Additional Information
Book Details
Abstract
Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters.
- Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology
- Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists
- Reports of potential drugs in early and late clinical stages of development
"This book is intended for research neuroscientists but can be effectively utilized by clinicians and students because of its clarity of style and excellent illustrations... Many excellent diagrams and charts are scattered throughout this volume. They make for easy conceptualization of the results of preclinical as well as phase one and two clinical trials... This book provides a much needed report on these exciting neuroprotective agents, several of which will be released by the FDA in the near future." --Thomas H. Jobe, MD, University of Illinois at Chicago College of Medicine for DOODY'S PUBLISHING REVIEWS