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PET Imaging of Lymphoma, An Issue of PET Clinics - E-Book

PET Imaging of Lymphoma, An Issue of PET Clinics - E-Book

Rebecca Elstrom | Stephen Schuster

(2012)

Additional Information

Book Details

Abstract

This issue provides a complete update on PET imaging of lymphoma, starting with a clinical assessment of lymphoma and the role of medical imaging. The role of structural imaging in lymphoma is then discussed.  From a Nuclear Medicine perspective, FDG-PET in lymphoma is reviewed, as is the role of FDG-PET in pediatric lymphoma.  Next, the role of non-FDG tracers in lymphoma is reviewed.  Other articles cover the role of fMRI and optical imaging in lymphoma, the role of diffusion-weighted MRI in lymphoma, FDG-PET in personalization of therapy in patients with lymphoma, and PET and radiation oncology in lymphoma.

Table of Contents

Section Title Page Action Price
Front Cover Cover
PET Imaging of Lymphoma: PET Clinics i
Copyright Page ii
Table of Contents vii
Contributors iii
Preface: PET Imaging of Lymphoma xiii
Chapter 1. Role of Structural Imaging in Lymphoma 1
STAGING AND RESPONSE ASSESSMENT IN LYMPHOMA 1
GROWTH AND DISTRIBUTION PATTERNS OF HL AND NHL 1
ROLE OF CROSS-SECTIONAL STRUCTURAL IMAGING IN LYMPHOMA 2
CROSS-SECTIONAL STRUCTURAL IMAGING MODALITIES IN LYMPHOMA: GENERAL CONSIDERATIONS CT 4
USEFULNESS OF CT AND MR IMAGING (AND US) IN SEVERAL BODY REGIONS 7
ADVANCED CT, MR IMAGING, AND US TECHNIQUES 12
SUMMARY 16
REFERENCES 16
Chapter 2. FDG-PET in Lymphoma: Nuclear Medicine Perspective 21
INITIAL STAGING 22
FDG-PET IN END-TREATMENT RESPONSE ASSESSMENT 24
PET FOR FOLLOW-UP OF LYMPHOMA 28
PET FOR RESPONSE PREDICTION BEFORE HIGH-DOSE SALVAGE THERAPY 28
SUMMARY 29
REFERENCES 29
Chapter 3. The Evolving Role of Medical Imaging in Lymphoma Management: The Clinician’s Perspective 35
INTRODUCTION TO LYMPHOMAS 35
DIAGNOSIS: THE ROLE OF IMAGING 37
STAGING: IMAGING OPTIONS 37
ASSESSMENT OF BONE MARROW INVOLVEMENT BY IMAGING 40
INTERIM IMAGING DURING THERAPY 40
ASSESSMENT OF RESIDUAL MASSES 41
FOLLOW-UP AFTER FINISHING TREATMENT AND MONITORING FOR RELAPSE 41
FUTURE ROLE OF IMAGING IN MANAGEMENT OF LYMPHOMAS 42
REFERENCES 42
Chapter 4. Review of Clinical Applications of Fluorodeoxyglucose-PET/Computed Tomography in Pediatric Patients with Lymphoma 47
PET/CT FOR INITIAL STAGING 47
PET/CT FOR INTERIM AND POSTTHERAPY STUDIES 49
PET/CT FOR EVALUATION OF NODAL AND EXTRANODAL DISEASE 51
FDG-PET/CT IN EVALUATION OF NODAL LESIONS 51
FDG-PET/CT IN EVALUATION OF EXTRANODAL LESIONS 52
ASSOCIATED INFLAMMATORY/INFECTIOUS FINDINGS 54
SUMMARY 54
REFERENCES 55
Chapter 5. Role of Positron Emission Tomography with Fludeoxyglucose F 18 in Personalization of Therapy in Patients with Lymphoma 57
CURRENT LEVEL OF EVIDENCE DLBCL 57
HL 60
OTHER LYMPHOMA SUBTYPES: RECENT HIGHLIGHTS 62
RECOMMENDATIONS 63
REFERENCES 63
Chapter 6. The Use of PET in Radiation Therapy for Lymphoma 67
CAN FDG-PET RESPONSE BE USED TO OMIT CONSOLIDATIVE RADIATION? 67
FDG-PET/CT IN RADIATION TREATMENT PLANNING FOR LYMPHOMA 68
SUMMARY 71
DOES RADIATION INTERFERE WITH EARLY INTERVAL FDG-PET SCANNING? 71
REFERENCES 71
Chapter 7. Evolving Importance of Diffusion-Weighted Magnetic Resonance Imaging in Lymphoma 73
CURRENT ROLE OF IMAGING IN LYMPHOMA 73
18F-FLUORODEOXYGLUCOSE PET/COMPUTED TOMOGRAPHY 73
WHOLE-BODY MAGNETIC RESONANCE IMAGING 74
BASICS OF (WHOLE-BODY) DWI 74
WHOLE-BODY DIFFUSION-WEIGHTED IMAGING 74
DEVELOPMENT OF WHOLE-BODY DWI 75
GENERAL CHALLENGES ASSOCIATED WITH THE EVALUATION OF WHOLE-BODY DWI 76
WHOLE-BODY DWI FOR THE STAGING OF LYMPHOMA 77
WHOLE-BODY DWI FOR THERAPY RESPONSE ASSESSMENT IN LYMPHOMA 78
SUMMARY 80
REFERENCES 80
Chapter 8. Novel PET Radiotracers for Potential Use in Management of Lymphoma 83
IMAGING TUMOR PROLIFERATION 83
SUMMARY 94
IMAGING TUMOR HYPOXIA 95
FMISO versus Cu-ATSM 96
SUMMARY 99
IMAGING TUMOR ANGIOGENESIS 99
SUMMARY 103
IMAGING APOPTOSIS 103
SUMMARY 106
IMAGING AMINO ACID METABOLISM 106
Chapter 9. Prediction and Early Detection of Response by NMR Spectroscopy and Imaging 119
ACKNOWLEDGMENTS 125
REFERENCES 125
Chapter 10. Diffuse Optical Technology: A Portable and Simple Method for Noninvasive Tissue Pathophysiology 127
REFERENCES 130
Index 133