Abstract

Cocaine abuse remains a major public health problem and contributes to many of our most disturbing social problems, including the spread of infectious disease, crime, violence, and neonatal drug exposure. Cocaine abuse results from a complex interplay of behavioral, pharmacological, and neurobiological determinants. While a complete understanding of cocaine abuse is currently beyond us, significant progress has been made in preclinical research on fundamental determinants of this disorder. These advances are critically reviewed in the first section of this volume. Important advances also have been made in characterizing the clinical pharmacology of cocaine, and those advances have been extended to understanding individual vulnerability to cocaine abuse, development of effective treatments, and discussions of policy. Those advances are critically reviewed in the third section of this volume. Contributors to the book were selected because of their status as internationally recognized leaders in their respective areas of scientific expertise. Moreover, each is a proponent of the importance of a rigorous, interdisciplinary scientific approach to effectively addressing the problem of cocaine abuse. As such, this volume offers a coherent, empirically-based conceptual framework for addressing cocaine abuse that has continuity from the basic research laboratory through the clinical and policy arenas. Each of the specific chapters is sufficiently detailed, in-depth and current to be valuable to informed readers with specific interests while also offering a comprehensive overview for those who might be less informed or have broader interests in cocaine abuse. This blend of critical review within each chapter with an explicitly conceptual continuity that spans all of the chapters makes this volume a unique contribution to cocaine abuse in particular and substance abuse in general.

• Discusses cocaine abuse within the context of current principles of psychology, pharmacology, neuroscience, genetics and epidemiology
• Chapters are all authored by scientific experts
• First of its kind book on cocaine abuse to recognize behavioral/environmental determinants
• Coverage is comprehensive
• Informative for experts and generalists alike

"Each of the 17 chapters elegantly weaves empirical research into discussions of the most plausible theories on topics that cover a wide array of questions... refreshingly, a great deal of conflicting literature and science is introduced, leaving the answers to future scientists and researchers to ponder and to investigate. Perhaps the most exciting aspect of this book is the way in which the data are presented. The assembled authors lead the reader through the basic and clinical research, cite the outcomes of the experiments already conducted, and finally, point to future areas of research that seem most likely to provide important discoveries... Texts like this one are an invaluable addition to a researcher's library..." --CONTEMPORARY PSYCHOLOGY