Abstract

Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs.
The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineering, neuromodulation devices, basic science, neuroanatomy, neurophysiology, imaging and mechanisms are emphasized. In addition to providing details pertaining to the state-of-the-art current practice, innovative and emerging applications are discussed in specific chapters. Finally, the textbook provides specific chapters focusing on the technical aspects of the various neuromodulation procedures as well as technical specifications of various implantable devices.
All of the contributors to Neuromodulation represent leading experts in the field. The editors are internationally renowned in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering. Neuromodulation will be the first and foremost authoritative text on neuromodulation therapies and will establish the gold standard that defines the field for years to come.

Key Features

• The first comprehensive reference on the emerging field of Neuromodulation
• Editors and authors include all leading figures in the field, and the leaders of the International Neuromodulation Society
• Over 90 chapters on topics ranging from a layout of the fundamentals (e.g. neuroanatomy, plasticity, bioelectrical effects, infusion therapies), solutions for the biomedical engineering challenges (e.g. materials, how to preserve normal function etc.), to a rundown of the existing applications and their future promise
• Over 1200 pages in splendid full color, richly illustrated
• Important areas of application include: control of chronic pain delivery of drugs to the nervous system via implanted devices control of epilepsy, Parkinson, etc. functional restoration, e.g. visual, auditory, restoration after stroke, restoration of motor function after traumatic events stimulation of body organs via neural devices (incl. the heart, abdominal organs, genitourinary organs) overview over newly emerging fields - control of obesity, blood pressure, tinnitus, brain injury, neurodegenerative diseases, brain-machine interfaces

"Neuromodulation will be the go-to-it reference work for this rapidly expanding and fascinating field. The editors have assembled an all-star group of contributors who comprehensively cover all aspects of neuromodulation in the treatment of human disease and dysfunction." - John D. Loeser, M.D., Departments of Neurological Surgery and Anesthesiology, University of Washington, Seattle, USA

"The greater than 40 year history of scientific inquiry into the interface between neural tissue and therapeutic electrical fields or targeted drug infusion has resulted in a body of rapidly growing evidence for positive effects when these technologies are applied to selected patients who suffer from chronic neurological diseases. The editors of Neuromodulation have organized a definitive knowledge resource for this growing and complex field by assembling many of the world leaders in basic neuroscience, electrical engineering and drug infusion technologies, and clinical investigation. Any new paradigm in medicine, such as neuromodulation, deserves such an outstanding text to help the clinician and researcher to navigate through novel concepts, clinical outcomes and promising new applications." -Richard E. Kuntz, M.D., M.Sc., Sr. Vice President and President, Medtronic Neuromodulation, Minneapolis, USA

"As it has become possible to directly interact with neural tissue, neuromodulation as a new and very promising field of therapeutic approaches has emerged on a very steep path of development. Since the first applications to the treatment of pain with electrical stimulation numerous newly developed methods, including direct electrical stimulation and drug infusion, targeting neural tissue from the cortex to the basal ganglia, spinal cord, and peripheral nerves have made it possible to develop new very powerful therapeutic approaches to serious clinical conditions. Every new branch soon produces its own ramifications and the neuromodulation looks like a very fast-growing tree. This timely publication provides a global and comprehensive review of the current state of the art technology from new and exciting perspectives. This book will be a milestone in the development of neuromodulation." - Alim Louis Benabid, Member Institut Universitaire de France, French Academy of Sciences, French Academy of Medicine, Royal Academy of Medicine of Belgium, Professor Emeritus of Biophysics at the Joseph Fourier University in Grenoble, Scientific Advisor at French Atomic Energy Commission, Grenoble, France

"Neuromodulation therapy has advanced dramatically in recent years and promises to grow into a multi-indication modality that will help millions who suffer from chronic pain and other – neurological diseases.…As, the awareness, acceptance, and use of Neuromodulation technologies grow, the thoughtful publication and updating of reference books like Neuromodulation will play a vital role in the sharing of knowledge and best practices, enabling the modality to reach its full clinical potential.…This book draws from the giants of Neuromodulation who have contributed greatly to the field’s expansion. It broadly captures the wisdom of many talented and caring people and shares it with the world. We will use this book and its future updates as a core resource to further strengthen our educational programs. I thank the editors and authors for their vision and ambitious efforts in making this important book a reality." - Christopher G. Chavez, President, Neuromodulation Division, St. Jude Medical, St. Paul, USA

"Scientific progress is accelerated when ground breaking developments are put into context for the next generation to explore. The editors of Neuromodulation have assembled a foundation of evidence that will spur the curious minds of scientists, clinicians, researchers and industry. This document will lead to new discoveries that reinforce the spirit of innovation and challenge our current beliefs. Congratulations to the authors and editors on assembling a reference for the ages." - Michael Onuscheck, Senior Vice President and President of Neuromodulation, Boston Scientific Corporation, Boston, USA