BOOK
Evolving Treatment Paradigms in Renal Cancer, An Issue of Urologic Clinics - E-Book
William C. Huang | Samir S. Taneja
(2012)
Additional Information
Book Details
Abstract
This issue of the Urologic Clinics provides a timely update on Renal Cancer and the evolving treatment standards in urology. Articles include Contemporary Imaging of the Renal Mass, Surgical Approach to Multifocal Renal Cancers, and Systemic Therapy Prior to Surgery. Effects of the various existing surgical approaches on long-term renal function is also discussed, along with a review of the current trends in surgical management of renal cancers with specific attention to utilization of laparoscopic approach, partial nephrectomy, ablative technologies and observation.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover\r | Cover | ||
| Evolving Treatment\rParadigms for Renal Cancer | i | ||
| Copyright Page\r | ii | ||
| Table of Contents\r | v | ||
| Contributors | iii | ||
| Foreword | xi | ||
| Chapter 1. Histologic Variants of Renal Cell Carcinoma: Does Tumor Type\rInfluence Outcome? | 1 | ||
| RENAL CELL CARCINOMA CLASSIFICATION\rAND OTHER PROGNOSTIC FACTORS | 1 | ||
| HISTOLOGIC TYPE OF RCC: MORPHOLOGIC, CLINICAL, AND MOLECULAR FEATURES OF EACH TYPE\rClear Cell RCC | 3 | ||
| OUTCOMES DATA BASED ON SERIES OF INDIVIDUAL HISTOLOGIC TYPES OF NON–CLEAR CELL COMPARED WITH CLEAR CELL RCC: Papillary RCC: Outcome with Focus on Type 1 Versus Type 2 | 5 | ||
| OUTCOME DATA IN LESS COMMON TYPES | 8 | ||
| OUTCOME ASSOCIATION ACROSS MAJOR\rHISTOLOGIC TYPES IN LOCALIZED RCC | 10 | ||
| DOES HISTOLOGIC TYPE INFLUENCE\rOUTCOME IN METASTATIC RCC? | 11 | ||
| SIGNIFICANCE OF HISTOLOGIC TYPE: INCORPORATION INTO PROGNOSTIC\rALGORITHMS IN RCC | 12 | ||
| SUMMARY | 12 | ||
| REFERENCES | 12 | ||
| Chapter 2. The Surgical Approach to Multifocal Renal Cancers: Hereditary Syndromes, Ipsilateral Multifocality, and\rBilateral Tumors | 15 | ||
| DEFINITIONS OF MULTIFOCALITY AND\rBILATERALITY | 15 | ||
| DESCRIPTION OF HEREDITARY RENAL\rSYNDROME PHENOTYPES | 16 | ||
| PRINCIPLES AND GOALS OF SURGICAL\rMANAGEMENT | 18 | ||
| WORKUP AND MANAGEMENT | 19 | ||
| TECHNICAL CONSIDERATIONS | 21 | ||
| SPECIAL FOLLOW-UP CONCERNS: RECURRENCE VERSUS DE NOVO TUMOR\rDEVELOPMENT | 23 | ||
| SUMMARY | 26 | ||
| REFERENCES | 26 | ||
| Chapter 3. Current Practice Patterns in the Surgical Management of Renal Cancer in\rthe United States | 31 | ||
| INTRODUCTION AND EPIDEMIOLOGY | 31 | ||
| OVERVIEW OF TREATMENT OPTIONS | 31 | ||
| TRENDS IN THE ADOPTION OF LRN\rVERSUS ORN | 32 | ||
| TRENDS IN THE ADOPTION OF PN | 34 | ||
| MINIMALLY INVASIVE PN | 38 | ||
| TRENDS IN THE USE OF ABLATIVE THERAPIES | 38 | ||
| TRENDS IN THE USE OF ACTIVE\rSURVEILLANCE | 39 | ||
| SUMMARY | 39 | ||
| REFERENCES | 39 | ||
| Chapter 4. Contemporary Imaging\rof the Renal Mass | 43 | ||
| ULTRASONOGRAPHY | 43 | ||
| CT | 43 | ||
| DUAL-ENERGY CT | 45 | ||
| MRI | 46 | ||
| ADVANCED MRI TECHNIQUES | 48 | ||
| SUMMARY | 50 | ||
| REFERENCES | 50 | ||
| Chapter 5. Approach to the Small Renal Mass: to Treat or\rNot to Treat | 53 | ||
| TREATMENT ALTERNATIVES AND CLINICAL\rGUIDELINES FOR SRM | 54 | ||
| PREDICTIVE MODELS FOR SRMS | 55 | ||
| SUMMARY | 59 | ||
| REFERENCES | 59 | ||
| Chapter 6. Does Renal Mass Ablation Provide Adequate Long-term\rOncologic Control? | 63 | ||
| THE RATIONALE FOR RA | 63 | ||
| INDICATIONS FOR RA | 63 | ||
| WHAT CONSTITUTES LONG-TERM\rONCOLOGIC SUCCESS? | 64 | ||
| MAKING SENSE OF DIFFERING EFFICA\rCYRATES BETWEEN RA SERIES | 64 | ||
| LONG-TERM OUTCOMES OF RFA | 65 | ||
| LONG-TERM OUTCOMES OF CRYOTHERAPY | 66 | ||
| ARE RFA AND CRYOTHERAPY EQUIVALENT? | 66 | ||
| COMPARISON WITH THE GOLD STANDARD:\rABLATION VERSUS SURGERY | 69 | ||
| FUTURE STUDIES | 71 | ||
| SUMMARY | 71 | ||
| REFERENCES | 71 | ||
| Chapter 7. The Influence of Surgical Approach to the Renal Mass\ron Renal Function | 73 | ||
| TREATMENT OPTIONS FOR PATIENTS WITH\rLOCALIZED KIDNEY TUMORS | 73 | ||
| AUA GUIDELINES | 74 | ||
| THE APPLICABILITY OF OUTCOMES OF\rDONOR NEPHRECTOMY | 74 | ||
| RADICAL NEPHRECTOMY | 75 | ||
| PARTIAL NEPHRECTOMY | 76 | ||
| THERMAL ABLATION | 77 | ||
| ACTIVE SURVEILLANCE | 77 | ||
| SUMMARY | 78 | ||
| REFERENCES | 78 | ||
| Chapter 8. Partial Nephrectomy: Contemporary Outcomes, Candidate Selection, and\rSurgical Approach | 81 | ||
| OUTCOMES: ONCOLOGIC, COMPLICATIONS,\rRENAL FUNCTION | 81 | ||
| CANDIDATE SELECTION | 85 | ||
| SURGICAL APPROACH | 87 | ||
| SUMMARY | 90 | ||
| REFERENCES | 90 | ||
| Chapter 9. Integration of Surgery and Systemic Therapy for Renal Cell\rCarcinoma | 93 | ||
| NOMENCLATURE | 93 | ||
| ADJUVANT THERAPY FOR RCC AT INCREASED\rRISK OF RELAPSE | 93 | ||
| NEOADJUVANT THERAPY FOR LOCALLY\rADVANCED RCC | 100 | ||
| INTEGRATING SURGERY AND SYSTEMIC\rTHERAPY IN METASTATIC DISEASE | 104 | ||
| SUMMARY | 108 | ||
| REFERENCES | 108 | ||
| Chapter 10. Defining an Individualized Treatment Strategy for Metastatic Renal\rCancer | 115 | ||
| RELEVANT BIOLOGIC PATHWAYS IN RCC | 115 | ||
| OVERVIEW OF TREATMENTS OF mRCC\rSurgery | 116 | ||
| PROGNOSTICATION | 118 | ||
| PREDICTING RESPONSE TO SYSTEMIC\rTHERAPY | 119 | ||
| TREATMENT PARADIGM BASED ON\rINDIVIDUALIZED FACTORS | 123 | ||
| FUTURE OF INDIVIDUALIZED THERAPY | 127 | ||
| SUMMARY | 127 | ||
| REFERENCES | 127 | ||
| Index | 133 |