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Correlative Light and Electron MIcroscopy

Correlative Light and Electron MIcroscopy

Thomas Muller-Reichert | Paul Verkade

(2012)

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Abstract

The combination of electron microscopy with transmitted light microscopy (termed correlative light and electron microscopy; CLEM) has been employed for decades to generate molecular identification that can be visualized by a dark, electron-dense precipitate. This new volume of Methods in Cell Biology covers many areas of CLEM, including a brief history and overview on CLEM methods, imaging of intermediate stages of meiotic spindle assembly in C. elegans embryos using CLEM, and capturing endocytic segregation events with HPF-CLEM.

  • Covers many areas of CLEM by the best international scientists in the field
  • Includes a brief history and overview on CLEM methods