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Book Details
Abstract
The first issue of Clinics in Chest Medicine to be published with this focus, this issue reviews bronchiectasis from numerous angles to provide comprehensive coverage on this important subject. Epidemiology, airway defense mechanisms, pathogenesis, imaging and genetic causes of bronchiectasis are discussed. Allergic bronchopulmonary aspergillosis is addressed, as well as non-tuberculous mycobacteria as a cause of bronchiectasis. Authors examine how to evaluate the success of therapy for bronchiectasis (what endpoints to use) and then discuss a variety of therapy options: inhaled and systemic antibiotic treatment, chest physiotherapy, pharmacologic agents for mucous clearance, antipinflammatory therapy and macrolides. Pulmonary resection and lung transplantation for bronchiectasis are reviewed. Recent advances in Cystic Fibrosis are also discussed.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Clinics in Chest Medicine | i | ||
| Copyright Page | ii | ||
| Table of Contents | v | ||
| Contributors | iii | ||
| CLINICS IN CHEST MEDICINE | ix | ||
| Preface | xi | ||
| Chapter 1. Airway Defense Mechanisms | 199 | ||
| MECHANICAL DEFENSES | 199 | ||
| INNATE IMMUNITY | 200 | ||
| ADAPTIVE IMMUNITY | 204 | ||
| SUMMARY | 205 | ||
| REFERENCES | 205 | ||
| Chapter 2. Pathogenesis of Bronchiectasis | 211 | ||
| PATHOLOGIC FEATURES OF BRONCHIECTASIS | 211 | ||
| PATHOGENESIS | 213 | ||
| HOST FACTORS | 214 | ||
| SUMMARY | 215 | ||
| REFERENCES | 216 | ||
| Chapter 3. The Initial Evaluation of Adults with Bronchiectasis | 219 | ||
| WHY DETERMINE AN ETIOLOGY? | 222 | ||
| HISTORY AND PHYSICAL EXAMINATION | 222 | ||
| IMAGING | 223 | ||
| ETIOLOGIC TESTING | 224 | ||
| PULMONARY FUNCTION TESTING | 227 | ||
| MICROBIOLOGIC TESTING | 228 | ||
| BRONCHOSCOPY | 228 | ||
| WHAT CAUSES IDIOPATHIC BRONCHIECTASIS? | 228 | ||
| SUMMARY | 229 | ||
| REFERENCES | 229 | ||
| Chapter 4. Imaging of Bronchiectasis | 233 | ||
| MULTIDETECTOR CT IMAGING TECHNIQUE | 233 | ||
| CT DIAGNOSIS: VISUAL INTERPRETATION | 236 | ||
| ADVANCED QUANTITATIVE IMAGE TECHNIQUES | 242 | ||
| SUMMARY | 245 | ||
| REFERENCES | 246 | ||
| Chapter 5. Genetic Causes of Bronchiectasis | 249 | ||
| ETIOLOGIC FACTORS | 250 | ||
| IMPAIRED MUCOCILIARY CLEARANCE | 251 | ||
| DISORDERS OF HUMORAL IMMUNITY | 254 | ||
| HYPERIMMUNOGLOBULIN E SYNDROME | 255 | ||
| OTHER | 256 | ||
| SUMMARY | 258 | ||
| ACKNOWLEDGMENTS | 258 | ||
| SUPPLEMENTARY DATA | 258 | ||
| REFERENCES | 258 | ||
| Chapter 6. Allergic Bronchopulmonary Aspergillosis | 265 | ||
| THE SPECTRUM OF ASPERGILLUS LUNG DISEASE | 265 | ||
| IMMUNOPATHOGENESIS OF ABPA | 266 | ||
| CLINICAL FEATURES | 268 | ||
| CLINICAL CLUES SUGGESTING A DIAGNOSIS OF ABPA IN ASTHMA | 269 | ||
| CLINICAL CLUES SUGGESTING A DIAGNOSIS OF ABPA IN CF | 270 | ||
| DIAGNOSIS OF ABPA IN PATIENTS WITH ASTHMA | 270 | ||
| DIAGNOSIS OF ABPA IN CF | 271 | ||
| DIFFERENTIAL DIAGNOSIS | 271 | ||
| STAGING OF ABPA | 272 | ||
| TREATMENT OF ABPA | 275 | ||
| MONITORING PATIENTS WITH ABPA | 277 | ||
| SUMMARY | 278 | ||
| REFERENCES | 278 | ||
| Chapter 8. Bronchiectasis and Nontuberculous Mycobacterial Disease | 283 | ||
| PATHOPHYSIOLOGY: CHICKEN AND EGG | 285 | ||
| PATHOPHYSIOLOGY: NTM ACQUISITION | 287 | ||
| DIAGNOSIS: NTM LUNG DISEASE IN BRONCHIECTASIS PATIENTS | 287 | ||
| THERAPY FOR NTM LUNG DISEASE | 289 | ||
| SUMMARY | 293 | ||
| REFERENCES | 293 | ||
| Chapter 9. Diffuse Panbronchiolitis | 297 | ||
| EPIDEMIOLOGY | 297 | ||
| CAUSE | 297 | ||
| PATHOLOGY | 298 | ||
| PATHOGENESIS | 298 | ||
| DIAGNOSIS | 299 | ||
| TREATMENT | 299 | ||
| POTENTIAL MECHANISM OF ACTION | 300 | ||
| RECENT ADVANCEMENTS IN CLINICAL APPLICATIONS OF MACROLIDE THERAPY | 302 | ||
| SUMMARY | 303 | ||
| ACKNOWLEDGMENTS | 303 | ||
| REFERENCES | 303 | ||
| Chapter 10. Recent Advances in Cystic Fibrosis | 307 | ||
| DISEASE EXPRESSION: GENETIC AND NONGENETIC FACTORS | 308 | ||
| PATHOPHYSIOLOGY | 311 | ||
| MICROBIOLOGY | 315 | ||
| RECENT AND EMERGING THERAPIES AND NEW APPROACHES TO THE DELIVERY OF CARE IN CF | 319 | ||
| OUTCOMES RESEARCH AND QI | 322 | ||
| ACKNOWLEDGMENTS | 324 | ||
| REFERENCES | 324 | ||
| Chapter 11. Evaluating Success of Therapy for Bronchiectasis What End Points to Use? | 329 | ||
| MANAGEMENT STRATEGIES FOR CHRONIC BRONCHECTASIS | 330 | ||
| TREATMENT END POINTS | 330 | ||
| SUMMARY | 347 | ||
| REFERENCES | 347 | ||
| Chapter 12. Chest Physiotherapy Techniques in Bronchiectasis | 351 | ||
| INDEPENDENT TECHNIQUES | 352 | ||
| ASSISTIVE COMPONENTS TO INDEPENDENT ACTS | 353 | ||
| DEVICE-DEPENDENT TECHNIQUES | 355 | ||
| NONINVASIVE VENTILATION | 357 | ||
| ADJUNCTS TO ACT | 357 | ||
| DISCUSSION | 358 | ||
| SUMMARY | 359 | ||
| REFERENCES | 359 | ||
| Chapter 13. Pharmacologic Agents for Mucus Clearance in Bronchiectasis | 363 | ||
| MUCOCILIARY SYSTEM | 363 | ||
| PATHOGENESIS | 364 | ||
| AGENTS FOR ENHANCED MUCUS CLEARANCE | 364 | ||
| MUCOLYTIC AGENTS | 368 | ||
| MUCOKINETIC AGENTS | 368 | ||
| OTHER AGENTS | 369 | ||
| SUMMARY | 369 | ||
| REFERENCES | 369 | ||
| Chapter 15. The Use of Antiinflammatory Therapy and Macrolides in Bronchiectasis | 371 | ||
| CORTICOSTEROIDS | 372 | ||
| MACROLIDES | 374 | ||
| OTHER ANTIINFLAMMATORY AGENTS | 376 | ||
| SUMMARY | 378 | ||
| REFERENCES | 378 | ||
| Chapter 16. Antimicrobial Therapy for Bronchiectasis | 381 | ||
| INTRODUCTION | 381 | ||
| MICROBIOLOGY OF BRONCHIECTASIS | 381 | ||
| INDICATIONS FOR ANTIBIOTICS IN BRONCHIECTASIS | 382 | ||
| ANTIBIOTICS FOR ACUTE EXACERBATIONS OF BRONCHIECTASIS | 382 | ||
| ANTIBIOTICS FOR CHRONIC MAINTENANCE THERAPY IN BRONCHIECTASIS | 383 | ||
| SUMMARY | 384 | ||
| REFERENCES | 384 | ||
| Chapter 17. Pulmonary Resection and Lung Transplantation for Bronchiectasis | 387 | ||
| INTRODUCTION | 387 | ||
| GENERAL PRINCIPLES | 388 | ||
| PREOPERATIVE ASSESSMENT | 388 | ||
| SURGICAL TECHNIQUE | 389 | ||
| COMPLICATIONS | 391 | ||
| OUTCOMES | 391 | ||
| LUNG TRANSPLANTATION | 394 | ||
| REFERENCES | 395 | ||
| Index | 397 |