Abstract

Classical histology has been augmented by
immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system.
This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method.
* The only book available that translates molecular genetics into cancer diagnosis
* Methods were developed by internationally-recognized experts and presented in step-by-step manner
* Results of each Immunohistochemical and in situ hybridization are presented in the form of color illustrations
“The basics of cell biology and molecular biology precede each section that describes defects in genetic/epigenetic control. Gaining an understanding of molecular genetic defects in cancer, authors then proceed to tell you how to measure the defects, which reinforces your understanding of the basic pathobiologic process. The latest therapies are discussed in the context of how to repair these molecular defects. Timely chapters on specific molecular topics in ovarian and gastrointestinal tumors are presented in the format of formal research papers. Extremely well written and succinct, a perfect marriage of information for students at any level, from medical student to professors of oncology.”
-- David J. Dabbs, M.D., Chief of Pathology, Magee Women’s Hospital University of Pittsburgh School of Medicine