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Current Concepts in Bone Pathology, An Issue of Surgical Pathology Clinics E-Book

Current Concepts in Bone Pathology, An Issue of Surgical Pathology Clinics E-Book

John D. Reith

(2012)

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Book Details

Abstract

Bone Tumor Radiology 101 for Pathologists; Update on Arthritis; Periprosthetic Infections; Bone Cytology: A Realistic Approach for Clinical Utilization; Benign Bone-Forming Tumors; Osteocarcoma Differential Diagnosis Considerations; Osteocarcoma Differential Diagnosis Considerations; Well-differentiated Cartilage Tumors; Chondrosarcoma Variants; Giant Cell Tumor: Overview and Update; Fibro-osseous Lesions; Round Cell Tumors; Vascular Tumors; Pseudotumors and Reactive Lesions; Practical Work-up of Metastatic Carcinoma; Update on Treatment of Bone Tumors

Table of Contents

Section Title Page Action Price
Front Cover Cover
Surgical Pathology Clinics i
Copyright Page ii
Table of Contents v
Contributors iii
Surgical Pathology Clinics viii
Bone Pathology: Pathology, Radiology, and Orthopedics ix
CHAPTER 1. BONE TUMOR RADIOLOGY 101 FOR PATHOLOGISTS 1
ABSTRACT 1
OVERVIEW: BONE IMAGING 1
SUMMARY 13
REFERENCES 13
CHAPTER 2. ARTHRITIS PATHOLOGY 15
ABSTRACT 15
OVERVIEW: BASIC CONCEPT OF ARTHRITIS 15
SUMMARY 64
REFERENCES 64
CHAPTER 3. THE ROLE OF THE PATHOLOGIST IN DIAGNOSING PERIPROSTHETIC INFECTION 67
ABSTRACT 67
OVERVIEW 67
DIAGNOSTIC TESTS FOR ARTHROPLASTY INFECTION 69
INTERPRETATION OF FROZEN SECTIONS OF PERI-IMPLANT TISSUES 70
MOLECULAR TECHNIQUES TO DIAGNOSE INFECTIONS 75
REFERENCES 76
CHAPTER 4. BONE CYTOLOGY: A REALISTIC APPROACH FOR CLINICAL USE 79
ABSTRACT 79
OVERVIEW: CRITICAL PREANALYTICAL FACTORS AND CONSIDERATIONS 79
BENIGN LESIONS 80
MALIGNANT LESIONS (PRIMARY) 87
HEMATOPOIETIC NEOPLASMS 94
REFERENCES 99
CHAPTER 5. BENIGN BONEFORMING TUMORS: APPROACH TO DIAGNOSIS AND CURRENT UNDERSTANDING OF PATHOGENESIS 101
ABSTRACT 101
OVERVIEW 101
OSTEOMAS 102
OSTEOID OSTEOMAS 105
OSTEOBLASTOMAS 109
SUMMARY 114
REFERENCES 114
CHAPTER 6. OSTEOSARCOMA: DIFFERENTIAL DIAGNOSTIC CONSIDERATIONS 117
ABSTRACT 117
OVERVIEW 117
CONVENTIONAL OGS, OSTEOBLASTIC TYPE VERSUS OSTEOBLASTOMA 119
CONVENTIONAL OGS, OSTEOBLASTIC TYPE VERSUS OSTEOID OSTEOMA 123
CONVENTIONAL OGS, OSTEOBLASTIC TYPE VERSUS FRACTURE CALLUS 123
CONVENTIONAL OGS, CHONDROBLASTIC TYPE, VERSUS CONVENTIONAL SKELETAL CHONDROSARCOMA 123
CONVENTIONAL OGS, CHONDROBLASTIC TYPE, VERSUS DEDIFFERENTIATED CHONDROSARCOMA 127
CONVENTIONAL OGS, CHONDROBLASTIC TYPE, VERSUS CLEAR CELL CHONDROSARCOMA 127
CONVENTIONAL OGS, FIBROBLASTIC TYPE, VERSUS FIBROSARCOMA OF BONE, UNDIFFERENTIATED PLEOMORPHIC SARCOMA OF BONE, AND PRIMARY LEIOMYOSARCOMA OF BONE 127
TELANGIECTATIC OGS VERSUS ANEURYSMAL BONE CYST 129
SMALL CELL OGS VERSUS OTHER SMALL ROUND CELL TUMORS OF BONE 131
LOW-GRADE INTRAOSSEOUS (CENTRAL) OGS VERSUS FIBROUS DYSPLASIA, OSTEOFIBROUS DYSPLASIA, AND DESMOPLASTIC FIBROMA 131
GIANT CELL-RICH OGS VERSUS GIANT CELL TUMOR OF BONE 134
PAROSTEAL OGS VERSUS FIBROUS DYSPLASIA 134
PAROSTEAL OGS VERSUS OSTEOCHONDROMA 134
PAROSTEAL OGS VERSUS HETEROTOPIC OSSIFICATION 135
PAROSTEAL OGS VERSUS SURFACE OSTEOMA 136
PAROSTEAL OGS VERSUS HIGH-GRADE SURFACE OSTEOSARCOMA 136
PERIOSTEAL OGS VERSUS CHONDROBLASTIC OGS 138
PERIOSTEAL OGS VERSUS HIGH-GRADE SURFACE OSTEOSARCOMA 139
PERIOSTEAL OGS VERSUS JUXTACORTICAL/ PERIOSTEAL CHONDROSARCOMA AND OSTEOCHONDROMA 139
JUXTACORTICAL OGS VERSUS REACTIVE SURFACE LESIONS 142
SUMMARY 143
REFERENCES 143
CHAPTER 7. WELL-DIFFERENTIATED CENTRAL CARTILAGE TUMORS OF BONE: AN OVERVIEW 147
ABSTRACT 147
OVERVIEW 147
CENTRAL CARTILAGE TUMORS: ENCHONDROMA VERSUS LOW-GRADE CHONDROSARCOMA 148
ENCHONDROMATOSIS 160
REFERENCES 160
CHAPTER 8. CHONDROSARCOMA VARIANTS 163
ABSTRACT 163
OVERVIEW 163
DEDIFFERENTIATED CHONDROSARCOMA 163
MESENCHYMAL CHONDROSARCOMA 167
CLEAR CELL CHONDROSARCOMA 173
EXTRASKELETAL” MYXOID CHONDROSARCOMA (CHORDOID SARCOMA) 176
REFERENCES 180
CHAPTER 9. GIANT CELL TUMOR OF BONE 183
ABSTRACT 183
OVERVIEW 183
RADIOGRAPHIC FEATURES OF GIANT CELL TUMOR OF BONE 184
GROSS FEATURES OF GIANT CELL TUMOR OF\r\nBONE 185
MICROSCOPIC FEATURES OF GIANT CELL TUMOR OF BONE 185
TUMOR BIOLOGY 186
DIAGNOSIS OF GIANT CELL TUMOR OF BONE 192
DIFFERENTIAL DIAGNOSIS OF GIANT CELL TUMOR OF BONE 192
BEHAVIOR AND PROGNOSIS OF GIANT CELL TUMOR OF BONE 198
SUMMARY: GIANT CELL TUMOR OF BONE 199
REFERENCES 199
CHAPTER 10. FIBRO-OSSEOUS LESIONS 201
ABSTRACT 201
FIBROUS DYSPLASIA 201
CLINICAL FEATURES OF FIBROUS DYSPLASIA 201
RADIOGRAPHIC FEATURES OF FIBROUS DYSPLASIA 202
GROSS FEATURES OF FIBROUS DYSPLASIA 204
MICROSCOPIC FEATURES OF FIBROUS DYSPLASIA 204
DIFFERENTIAL DIAGNOSIS OF FIBROUS DYSPLASIA 209
MOLECULAR PATHOLOGY OF FIBROUS DYSPLASIA 209
FIBROUS DYSPLASIA IN DIFFERENT ANATOMIC SITES 210
MCCUNE-ALBRIGHT AND MAZABRAUD SYNDROMES 210
TREATMENT OF FIBROUS DYSPLASIA 211
PROGNOSIS OF FIBROUS DYSPLASIA 211
OSTEOFIBROUS DYSPLASIA 211
CLINICAL FEATURES OF OSTEOFIBROUS DYSPLASIA 212
RADIOGRAPHIC FEATURES OF OSTEOFIBROUS DYSPLASIA 212
GROSS FEATURES OF OSTEOFIBROUS DYSPLASIA 212
MICROSCOPIC FEATURES OF OSTEOFIBROUS DYSPLASIA 212
IMMUNOHISTOCHEMISTRY OF OSTEOFIBROUS DYSPLASIA 213
DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF OSTEOFIBROUS DYSPLASIA 213
MOLECULAR PATHOLOGY OF OSTEOFIBROUS DYSPLASIA 216
TREATMENT AND PROGNOSIS OF OSTEOFIBROUS DYSPLASIA 216
ADAMANTINOMA OF LONG BONES 216
REFERENCES 226
CHAPTER 11. SMALL ROUND CELL TUMORS OF BONE 231
ABSTRACT 231
EWING SARCOMA/PRIMITIVE NEUROECTODERMAL TUMOR (EWING SARCOMA FAMILY OF TUMORS) 231
HEMATOPOIETIC NEOPLASMS OF BONE 242
SMALL CELL OSTEOSARCOMA 248
MESENCHYMAL CHONDROSARCOMA 249
METASTATIC DISEASE AND OTHER RARE TUMORS 250
DIAGNOSTIC APPROACH TO THE DIFFERENTIAL DIAGNOSIS 251
SUMMARY 252
REFERENCES 252
CHAPTER 12. PSEUDOTUMORS AND REACTIVE LESIONS 257
ABSTRACT 257
OVERVIEW 257
HETEROTOPIC BONE 257
TUMORAL CALCINOSIS 270
DIRECT BONE INJURY MIMICKING NEOPLASMS 274
FLORID REACTIVE BONE RESORPTION 277
GIANT CELL REPARATIVE GRANULOMA 280
REFERENCES 284
CHAPTER 13. SKELETAL METASTASIS 287
ABSTRACT 287
OVERVIEW OF BONE METASTASIS 287
METASTATIC CARCINOMA 287
METASTATIC MELANOMA 294
METASTATIC SARCOMA 296
REFERENCES 298
CHAPTER 14. TREATMENT OF BONE TUMORS 301
ABSTRACT 301
OSTEOSARCOMA 301
CHONDROSARCOMA 306
EWING SARCOMA 310
REFERENCES 314
Index 319