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Textbook of Pharmacognosy and Phytochemistry - E-Book

Textbook of Pharmacognosy and Phytochemistry - E-Book

Biren Shah | Avinash Seth

(2012)

Additional Information

Book Details

Abstract

Textbook of Pharmacognosy and Phytochemistry

This comprehensive textbook is primarily aimed at the course requirements of the B. Pharm. students. This book is specially designed to impart knowledge alternative systems of medicine as well as modern pharmacognosy. It would also serve as a valuable resource of information to other allied botanical and alternative healthcare science students as well as researchers and industrialists working in the field of herbal technology.

Only Textbook Offering...

Recent data on trade of Indian medicinal plants (till 2008)

Illustrated biosynthetic pathways of metabolites as well as extraction and isolation methodologies of medicinal compounds

Bioactivity determination and synthesis of herbal products of human interest

Information on Ayurvedic plants and Chinese system of medicine

Simple narrative text that will help the students quickly understand important concepts

Over 300 illustrations and 120 tables in order to help students memorize and recall vital concepts making this book a student’s companion cum teacher

A must buy for every student of pharmacognosy!


Table of Contents

Section Title Page Action Price
Front Cover\r Front Cover
Front Matter\r i
Copyright \r iv
Preface v
Contents vii
PART A Introduction to\rPharmacognosy\r 1
Chapter 1 - History, Definition and Scope of Pharmacognosy 3
1.1. Meaning of Pharmacognosy 3
1.2. Origin of Pharmacognosy 3
1.3. History of Pharmacognosy 4
Ancient China 4
Ancient Egypt 5
Ancient India 5
Ancient Greece and Rome 5
Isolation of phytochemicals 6
Structure activity relationship 6
Drugs obtained by partial synthesis of natural products 6
Natural products as models for synthesis of new drugs 6
Drugs of direct therapeutic uses 6
Biosynthetic pathways 6
Progress from 1960 onwards 6
Technical products 6
Pharmaceuticals aids 7
Discovery of new medicines from plants- nutraceutical use versus drug development 7
1.4. Scope of Pharmacognosy 7
1.5. Future of Pharmacognosy 8
1.6. Pharmacognostical Scheme 8
Biological Source 8
Geographical Source 9
Cultivation, Collection and Preparation 9
Morphological Characters 9
Microscopical Characters 9
Chemical Constituents 9
Uses 9
Substituents 9
Adulterants 9
Chemical Tests 9
Chapter 2 - Alternative Systems of Medicine 10
Introduction 10
Traditional Chinese Medicine System 10
Treatment 11
Indian Systems of Medicine 11
Ayurveda-The Indian System of Medicine 11
Basic principles of ayurveda 12
Diagnosis 12
Treatment 12
Properties of herbs 13
Branches of ayurveda 13
Siddha System of Medicine 13
Principle of Siddha system of medicine 14
Tridoshas according to Siddha medicine 14
Method of treatment 14
Siddha pharmacy 14
Unani System of Medicine 15
Diagnosis 16
Treatment 16
Homeopathic System of Medicine 16
Fundamental Principles of Homoeopathy 16
Law of similia 16
Law of simplex 16
Law of minimum 16
Drug proving 17
Drug dynamization or potentization 17
Preparation of potencies 17
Decimal scale 17
Centesimal scale 17
Millesimal scale 17
Vital force 17
Acute and chronic diseases 17
Individualization 17
Direction of cure 17
Aromatherapy 17
Origin of Aromatherapy 18
Mode of Action of Aroma Oils 18
Bach Flower Remedies 19
Tibetan System of Medicine 20
Interrogation 20
Visual Examination 20
Tactile Examination 20
Treatments 20
Diet 21
Behaviour Modification 21
Medicine 21
Physical Therapy 21
Chapter 3 - Classification of Drugs of Natural Origin 22
3.1. Introduction 22
Organized Drugs 22
Unorganized Drugs 22
3.2. Classification of Crude Drugs 22
Alphabetical Classification 23
Merits 23
Demerits 23
Taxonomical Classification 23
Merits 22
Demerits 22
Morphological Classification 24
Organized drugs 24
Unorganized drugs 24
Merits 24
PART B Pharmaceutical Botany \r 27
Chapter 4 - Morphology of Different Parts of Medicinal Plant 29
4.1. Introduction 29
4.2. History 29
Bentham and Hooker's System 30
Hutchinson's System of Classification 30
4.3. Study of Different Tissue Systems 31
Dermal Tissue System 31
Epidermis 31
Functions 31
Stomata 32
Trichomes 32
[A] Covering trichomes 33
[B] Glandular trichomes 33
Periderm 34
Vascular Tissue System 34
Function 34
[1] Xylem 34
[2] Phloem 35
[3] Cambium 36
Types of Vascular Bundles 36
Ground Tissue System 36
(a) Parenchyma 37
(b) Collenchyma 37
(c) Sclerenchyma 37
4.4. Cell Contents 38
Starch 38
Aleurone Grain 38
Calcium Oxalate Crystals 38
Calcium Carbonate 39
Fixed Oils and Fats 39
Mucilage 39
4.5. Cell Division 39
Mitosis 39
Prophase 39
Metaphase 39
Protometaphase 39
Anaphase 40
Telophase 40
Cytokinesis 40
Meiosis 40
Division I 40
Division II 41
4.6. Morphological Study 41
Morphology of Bark 41
Methods of collection of barks 42
Morphology of bark 42
Histology of barks 43
Morphology of Roots 43
[A] Functions of roots 43
[B] Various parts of a root 43
[C] Types of roots 43
Uses of roots 45
Morphology of Stems 45
I. Underground modifications of stems 45
II. Sub-aerial modifications of stems: 46
III. Aerial modification of stems 46
Uses of stems 47
Morphology of Leaves 47
[A] A typical angiospermic leaf consists of the following parts: 47
[B] Shape of the lamina of leaves 47
[C] Leaf margins 48
[D] Leaf apices 49
[E] Leaf bases 49
[F] Leaf surface 49
[G] Types of leaves 49
[H] Venation 50
[I] Phyllotaxy 50
[J] Modifications of Leaves 51
Morphology of Flowers 51
Arrangement of Floral Parts on Thalamus 52
Placentation 52
Pollination 52
Morphology of Inflorescence 53
Types of Inflorescences 53
Morphology of Seeds 54
Seed coat 54
Embryo 54
Endosperm 54
Special features of seeds 54
Functions of Seeds 54
Morphology of Fruits 55
Simple fruits 55
Aggregate fruits 55
Compound fruits 55
False fruits 55
Chapter 5 - Study of Different Families 57
5.1. Introduction 57
Floral Diagram 57
Floral Formula 58
5.2. Apocynaceae 58
5.3. Compositae 59
5.4. Convolulaceae 59
5.5. Cruciferae 60
5.6. Gramineae 60
5.7. Labiatae 61
5.8. Leguminosae 61
Papilionaceae 61
Caesalpinieae 62
Mimoseae 62
5.9. Liliaceae 62
5.10. Papaveraceae 63
5.11. Rubiaceae 63
5.12. Rutaceae 63
5.13. Scrophulariaceae 64
5.14. Solanaceae 64
5.15. Umbelliferae 65
PART C Cultivation, Collection, Production And Utillization Of Herbal Drugs \r 67
Chapter 6 - Cultivation, Collection and Processing of Herbal Drugs 69
6.1. Introduction 69
6.2. Soils, Seeds and Propagation Material 69
Methods of Plant Propagation 70
1. Sexual method (seed propagation) 70
Methods of sowing the seeds 70
2. Asexual method 70
Preparation and Types of Nursery Beds 71
Methods of Irrigation 71
6.3. Good Agricultural Practices 72
6.4. Factors Affecting Cultivation 72
Altitude 72
Temperature 73
Rainfall 73
Day Length and Day Light 73
Soil 73
Soil Fertility 73
Fertilizers and Manures 74
Pests and Pests Control 74
Microbes 74
Insects 74
Non insect pests 75
Weeds 75
General Methods of Pest Controls 76
Other Factors that Affect the Cultivated Plants 76
Air Pollution 76
Herbicide 76
6.5. Plant Hormones and Growth Regulators 76
Auxins 76
Production and occurrence 78
Functions of auxin 79
Cytokinins 79
Production and occurrence 79
Functions of cytokinin 80
Ethylene 80
Production and occurrence 80
Functions of ethylene 80
Gibberellins 81
Chapter 7 - Indian Trade in Medicinal and Aromatic Plants 88
Introduction 88
Indian Herbal Trade in World Wcenario 89
Medicinal Plant-based Industries in Indigenous System of Medicine 90
Export Potential of Indian Phyto-Pharmaceutical Products 91
Indian Medicinal Plants Used in Cosmetic and Aromatherapy 92
Indian Medicinal Plants in Crude form 92
Spices 92
Volatile Oils 92
Phenolics 92
Alkaloids 92
Sulphur Compounds 93
Export of Spices India 93
Chapter 8 - Utilization of Aromatic Plants and Derived Products 95
8.1. Introduction 95
Importance of aromatic plants 95
8.2. Impact of industrialization 95
Volatile oil 95
Essential oils 96
Indian scenario 96
World scenario 97
Future demand 97
Export of major essential oils from India 97
8.3. Toxocity of essential oils 97
8.4. Utilization of aromatic plants 98
Mentha Oil 98
Utilization of mentha oil and derived products 98
Eucalyptus oil 98
Utilization of eucalyptus oil 98
Geranium oil 98
Utilization of geranium oil 99
Vetiver oil (khus oil) 99
Utilization of vetiver oil 99
Sandalwood oil 99
Utilization of sandalwood oil 99
Utilization of sandalwood 99
Lemon grass oil 100
Utilization of lemon grass oil 100
Chapter 9 - Role of Medicinal Plants on National Economy 101
Introduction 101
Economic Growth Potential in Natural Health and Cosmetic Products 103
Future Economic Growth 103
Development of Herbal Medicinal Industry 104
Contribution to Economy of The People 104
PART D Annalytical Pharmacognosy \r 105
Chapter 10 - Drug Adulteration 107
Introduction 107
Adulteration 107
Types of Adulterants 107
Unintentional Adulteration 107
Name Confusion 108
Lack of Knowledge About Authentic Source 108
Similarity in Morphology 108
Lack of Authentic Plant 108
Similarity in Colour 108
Careless Collections 108
Unknown Reasons 108
Intentional Adulteration 108
Adulteration Using Manufactured Substances 108
Substitution Using Inferior Commercial Varieties 109
Substitution Using Exhausted Drugs 109
Substitution of Superficially Similar Inferior Natural Substances 109
Adulteration Using the Vegetative Part of the Same Plant 109
Addition of Toxic Materials 109
Adulteration of Powders 109
Addition of Synthetic Principles 109
Chapter 11 - Evaluation of Crude Drugs 110
Introduction 110
Organoleptic Evaluation 110
Microscopical Evaluation 110
Quantitative Microscopy (Lycopodium Spore Method) 111
Chemical Evaluation 111
Physical Evaluation 112
Solubility 112
Optical Rotation 112
Refractive Index 112
Specific Gravity 112
Viscosity 112
Melting Point 113
Moisture Content 113
Ultraviolet Light 113
Ash Values 113
Extractive Values 113
Extractive Values of Some Crude Drugs 113
Foreign Organic Matters 113
Biological Evaluation 114
Chapter 12 - Biological screening of herbal drugs 115
Introduction 115
Need for Phyto-Pharmacological Evaluation 115
New Strategies for Evaluating Natural Products 116
Errors in Screening Procedures 117
Screening Methods for Analgesic Agents 118
Centrally Acting Analgesics 118
Hot Plate Method 118
Haffner's Tail Clip Method 118
Tail Immersion Test 118
Radiant Heat Method 118
Formalin Test in Rats 118
Tooth Pulp Stimulation 118
Grid Shock Test 119
Electrical Stimulation of the Tail 119
Peripherally Acting Analgesics 119
Pain in Inflamed Tissue (Randall-Selitto Test) 119
Writhing Test 119
Screening Methods for Antidiabetic Agents 119
Models for Insulin-Dependent Diabetes Mellitus 119
Alloxan-Induced Diabetes 119
Streptozotocin-Induced Diabetes 120
Virus-Induced Diabetes 120
Insulin Antibodies-Induced Diabetes 120
Hormone-Induced Diabetes 120
Genetic Models 120
Nonobese Diabetic Mouse 120
Bio-Breeding Rat 121
Models for NIDDM 121
Streptozotocin-Induced Neonatal Model for NIDDM 121
Other Chemically Induced NIDDM Models 121
Adrenaline-Induced Acute Hyperglycaemia 121
Chelating Agents 121
Dithizone-Induced Diabetes 121
Models for Insulin Sensitivity and Insulinlike Activity 121
Euglycaemic Clamp Technique 121
Assay for Insulin and Insulin-Like Activity 121
Evaluation of Antidiarrhoeal Agents 122
Castor Oil-Induced Diarrhoea in Rats 122
Gastrointestinal Motility Tests 122
PGE2-Induced Enteropooling 122
Screening Methods for Antifertility Agents 122
Screening Methods for Antifertility Activity in Females 123
Screening Methods for Antiovulatory Activity 123
Cupric Acetate-Induced Ovulation in Rabbits 123
HCG-Induced Ovulation in Rats 123
Screening Methods for Oestrogenic Compounds: In Vivo Methods 123
Assay for Water Uptake 123
Four-Day Uterine Weight Assay 124
Vaginal Opening 124
Vaginal Cornification 124
The Experimental Procedure for Taking Vaginal Smears 124
Chick Oviduct Method 124
Screening Methods for Oestrogenic Compounds: In Vitro Methods 124
Potency Assay 124
Oestrogen Receptor-Binding Assay 125
Screening Methods for Antioestrogens: In Vivo Methods 125
Antagonism of Physiological Effects of Oestrogens 125
Screening Methods for Antioestrogens: In Vitro Methods 125
Aromatase Inhibition 125
Screening Methods for Progestins: In Vivo Methods 125
Proliferation of Uterine Endometrium in Oestrogenprimed Rabbits: Clauberg-McPhail Test 126
Pregnancy Maintenance Test 126
Carbonic Anhydrase Activity in Rabbit's Endometrium 126
Prevention of Abortion in Oxytocin-Treated Pregnant Rabbits 126
Deciduoma Reaction in Rats 126
Screening Methods for Progestins; In Vitro Methods 126
Progesterone Receptor-Binding Assay 126
Screening Method for Antiprogestational Activity 126
Antagonism of Physiological Effect of Progesterone 126
Screening Method for Antiimplantation Activity 127
Screening Mthods for Abortifacient Activity 127
Screening Methods for Antifertility Activity in Males 127
In Vivo Methods 127
In Vitro Methods 127
Screening Methods for Antiinflammatory Agents 129
Testing of Dugs Peventing Aute and Sub-Acute Inflammation 129
Paw Oedema 129
Croton Oil Ear Oedema In Rats and Mice 130
Pleurisy Test 130
Ultraviolet Erythema in Guinea Pigs 130
Oxazolone-Induced Ear Oedema in Mice 130
Granuloma Pouch Technique 130
Vascular Permeability 131
Testing of Drugs Preventing the Proliferative Phase (Granuloma Formation) of Inflammation 131
Cotton Pellet Granuloma 131
Adjuvant Arthritis in Rats 131
Sponge Implantation Technique 131
Glass Rod Granuloma 132
Screening Methods for Antipyretic Agents 132
Antipyretic Testing in Rats 132
PART E Biogenesis of Phytopharma - Ceuticals \r 139
Chapter 13 - General Biosynthetic Pathways of Secondary Metabolites 141
Introduction 141
The Building Blocks 141
Shikimic Acid Pathway 144
Acetate-Mevalonate Pathway 147
Acetate-Malonate Pathway 147
Biosynthesis of Carbohydrates 147
Biosynthesis of Glycosides 148
Biosynthesis of Alkaloids 148
Ornithine Derivatives 148
Biosynthesis of Tropane 148
Lysine Derivatives 149
Phenylalanine Derivatives 149
Tyrosine Derivatives 151
Biosynthesis of Morphine 151
Tryptophan Derivatives 151
Biosynthesis of Quinoline Alkaloids 151
Biosynthesis of Lysergic Acid 153
Biosynthesis of Phenolic Compounds 154
PART F Pharmacognostical Study Of Crude Drugs \r 157
Chapter 14 - Drugs Containing Carbohydrates and Derived Products 159
Introduction 159
Classification 159
Monosaccharides 159
Bioses 160
Trioses 160
Tetroses 160
Pentoses 160
Hexoses 160
Heptoses 160
Disaccharides 160
Trisaccharides 160
Tetrasaccharides 160
Polysaccharides 160
Tests for Carbohydrates 160
Reduction of Fehling's Solution 161
Molisch Test 161
Osazone Formation 161
Resorcinol Test for Ketones (Selivanoff's Test) 161
Test for Pentoses 161
Keller-Kiliani Test for Deoxysugars 161
Furfural Test 161
Biosynthesis of Carbohydrates 161
Production of Monosaccharides by Photosynthesis 161
Production of Sucrose 162
Acacia Gum 162
Synonyms 162
Biological Source 162
Geographical Source 162
Cultivation and Collection 162
Morphology 162
History 163
Chemical Constituents 163
Chemical Tests 163
Uses 163
Allied Drugs 163
Toxicology 163
Marketed Product 164
Guar Gum 164
Synonyms 164
Biological Source 164
Geographical Source 164
Cultivation, Collection and Preparation 164
Morphology 164
History 164
Chemical Constituents 165
Chemical Tests 165
Uses 165
Toxicology 165
Marketed Product 165
Honey 165
Synonyms 165
Biological Source 165
Geographical Source 165
Collection and Preparation 165
Morphology 166
History 166
Chemical Constituents 166
Chemical Tests 166
Uses 166
Adulterant and Substitutes 167
Toxicology 167
Marketed Product 167
Tragacanth 167
Synonyms 167
Biological Source 167
Geographical Source 167
Cultivation, Collection and Preparation 167
Morphology 159
Chemical Constituents 168
Chemical Tests 168
Uses 168
Adulterant and Substitutes 169
Toxicology 169
Sodium Alginate 169
Synonyms 169
Biological Source 169
Geographical Source 169
Collection and Preparation 169
Morphology 169
History 169
Identification Tests 169
Chemical Constituents 170
Uses 170
Marketed Product 170
Pectin 170
Biological Source 170
Geographical Source 170
Preparation 170
Morphology 171
Chemical Constituents 171
Chemical Tests 171
Uses 171
Toxicology 171
Karaya Gum 171
Synonyms 171
Biological Source 171
Geographical Source 171
Collection and Preparation 171
Morphology 172
History 172
Chemical Constituents 172
Chemical Test 172
Uses 172
Adulterant and Substitutes 172
Bael 172
Synonyms 172
Biological Source 172
Geographical Source 173
Collection 173
Chemical Constituents 173
Morphology 173
Uses 174
Substitutes 174
Marketed Products 174
Agar 174
Synonym 174
Botanical Source 174
Geographical Source 174
History 174
Collection 174
Morphology 175
Chemical Constituents 175
Chemical Tests 175
Uses 175
Substitutes and Adulterants 175
Manna 175
Biological Source 175
Geographical Source 176
Chapter 15 - Drugs Containing Alkaloids 185
Introduction 185
Definition 185
History 185
Classification 186
True Alkaloids 186
Protoalkaloids 186
Pseudoalkaloids 186
Atypical Alkaloids 187
Typical Alkaloids 187
Occurrence in Nature 188
Properties 189
Extraction 189
Method A 189
Method B 189
Chemical Tests 189
Dragendorff's Test 189
Mayer's Test 189
Hager's Test 189
Wagner's Test 189
Tannic Acid Test 189
Ammonia Reineckate Test 190
Tropane Alkaloids 190
Belladonna 190
Synonyms 190
Biological Source 190
Geographical Source 190
Cultivation and Collection 190
Characteristics 190
Microscopy 191
Chemical Constituents 191
Uses 191
Marketed Products 191
Datura Herb 191
Biological Source 191
Geographical Source 191
Characteristics 191
Microscopy 192
Chemical Constituents 192
Chemical Tests 192
Uses 192
Other Species 192
Marketed Products 192
Stramonium 193
Synonyms 193
Biological Source 193
Geographical Source 193
Cultivation and Collection 193
Characteristics 193
Microscopy 193
Chemical Constituents 193
Uses 194
Marketed Products 194
Hyoscyamus 194
Synonyms 194
Biological Source 194
Geographical Source 194
History 194
Cultivation and Collection 194
Characteristics 194
Microscopy 195
Chemical Constituents 195
Uses 195
Marketed Products 196
Coca Leaves 196
Synonyms 196
Biological Source 196
Geographical Source 196
Cultivation 196
Characteristics 196
Microscopy 196
Chemical Constituents 196
Uses 196
Adulterant 197
Duboisia 197
Synonyms 197
Biological Source 197
Geographical Source 197
Characteristics 197
Microscopy (Duboisia Myoporoides) 197
Chemical Constituents 197
Chemical Tests 198
Uses 198
Indole Alkaloids 198
Ergot 198
Synonyms 198
Biological Source 198
Geographical Source 198
Cultivation and Collection 198
Sphacelia or Honeydew or Asexual Stage 198
Sclerotium or Ascigerous or Sexual Stage 199
Ascospore Stage 199
Characteristics 199
Microscopy 199
Chemical Constituents 199
Chemical Tests 200
Uses 200
Rauwolfia 200
Synonyms 200
Biological Source 201
Geographical Source 201
Cultivation and Collection 201
Characteristics 201
Microscopy 201
Chemical Constituents 201
Chapter 16 - Drugs Containing Glycosides 232
16.1. Introduction 232
16.2. Classification 232
On the Basis of Glycone 232
On the Basis of Glycosidic Linkage 232
On the Basis of Aglycone 232
16.3. Distribution of Glycosides 233
16.4. Chemical Tests of Glycosides 233
Chemical Tests for Anthraquinone Glycosides 233
Borntrager's test 233
Modified borntrager's test 233
Chemical Tests for Saponin Glycosides 233
Haemolysis test 233
Foam test 233
Chemical Tests for Steroid and Triterpenoid Glycosides 233
Libermann burchard test 233
Salkowaski test 233
Antimony trichloride test 233
Trichloro acetic acid test 233
Tetranitro methane test 233
Zimmermann test 234
Chemical Tests for Cardiac Glycosides 234
Keller-kiliani test 234
Legal test 234
Baljet test 234
3,5-dinitro benzoic acid test 234
Chemical Tests for Coumarin Glycosides 234
FeCl3 test 234
Fluorescence test 234
Chemical Tests for Cynophoric Glycoside 234
Sodium picrate test 234
Ammonia test 234
Shinoda test 234
Vanillin HCl test 234
16.5. ISOLATION 234
Stas-Otto Method 234
16.6. ANTHRACENE GLYCOSIDES 235
Senna Leaf 235
Synonyms 235
Biological Source 235
Geographical Source 235
Cultivation and Collection 235
Characteristics 236
Microscopy 236
Chemical Constituents 236
Chemical Test 237
Uses 237
Adulterants 237
Marketed Products 238
Aloe 238
Biological Source 238
Geographical Source 238
Cultivation and Collection 238
Preparation of Aloe 238
Curacao or barbados aloe 238
Socotrine aloe 238
Zanzibar aloe 238
Cape aloe 238
Characteristics 238
Curacao aloe 238
Socotrine aloes 239
Zanziber aloes 239
Cape aloes 239
Chemical Constituents 239
Chemical Tests 239
Uses 240
Substituents and Adulterants 240
Marketed Products 240
Rhubarb 240
Synonyms 240
Biological Source 240
Geographical Source 240
Cultivation and Collection 240
Characteristics 240
Chemical Constituents 241
Chemical Tests 241
Uses 241
Marketed Products 241
Other Rhubarbs 241
Indian rhubarb 241
Chinese rhapontic (Rhapontic rhubarb) 242
Geographical Source 242
Cultivation and Collection 242
Characteristics 242
Microscopy 243
Chemical Constituents 243
Chemical Test 243
Uses 243
Substitutes 243
Marketed Products 244
16.7. STEROL OR CARDIAC GLYCOSIDES 244
Digitalis Leaves 244
Synonyms 244
Biological Sources 232
Geographical Sources 244
Cultivation and Collection 244
Morphology 245
Microscopy 245
Chemical Constituents 245
Chemical Tests 246
Uses 246
Adulterants 247
Marketed Products 247
Digitalis Lanata 247
Synonym 247
Biological Source 247
Geographical Source 247
Cultivation and Collection 247
Characteristics 247
Chemical Constituents 247
Uses 247
Thevetia 248
Synonyms 248
Biological Source 248
Geographical Source 248
Morphology 248
Chemical Constituents 248
Uses 249
Squill 249
Synonyms 249
Biological Source 249
Geographical Source 249
Cultivation and Collection 249
Characteristics 249
Chemical Constituents 249
Chemical Tests 250
Uses 250
Red Squill 250
Indian Squill 250
Synonyms 250
Biological Source 250
Geographical Source 250
Cultivation and Collection 250
Morphology 250
Microscopy 250
Chapter 17 - Drugs Containing Volatile Oils 280
Introduction 280
Classification of Volatile Oils 280
Extraction of Volatile Oils 280
Extraction by Distillation 280
Extraction by Scarification 280
Extraction by Non-Volatile Solvent 281
Extraction by Volatile Solvent 281
Terpenoids 281
Isoprene Rule 281
Special Isoprene Rule 281
Classification of Terpenoids 282
Evaluation of Volatile Oils 282
Chemical Tests 282
Storage of Volatile Oils 282
Pharmaceutical Applications 282
Volatile oils Containing Hydrocarbons 283
Turpentine Oil 283
Synonyms 283
Botanical Source 283
Geographical Source 283
Collection and Preparation 283
Characteristics 283
Chemical Constituents 283
Uses 283
Adulterants 283
Marketed Products 283
Volatile Oils Containing Alcohols 283
Peppermint 284
Synonym 284
Botanical Source 284
Geographical Source 284
Cultivation and Collection 284
Characteristics 284
Chemical Constituents 284
Uses 284
Adulterants 284
Marketed Products 284
Pudina 285
Synonyms 285
Biological Source 285
Geographical Source 285
History 285
Cultivation and Collection 285
Characteristics 285
Chemical Constituents 285
Uses 286
Marketed Products 286
Sandalwood Oil 286
Synonyms 286
Biological Source 286
Geographical Source 286
Cultivation 286
Characteristics 286
Microscopy 286
Chemical Constituents 287
Uses 287
Substitutes and Adulterants 287
Marketed Products 287
Volatile Oils Containing Aldehydes 287
Lemongrass Oil 287
Synonyms 287
Biological Source 287
Geographical Source 287
Cultivation 287
Characteristics 287
Chapter 18 - Drugs Containing Resins 318
Definition 318
Classification 318
Resin Acids 318
Resin Esters 318
Resin Alcohols 318
Resin Phenols 318
Glucoresins 318
Resenes 318
Oleoresins 319
Gum Resins 319
Oleogum Resins 319
Balsams 319
Chemical Composition 319
Isolation 319
Asafoetida 319
Synonyms 319
Biological Source 319
Geographical Source 319
Collection 319
Characteristics 320
Chemical Constituents 320
Chemical Tests 320
Uses 320
Adulteration 320
Allied Drugs 321
Marketed Products 321
Balsam of Peru 321
Synonyms 321
Biological Source 321
Geographical Source 321
Collection 321
Characteristics 321
Chemical Constituents 321
Chapter 19 - Drugs Containing Lipids 342
19.1. Introduction 342
19.2. Fixed Oils And Fats 342
Analytical Parameters for Fats and Oils 343
19.3. Waxes 343
Almond Oil 343
Biological Source 343
Geographical Source 343
Characteristics 343
Chemical Constituents 344
Uses 344
Marketed Products 344
Arachis Oil 344
Synonyms 344
Biological Source 344
Geographical Source 344
Characteristics 344
Cultivation 344
Chemical Constituents 345
Uses 345
Marketed Products 345
Castor Oil 345
Synonyms 345
Biological Source 345
Geographical Source 345
Preparation 345
Characteristics 346
Chapter 20 - Drugs Containing Tannins 362
Introduction 362
Classification 362
Hydrolysable Tannins 362
Nonhydrolysable or Condensed Tannins 363
Pseudotannins 363
Characteristics of Tannins 363
Biosynthesis of Tannins 363
Chemical Tests 363
Isolation 364
Medicinal Properties and Uses 364
Hydrolysable Tannins 364
Myrobalan 364
Synonyms 364
Biological Sources 364
Geographical Source 364
Collection and Preparation 364
Characteristics 365
Chemical Constituents 365
Uses 365
Marketed Products 365
Bahera 365
Synonyms 365
Biological Source 365
Geographical Source 365
Chapter 21 - Enzymes and Protein Drugs 377
Enzymes 377
Properties of Enzymes 377
Diastase 378
Synonym 378
Chapter 22 - Fibres, Sutures and Surgical Dressings 388
Introduction 388
History 388
Classification and Properties 388
Vegetable Fibres 389
Cotton 389
Synonyms 389
Biological Source 389
Geographical Source 389
History 389
Cultivation, Collection, and Preparation 390
Description 390
Chemical Constituents 390
Chemical Tests 390
Uses 390
Jute 390
Synonym 390
Biological Source 390
Geographical Source 390
History 390
Description 391
Preparation 391
Microscopy 391
Chemical Constituents 391
Uses 391
Flax 391
Biological Source 391
Geographical Source 391
History 391
Cultivation, Collection, and Preparation 391
Description 392
Microscopy 392
Chemical Composition 392
Chapter 23 - Drugs of Mineral Origin 399
Introduction 399
Kaolin 399
Synonyms 399
Source 399
History 399
Collection and Preparation 399
Description 399
PART G Extraction, Isolation And Purification Of Herbal Drugs \r 405
Chapter 24 - General Methods for Extraction, Isolation and Identification of Herbal Drugs 407
Introduction 407
Extraction Methods 407
Maceration 407
Percolation 408
Modified Percolation 408
Continuous Extraction 408
Soxhlet Extraction 408
Large-Scale Extraction 409
Supercritical Fluid Extraction 409
Advantages of SFE: 410
Disadvantages of SFE: 410
Types of Extracts 410
Aqueous Extracts 410
Isolation and Identification of Natural Products 411
Fractional Crystallization 411
Fractional Distillation 411
Fractional Liberation 411
Sublimation 411
Chromatography 411
Retention 412
Paper Chromatography (PC) 412
Thin Layer Chromatography 413
High-Performance Thin Layer Chromatography 413
Column Chromatography 413
Flash Column Chromatography 413
High-Performance Liquid Chromatography 413
Gas Chromatography 414
Spectroscopy 414
Ultraviolet-Visible Absorption Spectroscopy 415
Infrared Spectroscopy 415
Nuclear Magnetic Resonance Spectroscopy 415
Mass Spectroscopy 416
Chapter 25 - Isolation of Phytopharmaceuticals 417
Introduction 417
Isolation of atropine 417
Isolation 417
Identification 418
Thin Layer Chromatography of Atropine 418
Isolation of andrographolide 418
PART H Medicinal plant Biotechnology \r 435
Chapter 26 - Plant Tissue Culture 437
Introduction 437
Advantages of Tissue Culture Technique over the Conventional Cultivation Techniques 437
Availability of raw material 437
Fluctuation in supplies and quality 437
Patent rights 437
Political reasons 437
Easy purification of the compound 437
Modifications in chemical structure 437
Disease-free and desired propagule 437
Crop improvement 438
Biosynthetic pathway 438
Immobilization of cells 438
History 438
Basic Requirements for a Tissue Culture Laboratory 439
Equipment and Apparatus 439
Culture vessels and glassware 439
Equipment 439
Washing and storage facilities 440
Media preparation room 440
Sterilization Room 440
Aseptic chamber/area for transfer of culture 440
Incubation room or incubator 440
Data collection and recording the observation 441
General Procedures Involved in Plant Tissue Culture 441
Sterilization of Glassware Tools/Vessels 441
Cleaning of glassware 441
Preparation of Explant 441
Surface Sterilization of Explant 442
Seeds 442
Fruits 442
Stem 442
Leaves 442
Production of Callus from Explant 442
Proliferation of Callus 442
Sub-culturing of Callus 442
Suspension Culture 442
Culture Media 442
Media Composition 443
Inorganic nutrients 443
Organic nutrients 444
Plant growth regulators 444
Solidifying agents for solidification of the media 445
Gelling agent used to solidify liquid media 445
Media Preparation 445
Procedure 445
Concentration of the ingredients 446
Solution preparation 446
Semisolid media preparation 446
Sterilization of Culture Media 446
Types of Plant Tissue Cultures 446
Root Tip Culture 446
Leaves or Leaf Primordia Culture 446
Shoot Tip Culture 446
Complete Flower Culture 447
Anther and Pollens Culture 447
Ovule and Embryo Culture 447
Protoplast Culture 447
Hairy Root Culture 448
Establishment and Maintenance of various Cultures 448
Callus Culture 448
Initiation of callus culture 448
(a) Selection and preparation of explant 448
Preparation: 448
(b) Selection of culture medium 448
(c) Transfer of explant 448
(d) Incubation of culture 448
Induction 449
Cell division 449
Cell differentiation 449
Maintenance 449
Suspension Culture 449
Initiation of suspension culture 449
Growth pattern of suspension culture 450
Maintenance of suspension culture 451
Applications of Plant Tissue Culture 451
Production of Phytopharmaceuticals 451
Biochemical Conversion (Bio-transformation) 452
Clonal Propagation (Micro-Propagation) 452
Somaclonal Variation 452
Immobilization of Plant Cells 452
PART I Micellaneous\r 453
Chapter 27 - Ayurvedic Pharmacy 455
27.1. Introduction 455
27.2. Market potential 455
27.3. Asava and arista 455
Definition 455
Method of Preparation for Arista 455
Method of Preparation for Asava 456
General Precautions 456
Chapter 28 - Marine Pharmacognosy 461
28.1. Introduction 461
28.2. Marine organisms as potential source of drugs 461
28.3. Antiviral agents 462
Ara-A 462
Eudistomins 462
Didemnins 462
Avarol and Avarones 463
Patellazole B 463
Fucoidan 463
28.4. Antimicrobial agents 465
28.5. Antiparasitic agents 465
-Kainic Acid 465
Domoic Acid 465
Laminine 465
Bengamide F 466
Cucumechinoside F 466
28.6. Anticancer agents 466
Bryostatin I 466
28.7. Antispasmodic agents 467
Agelasidine A 467
28.8. Cardiovascular agents 467
Eledoisin 467
Octopamine 467
28.9. Antiinflammatory agents 467
28.10. Insecticides 468
28.11. Anticoagulants 468
28.12. Prostaglandins 468
28.13. Marine toxins 468
Tetrodotoxin 468
Saxitoxin 469
Ciguatoxin 469
Holothurin A 469
Aplysins 469
Lophotoxin 469
Lyngbyatoxin 469
28.14. Conclusion 470
Chapter 29 - Nutraceuticals and Cosmeceuticals 471
Nutraceuticals 471
Classification 471
Inorganic Mineral Supplements 472
Vitamin Supplement 472
Digestive Enzymes 472
Probiotics 473
Prebiotics 473
Dietary Fibres 473
Cereals and Grain 473
Health Drinks 474
Antioxidants 474
Polyunsaturated Fatty Acids 474
Herbs as Functional Foods 475
Flaxseeds 475
Ginkgo biloba 475
Spirulina 475
Ginseng 476
Garlic organosulphur compounds 476
Tea catechins 476
Citrus limonoids 477
Soya products 477
Tomato lycopenes 477
Momordica charantia 478
Turmeric curcuminoids 478
Black cohosh 478
Fenugreek 478
Market scenario of nutraceuticals 478
Regulatory obstacles 479
Standards and quality control 479
Emerging scenario 479
Conclusions 479
Cosmeceuticals 479
Skin cosmeceuticals 480
Sunscreens 481
Moisturizers 482
Bleaching Agents 482
Hair cosmeceuticals 482
Other cosmeceuticals 483
Regulatory aspects 483
Conclusions 483
Chapter 30 - Natural Pesticides 484
30.1. Introduction 484
30.2. Methods of Pest Control 484
Natural Controls 484
Artificial Control 484
30.3. Classification 485
Insecticides 485
Herbicides 485
Fungicides 485
Rodenticides 485
30.4. Essentials of a Good Pesticide 486
Pyrethrum Flowers 486
Synonym 486
Biological Source 486
Geographical Source 486
Cultivation and Collection 486
Characteristics 486
Chemical Constituents 486
Uses 487
Derris Roots 487
Synonym 487
Biological Source 487
Geographical Source 487
Characteristics 487
Microscopy 488
Chapter 31 - Poisonous Plants 495
31.1. Introduction 495
31.2. Definition of Poisonous Plants 495
31.3. Toxic Constituents of the Plants 495
31.4. Factors Determining the Toxicity of Plants 496
31.5. Classification of Poisonous Plants 497
Poisoning by Plants with Anticholinergic (Antimuscarinic) Poisons 497
Atropa Belladonna L 497
Family 497
Common Names 497
Description 497
Toxic Part 497
Toxins 497
Clinical Findings 497
Management 497
Poisoning by Plants with Calcium Oxalate Crystals 498
Alocasia Species 498
Chapter 32 - Natural Allergens 507
32.1. Allergens 507
32.2. What is Allergy 507
32.3. Types of Allergens 507
Inhalant Allergens 507
Pollen allergens 508
Ingestant Allergens 508
Injectant Allergens 508
Contactant Allergens 508
Infectant Allergens 509
Chapter 33 - Natural Colours and Dyes 510
33.1. Introduction 510
33.2. History 510
33.3. Types of natural dyes and mordants 511
Mordant 511
33.4. Natural dyes obtained from plants 511
Medicinal Properties of Natural Dyes 512
33.5. Natural dyes obtained from minerals 513
33.6. Natural dyes obtained from animals 513
33.7. Characterization of dyes 513
33.8. Chemistry of natural dyes 513
33.9. Preparation of dyes 513
33.10. Advantages And Limitations Of Natural Dyes 514
33.11. Technology for production of natural dyes 514
33.12. Genetic variation and dye content 514
33.13. Conclusions 515
Chapter 34 - Hallucinogenic Plants 516
34.1. Introduction 516
34.2. Medical Uses of Hallucinogens 516
Belladonna 517
PART J Traditional Drugs Of India \r 523
Chapter 35 - Detail Study of Traditional Drugs of India 525
Introduction 525
Adusa 525
Synonym 525
Regional Names 525
Biological Source 525
Family 525
Habitat 526
Macroscopy 526
Microscopy 526
Standards 526
Chemical Constituents 526
Uses 526
Marketed Formulations 526
Amla 526
Synonyms 526
Regional Names 526
Biological Source 526
Family 526
Habitat 527
Macroscopy 527
Microscopy 527
Standards 527
Chemical Constituents 527
Uses 527
Marketed Formulations 527
Apamarga 528
Synonym 528
Regional Names 528
Biological Source 528
Family 528
Habitat 528
Macroscopy 528
Index\r 555
A 555
B 557
C 558
D 560
E 560
F 561
G 561
H 562
I 562
J 563
K 563
L 563
M 564
N 565
O 565
P 566
Q 567
R 567
S 568
T 569
U 570
V 570
W 571
X 571
Y 571
Z 571
Biological Index 572
A 572
B 573
C 573
D 574
E 574
F 574
G 574
H 575
I 575
J 575
K 575
L 575
M 575
N 576
O 576
P 576
Q 577
R 577
S 577
T 577
U 578
V 578
W 578
X 578
Z 578