BOOK
Interstitial Lung Disease, An Issue of Clinics in Chest Medicine - E-Book
Talmadge E King | Harold R Collard | Luca Richeldi
(2012)
Additional Information
Book Details
Abstract
The guest editors for this issue, Talmadge King, Harold Collard, celebrated pulmonary specialists from UCSF, and Luca Richeldi, renowned visiting professor to UCSF from University of Modena, Italy, bring together a state-of-the-art issue on the important topic of Interstitial Lung Diseases (ILD). This comprehensive issue reviews the approach to diagnosis of ILD, radiology if ILD, pathology of ILD. Idiopathic pulmonary fibrosis is discussed, including phenotypes and comorbidities, acute exacerbation and accelerated decline, management, and pathobiology of novel approaches to therapy. Connective Tissue ILD, Chronic Hypersensitivity Pneumonitis, familial ILD and smoking-related ILD, and non-specific interstitial pneumonia are reviewed. In the final article, lung transplantation is discussed.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Clinics in Chest Medicine | i | ||
| Copyright Page | ii | ||
| Table of Contents | vii | ||
| Contributors | iii | ||
| Clinics in Chest Medicine | xi | ||
| Preface | xiii | ||
| Chapter 1. Approach to the Diagnosis of Interstitial Lung Disease | 1 | ||
| CLINICAL EVALUATION | 1 | ||
| PHYSICAL EXAMINATION | 3 | ||
| LABORATORY TESTING | 4 | ||
| PULMONARY FUNCTION TESTING | 4 | ||
| RADIOLOGIC ASSESSMENT | 5 | ||
| BRONCHOSCOPY | 5 | ||
| SURGICAL LUNG BIOPSY | 7 | ||
| ASSESSMENT OF PH | 7 | ||
| DIAGNOSTIC ALGORITHM | 9 | ||
| CLASSIFICATION OF DISEASE BEHAVIOR | 9 | ||
| REFERENCES | 9 | ||
| Chapter 2. Radiological Approach to Interstitial Lung Disease: A Guide for the Nonradiologist | 11 | ||
| BASIC ARCHITECTURE OF THE LUNG INTERSTITIUM | 11 | ||
| APPROACH TO HRCT | 11 | ||
| INCREASED ATTENUATION | 12 | ||
| DECREASED ATTENUATION | 13 | ||
| SPECIFIC DISEASES | 14 | ||
| IDIOPATHIC INTERSTITIAL PNEUMONIAS | 16 | ||
| COLLAGEN VASCULAR DISEASES | 22 | ||
| SUMMARY | 24 | ||
| REFERENCES | 24 | ||
| Chapter 3. Histopathologic Approach to the Surgical Lung Biopsy in Interstitial Lung Disease | 27 | ||
| WHAT DOES NORMAL LOOK LIKE | 27 | ||
| IS THIS ACUTE LUNG INJURY | 28 | ||
| IS THERE FIBROSIS | 29 | ||
| IS THIS USUAL INTERSTITIAL PNEUMONIA | 29 | ||
| IS THIS NONSPECIFIC INTERSTITIAL PNEUMONIA | 32 | ||
| IS THE FIBROSIS BRONCHIOLOCENTRIC | 33 | ||
| IS THE BIOPSY TOO CELLULAR OR INFLAMED | 33 | ||
| IS THIS CELLULAR NONSPECIFIC INTERSTITIAL PNEUMONIA | 34 | ||
| ARE THERE GRANULOMAS | 34 | ||
| HOW CAN THE GRANULOMAS BE FURTHER CLASSIFIED | 34 | ||
| THIS LOOKS NORMAL, WHAT AM I MISSING | 37 | ||
| IS THERE A DIAGNOSIS THAT I AM FORGETTING | 39 | ||
| REFERENCES | 39 | ||
| Chapter 4. Idiopathic Pulmonary Fibrosis: Diagnosis and Epidemiology | 41 | ||
| THE DIAGNOSIS OF IPF | 41 | ||
| THE EPIDEMIOLOGY OF IPF | 42 | ||
| SUMMARY | 48 | ||
| REFERENCES | 49 | ||
| Chapter 5. Idiopathic Pulmonary Fibrosis: Phenotypes and Comorbidities | 51 | ||
| ARE THERE DISTINCT PHENOTYPES IN IPF? | 51 | ||
| OTHER COMORBIDITIES IN IPF | 53 | ||
| SUMMARY | 55 | ||
| REFERENCES | 55 | ||
| Chapter 6. Acute Exacerbation of Idiopathic Pulmonary Fibrosis | 59 | ||
| INCIDENCE | 59 | ||
| RISK FACTORS | 61 | ||
| ETIOLOGY | 61 | ||
| PATHOGENESIS AND PATHOBIOLOGY | 62 | ||
| PRECIPITATING FACTORS | 63 | ||
| BIOMARKERS | 63 | ||
| PATHOLOGY | 64 | ||
| RADIOLOGY | 64 | ||
| DIAGNOSIS | 64 | ||
| TREATMENT | 64 | ||
| ACUTE RESPIRATORY WORSENING OF OTHER CONDITIONS | 65 | ||
| SUMMARY | 65 | ||
| ACKNOWLEDGMENTS | 65 | ||
| REFERENCES | 65 | ||
| Chapter 7. Idiopathic Pulmonary Fibrosis: Pathobiology of Novel Approaches to Treatment | 69 | ||
| THE PATHOGENESIS OF IPF: SHIFTING PARADIGMS | 69 | ||
| TREATMENT DEVELOPMENT CHALLENGES: AN EMBARRASSMENT OF RICHES BUT A LACK OF TOOLS | 71 | ||
| THE IPF TREATMENT LANDSCAPE: PAST AND PRESENT | 71 | ||
| WHAT CAN BE LEARNT FROM IPF TRAIL FAILURES? | 72 | ||
| EMERGING TREATMENT TARGETS IN IPF | 73 | ||
| SUMMARY | 78 | ||
| REFERENCES | 78 | ||
| Chapter 8. Management of Idiopathic Pulmonary Fibrosis | 85 | ||
| PHARMACOLOGIC TREATMENTS | 85 | ||
| MANAGEMENT OF COMORBIDITIES | 89 | ||
| MANAGEMENT OF ACUTE EXACERBATION OF IPF | 89 | ||
| NONPHARMACOLOGIC TREATMENTS | 90 | ||
| LUNG TRANSPLANTATION | 91 | ||
| SUMMARY | 91 | ||
| REFERENCES | 92 | ||
| Chapter 9. Genetic Interstitial Lung Disease | 95 | ||
| GENETIC DISORDERS AFFECTING MULTIPLE ORGANS, INCLUDING THE LUNG | 95 | ||
| GENETIC DISEASES PRIMARILY AFFECTING THE LUNG | 99 | ||
| CLINICAL MANAGEMENT OF GENETIC INTERSTITIAL LUNG DISEASES | 103 | ||
| REFERENCES | 105 | ||
| Chapter 10. Nonspecific Interstitial Pneumonia | 111 | ||
| THE CLINICAL ENTITY OF NONSPECIFIC INTERSTITIAL PNEUMONITIS | 111 | ||
| HISTORY OF THE NOMENCLATURE OF IIPS | 111 | ||
| NSIP HISTOPATHOLOGIC PATTERN | 112 | ||
| THE AMERICAN THORACIC SOCIETY WORKING GROUP ON IDIOPATHIC NSIP | 113 | ||
| CLINICAL PRESENTATION | 113 | ||
| RADIOGRAPHY | 114 | ||
| DIAGNOSTIC APPROACH | 115 | ||
| PROGNOSIS | 116 | ||
| UCTD | 116 | ||
| MANAGEMENT AND TREATMENT | 117 | ||
| REFERENCES | 119 | ||
| Chapter 11. Interstitial Lung Disease in the Connective Tissue Diseases | 123 | ||
| GENERAL APPROACH | 124 | ||
| SYSTEMIC SCLEROSIS (SCLERODERMA) | 132 | ||
| IDIOPATHIC INFLAMMATORY MYOPATHIES | 134 | ||
| SJO¨ GREN SYNDROME | 136 | ||
| SLE | 138 | ||
| SUMMARY | 139 | ||
| REFERENCES | 139 | ||
| Chapter 12. Chronic Hypersensitivity Pneumonitis | 151 | ||
| CAUSATIVE AGENTS | 151 | ||
| EPIDEMIOLOGY | 154 | ||
| PATHOGENESIS | 154 | ||
| PATHOLOGY | 155 | ||
| CLINICAL FEATURES | 155 | ||
| INVESTIGATIONS | 156 | ||
| DIAGNOSIS | 158 | ||
| NATURAL HISTORY AND PROGNOSIS | 159 | ||
| MANAGEMENT | 160 | ||
| SUMMARY | 160 | ||
| REFERENCES | 161 | ||
| Chapter 13. Smoking-Related Interstitial Lung Diseases | 165 | ||
| SMOKING AND ILD | 165 | ||
| MECHANISMS BY WHICH TOBACCO SMOKE MAY PROMOTE ILD | 167 | ||
| RB-ILD | 168 | ||
| DIP | 169 | ||
| PLCH | 170 | ||
| ACUTE ILD ASSOCIATED WITH SMOKING | 172 | ||
| SMOKING AND PULMONARY FIBROSIS | 172 | ||
| ILDs THAT ARE LESS COMMON IN SMOKERS | 173 | ||
| SUMMARY | 173 | ||
| REFERENCES | 174 | ||
| Chapter 14. Lung Transplantation for Interstitial Lung Disease | 179 | ||
| WHO SHOULD BE REFERRED AND LISTED FOR TRANSPLANT? | 179 | ||
| DISEASE-SPECIFIC CONSIDERATIONS | 183 | ||
| SUMMARY | 186 | ||
| REFERENCES | 186 | ||
| Index | 191 |