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The Lymphatic System in Thoracic Oncology,  An Issue of Thoracic Surgery Clinics - E-Book

The Lymphatic System in Thoracic Oncology, An Issue of Thoracic Surgery Clinics - E-Book

Federico Venuta | Erino A. Rendina

(2012)

Additional Information

Book Details

Abstract

The aim of this issue is to provide the thoracic surgeon with information about the staging and treatment of cancer to the mediastinal lymph nodes. The issue includes articles on the anatomy and physiology of the lymph nodes, imaging of the lymph nodes, and various techniques for diagnosing and dissecting the lymph nodes, including video-assisted mediastinoscopic lymphadenectomy and transcervical extended mediastinal lymphadenectomy.

Table of Contents

Section Title Page Action Price
Front Cover\r Cover
The Lymphatic System in\rThoracic Oncology i
Copyright Page ii
Table of Contents v
Contributors iii
Preface: The Lymphatic System in Thoracic Oncology ix
Chapter 1. Anatomy and Physiology of the Thoracic Lymphatic\rSystem 139
GENERALITIES ON THORACIC LYMPHATICS 139
LYMPHATIC SYSTEM OF THORACIC ORGANSAND STRUCTURES 140
LYMPHATIC COLLECTORS OF THE MEDIASTINUM 145
NODAL CHAINS OF THE MEDIASTINUM 145
ANATOMIC DISTRIBUTION OF MEDIASTINAL NODES AND NODE CLASSIFICATION FOR LUNG CANCER 146
ANATOMIC DISTRIBUTION OF THE MEDIASTINAL NODES AND NODES CLASSIFICATION FOR ESOPHAGEAL CANCER 151
ANATOMY AND PHYSIOLOGY OF THE THORACIC DUCT 151
SUMMARY 151
REFERENCES 151
Chapter 2. Computed Tomography and Magnetic Resonance Imaging of the Thoracic Lymphatic System 155
CHEST RADIOGRAPHY 155
CT AND MRI OF THE THORACIC\rLYMPHATIC SYSTEM 156
REFERENCES 159
Chapter 3. PET Staging of Mediastinal Lymph Nodes in Thoracic Oncology 161
NON–SMALL CELL LUNG CANCER 161
ESOPHAGEAL CANCER 163
SUMMARY 165
REFERENCES 165
Chapter 4. MicroRNAs and Lymph Node Metastatic Disease in Lung Cancer 167
MICRORNA BIOGENESIS 168
MICRORNAS ALTERED IN LUNG CANCER:\rONCOGENES AND TUMOR SUPPRESSORS 168
ROLE OF MICRORNAS IN METASTATIC\rPROGRESSION 170
MICRORNA INVOLVEMENT IN LYMPH NODE\rMETASTASIS IN LUNG CANCER 171
MICRORNA EXPRESSION AS A PREDICTIVE\rMARKER FOR LYMPH NODE METASTASIS 171
HYPERMETHYLATION OF SPECIFIC MICRORNA GENOMIC LOCI AS A PREDICTIVE\rMARKER FOR LYMPH NODE METASTASIS 172
MICRORNAS ARE DIFFERENTIALLY EXPRESSED BETWEEN PRIMARY TUMORS\rAND METASTATIC LYMPH NODES 172
SUMMARY 173
REFERENCES 173
Chapter 5. Invasive Staging of Mediastinal Lymph Nodes: Mediastinoscopy and Remediastinoscopy 177
MEDIASTINOSCOPY 178
REMEDIASTINOSCOPY 184
SUPPLEMENTARY DATA 186
REFERENCES 186
Chapter 6. Ultrasound-Guided Transbronchial and Transesophageal Needle Biopsy in the Mediastinal Staging of Lung Cancer 191
EBUS 191
EUS 194
COMBINED ULTRASONOGRAPHY 196
DIAGNOSTIC YIELD 197
SPECIAL CONSIDERATIONS 198
SUMMARY 201
REFERENCES 201
Chapter 7. Sentinel Lymph Nodein Lung Cancer\rSurgery 205
THE CONCEPT OF SENTINEL LYMPH NODE\rIN NSCLC 206
SLN TECHNIQUES 207
THE AUTHORS’ EXPERIENCE 208
RESULTS 210
COMMENT 211
REFERENCES 212
Chapter 8. Thoracoscopic and Robotic Dissection of Mediastinal\rLymph Nodes 215
ANATOMY 215
INDICATIONS 216
THORACOSCOPIC LYMPH NODE DISSECTION 217
ROBOTIC DISSECTION OF MEDIASTINAL\rNODES 218
SUMMARY 218
REFERENCES 218
Chapter 9. Video-Assisted Mediastinoscopic Lymphadenectomy\rand Transcervical Extended Mediastinal Lymphadenectomy 219
MATERIAL AND METHODS 219
SURGICAL TECHNIQUE OF VAMLA 219
SURGICAL TECHNIQUE OF TEMLA 220
RESULTS 223
DISCUSSION 224
REFERENCES 224
Chapter 10. The Role of Lymphadenectomy in Lung Cancer Surgery 227
LYMPH NODE DRAINAGE PATTERNS 227
CLASSIFICATION OF LYMPH NODE\rINVOLVEMENT 228
TECHNIQUES FOR INTRAOPERATIVE LYMPH NODE REMOVAL AND EXTENT OF LYMPH NODE DISSECTION 229
IMPACT OF LYMPHADENECTOMY ON SURVIVAL AND RECURRENCE RATE 230
ACCURACY OF STAGING 232
COMPLICATIONS OF LYMPH NODE\rDISSECTION 233
SURGICAL APPROACHES FOR MLND 234
ACKNOWLEDGMENTS 234
REFERENCES 234
Chapter 11. The Impact of Complete Lymph Node Dissection for Lung Cancer on the Postoperative Course 239
DEFINITIONS 239
COMPARISON BETWEEN LNS AND LND 240
GERMAN STUDY 240
JAPANESE STUDY 241
CHINESE STUDY 241
AMERICAN STUDY 241
REFERENCES 242
Chapter 12. The Impact of Chemotherapy on the\rLymphatic System in Thoracic Oncology 243
IMPACT OF ADJUVANT TREATMENT ON THORACIC LYMPH NODE INVOLVEMENT 244
IMPACT OF NEOADJUVANT TREATMENT ON THORACIC LYMPH NODE INVOLVEMENT 245
COMMENT 247
SUMMARY 248
REFERENCES 248
Index 251