Abstract

There is a vast and often bewildering array of synthetic methods and reagents available to organic chemists today. The Best Synthetic Methods series allows the practising synthetic chemist to choose between all the alternatives and assess their real advantages and limitations.

Each chapter in Carbohydrates details a particular theme associated with carbohydrate synthesis. A brief review of the subject area is provided, but the emphasis in all cases is on describing efficient practical methods to effect the transformations described.

In order for the roles of carbohydrates to be thoroughly analysed and assessed, glycobiologists require access to defined target carbohydrates in useful quantities. Thus carbohydrates and glycoconjugates are now recognized as important targets for total synthesis programmes and it is essential to develop efficient regio- and stereoselective methods for the synthesis of carbohydrates. Whilst carbohydrates can sometimes be isolated from natural sources, synthetic strategies often offer the advantage of allowing access to larger quantities of material as well as entry to analogues of the natural carbohydrates.

• The latest volume in the long standing Best Synthetic Methods series
• Clear chapter by chapter breakdown of carbohydrate synthesis themes with examples of good practical methods for common carbohydrate syntheses

"The book certainly belongs in every laboratory dealing with oligosaccharide synthesis. While the critical reader might also long for information on redox processes, inversion of configuration, and chain elongation, undoubtedly, this monograph is a very useful source of practical methods used for the preparation of carbohydrate building blocks and construction of the glycosidic bond. I expect that the book edited by Osborn will become an excellent and timely addition to the bookshelf that already features a comprehensive collection of Methods in Carbohydrate Chemistry, edited by Whistler and Wolfrom/BeMiller of the 1960s and 1970s, and Preparative Carbohydrate Chemistry, edited by Hanessian (1997). Virtually every researcher, ranging from a senior postdoctoral fellow to a very inexperienced undergraduate student just starting to learn this exciting area of organic chemistry, will find a wealth of useful and readily accessible material. The book is highly recommended. "
Demchenko, A.V.; Carbohydr. Res. 2005, 340, 173-174.