Menu Expand
SD - Weedon's Skin Pathology E-Book

SD - Weedon's Skin Pathology E-Book

David Weedon

(2009)

Additional Information

Book Details

Abstract

Thoroughly revised and up-dated, this comprehensive, authoritative reference will help both the experienced and novice practitioner diagnose skin diseases and disorders more accurately and effectively. A superb full colour art programme illustrates the salient pathological features of both neoplastic and non-neoplastic conditions and will help the reader easily interpret key clinical and diagnostic points. This single–authored text incorporates the wealth of Dr Weedon’s own personal observations and experience in his approach to the diagnosis and interpretation of skin biopsies and is full of useful diagnostic clues and pearls. This remarkable book is an indispensable resource for all those involved in the identification and evaluation of skin disorders.

  • Encyclopedic reference work that discusses established disorders, unusual and rare disease entities as well as incompletely defined entities.
  • The book is comprehensive enough to meet the requirements of trainee and practicing dermatopathologists or pathologists when reporting on the histopathology of skin specimens.
  • A single authored text that presents an internationally recognized master diagnostician’s personal philosophy and skill in dealing with the diagnosis of skin biopsies.Provides a uniformity, clarity and internal consistency of approach and style that other books cannot match.
  • Over 1,200 large-sized, high quality illustrations.
  • Will facilitate an accurate diagnosis by accurately reproducing in the book what is seen through the microscope and thereby help identify the characteristic features of the lesion demonstrated.
  • For many of the features listed there will be practical advice on pitfalls and how to avoid them drawn from Dr Weedon’s unrivalled personal experience.Will facilitate the daily practice of dermatopathology and save the practitioner a lot of time and money.
  • Tables and boxes that organize diseases into groups, synthesize diagnostic criteria and list differential diagnoses makes the book user friendly and the information easy-to-access.
  • Remarkably authoritative, comprehensive, current and relevant reference list for each entity. There are over 35,000 references in the text.This degree of inclusivity facilitates the identification of both key articles and more rare and unusual reports. References only available online in this single volume version.
  • New sections on treatment that highlight recent treatment trials and guidelines.
  • Clinical descriptions updated.
  • Brand new illustrations incorporated throughout.
  • 14,000 new references.
  • Latest IHC and molecular techniques set within context of histopathological diagnosis.
  • OMIM (online Mendelian Inheritance in Man) numbers added for all relevant diseases to provide access to continous update on the scientific basis of hereditary disease.
  • Text and images available online via Expert Consult.

Table of Contents

Section Title Page Action Price
Front cover cover
Half title page i
Title page iii
Copyright page iv
Table of contents v
Preface vii
Part I: INTRODUCTION 1
Chapter 1: An approach to the interpretation of skin biopsies 3
INTRODUCTION 4
MAJOR TISSUE REACTION PATTERNS 4
MINOR TISSUE REACTION PATTERNS 12
PATTERNS OF INFLAMMATION 16
References 18
Chapter 2: Diagnostic clues 19
FEATURES OF PARTICULAR PROCESSES 20
HISTOLOGICAL FEATURES – WHAT DO THEY SUGGEST? 22
CLUES TO A PARTICULAR DISEASE 29
GENERAL HELPFUL HINTS AND CAUTIONS 31
Part II: TISSUE REACTION\rPATTERNS 33
Chapter 3: The lichenoid reaction pattern (‘interface dermatitis’) 35
INTRODUCTION 36
LICHENOID (INTERFACE) DERMATOSES 38
POIKILODERMAS 66
OTHER LICHENOID (INTERFACE) DISEASES 68
References 70
Chapter 4: The psoriasiform reaction pattern 71
INTRODUCTION 72
MAJOR PSORIASIFORM DERMATOSES 72
OTHER PSORIASIFORM DERMATOSES 87
Chapter 5: The spongiotic reaction pattern 93
INTRODUCTION 94
NEUTROPHILIC SPONGIOSIS 95
EOSINOPHILIC SPONGIOSIS 96
MILIARIAL SPONGIOSIS 97
FOLLICULAR SPONGIOSIS 99
PITYRIASIFORM SPONGIOSIS 100
OTHER SPONGIOTIC DISORDERS 102
Chapter 6: The vesiculobullous reaction pattern 123
INTRODUCTION 124
INTRACORNEAL AND SUBCORNEAL BLISTERS 126
INTRAEPIDERMAL BLISTERS 133
SUPRABASILAR BLISTERS 135
SUBEPIDERMAL BLISTERS – A CLASSIFICATION 140
SUBEPIDERMAL BLISTERS WITH LITTLE INFLAMMATION 141
SUBEPIDERMAL BLISTERS WITH LYMPHOCYTES 150
SUBEPIDERMAL BLISTERS WITH EOSINOPHILS 153
SUBEPIDERMAL BLISTERS WITH NEUTROPHILS 159
SUBEPIDERMAL BLISTERS WITH MAST CELLS 167
MISCELLANEOUS BLISTERING DISEASES 167
Chapter 7: The granulomatous reaction pattern 169
INTRODUCTION 170
SARCOIDAL GRANULOMAS 170
TUBERCULOID GRANULOMAS 173
NECROBIOTIC (COLLAGENOLYTIC) GRANULOMAS 177
SUPPURATIVE GRANULOMAS 184
FOREIGN BODY GRANULOMAS 186
XANTHOGRANULOMAS 187
MISCELLANEOUS GRANULOMAS 187
COMBINED GRANULOMATOUS AND LICHENOID PATTERN 194
References 194
Chapter 8: The vasculopathic reaction pattern 195
INTRODUCTION 196
NON-INFLAMMATORY PURPURAS 196
VASCULAR OCCLUSIVE DISEASES 197
URTICARIAS 202
ACUTE VASCULITIS 207
NEUTROPHILIC DERMATOSES 218
CHRONIC LYMPHOCYTIC VASCULITIS 225
VASCULITIS WITH GRANULOMATOSIS 238
MISCELLANEOUS VASCULAR DISORDERS 243
References 244
Part III: THE EPIDERMIS 245
Chapter 9: Disorders of epidermal maturation and keratinization 247
INTRODUCTION 248
ICHTHYOSES 249
PALMOPLANTAR KERATODERMAS AND RELATED CONDITIONS 257
CORNOID LAMELLATION 262
EPIDERMOLYTIC HYPERKERATOSIS 264
ACANTHOLYTIC DYSKERATOSIS 265
HYPERGRANULOTIC DYSCORNIFICATION 272
COLLOID KERATOSIS 272
DISCRETE KERATOTIC LESIONS 272
MISCELLANEOUS EPIDERMAL GENODERMATOSES 274
MISCELLANEOUS DISORDERS 278
References 279
Chapter 10: Disorders of pigmentation 281
INTRODUCTION 282
DISORDERS CHARACTERIZED BY HYPOPIGMENTATION 282
DISORDERS CHARACTERIZED BY HYPERPIGMENTATION 290
References 299
Part IV: THE DERMIS AND\rSUBCUTIS 301
Chapter 11: Disorders of collagen 303
INTRODUCTION 304
SCLERODERMA 304
SCLERODERMOID DISORDERS 311
OTHER HYPERTROPHIC COLLAGENOSES 316
ATROPHIC COLLAGENOSES 321
PERFORATING COLLAGENOSES 324
VARIABLE COLLAGEN CHANGES 326
SYNDROMES OF PREMATURE AGING 328
References 329
Chapter 12: Disorders of elastic tissue 331
INTRODUCTION 332
INCREASED ELASTIC TISSUE 333
SOLAR ELASTOTIC SYNDROMES 339
DECREASED ELASTIC TISSUE 344
VARIABLE OR MINOR ELASTIC TISSUE CHANGES 350
References 351
Chapter 13: Cutaneous mucinoses 353
INTRODUCTION 354
DERMAL MUCINOSES 355
FOLLICULAR MUCINOSES 364
EPITHELIAL MUCINOSES 367
MUCOPOLYSACCHARIDOSES 367
References 367
Chapter 14: Cutaneous deposits 369
INTRODUCTION 370
CALCIUM, BONE, AND CARTILAGE 370
HYALINE DEPOSITS 376
PIGMENT AND RELATED DEPOSITS 387
CUTANEOUS IMPLANTS 394
MISCELLANEOUS DEPOSITS 395
References 396
Chapter 15: Diseases of cutaneous appendages 397
INFLAMMATORY DISEASES OF THE PILOSEBACEOUS APPARATUS 399
HAIR SHAFT ABNORMALITIES 411
ALOPECIAS 417
MISCELLANEOUS DISORDERS 431
References 440
Chapter 16: Cysts, sinuses, and pits 441
INTRODUCTION 442
APPENDAGEAL CYSTS 442
DEVELOPMENTAL CYSTS 450
MISCELLANEOUS CYSTS 453
LYMPHATIC CYSTS 456
SINUSES 456
PITS 456
References 457
Chapter 17: Panniculitis 459
INTRODUCTION 460
SEPTAL PANNICULITIS 460
LOBULAR PANNICULITIS 463
PANNICULITIS SECONDARY TO LARGE VESSEL VASCULITIS 477
References 477
Part V: THE SKIN IN SYSTEMIC\rAND MISCELLANEOUS\rDISEASES 479
Chapter 18: Metabolic and storage diseases 481
INTRODUCTION 482
VITAMIN AND DIETARY DISTURBANCES 482
LYSOSOMAL STORAGE DISEASES 484
NECROLYTIC ERYTHEMAS 488
MISCELLANEOUS METABOLIC AND SYSTEMIC DISEASES 492
References 500
Chapter 19: Miscellaneous conditions 501
References 509
Chapter 20: Cutaneous drug reactions 511
INTRODUCTION 512
CLINICOPATHOLOGICAL REACTIONS 513
OFFENDING DRUGS 518
References 523
Chapter 21: Reactions to physical agents 525
INTRODUCTION 526
REACTIONS TO TRAUMA AND IRRITATION 526
REACTIONS TO RADIATION 527
REACTIONS TO HEAT AND COLD 529
REACTIONS TO LIGHT (PHOTODERMATOSES) 531
References 540
Part VI: INFECTIONS AND\rINFESTATIONS 541
Chapter 22: Cutaneous infections and infestations – histological patterns 543
Chapter 23: Bacterial and rickettsial infections 547
INTRODUCTION 548
SUPERFICIAL PYOGENIC INFECTIONS 548
DEEP PYOGENIC INFECTIONS (CELLULITIS) 551
CORYNEBACTERIAL INFECTIONS 554
NEISSERIAL INFECTIONS 556
MYCOBACTERIAL INFECTIONS 556
MISCELLANEOUS BACTERIAL INFECTIONS 566
CHLAMYDIAL INFECTIONS 571
RICKETTSIAL INFECTIONS 572
References 572
Chapter 24: Spirochetal infections 573
INTRODUCTION 574
TREPONEMATOSES 574
BORRELIOSES 578
References 580
Chapter 25: Mycoses and algal infections 581
INTRODUCTION 582
SUPERFICIAL FILAMENTOUS INFECTIONS 582
YEAST INFECTIONS 588
SYSTEMIC MYCOSES 594
INFECTIONS BY DEMATIACEOUS FUNGI 596
MYCETOMA AND MORPHOLOGICALLY SIMILAR CONDITIONS 600
ZYGOMYCOSES 603
HYALOHYPHOMYCOSES 603
MISCELLANEOUS MYCOSES 605
ALGAL INFECTIONS 605
References 606
Chapter 26: Viral diseases 607
INTRODUCTION 608
POXVIRIDAE 608
HERPESVIRIDAE 613
PAPOVAVIRIDAE (PAPILLOMAVIRIDAE) 619
PARVOVIRIDAE 625
PICORNAVIRIDAE 626
TOGAVIRIDAE 626
FLAVIVIRIDAE 627
PARAMYXOVIRIDAE 628
RETROVIRIDAE 629
OTHER VIRAL DISEASES 630
References 631
Chapter 27: Protozoal infections 633
INTRODUCTION 634
AMEBAE 634
FLAGELLATES 635
COCCIDIA 638
SPOROZOA 638
MISCELLANEOUS 639
References 639
Chapter 28: Marine injuries 641
INTRODUCTION 642
CNIDARIANS 642
MOLLUSCS 643
ECHINODERMS 643
SPONGES 643
SEAWEED 643
VENOMOUS FISH 643
References 643
Chapter 29: Helminth infestations 645
INTRODUCTION 646
TREMATODE INFESTATIONS 646
CESTODE INFESTATIONS 646
NEMATODE INFESTATIONS 648
References 650
Chapter 30: Arthropod-induced diseases 651
INTRODUCTION 652
ARACHNIDS 652
INSECTS 658
References 663
Part VII: TUMORS 665
Chapter 31: Tumors of the epidermis 667
INTRODUCTION 668
EPIDERMAL AND OTHER NEVI 668
PSEUDOEPITHELIOMATOUS HYPERPLASIA 670
ACANTHOMAS 671
EPIDERMAL DYSPLASIAS 676
INTRAEPIDERMAL CARCINOMAS 679
MALIGNANT TUMORS 682
MISCELLANEOUS ‘TUMORS’ 701
References 708
Chapter 32: Lentigines, nevi, and melanomas 709
INTRODUCTION 710
LESIONS WITH BASAL MELANOCYTE PROLIFERATION 710
MELANOCYTIC NEVI 713
DERMAL MELANOCYTIC LESIONS 727
ATYPICAL NEVOMELANOCYTIC LESIONS 731
MALIGNANT MELANOCYTIC LESIONS 734
References 756
Chapter 33: Tumors of cutaneous appendages 757
HAIR FOLLICLE TUMORS 758
SEBACEOUS TUMORS 772
APOCRINE TUMORS 779
ECCRINE TUMORS 794
COMPLEX ADNEXAL TUMORS 805
Chapter 34: Tumors and tumor-like proliferations of fibrous and related tissues 809
INTRODUCTION 810
ACRAL ANGIOFIBROMAS 810
FIBROUS OVERGROWTHS, FIBROMATOSES, MYOFIBROBLASTIC PROLIFERATIONS, AND FIBROSARCOMA 813
FIBROHISTIOCYTIC TUMORS 827
PRESUMPTIVE SYNOVIAL AND TENDON SHEATH TUMORS 839
MISCELLANEOUS ENTITIES 842
References 844
Chapter 35: Tumors of fat 845
References 855
Chapter 36: Tumors of muscle, cartilage, and bone 857
TUMORS OF SMOOTH MUSCLE 858
TUMORS OF STRIATED MUSCLE 862
TUMORS OF CARTILAGE 864
TUMORS OF BONE 864
References 865
Chapter 37: Neural and neuroendocrine tumors 867
INTRODUCTION 868
NERVE SHEATH TUMORS 868
HERNIATIONS AND ECTOPIAS 881
NEUROENDOCRINE TUMORS 882
References 886
Chapter 38: Vascular tumors 887
INTRODUCTION 888
HAMARTOMAS AND MALFORMATIONS 888
VASCULAR DILATATIONS (TELANGIECTASES) 894
VASCULAR PROLIFERATIONS (HYPERPLASIAS AND BENIGN NEOPLASMS) 897
TUMORS WITH VARIABLE OR UNCERTAIN BEHAVIOR 913
MALIGNANT TUMORS 919
TUMORS WITH A SIGNIFICANT VASCULAR COMPONENT 924
References 925
Chapter 39: Cutaneous metastases 927
INTRODUCTION 928
CLINICAL AND MORPHOLOGICAL FEATURES 928
References 936
Chapter 40: Cutaneous infiltrates – non-lymphoid 937
INTRODUCTION 938
NEUTROPHIL INFILTRATES 938
EOSINOPHIL INFILTRATES 938
PLASMA CELL INFILTRATES 943
MAST CELL INFILTRATES 947
HISTIOCYTIC INFILTRATES (NON-LANGERHANS CELL) 951
XANTHOMATOUS INFILTRATES 961
LANGERHANS CELL INFILTRATES 965
References 970
Chapter 41: Cutaneous infiltrates – lymphomatous and leukemic 971
INTRODUCTION 972
CUTANEOUS T-CELL AND NK-CELL LYMPHOMAS 973
CUTANEOUS B-CELL LYMPHOMAS 987
PRECURSOR HEMATOLOGIC NEOPLASM 993
OTHER T/NK-CELL LYMPHOMAS THAT MAY INVOLVE THE SKIN 994
OTHER B-CELL LYMPHOMAS THAT MAY INVOLVE THE SKIN 996
OTHER LYMPHOMAS 998
CUTANEOUS INFILTRATES OF LEUKEMIAS 999
LYMPHOID HYPERPLASIAS MIMICKING PRIMARY LYMPHOMA 1000
MISCELLANEOUS 1003
References 1005
Index 1007