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Book Details
Abstract
Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies.
The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas.
- over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits
- a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals
- a chapter on common artifacts that may be observed in histological glass slides
- extensive references to each lesion described
- aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front cover | cover | ||
| Background Lesions in Laboratory Animals | i | ||
| Copyright page | iv | ||
| Table of Contents | v | ||
| Foreword | vi | ||
| Preface | vii | ||
| References | vii | ||
| Acknowledgments | viii | ||
| Dedication | viii | ||
| Contributors | ix | ||
| 1 Non-human primates: | 1 | ||
| Introduction | 1 | ||
| Cardiovascular system | 1 | ||
| Hemolymphoreticular system | 3 | ||
| Respiratory system | 4 | ||
| Gastrointestinal system | 5 | ||
| Liver and biliary system | 8 | ||
| Urinary system | 9 | ||
| Urinary bladder | 10 | ||
| Endocrine system | 10 | ||
| Muscles, bones and joints | 12 | ||
| Brain and nervous system | 12 | ||
| References | 13 | ||
| 2 Wistar and Sprague–Dawley rats | 17 | ||
| Introduction | 17 | ||
| Cardiovascular system | 17 | ||
| Hemolymphoreticular system | 18 | ||
| Respiratory system | 20 | ||
| Gastrointestinal system | 23 | ||
| Liver and biliary system | 25 | ||
| Urinary system | 28 | ||
| Endocrine glands | 30 | ||
| Skin and appendages | 32 | ||
| Muscle, bones and joints | 33 | ||
| Brain and nervous system | 33 | ||
| Eye and ear | 35 | ||
| References | 36 | ||
| 3 Beagle dog | 37 | ||
| Introduction | 37 | ||
| Cardiovascular system | 37 | ||
| Hemolymphoreticular system | 38 | ||
| Respiratory system | 38 | ||
| Gastrointestinal system | 39 | ||
| Liver and biliary system | 40 | ||
| Urinary system | 41 | ||
| Endocrine glands | 41 | ||
| Skin and appendages | 43 | ||
| Muscles, bones and joints | 43 | ||
| Brain and nervous system | 43 | ||
| Acknowledgments | 44 | ||
| References | 44 | ||
| 4 Mouse | 45 | ||
| Introduction | 45 | ||
| Cardiovascular system | 45 | ||
| Hemolymphoreticular system | 46 | ||
| Respiratory system | 49 | ||
| Gastrointestinal system | 50 | ||
| Liver and biliary system | 53 | ||
| Pancreas | 56 | ||
| Urinary system | 57 | ||
| Endocrine glands | 59 | ||
| Skin and appendages | 61 | ||
| Muscles, bones and joints | 62 | ||
| Brain and nervous system | 64 | ||
| Eye and Ear | 65 | ||
| Systemic disease | 66 | ||
| References | 67 | ||
| 5 Hamsters and guinea pigs | 73 | ||
| Hamsters | 73 | ||
| Introduction | 73 | ||
| Cardiovascular system | 73 | ||
| Hemolymphoreticular system | 73 | ||
| Respiratory system | 73 | ||
| Gastrointestinal system | 74 | ||
| Liver and biliary system | 74 | ||
| Urinary system | 75 | ||
| Endocrine glands | 75 | ||
| Skin and appendages | 76 | ||
| Reproductive system | 76 | ||
| Muscle, bones and joints | 77 | ||
| Eye and ear | 77 | ||
| Guinea pigs | 77 | ||
| Introduction | 77 | ||
| Cardiovascular system | 78 | ||
| Hemolymphoreticular system | 78 | ||
| Respiratory system | 78 | ||
| Gastrointestinal system | 78 | ||
| Liver and biliary system | 78 | ||
| Urinary system | 78 | ||
| Reproductive system | 78 | ||
| Muscles, bones and joints | 78 | ||
| Brain and nervous system | 78 | ||
| References | 78 | ||
| 6 Minipigs | 81 | ||
| Introduction | 81 | ||
| Cardiovascular system | 81 | ||
| Hemolymphoreticular system | 81 | ||
| Respiratory system | 82 | ||
| Gastrointestinal system | 82 | ||
| Liver and biliary system | 83 | ||
| Urinary system | 83 | ||
| Endocrine glands | 84 | ||
| Skin and appendages | 84 | ||
| Reproductive system | 84 | ||
| Muscles, bones and joints | 84 | ||
| Brain and nervous system | 84 | ||
| Eye and ear | 84 | ||
| References | 85 | ||
| 7 New Zealand White rabbit | 87 | ||
| Introduction | 87 | ||
| Cardiovascular system | 87 | ||
| Hemolymphoreticular system | 87 | ||
| Respiratory system | 87 | ||
| Gastrointestinal system | 88 | ||
| Liver and biliary system | 88 | ||
| Pancreas | 89 | ||
| Urinary system | 89 | ||
| Endocrine system | 90 | ||
| Skin and appendages | 90 | ||
| Reproductive system | 90 | ||
| Mammary gland | 90 | ||
| Muscle, bones and joints | 91 | ||
| Brain and nervous system | 91 | ||
| Eye and ear | 91 | ||
| Metabolic diseases | 91 | ||
| References | 91 | ||
| 8 Artifacts in histopathology | 93 | ||
| Introduction | 93 | ||
| Before death/ante mortem | 93 | ||
| Postmortem/necropsy | 93 | ||
| Fixation | 94 | ||
| Processing | 95 | ||
| Cutting | 96 | ||
| Mounting onto glass slides | 97 | ||
| Staining | 97 | ||
| Cover slipping | 98 | ||
| Artifacts in the central nervous system (CNS) and special senses | 98 | ||
| Acknowledgments | 99 | ||
| References | 99 | ||
| 9 Reproduction of the rat, mouse, dog, non-human primate and minipig | 101 | ||
| Introduction | 101 | ||
| Reproduction: male | 101 | ||
| Male reproductive tract | 101 | ||
| Recognizing normal spermatogenesis in the testis | 101 | ||
| Rat and mouse | 101 | ||
| Immaturity, peripuberty, maturity | 101 | ||
| Congenital or developmental lesions | 102 | ||
| Lesions seen in young animals: testes | 102 | ||
| Tubular degeneration/atrophy | 102 | ||
| Lesions seen in young animals: epididymides | 103 | ||
| Age-related lesions: testes and epididymides | 103 | ||
| Age-related lesions: accessory sex organs and penis | 104 | ||
| Dog | 105 | ||
| Immaturity, peripuberty, maturity | 105 | ||
| Lesions seen in young mature animals: testes | 107 | ||
| Lesions observed in young mature animals: testes | 108 | ||
| Lesions seen in young mature animals: prostate | 108 | ||
| Non-human primate | 109 | ||
| Seasonal changes | 109 | ||
| Incidental findings | 109 | ||
| Minipig | 110 | ||
| Immaturity, peripuberty and maturity | 110 | ||
| Incidental findings in mature animals | 110 | ||
| Reproduction: female | 110 | ||
| Female reproductive tract | 110 | ||
| Rat and mouse | 111 | ||
| Immaturity and peripuberty | 111 | ||
| Changes associated with estrus cyclicity in young rodents | 111 | ||
| Background pathology in young rodents | 112 | ||
| Reproductive senescence in aging rodents | 112 | ||
| Background pathology in aging rodents | 113 | ||
| Ovaries | 114 | ||
| Uterus and cervix | 114 | ||
| Vagina | 115 | ||
| Mammary gland | 115 | ||
| Clitoral gland | 116 | ||
| Dog | 116 | ||
| Immaturity and peripuberty | 116 | ||
| Changes associated with estrus cyclicity in dogs | 116 | ||
| Anestrus | 116 | ||
| Pro-estrus | 117 | ||
| Estrus | 117 | ||
| Diestrus | 118 | ||
| Background changes in the young adult dog | 118 | ||
| Non-human primates | 119 | ||
| Immaturity and puberty | 119 | ||
| Changes associated with female cyclicity | 119 | ||
| Background changes in the non-human primate reproductive tract | 120 | ||
| Minipig | 121 | ||
| References | 121 | ||
| Subject index | 123 | ||
| A | 123 | ||
| B | 123 | ||
| C | 124 | ||
| D | 124 | ||
| E | 124 | ||
| F | 125 | ||
| G | 125 | ||
| H | 125 | ||
| I | 126 | ||
| J | 126 | ||
| K | 126 | ||
| L | 126 | ||
| M | 127 | ||
| N | 128 | ||
| O | 128 | ||
| P | 128 | ||
| R | 129 | ||
| S | 129 | ||
| T | 129 | ||
| U | 130 | ||
| V | 130 | ||
| W | 130 | ||
| X | 130 | ||
| Y | 130 | ||
| Z | 130 |