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Guide to Techniques in Mouse Development, Part A

Guide to Techniques in Mouse Development, Part A

Paul Wassarman | Philippe M. Soriano

(2010)

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Abstract

Guide to Techniques in Mouse Development, Part A comprehensively covers new technologies and methodologies that have appeared for the study of mouse development.

  • Update of volume 225 of Methods in Enzymology, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993
  • Covers new technologies and methodologies, including:
    • new techniques for the cryopreservation of gametes and embryos
    • production of transgenic and null (knockout) animals (use of ES cells)
    • generation of conditional/inducible mutant animals
    • use of gene-trap mutagenesis
    • analysis of allele-specific expresion
    • use of new reporter constructs
    • humanizing of transgenic animals
    • transcript profiling of mouse development
    • imaging of mouse development
    • rederivation of animals and use of mouse genomics