BOOK
Recent Advancements in Neuromuscular Medicine, An Issue of Physical Medicine and Rehabilitation Clinics - E-Book
(2012)
Additional Information
Book Details
Abstract
Issue will cover: sinle muscle fiber electrophysiology, skinned muscle fibers, magnetic resonance imaging in muscular dystrophy, ultrasound of nerve and muscle, microgenomics of the motor neuron system, and electrodiagnostic studies in animal models.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Physical Medicine and Rehabilitation Clinics of North America | i | ||
| Copyright Page | ii | ||
| Table of Contents | ix | ||
| Dedication | xvii | ||
| Contributors | iii | ||
| Preface: Advancing Neuromuscular Medicine Through Integration, Translation, and Collaboration | xv | ||
| Chapter 1. Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy | 1 | ||
| MUSCLE IMAGING | 2 | ||
| DUCHENNE MUSCULAR DYSTROPHY | 2 | ||
| POTENTIAL USES OF MRI IN DMD | 3 | ||
| MRI AS A BIOMARKER FOR CLINICAL TRIALS | 7 | ||
| SUMMARY | 8 | ||
| ACKNOWLEDGMENTS | 8 | ||
| REFERENCES | 8 | ||
| Chapter 2. Techniques in Assessing Fatigue in Neuromuscular Diseases | 11 | ||
| DEFINITION OF FATIGUE | 11 | ||
| SYSTEMATIC APPROACH OF FATIGUE IN NEUROMUSCULAR DISEASES | 12 | ||
| PHYSICAL FATIGABILITY HAS A CENTRAL OR PERIPHERAL ORIGIN | 16 | ||
| SUMMARY | 20 | ||
| REFERENCES | 20 | ||
| Chapter 3. The Utility of Electromyography and Mechanomyography for Assessing Neuromuscular Function: A Noninvasive Approach | 23 | ||
| ELECTROMYOGRAPHY | 23 | ||
| EMG RESPONSES TO ISOMETRIC AND DYNAMIC SUBMAXIMAL TO MAXIMAL MUSCLE ACTIONS | 25 | ||
| USING EMG TO IDENTITY FATIGUE THRESHOLD | 25 | ||
| MMG RESPONSES TO ISOMETRIC AND DYNAMIC SUBMAXIMAL TO MAXIMAL MUSCLE ACTIONS | 28 | ||
| POTENTIAL APPLICATION OF EMG AND MMG WITH CLINICAL POPULATIONS | 28 | ||
| USING MMG FOR CONTINUOUS MUSCLE ACTIONS | 28 | ||
| SUMMARY | 29 | ||
| REFERENCES | 29 | ||
| Chapter 4. Novel Concepts Integrated in Neuromuscular Assessments for Surgical Restoration of Arm and Hand Function in Tetraplegia | 33 | ||
| ANATOMY AND CLINICAL EXAMINATION | 34 | ||
| PLANNING OF RECONSTRUCTION | 35 | ||
| NEW DEVELOPMENTS | 43 | ||
| ACKNOWLEDGMENTS | 47 | ||
| REFERENCES | 47 | ||
| Chapter 5. The Effects of Activeand Passive Stretching on Muscle Length | 51 | ||
| WHAT IS KNOWN ABOUT MUSCLE LENGTH ADAPTATION? | 52 | ||
| IS CONTRACTILE ACTIVITY NECESSARY TO ADJUST MUSCLE LENGTH? | 52 | ||
| WHAT DOES PASSIVE STRETCH DO AND NOT DO? | 53 | ||
| DOES REMODELING OF THE CONNECTIVE TISSUE DECREASE STIFFNESS? | 54 | ||
| SUMMARY | 55 | ||
| REFERENCES | 55 | ||
| Chapter 6. Hypohomocysteinemia: A Potentially Treatable Cause of Peripheral Neuropathology? | 59 | ||
| CLINICAL RAMIFICATIONS | 61 | ||
| DISCUSSION | 62 | ||
| REFERENCES | 64 | ||
| Chapter 7. Regional and Whole-Body Dual-Energy X-Ray Absorptiometry to Guide Treatment and Monitor Disease Progression in Neuromuscular Disease | 67 | ||
| DUAL-ENERGY X-RAY ABSORPTIOMETRY | 67 | ||
| REGIONAL DEXA | 68 | ||
| ADVANTAGES OF DEXA | 68 | ||
| DISADVANTAGES OF DEXA | 69 | ||
| DEXA IN NEUROMUSCULAR DISEASES | 70 | ||
| CLINICAL APPLICATIONS OF DEXA | 71 | ||
| SUMMARY | 72 | ||
| REFERENCES | 72 | ||
| Chapter 8. Establishing Clinical End Points of Respiratory Functionin Large Animals for Clinical Translation | 75 | ||
| RESPIRATORY ASSESSMENT IN NMD PATIENTS | 75 | ||
| INSPIRATORY MUSCLE WEAKNESS | 76 | ||
| INSPIRATORY MUSCLE FATIGUE | 77 | ||
| EXPIRATORY MUSCLE DYSFUNCTION | 78 | ||
| RESPIRATORY ASSESSMENT IN THE DOG | 82 | ||
| SUMMARY | 91 | ||
| REFERENCES | 91 | ||
| Chapter 9. New Opportunities and Novel Paradigms to Support Neuromuscular Research | 95 | ||
| CORE DESCRIPTIONS | 97 | ||
| NSMRC OPPORTUNITIES FOR REHABILITATION RESEARCHERS | 102 | ||
| THE NSMRC SHARES ITS EXPERTISE IN MUSCLE WITH THE REHABILITATION COMMUNITY | 102 | ||
| REFERENCES | 104 | ||
| Chapter 10. Skeletal Muscle Edema in Muscular Dystrophy: Clinical and Diagnostic Implications | 107 | ||
| PROGRESSION OF MUSCLE CHANGE ASSESSMENT WITH IMAGING | 108 | ||
| PATTERNS OF MUSCLE CHANGE IN MUSCULAR DYSTROPHY | 111 | ||
| QUANTIFYING CHANGES IN MUSCLE | 113 | ||
| FUTURE | 119 | ||
| SUMMARY | 119 | ||
| REFERENCES | 119 | ||
| Chapter 11. Cardiac MRI in Muscular Dystrophy: An Overview and Future Directions | 123 | ||
| STRAIN AS AN EARLY INDICATOR OF HEART PROBLEMS | 126 | ||
| COMPLEXITY OF INTERPRETING STRAIN METRICS | 127 | ||
| STRAIN ACROSS THE LONGITUDINAL COURSE | 127 | ||
| STRAIN AS A TREATMENT INDEX | 128 | ||
| TREATMENT INDEXES: STRAIN IN OTHER METHODS | 128 | ||
| T2 MEASUREMENT | 128 | ||
| LGE | 129 | ||
| DUCHENNE MUSCULAR DYSTROPHY (FEMALE CARRIERS) | 129 | ||
| THE FULL PICTURE IN MUSCULAR DYSTROPHY: CARDIAC MAGNETIC RESONANCE + STRAIN + LGE + T2: WHAT, WHEN, AND WHERE? | 130 | ||
| REFERENCES | 130 | ||
| Chapter 12. Neuromuscular Ultrasonography: Quantifying Muscle and Nerve Measurements | 133 | ||
| MUSCLE ULTRASONOGRAPHY | 134 | ||
| QUANTIFICATION OF NERVE ULTRASONOGRAPHY | 142 | ||
| SUMMARY | 144 | ||
| REFERENCES | 144 | ||
| Chapter 13. The Paradox of Muscle Hypertrophy in Muscular Dystrophy | 149 | ||
| VARIABLE MUSCLE INVOLVEMENT AND HYPERTROPHY | 150 | ||
| POSTURAL INSTABILITY AND CONTRACTURES | 156 | ||
| MECHANISMS CONTRIBUTING TO MUSCLE HYPERTROPHY | 162 | ||
| MYOSTATIN INHIBITION IN MUSCLE DISEASE | 163 | ||
| SUMMARY | 166 | ||
| REFERENCES | 166 | ||
| Chapter 14. Exercise Testing in Metabolic Myopathies | 173 | ||
| OVERVIEW OF METABOLIC MYOPATHIES | 173 | ||
| THE METABOLIC RESPONSES TO EXERCISE | 174 | ||
| GLYCOGEN STORAGE DISEASE | 176 | ||
| FATTY ACID OXIDATION DEFECT | 177 | ||
| MITOCHONDRIAL MYOPATHIES | 178 | ||
| EXERCISE TESTING IN METABOLIC MYOPATHIES | 178 | ||
| FOREARM EXERCISE TESTING | 179 | ||
| AEROBIC EXERCISE TESTING | 181 | ||
| SUMMARY | 184 | ||
| ACKNOWLEDGMENTS | 184 | ||
| REFERENCES | 184 | ||
| Chapter 15. Nutrition Strategies to Improve Physical Capabilities in Duchenne Muscular Dystrophy | 187 | ||
| CHARACTERISTICS OF DMD | 188 | ||
| WHY NUTRITIONAL AND PHYSICAL ACTIVITY THERAPIES? | 189 | ||
| WHAT IS CURRENTLY KNOWN | 189 | ||
| GTE | 190 | ||
| RECOMMENDATIONS | 195 | ||
| SUMMARY | 195 | ||
| REFERENCES | 196 | ||
| Chapter 16. Aging of Human Muscle: Understanding Sarcopenia at the Single Muscle Cell Level | 201 | ||
| WHOLE-MUSCLE WEAKNESS | 203 | ||
| WEAKNESS OF SINGLE MUSCLE FIBERS | 204 | ||
| PHYSIOLOGIC, CELLULAR, AND MOLECULAR CONTRIBUTORS TO SARCOPENIA AND WEAKNESS | 205 | ||
| COUNTERMEASURES | 206 | ||
| REFERENCES | 206 | ||
| Index | 209 |