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Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

Douglas M. Fambrough | Dale J. Benos

(1999)

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Abstract

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.

  • Summarizes current state of amiloride-sensitive sodium channel field
  • Analyzes structure-function of epithelial sodium channels
  • Discusses immunolocalization of epithelial sodium channels
  • Examines hormonal regulation of sodium channels
  • Discusses sodium channels in lymphocytes, kidney, and lung
  • Considers mechanosensitivity of sodium channels
  • Provides ideas on sodium channels and disease