 25 | ||
Case Studies Dilated Cardiomopathy | 30 | ||
Case 1 | 30 | ||
On Examination | 30 | ||
Investigations | 30 | ||
Management | 31 | ||
Diagnosis | 31 | ||
Plan | 31 | ||
Case 2 | 32 | ||
On Examination | 32 | ||
Investigations | 32 | ||
Diagnosis | 35 | ||
Plan | 35 | ||
Case 3 | 35 | ||
On Examination | 35 | ||
Investigations | 35 | ||
Diagnosis | 37 | ||
Case 4 | 38 | ||
On Examination | 38 | ||
Investigations | 38 | ||
Diagnosis | 39 | ||
Dilated Cardiomopathy in Children | 40a | ||
Introduction | 40 | ||
Dilated Cardiomyopathy | 40 | ||
Diagnostic Approach for Dilated Cardiomyopathy in Children | 44 | ||
History and Physical Examination | 48 | ||
Chest X-ray | 49 | ||
EKG | 50 | ||
Echocardiography | 52 | ||
Metabolic and Genetic Work-up | 54 | ||
Muscle Enzyme Assays | 45 | ||
Endomyocardial Biopsy | 56 | ||
Viral Studies | 57 | ||
Screening Family Members | 57 | ||
Treatment | 58 | ||
Supportive Treatment | 59 | ||
Digoxin and Diuretics | 59 | ||
Intravenous Inotropes and Vasodilators | 59 | ||
Angiotensin Converting Enzyme (ACE) Inhibitors | 59 | ||
Beta-blockers and Carvedilol | 60 | ||
Anticoagulation and Aspirin | 61 | ||
Etiology-Specific\" Treatment | 62 | ||
L-carnitine | 62 | ||
Immunoglobulins | 63 | ||
Immunosuppressive Treatment | 63 | ||
Surgical Options for the Treatment of End-stage Heart Disease | 63 | ||
Reduction Cardiomyoplasty | 63 | ||
Assist Devices and Artificial Heart | 63 | ||
Transplantation | 64 | ||
Management of Extreme Heart Failure and Cardiogenic Shock | 64 | ||
Initial Treatment | 65 | ||
Pharmacologic Support | 65 | ||
Inotropes | 65 | ||
Phosphodiesterase Inhibitors | 66 | ||
Vasodilators | 66 | ||
Support of Vital Organ Function | 67 | ||
Ventilatory Support | 67 | ||
Support of Renal Function | 67 | ||
Gastrointestinal and Nutritional Support | 68 | ||
Management of Associated Infection | 68 | ||
Prognosis of Dilated Cardiomyopathy | 68 | ||
Conclusions | 69 | ||
Case Study Dilated Cardiomopathy in Children | 75 | ||
Clinical Case | 75 | ||
Dilated Cardiomyopathy in Children: Management Algorithms | 77 | ||
Surgical Treatment of Dilated Cardiomyopathy | 83b | ||
Treatment Options for Dilated Cardiomyopathy | 84 | ||
Management of Dilated Cardiomyopathy | 84 | ||
Surgical Treatment of Dilated Cardiomyopathy | 85 | ||
Dynamic Cardiomyoplasty | 85 | ||
Ventricular Reduction Surgery (Partial Left Ventriculectomy/Batista Procedure) | 86 | ||
Ventricular Assist Devices | 88 | ||
Heart Transplantation | 89 | ||
Total Artificial Heart | 90 | ||
Stem Cell Therapy for Cardiomyopathy | 91 | ||
Summary | 95 | ||
Forthcoming Books | 97 |