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Sphingolipid Metabolism and Cell Signaling, Part A

Sphingolipid Metabolism and Cell Signaling, Part A

John N. Abelson | Melvin I. Simon | Alfred H. Merrill, Jr. | Yusuf A. Hannun

(1999)

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Abstract

Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets.
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