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Consultations in Feline Internal Medicine, Volume 6 -  E-Book

Consultations in Feline Internal Medicine, Volume 6 - E-Book

John R. August

(2009)

Additional Information

Abstract

Completely revised and updated with 80 all-new chapters covering the most important information on current diagnostic, treatment, and preventive challenges facing feline practitioners today, Consultations in Feline Internal Medicine is an invaluable addition to every small animal clinician’s library. Full-color illustrations and expert contributions help you master and apply the latest advances in feline nutrition, emerging diseases, pet overpopulation, advanced imaging, and more with a comprehensive, clinically relevant approach.

  • More than 100 worldwide leaders in small animal practice provide expert insight across the full spectrum of feline internal medicine.
  • Extensive references make it easy to find additional information about specific topics most important to your practice.
  • Current, evidence-based coverage reflects the latest findings and reports on pressing topics such as:
    • Upper Respiratory Tract Aspergillosis
    • Exocrine Pancreatic Insufficiency
    • Diagnostic Imaging of the Ear
    • Cardiac Blood Tests
    • Urological Interventional Techniques

  • A new section on feline nutrition highlights the impact of nutritional considerations on feline health.
  • A dynamic full-color design, incorporating hundreds of NEW illustrations and tables, clarifies concepts and helps you interpret clinical data.

  • Table of Contents

    Section Title Page Action Price
    Front cover cover
    Half title page i
    Title page iii
    Copyright page iv
    Dedication v
    Preface vii
    Section Editors ix
    Contributors xiii
    Table of contents xxi
    Part I: Infectious Diseases 1
    Chapter 1: Pyothorax 3
    EPIDEMIOLOGY 3
    ETIOPATHOGENESIS 3
    HISTORY AND CLINICAL SIGNS 4
    DIFFERENTIAL DIAGNOSIS 5
    DIAGNOSIS 5
    TREATMENT 8
    PROGNOSIS 11
    PROPHYLAXIS 11
    REFERENCES 11
    Chapter 2: Influenza Infections 13
    ETIOLOGY 13
    EPIDEMIOLOGY 14
    PATHOGENESIS 14
    TRANSMISSION 14
    CLINICAL SIGNS 15
    DIFFERENTIAL DIAGNOSIS 15
    DIAGNOSIS 15
    TREATMENT 15
    MANAGEMENT 16
    CONTROL 16
    PREVENTION 17
    PATHOLOGICAL FINDINGS 17
    References 17
    Chapter 3: The Role of Wolbachia in Heartworm Infection 19
    ETIOLOGY 19
    EPIDEMIOLOGY 20
    PATHOGENESIS 21
    TRANSMISSION 23
    CLINICAL SIGNS 23
    DIAGNOSIS 24
    TREATMENT 24
    CONTROL AND PREVENTION 25
    PATHOLOGICAL FINDINGS 25
    REFERENCES 25
    Chapter 4: Cytauxzoon Infections 27
    ETIOLOGY 27
    EPIDEMIOLOGY 27
    PATHOGENESIS 29
    TRANSMISSION 29
    CLINICAL SIGNS 30
    DIFFERENTIAL DIAGNOSIS 30
    DIAGNOSIS 30
    TREATMENT 32
    PREVENTION 33
    PATHOLOGICAL FINDINGS 33
    REFERENCES 34
    Chapter 5: Upper Respiratory Tract Aspergillosis 36
    ETIOLOGY 36
    EPIDEMIOLOGY AND RISK FACTORS 38
    PATHOGENESIS 39
    HISTORY AND CLINICAL SIGNS 40
    DIFFERENTIAL DIAGNOSIS 42
    DIAGNOSIS 43
    TREATMENT AND PROGNOSIS 48
    SUMMARY 50
    REFERENCES 51
    Chapter 6: Progress on Diagnosis of Retroviral Infections 53
    FELINE LEUKEMIA VIRUS 53
    FELINE IMMUNODEFICIENCY VIRUS 56
    AMERICAN ASSOCIATION OF FELINE PRACTITIONERS’ RECOMMENDATIONS FOR RETROVIRAL DIAGNOSIS 59
    RETROVIRAL DIAGNOSTIC TESTING IN ANIMAL SHELTERS 59
    REFERENCES 60
    Chapter 7: Diagnosis and Treatment of Feline Infectious Peritonitis 62
    DIAGNOSIS 64
    TREATMENT 70
    CONTROL OF INFECTION 73
    REFERENCES 74
    Part II: Nutrition in Health and Disease 77
    Chapter 8: Dietary Therapy of Chronic Diarrhea 79
    KEY NUTRIENTS IN GASTROINTESTINAL HEALTH AND DISEASE 79
    APPLYING NUTRITIONAL CONCEPTS TO MANAGEMENT OF DIARRHEA 82
    SUMMARY 85
    REFERENCES 86
    Chapter 9: Dietary Therapy of Diseases of the Lower Urinary Tract 88
    INCIDENCE 88
    FELINE LOWER URINARY TRACT DISEASE 88
    SUMMARY 95
    REFERENCES 95
    Chapter 10: Metabolism, Diet, and Obesity 98
    DEFINITION 98
    PATHOGENESIS 99
    TREATMENT 101
    REFERENCES 102
    Chapter 11: Probiotics in Feline Medicine 104
    HISTORY OF PROBIOTIC HEALTH CLAIMS 104
    MECHANISMS OF PROBIOTIC ACTION 105
    CURRENT APPLICATIONS AND USES OF PROBIOTICS IN HUMAN BEINGS 107
    PROBIOTIC THERAPY IN DOGS 109
    PROBIOTIC THERAPY IN CATS 110
    REGULATORY ISSUES 110
    PROPER LABELING 111
    SAFETY 111
    FUTURE CONSIDERATIONS 112
    REFERENCES 113
    Chapter 12: Critical Care Nutrition 116
    IMPORTANCE OF NUTRITION DURING CRITICAL ILLNESS 116
    INDICATIONS FOR NUTRITIONAL SUPPORT 116
    NUTRITIONAL ASSESSMENT 117
    GOALS OF NUTRITIONAL SUPPORT 117
    NUTRITIONAL PLAN 117
    CALCULATING NUTRITIONAL REQUIREMENTS 118
    ENTERAL NUTRITION 118
    PARENTERAL NUTRITION 119
    MONITORING AND REASSESSMENT 123
    PHARMACOLOGICAL AGENTS IN NUTRITIONAL SUPPORT 124
    FUTURE DIRECTION IN CRITICAL CARE NUTRITION 125
    SUMMARY 125
    REFERENCES 125
    Chapter 13: Unconventional Diets 127
    REGULATORY DEFINITIONS 127
    HOME-PREPARED DIETS 128
    RAW FOOD FEEDING: ADDITIONAL CONSIDERATIONS 133
    VEGETARIAN AND VEGAN FEEDING 134
    SUPPLEMENTS AND NUTRACEUTICALS 134
    REFERENCES 135
    Chapter 14: Nutritional Management of Chronic Kidney Disease 137
    ENERGY 137
    PROTEIN 138
    FLUID BALANCE 140
    ELECTROLYTES 140
    ACID-BASE BALANCE 141
    MISCELLANEOUS NUTRIENTS 141
    CLINICAL EFFICACY 141
    SUMMARY 142
    REFERENCES 142
    Part III: Gastrointestinal System 145
    Chapter 15: Gastrointestinal Function Testing 147
    THE ROLE OF GI FUNCTION TESTS 147
    MOTILITY 147
    DIGESTION 151
    ABSORPTION 152
    PERMEABILITY TESTING 153
    IMMUNOLOGICAL RESPONSES 154
    SUMMARY 155
    REFERENCES 155
    Chapter 16: Ultrasonographic Imaging of the Gastrointestinal Tract 157
    METHOD OF EVALUATION 157
    NORMAL ANATOMY 159
    IMAGING OF SPECIFIC GASTROINTESTINAL DISORDERS 163
    ASPIRATION 184
    REFERENCES 185
    Chapter 17: Diagnosis and Treatment of Low-Grade Alimentary Lymphoma 187
    CLASSIFICATION OF ALIMENTARY LYMPHOMA 187
    EPIDEMIOLOGY 188
    RISK FACTORS 188
    SIGNALMENT 189
    HISTORY AND CLINICAL SIGNS 189
    Differential Diagnosis 189
    Diagnosis 191
    TREATMENT AND PROGNOSIS 196
    SUMMARY 197
    REFERENCES 197
    Chapter 18: Gastrointestinal Protozoal Infections 200
    COCCIDIANS 200
    FLAGELLATES 204
    OTHER ENTERIC PROTOZOANS 209
    REFERENCES 210
    Chapter 19: Inflammatory Liver Diseases 213
    ETIOLOGY AND PATHOGENESIS 214
    CLASSIFICATION 216
    ACUTE NEUTROPHILIC FORM OF CHOLANGITIS/CHOLANGIOHEPATITIS 216
    CHRONIC NEUTROPHILIC FORM OF CHOLANGITIS/CHOLANGIOHEPATITIS 219
    LYMPHOCYTIC CHOLANGITIS/CHOLANGIOHEPATITIS 221
    LYMPHOCYTIC PORTAL HEPATITIS 222
    CHOLANGITIS ASSOCIATED WITH LIVER FLUKES 223
    SUMMARY 223
    REFERENCES 224
    Chapter 20: Exocrine Pancreatic Insufficiency 225
    EPIDEMIOLOGY 225
    ETIOLOGY AND PATHOGENESIS 226
    CLINICAL PICTURE AND DIAGNOSIS 227
    MANAGEMENT 229
    PROGNOSIS 230
    SUMMARY 230
    REFERENCES 231
    Chapter 21: Antiemetic Therapy 232
    PHYSIOLOGY OF EMESIS 232
    ANTIEMETIC AGENTS 232
    RATIONAL CLINICAL USE OF ANTIEMETICS 236
    REFERENCES 238
    Chapter 22: Therapeutic Approach to Cats with Chronic Diarrhea 240
    ANTIPARASITIC AGENTS 240
    NUTRITION 242
    NUTRITIONAL SUPPLEMENTS 243
    ANTIBIOTICS 243
    IMMUNOSUPPRESSANTS 244
    COBALAMIN 245
    MISCELLANEOUS AGENTS 245
    SUMMARY 246
    REFERENCES 246
    Part IV: Endocrine and Metabolic Disease 249
    Chapter 23: Answers to Commonly Asked Endocrine Diagnostic Questions 251
    GENERAL QUESTIONS 251
    QUESTIONS ABOUT ADRENAL FUNCTION TESTING 251
    QUESTIONS ABOUT THYROID FUNCTION TESTING 252
    QUESTIONS ABOUT ACROMEGALY 253
    REFERENCES 253
    Chapter 24: Primary Hyperaldosteronism 254
    THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND CLASSIFICATION OF HYPERALDOSTERONISM 254
    OVERVIEW OF PRIMARY HYPERALDOSTERONISM IN HUMAN BEINGS 255
    FELINE PRIMARY HYPERALDOSTERONISM 257
    FELINE PRIMARY HYPERALDOSTERONISM: ADRENAL ADENOMA AND CARCINOMA 257
    FELINE PRIMARY HYPERALDOSTERONISM: IDIOPATHIC HYPERPLASIA 263
    DIAGNOSTIC CHALLENGES FOR THE FUTURE 264
    CASE EXAMPLE 1: ADRENOCORTICAL TUMOR 264
    CASE EXAMPLE 2: IDIOPATHIC HYPERPLASIA 265
    REFERENCES 266
    Chapter 25: Hyperthyroidism and the Kidneys 268
    RENAL FUNCTION IN HYPERTHYROIDISM 268
    DIAGNOSIS OF HYPERTHYROIDISM IN CATS WITH KIDNEY DISEASE 268
    CAN POSTTREATMENT RENAL INSUFFICIENCY BE PREDICTED? 269
    ARE SOME TREATMENTS SAFER THAN OTHERS? 270
    METHIMAZOLE TRIALS 270
    TREATMENT OF POSTTREATMENT RENAL INSUFFICIENCY 271
    MANAGING HYPERTENSION 271
    REFERENCES 272
    Chapter 26: Home Monitoring of Blood Glucose in Cats with Diabetes Mellitus 274
    MONITORING IN THE HOSPITAL 274
    SELF-MONITORING OF BLOOD GLUCOSE IN HUMAN BEINGS WITH DIABETES MELLITUS 276
    HOME MONITORING OF BLOOD GLUCOSE BY CAT OWNERS 276
    CASE EXAMPLE 1 282
    CASE EXAMPLE 2 283
    REFERENCES 284
    Chapter 27: Use of Long-Acting Insulin in the Treatment of Diabetes Mellitus 286
    GOALS OF THERAPY 286
    PATHOGENESIS OF FELINE DIABETES MELLITUS 286
    TYPE 2 DIABETES MELLITUS 287
    DIAGNOSIS OF DIABETES MELLITUS 287
    GLUCOSE TOXICITY 288
    PREDICTORS OF DIABETIC REMISSION 288
    INSULIN CHOICE 288
    MODE OF ACTION OF GLARGINE 289
    MODE OF ACTION OF DETEMIR 289
    STORAGE OF GLARGINE AND DETEMIR 289
    DURATION OF ACTION AND ONCE- OR TWICE-DAILY ADMINISTRATION 289
    HYPOGLYCEMIA 290
    SOMOGYI EFFECT 290
    DIET 290
    WEIGHT MANAGEMENT 290
    MONITORING 291
    DOSING 291
    DOSE VARIATIONS 294
    HOME MONITORING 294
    MANAGEMENT OF CATS IN REMISSION 295
    SUMMARY 295
    REFERENCES 295
    Chapter 28: Diabetic Emergencies 297
    DEFINITION AND PATHOPHYSIOLOGY OF DIABETIC KETOACIDOSIS 297
    DEFINITION AND PATHOPHYSIOLOGY OF THE HYPEROSMOLAR HYPERGLYCEMIC STATE 298
    RISK FACTORS FOR DKA OR HHS 298
    CLINICAL SIGNS AND PHYSICAL EXAMINATION FINDINGS IN CATS WITH DKA OR HHS 298
    CLINICAL PATHOLOGY OF DKA OR HHS 299
    DIFFERENTIAL DIAGNOSES 300
    TREATMENT OF DKA OR HHS 300
    OUTCOME OF PATIENTS WITH DKA OR HHS 302
    INSULIN OVERDOSE 302
    REFERENCES 302
    Chapter 29: Acromegaly 304
    ETIOLOGY 304
    EPIDEMIOLOGY 304
    PATHOGENESIS 305
    CLINICAL SIGNS 306
    DIAGNOSIS 308
    TREATMENT 311
    ADDITIONAL MANAGEMENT AND PROGNOSIS 313
    REFERENCES 314
    Part V: Dermatology 317
    Chapter 30: Anatomy of the Ear in Health and Disease 319
    EAR PINNA 319
    EAR CANALS 322
    TYMPANIC MEMBRANE 324
    MIDDLE EAR (TYMPANIC CAVITY) 325
    FIBEROPTIC VIDEO ENHANCED OTOSCOPY VERSUS STANDARD OTOSCOPY 327
    EXAMINATION SUMMARY 328
    REFERENCES 330
    Chapter 31: Diagnostic Imaging of the Ear 331
    IMAGING OPTIONS 331
    INDICATIONS FOR IMAGING CATS 333
    GENERAL PROCEDURES FOR IMAGING CATS 334
    COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING 336
    IMAGE INTERPRETATION 336
    COMMON FELINE EAR DISEASES 337
    SUMMARY 342
    REFERENCES 345
    Chapter 32: Medical Management of Otitis 347
    ETIOLOGY AND PATHOGENESIS 347
    CLINICAL SIGNS 348
    DIAGNOSIS 349
    DIAGNOSTIC TESTS 349
    SELECTED EAR DISEASES OF CATS 350
    OTOTOXICITY CONCERNS 356
    REFERENCES 357
    Chapter 33: Rush and Conventional Immunotherapy 358
    DESIGNING THE TREATMENT PLAN 358
    THERAPEUTIC OPTIONS 358
    ALLERGEN-SPECIFIC IMMUNOTHERAPY 359
    RUSH ALLERGEN-SPECIFIC IMMUNOTHERAPY 363
    CONCURRENT USE OF MEDICATIONS 364
    REFERENCES 366
    Chapter 34: Methicillin-Resistant Staphylococci 368
    ETIOLOGY OF STAPHYLOCOCCAL INFECTIONS 368
    ETIOLOGY OF METHICILLIN RESISTANCE 368
    EPIDEMIOLOGY 369
    PATHOGENESIS 370
    TRANSMISSION 370
    CLINICAL SIGNS 371
    DIAGNOSIS 371
    TREATMENT 372
    MANAGEMENT 372
    REFERENCES 373
    Chapter 35: Acne 375
    ETIOLOGY AND PATHOGENESIS 375
    CLINICAL SIGNS 375
    DIAGNOSIS 375
    HISTOPATHOLOGICAL FEATURES 377
    TREATMENT 378
    SYSTEMIC THERAPEUTIC OPTIONS 380
    PROGNOSIS 380
    REFERENCES 380
    Chapter 36: Use of Interferon Omega for Skin Diseases 382
    REVIEW OF COMPOUND 382
    MECHANISM OF ACTION 383
    USE IN SKIN DISEASES 385
    REFERENCES 388
    Chapter 37: How to Treat Common Parasites Safely 390
    FLEAS 390
    MOSQUITO AND CULICOIDES HYPERSENSITIVITY 396
    TICKS 397
    DEMODICOSIS 397
    EAR MITES (OTODECTES CYNOTIS) 397
    FELINE SCABIES (NOTOEDRES CATI) 397
    CHEYLETIELLOSIS 398
    CAT FUR MITE (LYNXACARUS RADOVSKY) 398
    PEDICULOSIS 398
    REFERENCES 398
    Part VI: Cardiology and Respiratory Disorders 399
    Chapter 38: Cardiac Blood Tests 401
    NATRIURETIC PEPTIDES 401
    DETECTION OF UNDERLYING HEART DISEASE 401
    ASSESSMENT OF DISEASE SEVERITY 402
    DETECTING HEART FAILURE IN THE CAT WITH RESPIRATORY SIGNS 402
    PROGNOSTIC VALUE AND GUIDE TO TREATMENT 402
    CARDIAC TROPONINS 403
    LIMITATIONS OF CARDIAC BLOOD TESTING 404
    REFERENCES 404
    Chapter 39: Genetic Screening of Familial Hypertrophic Cardiomyopathy 406
    ETIOLOGY 406
    EPIDEMIOLOGY 408
    REFERENCES 409
    Chapter 40: Diastolic Dysfunction in Feline Cardiomyopathies 410
    DEFINITION 410
    PHYSIOLOGY 411
    DETERMINANTS OF DIASTOLIC FUNCTION 411
    PATHOGENESIS OF DIASTOLIC DYSFUNCTION 412
    ASSESSMENT OF DIASTOLIC FUNCTION 413
    THERAPY 417
    REFERENCES 418
    Chapter 41: Congenital Heart Disease 420
    MITRAL VALVE DYSPLASIA 420
    TRICUSPID VALVE DYSPLASIA 421
    PATENT DUCTUS ARTERIOSUS 422
    PULMONIC STENOSIS 422
    VENTRICULAR SEPTAL DEFECT 423
    PERITONEOPERICARDIAL DIAPHRAGMATIC HERNIA 423
    ATRIOVENTRICULAR CANAL DEFECTS OR ATRIOVENTRICULAR SEPTAL DEFECTS 423
    SUPRAVALVULAR MITRAL STENOSIS AND COR TRIATRIATUM SINISTER 425
    DOUBLE-OUTLET RIGHT VENTRICLE 426
    DOUBLE-CHAMBERED RIGHT VENTRICLE 426
    RIGHT-TO-LEFT SHUNTING (REVERSE) PATENT DUCTUS ARTERIOSUS 426
    TRUNCUS ARTERIOSUS 427
    PULMONARY ARTERY STENOSIS 427
    REFERENCES 427
    Chapter 42: Rhythm Disturbances: Recognition and Therapy 429
    IDENTIFICATION OF RHYTHM DISTURBANCES 429
    SINUS RHYTHM AND SINUS TACHYCARDIA 430
    SINUS BRADYCARDIA AND SINUS ARRHYTHMIA 431
    SUPRAVENTRICULAR TACHYARRHYTHMIAS 431
    ABNORMALITIES OF ATRIOVENTRICULAR NODAL CONDUCTION 433
    VENTRICULAR PREEXCITATION 434
    VENTRICULAR ARRHYTHMIAS 435
    REFERENCES 437
    Chapter 43: Pathology of Primary Myocardial Disease 438
    THE ROLE OF CARDIOVASCULAR PATHOLOGY IN PRACTICE 438
    CARDIOVASCULAR PATHOLOGY IN HEART FAILURE 438
    MYOCARDIAL DISEASES (CARDIOMYOPATHIES) 439
    MISCELLANEOUS CARDIOVASCULAR DISEASES AND CONDITIONS 445
    REFERENCES 445
    Chapter 44: Asthma 447
    PATHOPHYSIOLOGY 447
    CLINICAL FINDINGS IN FELINE ASTHMA 449
    DIAGNOSIS 449
    TREATMENT 451
    REASONABLE EXPECTATIONS 457
    REFERENCES 458
    Chapter 45: Bronchoscopy 459
    CASE SELECTION 459
    COMPLICATIONS 459
    ENDOSCOPES 460
    ANESTHESIA 460
    PROCEDURE 460
    SAMPLE HANDLING 463
    SUMMARY 463
    REFERENCES 464
    Part VII: Urinary System 465
    Chapter 46: Commercial Pet Food–Related Nephrotoxicity 467
    ETIOLOGY 467
    PATHOGENESIS 467
    CLINICAL SIGNS 469
    DIAGNOSIS 469
    TREATMENT 471
    PROGNOSIS 472
    CONTROL AND PREVENTION 472
    REFERENCES 473
    Chapter 47: Linking Treatment to Staging in Chronic Kidney Disease 475
    ESTABLISHING A DIAGNOSIS OF CHRONIC KIDNEY DISEASE 475
    INITIAL EVALUATION OF CATS WITH CHRONIC KIDNEY DISEASE 477
    STAGING OF CHRONIC KIDNEY DISEASE 477
    RENAL EVALUATION AND SPECIFIC THERAPY 478
    EVALUATION OF PROGRESSION AND RENOPROTECTIVE THERAPY 478
    PATIENT EVALUATION AND SYMPTOMATIC THERAPY 480
    ADDITIONAL PATIENT EVALUATIONS 481
    SUMMARY 481
    REFERENCES 481
    Chapter 48: Survival and Outcome of Kidney Disease 483
    CHRONIC KIDNEY DISEASE 483
    ACUTE KIDNEY INJURY 486
    REFERENCES 487
    Chapter 49: Managing and Monitoring Systemic Hypertension 489
    EPIDEMIOLOGY OF HYPERTENSION 489
    END-ORGAN DAMAGE 490
    MEASUREMENT OF BLOOD PRESSURE 491
    MEASUREMENT OF BLOOD PRESSURE BY THE DOPPLER METHOD 492
    DECIDING TO TREAT FOR SYSTEMIC HYPERTENSION 494
    TREATMENT OF SYSTEMIC HYPERTENSION 494
    THERAPEUTIC END-POINTS 496
    FOLLOW-UP EVALUATIONS 497
    SUMMARY 497
    REFERENCES 497
    Chapter 50: Purine Uroliths 499
    WHAT ARE PURINES? 499
    WHAT IS URIC ACID? 499
    WHAT ARE THE PATHOPHYSIOLOGICAL METHODS OF URATE UROLITH FORMATION? 500
    WHY DO CATS FORM URATE UROLITHS? 502
    HOW ARE URATE STONES DIAGNOSED IN CATS? 503
    ONCE STONES ARE DETECTED, HOW SHOULD THEY BE MANAGED? 504
    HOW CAN URATE UROLITH RECURRENCE BE PREVENTED? 504
    REFERENCES 507
    Chapter 51: Urinary Tract Tumors 509
    RENAL TUMORS 509
    LOWER URINARY TRACT NEOPLASIA 510
    REFERENCES 514
    Chapter 52: Urological Interventional Techniques in the Feline Patient 516
    BACKGROUND—INTERVENTIONS IN HUMAN UROLOGY 516
    EQUIPMENT 517
    DISEASES OF THE UPPER URINARY COLLECTION SYSTEM: RENAL PELVIS AND URETER 517
    DISEASES OF THE LOWER URINARY COLLECTION SYSTEM: URINARY BLADDER AND URETHRA 524
    REFERENCES 529
    Part VIII: Neurology 531
    Chapter 53: Intervertebral Disk Disease 533
    ANATOMY OF THE INTERVERTEBRAL DISK 533
    EPIDEMIOLOGY AND PATHOGENESIS 533
    CLINICAL SIGNS 535
    DIFFERENTIAL DIAGNOSIS 535
    DIAGNOSIS 536
    TREATMENT AND PROGNOSIS 537
    NEUROPATHOLOGICAL FINDINGS 538
    REFERENCES 538
    Chapter 54: Novel Anticonvulsant Therapies 540
    PRINCIPLES OF ANTICONVULSANT THERAPY 540
    TRADITIONAL ANTICONVULSANT THERAPIES 544
    NOVEL ANTICONVULSANT THERAPIES 545
    EMERGENCY ANTICONVULSANT THERAPY 546
    REFERENCES 547
    Chapter 55: Brain Tumors: Clinical Spectrum 548
    INCIDENCE AND ETIOLOGY 548
    SIGNALMENT 549
    CLINICAL SIGNS 549
    DIAGNOSIS 549
    TREATMENT 552
    PROGNOSIS 554
    CLASSIFICATION OF TUMORS 554
    REFERENCES 565
    Chapter 56: Gene Therapy for Lysosomal Storage Diseases 568
    ALPHA-MANNOSIDOSIS 568
    NEURONAL CEROID LIPOFUSCINOSIS 570
    GALACTOSYLCERAMIDE LIPIDOSIS 570
    GANGLIOSIDOSES 570
    GLYCOGENOSES 570
    MUCOLIPIDOSIS 570
    MUCOPOLYSACCHARIDOSES 570
    SPHINGOMYELINOSES 572
    THERAPY OF LYSOSOMAL STORAGE DISEASES 572
    REFERENCES 575
    Chapter 57: Tremor Syndromes 579
    CLASSIFICATION OF TREMOR 579
    PATHOPHYSIOLOGY 581
    DIAGNOSTIC APPROACH 584
    DIFFERENTIAL DIAGNOSIS 585
    TREATMENT 590
    MOVEMENT DISORDERS THAT MIMIC TREMOR 590
    REFERENCES 591
    Chapter 58: Metabolic Encephalopathy: 595
    ORGANIC ACIDS 595
    DIAGNOSING ORGANIC ACID DISORDERS 595
    D-LACTIC ACIDOSIS WITH GASTROINTESTINAL DISEASE 597
    METHYLMALONIC ACIDURIA AND COBALAMIN DEFICIENCY 598
    CONGENITAL COBALAMIN DEFICIENCY 599
    INBORN ERRORS OF METABOLISM 600
    THERAPY FOR ORGANIC ACIDURIAS 600
    SUMMARY 601
    REFERENCES 601
    Chapter 59: Myopathic Disorders 602
    ACQUIRED MYOPATHIES 603
    INHERITED MYOPATHIES 607
    MISCELLANEOUS MYOPATHIES 612
    SUMMARY 613
    REFERENCES 613
    Part IX: Hematopoietic and Lymphatic Systems 615
    Chapter 60: Immune-Mediated Hemolytic Anemia 617
    ETIOLOGY AND PATHOGENESIS 617
    EPIDEMIOLOGY 618
    SIGNALMENT 619
    HISTORY 619
    CLINICAL AND LABORATORY FINDINGS 619
    DIAGNOSTIC IMAGING 621
    DIFFERENTIAL DIAGNOSIS 621
    DIAGNOSIS 621
    TREATMENT 623
    COURSE OF DISEASE AND PROGNOSIS 625
    REFERENCES 626
    Chapter 61: Blood Types of the Domestic Cat 628
    BRIEF OVERVIEW 628
    SEROLOGICAL TECHNIQUES FOR FELINE BLOOD TYPE DETECTION 628
    THE Mik ANTIGEN: A NEW BLOOD TYPE 629
    MOLECULAR STRUCTURES OF FELINE BLOOD TYPES 630
    GENETIC BASIS OF FELINE BLOOD TYPES 630
    CLINICAL IMPLICATIONS OF GENETIC BLOOD TYPING 632
    BLOOD TYPE FREQUENCIES OF THE AB SYSTEM 633
    REFERENCES 637
    Chapter 62: Disseminated Intravascular Coagulation 639
    ETIOLOGY 639
    EPIDEMIOLOGY 640
    COAGULATION IN THE NORMAL STATE 640
    CLINICAL FEATURES 643
    DIFFERENTIAL DIAGNOSIS 643
    PATHOLOGICAL FINDINGS 643
    DIAGNOSIS 643
    TREATMENT 648
    PROGNOSIS 649
    SUMMARY 650
    REFERENCES 650
    Chapter 63: Selection of Treatment Protocols for Lymphoma 652
    REVIEW OF PROTOCOLS 652
    FACTORS IMPACTING THE CAT OWNER’S DECISION ABOUT LYMPHOMA TREATMENT 654
    FACTORS INFLUENCING THE VETERINARIAN’S SELECTION OF LYMPHOMA TREATMENT PROTOCOL 655
    FACTORS INFLUENCING THE SELECTION OF A LYMPHOMA TREATMENT PROTOCOL 658
    REFERENCES 659
    Chapter 64: Feline Bone Marrow Disorders 661
    HISTOPATHOLOGICAL ALTERATIONS IN BONE MARROW 662
    SPECIFIC BONE MARROW DISORDERS 664
    SUMMARY 669
    REFERENCES 669
    Chapter 65: Plasma Cell Disorders 671
    MULTIPLE MYELOMA AND RELATED PLASMA CELL DISORDERS 671
    SOLITARY OSSEOUS AND EXTRAMEDULLARY PLASMACYTOMAS 680
    REFERENCES 682
    Chapter 66: Clinical Use of Erythropoietin in Feline Medicine 684
    ERYTHROPOIESIS-STIMULATING AGENTS (ESA) 684
    BENEFITS OF TREATMENT OF ANEMIA 686
    INDICATIONS FOR ERYTHROPOIESIS-STIMULATING AGENTS 686
    GUIDELINES FOR USE OF ERYTHROPOIESIS-STIMULATING AGENTS 688
    ADJUVANT THERAPY: IRON 688
    COMPLICATIONS OF THE USE OF ERYTHROPOIETIN 689
    SUMMARY 690
    REFERENCES 691
    Part X: Oncology 695
    Chapter 67: Mast Cell Tumors 697
    ETIOLOGY OF MAST CELL TUMORS 697
    FELINE MAST CELL TUMORS: CUTANEOUS 697
    FELINE MAST CELL TUMORS: VISCERAL-SPLENIC 699
    FELINE MAST CELL TUMORS: VISCERAL-INTESTINAL 700
    SUMMARY 701
    REFERENCES 701
    Chapter 68: Cardiac Neoplasia 703
    CLINICAL SIGNS 703
    DIAGNOSIS 703
    TREATMENT 704
    LYMPHOMA 704
    CHEMODECTOMA 704
    HEMANGIOSARCOMA 705
    REFERENCES 705
    Chapter 69: Tumors of the Ear 707
    INCIDENCE AND ETIOLOGY 707
    BIOLOGICAL BEHAVIOR AND PATHOGENESIS 709
    CLINICAL SIGNS ASSOCIATED WITH EAR TUMORS 710
    DIAGNOSIS AND STAGING OF EAR TUMORS 711
    TREATMENT FOR EAR TUMORS 714
    PREVENTION OF EAR TUMORS 716
    SUMMARY 716
    REFERENCES 716
    Chapter 70: Ocular Tumors 718
    PRIMARY TUMORS 718
    SECONDARY (METASTATIC) TUMORS 724
    SUMMARY 725
    REFERENCES 725
    Chapter 71: The Dilemmas of Cytological Evaluation of the Feline Lymph Node 728
    SAMPLE ACQUISITION AND SMEAR PREPARATION OF LYMPH NODES 728
    NORMAL LYMPH NODE CYTOLOGY 728
    ABNORMAL LYMPH NODE CYTOLOGY: THE INITIAL DILEMMA 729
    THE REACTIVE HYPERPLASTIC LYMPH NODE DILEMMA 730
    THE INFLAMMATORY LYMPH NODE DILEMMA 730
    THE NEOPLASTIC LYMPH NODE DILEMMA 734
    SUMMARY 738
    REFERENCES 738
    Chapter 72: Facilitating Client Grief 742
    RELAYING DIFFICULT NEWS 742
    EUTHANASIA 743
    POSTEUTHANASIA AND THE GRIEVING PROCESS 744
    SPECIAL NEEDS CLIENTS 746
    SUMMARY 748
    REFERENCES 748
    Chapter 73: Chemotherapy Administration 749
    CHEMOTHERAPY SAFETY 749
    RECORD KEEPING 750
    CHEMOTHERAPY ADMINISTRATION 753
    POSTCHEMOTHERAPY CLEAN-UP 757
    CLIENT COMMUNICATION 757
    SUMMARY 757
    REFERENCES 759
    Part XI: Population Medicine 761
    Chapter 74: Shelter Population Health Management 763
    FACILITY AS IT RELATES TO POPULATION HEALTH 763
    ENVIRONMENTAL INFECTION CONTROL 765
    INFECTIOUS DISEASE POLICIES AND PROTOCOLS 767
    NUTRITION 771
    DISEASE SURVEILLANCE 771
    POPULATION HEALTH CHALLENGES 771
    SUMMARY 774
    REFERENCES 774
    Chapter 75: A Review of Neutering Cats 776
    IMPLICATIONS FOR FELINE WELFARE 776
    BENEFITS OF NEUTERING ON HEALTH 777
    VETERINARY MEDICAL GUIDELINES FOR SPAY-NEUTER PROGRAMS 778
    SPECIAL CONCERNS FOR FELINE PATIENTS IN THE SPAY-NEUTER CLINIC 779
    SURGICAL TECHNIQUES 781
    OPTIMIZING SUCCESS OF SPAY-NEUTER PROGRAMS 789
    SUMMARY 790
    REFERENCES 790
    Chapter 76: Genetic Testing in Domestic Cats 793
    GENETIC STRUCTURE OF THE CAT 793
    DOMESTIC CAT MUTATIONS 794
    TYPES OF GENETIC MUTATIONS 796
    GENETIC TESTING VALIDATION 797
    GENETIC TESTING ACCURACY 797
    GENETIC TESTING IN HYBRID BREEDS 799
    SUMMARY 799
    REFERENCES 800
    Chapter 77: Understanding Population Dynamics Models: 803
    BACKGROUND OF POPULATION DYNAMICS MODELS 803
    DEFINITIONS 804
    APPROACHES TO POPULATION DYNAMICS MODELING 805
    WHAT DATA ARE NEEDED? 806
    EVALUATING THE MODEL 807
    RECENT EXAMPLES 808
    SUMMARY 809
    REFERENCES 809
    Chapter 78: Hospice “Pawspice” 811
    RATIONALE FOR FELINE PAWSPICE CARE 812
    DISMISSED CLIENTS GO ELSEWHERE 812
    BARRIERS TO PROVIDING PAWSPICE CARE 813
    HOW DOES ONE START? 814
    VALIDATE “THE BOND” 815
    RECOGNIZE ANTICIPATORY GRIEF 815
    FEARFUL OWNERS 815
    QUALITY OF LIFE SCALE HELPS DECISION-MAKING 816
    USING THE HHHHHMM QUALITY OF LIFE SCALE 817
    SPECIFIC DISEASE CONDITIONS 818
    IMMUNONUTRITION AND CHEMOPREVENTION 821
    INTERNET AND NETWORKING 821
    DAY CARE 821
    EUTHANASIA FOR THE PAWSPICE CAT 821
    REFERENCES 823
    Chapter 79: Alternative Modalities in Feline Practice 825
    ACUPUNCTURE 826
    CHIROPRACTIC/SPINAL MANIPULATION 829
    CHINESE AND WESTERN HERBS 831
    REFERENCES 833
    Chapter 80: Catteries: 834
    REPRODUCTIVE PHYSIOLOGY 834
    INFERTILITY 839
    COMPONENTS IN A CATTERY HERD HEALTH PROGRAM 845
    SUMMARY 845
    REFERENCES 845
    Index 849