Abstract

Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer.

• Contains cutting-edge information on focused topics written by expert scientists
• Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines
• Attempts molecular pathophysiology which links basic science and the clinic
• Presents critical assessment of controversial topics

Praise for the Serial

"Recommended not only to pharmacologists but also to all those in related disciplines." --NATURE

"The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated." --H.E. Kaufmann in CHEMOTHERAPY

"Superb reading material." --JOURNAL OF PHARMACEUTICAL SCIENCES

Praise for the Volume

"...a must in the library of researchers in the area of free radical biology... it presents an invaluable indepth critical coverage of topics inherent in the 'antioxidant literature' and ranging from basic physical chemistry concepts to clinical therapy, prevention, and epidemiological perspectives... an excellent book, highly recommended, on topics of great current interest." --Enrique Cadenas for FREE RADICAL RESEARCH

"Comprehensive, concise, well-referenced and original, this book also includes appropriate illustrations to explain the text... This book covers the complete spectrum of the topics dealing with molecular actions of natural and synthetic antioxidants and their potential role in disease states and therapeutic strategies." --Arshad Rahman, PhD, Rush Medical College of Rush University for DOODY'S PUBLISHING REVIEWS

"Comprehensive, concise, well-referenced and original, this book also includes appropriate illustrations to explain the text. The layout is simple and appealing... Weighted numerical score: 90 - 4 stars!" --Arshad Rahman in DOODY PUBLISHING