BOOK
Gynecologic Cancer, An Issue of Hematology/Oncology Clinics of North America - E-Book
(2012)
Additional Information
Book Details
Abstract
Topics include:Genetic Risk and Gynecologic Cancer, Current Management of Preinvasive Cervical Neoplasia, Current Surgical Management of Cervical Neoplasia, Current Surgical Management of Ovarian Cancer, Current Management of Trophoblastic Disease, and New Developments in Radiation Management and Gynecologic Cancers
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Hematology/Oncology Clinics of North America | i | ||
| Copyright Page | ii | ||
| Table of Contents | vii | ||
| Contributors | iii | ||
| Preface: Gynecologic Cancer | xi | ||
| Chapter 1. The Epidemiology of Endometrial and Ovarian Cancer | 1 | ||
| TUMOR HETEROGENEITY AS IT MAY AFFECT EPIDEMIOLOGIC ASSOCIATIONS | 1 | ||
| AGE AND GEOGRAPHIC DISTRIBUTION | 3 | ||
| RISK FACTORS | 4 | ||
| MECHANISMS | 6 | ||
| STRATEGIES FOR PREVENTION | 8 | ||
| SUMMARY | 8 | ||
| REFERENCES | 9 | ||
| Chapter 2. Genetic Risk and Gynecologic Cancers | 13 | ||
| HBOC SYNDROME | 13 | ||
| LYNCH SYNDROME | 18 | ||
| OTHER SYNDROMES | 22 | ||
| SUMMARY | 22 | ||
| REFERENCES | 22 | ||
| Chapter 3. Management of Cervical Precancers: A Global Perspective | 31 | ||
| EPIDEMIOLOGY OF CERVICAL CANCER | 32 | ||
| HPV: EPIDEMIOLOGY AND MOLECULAR BIOLOGY | 33 | ||
| HPV INFECTION, IMMUNE SURVEILLANCE, AND DEVELOPMENT OF NEOPLASIA | 33 | ||
| SCREENING AND DIAGNOSIS OF CERVICAL PRECANCERS | 34 | ||
| MANAGEMENT OF SCREENING ABNORMALITIES | 36 | ||
| TREATMENT OPTIONS | 36 | ||
| SCREENING IN DEVELOPING SETTINGS | 37 | ||
| LIMITATIONS OF SCREENING SERVICES WORLDWIDE | 38 | ||
| HPV VACCINATION | 39 | ||
| SUMMARY | 40 | ||
| REFERENCES | 40 | ||
| Chapter 4. Current Management of Vulvar Cancer | 45 | ||
| STAGING | 46 | ||
| SURGICAL MANAGEMENT | 48 | ||
| MANAGEMENT OF STAGE I TO II VULVAR CANCER | 48 | ||
| SENTINEL LYMPH NODE BIOPSY | 54 | ||
| MANAGEMENT OF STAGE III TO IV VULVAR CANCER | 56 | ||
| SUMMARY | 58 | ||
| REFERENCES | 59 | ||
| Chapter 5. Surgical Management of Cervical Carcinoma | 63 | ||
| RADICAL HYSTERECTOMY FOR EARLY-STAGE DISEASE | 64 | ||
| MINIMALLY INVASIVE APPROACHES TO RADICAL HYSTERECTOMY | 66 | ||
| FERTILITY-SPARING RADICAL SURGERY | 67 | ||
| SURGICAL STAGING | 70 | ||
| PELVIC EXENTERATION | 72 | ||
| SUMMARY | 74 | ||
| REFERENCES | 74 | ||
| Chapter 6. Current Surgical Management of Endometrial Cancer | 79 | ||
| EARLY-STAGE DISEASE | 79 | ||
| ADVANCED-STAGE DISEASE | 87 | ||
| SUMMARY | 88 | ||
| REFERENCES | 88 | ||
| Chapter 7. Current Surgical Management of Ovarian Cancer | 93 | ||
| SURGICAL STAGING | 94 | ||
| TUMOR DEBULKING | 98 | ||
| PALLIATIVE SURGERY | 104 | ||
| REFERENCES | 105 | ||
| Chapter 8. Current Management of Gestational Trophoblastic Neoplasia | 111 | ||
| EPIDEMIOLOGY | 112 | ||
| PATHOLOGY | 112 | ||
| CLINICAL PRESENTATION | 113 | ||
| WORKUP | 113 | ||
| STAGING AND RISK ASSESSMENT | 114 | ||
| TREATMENT OF LOW-RISK GTN | 115 | ||
| TREATMENT OF HIGH-RISK GTN | 118 | ||
| MANAGEMENT OF CENTRAL NERVOUS SYSTEM METASTASES | 119 | ||
| MANAGEMENT OF PULMONARY METASTASES | 119 | ||
| MANAGEMENT OF HEPATIC METASTASES | 120 | ||
| MANAGEMENT OF RECURRENT AND CHEMORESISTANT GTN | 121 | ||
| MANAGEMENT OF COMPLICATIONS | 122 | ||
| MANAGEMENT OF PSTT AND ETT | 122 | ||
| FOLLOW-UP AFTER TREATMENT OF GTN | 123 | ||
| PERSISTENT LOW LEVELS OF HCG (QUIESCENT GTN) | 123 | ||
| SUBSEQUENT PREGNANCY EXPERIENCE | 124 | ||
| PSYCHOSOCIAL CONSEQUENCES OF GTN | 125 | ||
| REFERENCES | 125 | ||
| Chapter 9. New Biologic Agents for the Treatment of Gynecologic Cancers | 133 | ||
| ANTIANGIOGENESIS THERAPIES | 133 | ||
| PARP INHIBITORS | 141 | ||
| HH PATHWAY INHIBITORS | 142 | ||
| FR INHIBITORS | 144 | ||
| EGFR INHIBITORS | 145 | ||
| PI3K/AKT PATHWAY INHIBITORS | 147 | ||
| FUTURE DIRECTIONS OF TARGETED THERAPIES FOR GYNECOLOGIC CANCERS | 149 | ||
| SUMMARY | 149 | ||
| REFERENCES | 149 | ||
| Chapter 10. \rAdvances in the Use of Radiation for Gynecologic Cancers | 157 | ||
| CERVICAL CANCER | 157 | ||
| ENDOMETRIAL CANCER | 161 | ||
| VULVAR CANCER | 164 | ||
| SUMMARY | 165 | ||
| REFERENCES | 165 | ||
| Chapter 11. Contemporary Quality of Life Issues Affecting Gynecologic Cancer Survivors | 169 | ||
| CANCER, TREATMENT, AND SEXUALITY | 170 | ||
| REPRODUCTIVE ISSUES | 173 | ||
| SURGICAL TREATMENT AND RISK OF LYMPHEDEMA OF THE LOWER EXTREMITY | 174 | ||
| HRQOL AND PROS IN CLINICAL TRIALS | 176 | ||
| PALLIATIVE CHEMOTHERAPY: HRQOL IMPLICATIONS | 178 | ||
| BOWEL OBSTRUCTION | 181 | ||
| HRQOL, UTILITY, AND COST EFFECTIVENESS | 181 | ||
| CONNECTION AND CARE | 181 | ||
| REFERENCES | 182 | ||
| Index | 195 |