Additional Information
Book Details
Abstract
Thoroughly revised and up-dated, this comprehensive, authoritative reference will help both the experienced and novice practitioner diagnose skin diseases and disorders more accurately and effectively. A superb full colour art programme illustrates the salient pathological features of both neoplastic and non-neoplastic conditions and will help the reader easily interpret key clinical and diagnostic points. This single–authored text incorporates the wealth of Dr Weedon’s own personal observations and experience in his approach to the diagnosis and interpretation of skin biopsies and is full of useful diagnostic clues and pearls. This remarkable book is an indispensable resource for all those involved in the identification and evaluation of skin disorders.
- Encyclopedic reference work that discusses established disorders, unusual and rare disease entities as well as incompletely defined entities.
- The book is comprehensive enough to meet the requirements of trainee and practicing dermatopathologists or pathologists when reporting on the histopathology of skin specimens.
- A single authored text that presents an internationally recognized master diagnostician’s personal philosophy and skill in dealing with the diagnosis of skin biopsies.Provides a uniformity, clarity and internal consistency of approach and style that other books cannot match.
- Over 1,200 large-sized, high quality illustrations.
- Will facilitate an accurate diagnosis by accurately reproducing in the book what is seen through the microscope and thereby help identify the characteristic features of the lesion demonstrated.
- For many of the features listed there will be practical advice on pitfalls and how to avoid them drawn from Dr Weedon’s unrivalled personal experience.Will facilitate the daily practice of dermatopathology and save the practitioner a lot of time and money.
- Tables and boxes that organize diseases into groups, synthesize diagnostic criteria and list differential diagnoses makes the book user friendly and the information easy-to-access.
- Remarkably authoritative, comprehensive, current and relevant reference list for each entity. There are over 35,000 references in the text.This degree of inclusivity facilitates the identification of both key articles and more rare and unusual reports. References only available online in this single volume version.
- New sections on treatment that highlight recent treatment trials and guidelines.
- Clinical descriptions updated.
- Brand new illustrations incorporated throughout.
- 14,000 new references.
- Latest IHC and molecular techniques set within context of histopathological diagnosis.
- OMIM (online Mendelian Inheritance in Man) numbers added for all relevant diseases to provide access to continous update on the scientific basis of hereditary disease.
- Text and images available online via Expert Consult.
Table of Contents
Section Title | Page | Action | Price |
---|---|---|---|
Front cover | cover | ||
Half title page | i | ||
Title page | iii | ||
Copyright page | iv | ||
Table of contents | v | ||
Preface | vii | ||
Part I: INTRODUCTION | 1 | ||
Chapter 1: An approach to the interpretation of skin biopsies | 3 | ||
INTRODUCTION | 4 | ||
MAJOR TISSUE REACTION PATTERNS | 4 | ||
MINOR TISSUE REACTION PATTERNS | 12 | ||
PATTERNS OF INFLAMMATION | 16 | ||
References | 18 | ||
Chapter 2: Diagnostic clues | 19 | ||
FEATURES OF PARTICULAR PROCESSES | 20 | ||
HISTOLOGICAL FEATURES – WHAT DO THEY SUGGEST? | 22 | ||
CLUES TO A PARTICULAR DISEASE | 29 | ||
GENERAL HELPFUL HINTS AND CAUTIONS | 31 | ||
Part II: TISSUE REACTION\rPATTERNS | 33 | ||
Chapter 3: The lichenoid reaction pattern (‘interface dermatitis’) | 35 | ||
INTRODUCTION | 36 | ||
LICHENOID (INTERFACE) DERMATOSES | 38 | ||
POIKILODERMAS | 66 | ||
OTHER LICHENOID (INTERFACE) DISEASES | 68 | ||
References | 70 | ||
Chapter 4: The psoriasiform reaction pattern | 71 | ||
INTRODUCTION | 72 | ||
MAJOR PSORIASIFORM DERMATOSES | 72 | ||
OTHER PSORIASIFORM DERMATOSES | 87 | ||
Chapter 5: The spongiotic reaction pattern | 93 | ||
INTRODUCTION | 94 | ||
NEUTROPHILIC SPONGIOSIS | 95 | ||
EOSINOPHILIC SPONGIOSIS | 96 | ||
MILIARIAL SPONGIOSIS | 97 | ||
FOLLICULAR SPONGIOSIS | 99 | ||
PITYRIASIFORM SPONGIOSIS | 100 | ||
OTHER SPONGIOTIC DISORDERS | 102 | ||
Chapter 6: The vesiculobullous reaction pattern | 123 | ||
INTRODUCTION | 124 | ||
INTRACORNEAL AND SUBCORNEAL BLISTERS | 126 | ||
INTRAEPIDERMAL BLISTERS | 133 | ||
SUPRABASILAR BLISTERS | 135 | ||
SUBEPIDERMAL BLISTERS – A CLASSIFICATION | 140 | ||
SUBEPIDERMAL BLISTERS WITH LITTLE INFLAMMATION | 141 | ||
SUBEPIDERMAL BLISTERS WITH LYMPHOCYTES | 150 | ||
SUBEPIDERMAL BLISTERS WITH EOSINOPHILS | 153 | ||
SUBEPIDERMAL BLISTERS WITH NEUTROPHILS | 159 | ||
SUBEPIDERMAL BLISTERS WITH MAST CELLS | 167 | ||
MISCELLANEOUS BLISTERING DISEASES | 167 | ||
Chapter 7: The granulomatous reaction pattern | 169 | ||
INTRODUCTION | 170 | ||
SARCOIDAL GRANULOMAS | 170 | ||
TUBERCULOID GRANULOMAS | 173 | ||
NECROBIOTIC (COLLAGENOLYTIC) GRANULOMAS | 177 | ||
SUPPURATIVE GRANULOMAS | 184 | ||
FOREIGN BODY GRANULOMAS | 186 | ||
XANTHOGRANULOMAS | 187 | ||
MISCELLANEOUS GRANULOMAS | 187 | ||
COMBINED GRANULOMATOUS AND LICHENOID PATTERN | 194 | ||
References | 194 | ||
Chapter 8: The vasculopathic reaction pattern | 195 | ||
INTRODUCTION | 196 | ||
NON-INFLAMMATORY PURPURAS | 196 | ||
VASCULAR OCCLUSIVE DISEASES | 197 | ||
URTICARIAS | 202 | ||
ACUTE VASCULITIS | 207 | ||
NEUTROPHILIC DERMATOSES | 218 | ||
CHRONIC LYMPHOCYTIC VASCULITIS | 225 | ||
VASCULITIS WITH GRANULOMATOSIS | 238 | ||
MISCELLANEOUS VASCULAR DISORDERS | 243 | ||
References | 244 | ||
Part III: THE EPIDERMIS | 245 | ||
Chapter 9: Disorders of epidermal maturation and keratinization | 247 | ||
INTRODUCTION | 248 | ||
ICHTHYOSES | 249 | ||
PALMOPLANTAR KERATODERMAS AND RELATED CONDITIONS | 257 | ||
CORNOID LAMELLATION | 262 | ||
EPIDERMOLYTIC HYPERKERATOSIS | 264 | ||
ACANTHOLYTIC DYSKERATOSIS | 265 | ||
HYPERGRANULOTIC DYSCORNIFICATION | 272 | ||
COLLOID KERATOSIS | 272 | ||
DISCRETE KERATOTIC LESIONS | 272 | ||
MISCELLANEOUS EPIDERMAL GENODERMATOSES | 274 | ||
MISCELLANEOUS DISORDERS | 278 | ||
References | 279 | ||
Chapter 10: Disorders of pigmentation | 281 | ||
INTRODUCTION | 282 | ||
DISORDERS CHARACTERIZED BY HYPOPIGMENTATION | 282 | ||
DISORDERS CHARACTERIZED BY HYPERPIGMENTATION | 290 | ||
References | 299 | ||
Part IV: THE DERMIS AND\rSUBCUTIS | 301 | ||
Chapter 11: Disorders of collagen | 303 | ||
INTRODUCTION | 304 | ||
SCLERODERMA | 304 | ||
SCLERODERMOID DISORDERS | 311 | ||
OTHER HYPERTROPHIC COLLAGENOSES | 316 | ||
ATROPHIC COLLAGENOSES | 321 | ||
PERFORATING COLLAGENOSES | 324 | ||
VARIABLE COLLAGEN CHANGES | 326 | ||
SYNDROMES OF PREMATURE AGING | 328 | ||
References | 329 | ||
Chapter 12: Disorders of elastic tissue | 331 | ||
INTRODUCTION | 332 | ||
INCREASED ELASTIC TISSUE | 333 | ||
SOLAR ELASTOTIC SYNDROMES | 339 | ||
DECREASED ELASTIC TISSUE | 344 | ||
VARIABLE OR MINOR ELASTIC TISSUE CHANGES | 350 | ||
References | 351 | ||
Chapter 13: Cutaneous mucinoses | 353 | ||
INTRODUCTION | 354 | ||
DERMAL MUCINOSES | 355 | ||
FOLLICULAR MUCINOSES | 364 | ||
EPITHELIAL MUCINOSES | 367 | ||
MUCOPOLYSACCHARIDOSES | 367 | ||
References | 367 | ||
Chapter 14: Cutaneous deposits | 369 | ||
INTRODUCTION | 370 | ||
CALCIUM, BONE, AND CARTILAGE | 370 | ||
HYALINE DEPOSITS | 376 | ||
PIGMENT AND RELATED DEPOSITS | 387 | ||
CUTANEOUS IMPLANTS | 394 | ||
MISCELLANEOUS DEPOSITS | 395 | ||
References | 396 | ||
Chapter 15: Diseases of cutaneous appendages | 397 | ||
INFLAMMATORY DISEASES OF THE PILOSEBACEOUS APPARATUS | 399 | ||
HAIR SHAFT ABNORMALITIES | 411 | ||
ALOPECIAS | 417 | ||
MISCELLANEOUS DISORDERS | 431 | ||
References | 440 | ||
Chapter 16: Cysts, sinuses, and pits | 441 | ||
INTRODUCTION | 442 | ||
APPENDAGEAL CYSTS | 442 | ||
DEVELOPMENTAL CYSTS | 450 | ||
MISCELLANEOUS CYSTS | 453 | ||
LYMPHATIC CYSTS | 456 | ||
SINUSES | 456 | ||
PITS | 456 | ||
References | 457 | ||
Chapter 17: Panniculitis | 459 | ||
INTRODUCTION | 460 | ||
SEPTAL PANNICULITIS | 460 | ||
LOBULAR PANNICULITIS | 463 | ||
PANNICULITIS SECONDARY TO LARGE VESSEL VASCULITIS | 477 | ||
References | 477 | ||
Part V: THE SKIN IN SYSTEMIC\rAND MISCELLANEOUS\rDISEASES | 479 | ||
Chapter 18: Metabolic and storage diseases | 481 | ||
INTRODUCTION | 482 | ||
VITAMIN AND DIETARY DISTURBANCES | 482 | ||
LYSOSOMAL STORAGE DISEASES | 484 | ||
NECROLYTIC ERYTHEMAS | 488 | ||
MISCELLANEOUS METABOLIC AND SYSTEMIC DISEASES | 492 | ||
References | 500 | ||
Chapter 19: Miscellaneous conditions | 501 | ||
References | 509 | ||
Chapter 20: Cutaneous drug reactions | 511 | ||
INTRODUCTION | 512 | ||
CLINICOPATHOLOGICAL REACTIONS | 513 | ||
OFFENDING DRUGS | 518 | ||
References | 523 | ||
Chapter 21: Reactions to physical agents | 525 | ||
INTRODUCTION | 526 | ||
REACTIONS TO TRAUMA AND IRRITATION | 526 | ||
REACTIONS TO RADIATION | 527 | ||
REACTIONS TO HEAT AND COLD | 529 | ||
REACTIONS TO LIGHT (PHOTODERMATOSES) | 531 | ||
References | 540 | ||
Part VI: INFECTIONS AND\rINFESTATIONS | 541 | ||
Chapter 22: Cutaneous infections and infestations – histological patterns | 543 | ||
Chapter 23: Bacterial and rickettsial infections | 547 | ||
INTRODUCTION | 548 | ||
SUPERFICIAL PYOGENIC INFECTIONS | 548 | ||
DEEP PYOGENIC INFECTIONS (CELLULITIS) | 551 | ||
CORYNEBACTERIAL INFECTIONS | 554 | ||
NEISSERIAL INFECTIONS | 556 | ||
MYCOBACTERIAL INFECTIONS | 556 | ||
MISCELLANEOUS BACTERIAL INFECTIONS | 566 | ||
CHLAMYDIAL INFECTIONS | 571 | ||
RICKETTSIAL INFECTIONS | 572 | ||
References | 572 | ||
Chapter 24: Spirochetal infections | 573 | ||
INTRODUCTION | 574 | ||
TREPONEMATOSES | 574 | ||
BORRELIOSES | 578 | ||
References | 580 | ||
Chapter 25: Mycoses and algal infections | 581 | ||
INTRODUCTION | 582 | ||
SUPERFICIAL FILAMENTOUS INFECTIONS | 582 | ||
YEAST INFECTIONS | 588 | ||
SYSTEMIC MYCOSES | 594 | ||
INFECTIONS BY DEMATIACEOUS FUNGI | 596 | ||
MYCETOMA AND MORPHOLOGICALLY SIMILAR CONDITIONS | 600 | ||
ZYGOMYCOSES | 603 | ||
HYALOHYPHOMYCOSES | 603 | ||
MISCELLANEOUS MYCOSES | 605 | ||
ALGAL INFECTIONS | 605 | ||
References | 606 | ||
Chapter 26: Viral diseases | 607 | ||
INTRODUCTION | 608 | ||
POXVIRIDAE | 608 | ||
HERPESVIRIDAE | 613 | ||
PAPOVAVIRIDAE (PAPILLOMAVIRIDAE) | 619 | ||
PARVOVIRIDAE | 625 | ||
PICORNAVIRIDAE | 626 | ||
TOGAVIRIDAE | 626 | ||
FLAVIVIRIDAE | 627 | ||
PARAMYXOVIRIDAE | 628 | ||
RETROVIRIDAE | 629 | ||
OTHER VIRAL DISEASES | 630 | ||
References | 631 | ||
Chapter 27: Protozoal infections | 633 | ||
INTRODUCTION | 634 | ||
AMEBAE | 634 | ||
FLAGELLATES | 635 | ||
COCCIDIA | 638 | ||
SPOROZOA | 638 | ||
MISCELLANEOUS | 639 | ||
References | 639 | ||
Chapter 28: Marine injuries | 641 | ||
INTRODUCTION | 642 | ||
CNIDARIANS | 642 | ||
MOLLUSCS | 643 | ||
ECHINODERMS | 643 | ||
SPONGES | 643 | ||
SEAWEED | 643 | ||
VENOMOUS FISH | 643 | ||
References | 643 | ||
Chapter 29: Helminth infestations | 645 | ||
INTRODUCTION | 646 | ||
TREMATODE INFESTATIONS | 646 | ||
CESTODE INFESTATIONS | 646 | ||
NEMATODE INFESTATIONS | 648 | ||
References | 650 | ||
Chapter 30: Arthropod-induced diseases | 651 | ||
INTRODUCTION | 652 | ||
ARACHNIDS | 652 | ||
INSECTS | 658 | ||
References | 663 | ||
Part VII: TUMORS | 665 | ||
Chapter 31: Tumors of the epidermis | 667 | ||
INTRODUCTION | 668 | ||
EPIDERMAL AND OTHER NEVI | 668 | ||
PSEUDOEPITHELIOMATOUS HYPERPLASIA | 670 | ||
ACANTHOMAS | 671 | ||
EPIDERMAL DYSPLASIAS | 676 | ||
INTRAEPIDERMAL CARCINOMAS | 679 | ||
MALIGNANT TUMORS | 682 | ||
MISCELLANEOUS ‘TUMORS’ | 701 | ||
References | 708 | ||
Chapter 32: Lentigines, nevi, and melanomas | 709 | ||
INTRODUCTION | 710 | ||
LESIONS WITH BASAL MELANOCYTE PROLIFERATION | 710 | ||
MELANOCYTIC NEVI | 713 | ||
DERMAL MELANOCYTIC LESIONS | 727 | ||
ATYPICAL NEVOMELANOCYTIC LESIONS | 731 | ||
MALIGNANT MELANOCYTIC LESIONS | 734 | ||
References | 756 | ||
Chapter 33: Tumors of cutaneous appendages | 757 | ||
HAIR FOLLICLE TUMORS | 758 | ||
SEBACEOUS TUMORS | 772 | ||
APOCRINE TUMORS | 779 | ||
ECCRINE TUMORS | 794 | ||
COMPLEX ADNEXAL TUMORS | 805 | ||
Chapter 34: Tumors and tumor-like proliferations of fibrous and related tissues | 809 | ||
INTRODUCTION | 810 | ||
ACRAL ANGIOFIBROMAS | 810 | ||
FIBROUS OVERGROWTHS, FIBROMATOSES, MYOFIBROBLASTIC PROLIFERATIONS, AND FIBROSARCOMA | 813 | ||
FIBROHISTIOCYTIC TUMORS | 827 | ||
PRESUMPTIVE SYNOVIAL AND TENDON SHEATH TUMORS | 839 | ||
MISCELLANEOUS ENTITIES | 842 | ||
References | 844 | ||
Chapter 35: Tumors of fat | 845 | ||
References | 855 | ||
Chapter 36: Tumors of muscle, cartilage, and bone | 857 | ||
TUMORS OF SMOOTH MUSCLE | 858 | ||
TUMORS OF STRIATED MUSCLE | 862 | ||
TUMORS OF CARTILAGE | 864 | ||
TUMORS OF BONE | 864 | ||
References | 865 | ||
Chapter 37: Neural and neuroendocrine tumors | 867 | ||
INTRODUCTION | 868 | ||
NERVE SHEATH TUMORS | 868 | ||
HERNIATIONS AND ECTOPIAS | 881 | ||
NEUROENDOCRINE TUMORS | 882 | ||
References | 886 | ||
Chapter 38: Vascular tumors | 887 | ||
INTRODUCTION | 888 | ||
HAMARTOMAS AND MALFORMATIONS | 888 | ||
VASCULAR DILATATIONS (TELANGIECTASES) | 894 | ||
VASCULAR PROLIFERATIONS (HYPERPLASIAS AND BENIGN NEOPLASMS) | 897 | ||
TUMORS WITH VARIABLE OR UNCERTAIN BEHAVIOR | 913 | ||
MALIGNANT TUMORS | 919 | ||
TUMORS WITH A SIGNIFICANT VASCULAR COMPONENT | 924 | ||
References | 925 | ||
Chapter 39: Cutaneous metastases | 927 | ||
INTRODUCTION | 928 | ||
CLINICAL AND MORPHOLOGICAL FEATURES | 928 | ||
References | 936 | ||
Chapter 40: Cutaneous infiltrates – non-lymphoid | 937 | ||
INTRODUCTION | 938 | ||
NEUTROPHIL INFILTRATES | 938 | ||
EOSINOPHIL INFILTRATES | 938 | ||
PLASMA CELL INFILTRATES | 943 | ||
MAST CELL INFILTRATES | 947 | ||
HISTIOCYTIC INFILTRATES (NON-LANGERHANS CELL) | 951 | ||
XANTHOMATOUS INFILTRATES | 961 | ||
LANGERHANS CELL INFILTRATES | 965 | ||
References | 970 | ||
Chapter 41: Cutaneous infiltrates – lymphomatous and leukemic | 971 | ||
INTRODUCTION | 972 | ||
CUTANEOUS T-CELL AND NK-CELL LYMPHOMAS | 973 | ||
CUTANEOUS B-CELL LYMPHOMAS | 987 | ||
PRECURSOR HEMATOLOGIC NEOPLASM | 993 | ||
OTHER T/NK-CELL LYMPHOMAS THAT MAY INVOLVE THE SKIN | 994 | ||
OTHER B-CELL LYMPHOMAS THAT MAY INVOLVE THE SKIN | 996 | ||
OTHER LYMPHOMAS | 998 | ||
CUTANEOUS INFILTRATES OF LEUKEMIAS | 999 | ||
LYMPHOID HYPERPLASIAS MIMICKING PRIMARY LYMPHOMA | 1000 | ||
MISCELLANEOUS | 1003 | ||
References | 1005 | ||
Index | 1007 |