BOOK
Insulin-Like Growth Factors in Health and Disease, An Issue of Endocrinology and Metabolism Clinics - E-Book
Claire M. Perks | Jeff M.P. Holly
(2012)
Additional Information
Book Details
Abstract
This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs). The physiology is examined, including the latest in what we have learned from animal models as well as humans. The issue also covers IGFs and IGF system in the following: growth disorders; adipogenesis and obesity; muscle function and disease; bone; cancer; cardiac function and disease; normal and diseased kidney; peripheral nervous systems; gastrointestinal diseases; diabetes and metabolism; and IGF-1 central/degenerative diseases.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Endocrinology and Metabolism Clinics of North America | i | ||
| Copyright Page | ii | ||
| Table of Contents | v | ||
| Contributors | iii | ||
| Forthcoming Issues | ix | ||
| Foreword | xi | ||
| Preface | xv | ||
| Chapter 1. Insulin-Like Growth Factor-1 Physiology: Lessons from Mouse Models | 231 | ||
| INTRODUCTION | 231 | ||
| IGF-1 SYSTEM IN NORMAL PHYSIOLOGY | 232 | ||
| REFERENCES | 239 | ||
| Chapter 2. Insulin-Like Growth Factor Physiology: What we have Learned from Human Studies | 249 | ||
| BACKGROUND | 249 | ||
| SYSTEMIC MODUS OPERANDI | 250 | ||
| DISTINCTIONS BETWEEN HUMANS AND EXPERIMENTAL MODELS | 253 | ||
| IGF-II AND METABOLISM | 255 | ||
| IGF-I AND NUTRITIONAL PROGRAMMING | 257 | ||
| AGING AND THE ELDERLY | 258 | ||
| REFERENCES | 259 | ||
| Chapter 3. The Insulin-Like Growth Factors and Growth Disorders of Childhood | 265 | ||
| INTRODUCTION | 265 | ||
| GROWTH DISORDERS CAUSED BY GH/IGF PATHWAY DEFECTS | 266 | ||
| IGF IN THE CIRCULATION | 271 | ||
| TREATMENT OF PRIMARY IGFD | 273 | ||
| FUTURE DEVELOPMENTS | 276 | ||
| REFERENCES | 277 | ||
| Chapter 4. The Insulin-Like Growth Factors in Adipogenesis and Obesity | 283 | ||
| EXPERIMENTAL/IN VITRO EVIDENCE | 285 | ||
| CLINICAL CONSIDERATIONS | 287 | ||
| OPEN QUESTIONS | 291 | ||
| REFERENCES | 291 | ||
| Chapter 5. Multifaceted Role of Insulin-Like Growth Factors and Mammalian Target of Rapamycin in Skeletal Muscle | 297 | ||
| INSULIN-LIKE GROWTH FACTOR AND MAMMALIAN TARGET OF RAPAMYCIN IN SKELETAL MUSCLE HEALTH: THE WHYS AND THE WHEREFORES | 297 | ||
| MUSCLE IGFs AND NUTRITION: SUBSTRATES AND SIGNALING | 298 | ||
| MUSCLE IGFs AND EXERCISE: MAY THE FORCE BE WITH YOU | 302 | ||
| OH MY: MYOSTATIN AND FOLLISTATIN SIGNAL VIA THE IGF-IR AND mTOR | 303 | ||
| GLUCOCORTICOIDS AND ANDROGENS: A TALE OF TWO STEROID HORMONES IN THE CONTROL OF MUSCLE MASS | 304 | ||
| IMMOBILIZED MUSCLE: A CAST OF CHARACTERS INVOLVED IN MUSCLE ATROPHY | 308 | ||
| ALCOHOL INDUCES LEUCINE AND IGF-I RESISTANCE IN SKELETAL MUSCLE | 309 | ||
| SUMMARY | 310 | ||
| REFERENCES | 311 | ||
| Chapter 6. The Insulin-Like Growth Factor System in Bone: Basic and Clinical Implications | 323 | ||
| INTRODUCTION | 323 | ||
| IGF-I REGULATORY SYSTEM AND BONE | 324 | ||
| ANIMAL STUDIES | 325 | ||
| ROLE OF THE IGFBPs IN THE SKELETON | 326 | ||
| ROLE OF IGF-I IN THE SKELETON | 328 | ||
| SUMMARY | 330 | ||
| REFERENCES | 330 | ||
| Chapter 7. The Insulin-Like Growth Factor System in Cancer | 335 | ||
| THE INSULIN-LIKE GROWTH FACTOR SYSTEM AND CANCER RISK | 335 | ||
| THE IGF SYSTEM IN CELLULAR PROLIFERATION AND SURVIVAL | 336 | ||
| THE INSULIN RECEPTOR AND HYBRID RECEPTORS | 336 | ||
| SIGNAL TRANSDUCTION CROSS-TALK | 338 | ||
| IGF-BINDING PROTEINS | 339 | ||
| SPECIFIC CANCERS | 340 | ||
| SUMMARY | 342 | ||
| REFERENCES | 343 | ||
| Chapter 8. Insulin-Like Growth Factors in Normal and Diseased Kidney | 351 | ||
| INTRODUCTION | 351 | ||
| PHYSIOLOGY OF THE IGF SYSTEM IN THE KIDNEY | 352 | ||
| THE IGF SYSTEM IN SELECTED RENAL DISEASES | 358 | ||
| THERAPEUTIC IMPLICATIONS | 362 | ||
| SUMMARY | 364 | ||
| REFERENCES | 365 | ||
| Chapter 9. Insulin-Like Growth Factors in the Peripheral Nervous System | 375 | ||
| INTRODUCTION | 375 | ||
| THE IGF SYSTEM IN THE PNS | 376 | ||
| IGFs IN PNS DISEASES | 380 | ||
| SUMMARY | 386 | ||
| ACKNOWLEDGMENTS | 386 | ||
| REFERENCES | 386 | ||
| Chapter 10. Insulin-Like Growth Factor-1 and Central Neurodegenerative Diseases | 395 | ||
| INTRODUCTION | 396 | ||
| IGF-1, AGING, AND NEURODEGENERATION | 396 | ||
| ROLE OF IGF-1 IN PATHOLOGIC CASCADES ASSOCIATED WITH NEURODEGENERATION | 397 | ||
| INFLAMMATION | 398 | ||
| IS IGF-1 BENEFICIAL OR DETRIMENTAL IN NEURODEGENERATIVE DISEASES? | 400 | ||
| SUMMARY | 403 | ||
| REFERENCES | 403 | ||
| Chapter 11. Insulin-Like Growth Factors in the Gastrointestinal Tract and Liver | 409 | ||
| OVERVIEW AND DISCOVERY OF INSULIN-LIKE GROWTH FACTORS | 409 | ||
| INSULIN-LIKE GROWTH FACTOR GENES AND PROTEINS IN THE GASTROINTESTINAL TRACT AND LIVER | 410 | ||
| INSULIN-LIKE GROWTH FACTOR RECEPTOR GENES AND PROTEINS | 411 | ||
| IGFBP GENE AND PROTEIN FAMILY IN THE GASTROINTESTINAL TRACT | 412 | ||
| BIOLOGY OF THE INSULIN-LIKE GROWTH FACTOR FAMILY IN THE GASTROINTESTINAL TRACT | 413 | ||
| INSULIN-LIKE GROWTH FACTOR FAMILY DISTRIBUTION IN THE GASTROINTESTINAL TRACT | 413 | ||
| INSULIN-LIKE GROWTH FACTOR STIMULATES CELLULAR PROLIFERATION | 415 | ||
| INSULIN-LIKE GROWTH FACTOR IN PROSURVIVAL | 416 | ||
| INSULIN-LIKE GROWTH FACTOR IS PROFIBROGENIC | 416 | ||
| INSULIN-LIKE GROWTH FACTOR IN GASTROINTESTINAL CANCERS | 417 | ||
| SUMMARY | 417 | ||
| REFERENCES | 418 | ||
| Chapter 12.Metabolic Actions of Insulin-Like Growth Factor-I in Normal Physiology and Diabetes | 425 | ||
| INTRODUCTION | 425 | ||
| NUTRIENT REGULATION OF IGF-I SECRETION | 426 | ||
| METABOLIC EFFECTS OF IGF-I | 427 | ||
| PROTEIN METABOLISM | 428 | ||
| FAT METABOLISM | 429 | ||
| EFFECTS ON CARBOHYDRATE METABOLISM | 430 | ||
| IGF-I AND THE METABOLIC SYNDROME | 432 | ||
| GENETIC STUDIES | 434 | ||
| SUMMARY | 437 | ||
| REFERENCES | 437 | ||
| Index | 445 |