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The Human Body in Health and Illness - E-Book

The Human Body in Health and Illness - E-Book

Barbara Herlihy

(2017)

Additional Information

Book Details

Abstract

Learn the A&P you’ll really use in practice! The Human Body in Health and Illness, 6th Edition uses hundreds of illustrations, colorful cartoons, and an easy-to-read approach to simplify Anatomy & Physiology concepts. Organized by body system, this resource shows how each organ is designed to work by including clear, step-by-step explanations, clinical examples, and online animations. It also demonstrates what happens to the body when a system does not function properly. Written by well-known author and educator Barbara Herlihy, this resource makes it easier and more fun to learn A&P concepts — and gives you the basic background you need to begin a healthcare career.

  • Full-color illustrations simplify difficult concepts and complex processes, accurately depicting anatomy, physiology, and disease. 
  • Colorful cartoons use humor to clarify and reinforce the content, making it more memorable, accessible, and easy to understand.
  • Interesting analogies, examples, and anecdotes make learning easier and bring science to life.
  • Key terms and objectives begin every chapter, setting learning expectations and goals, with terms defined in a comprehensive glossary. 
  • Useful learning and review features include Re-Think questions, Ramp It Up! and As You Age boxes, plus Did You Know boxes with clinical scenarios and historical vignettes. 
  • Focus on medical terminology includes Medical Terminology and Disorders tables with pronunciations, derivations, and word parts, along with references to commonly used medical terminology.
  • Evolve companion website enhances your understanding with animations, learning activities, and review tools.
  • A study guide offers fun and practical exercises to help you review, understand, and remember basic A&P. Sold separately.
  • New animations bring difficult concepts to life.
  • New illustrations show more step-by-step processes, and include new review questions to help you understand the concepts depicted. 
  • UPDATED content includes additional chapter review questions.
  • NEW! More pronunciations and new med term activities are included.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Contents ES1
The Human Bodyin Healthand Illness i
Copyright ii
IFC iii
Dedication iv
Acknowledgments v
TO THE INSTRUCTOR vi
TEXTBOOK STRENGTHS vi
CLASSROOM RESOURCES vii
STUDY GUIDE vii
EVOLVE INSTRUCTOR LEARNING RESOURCES vii
TEACH Instructor Resource on Evolve vii
TO THE STUDENT ix
KEY TERMS ix
OBJECTIVES ix
ILLUSTRATIONS ix
?DO YOU KNOW… ix
?RAMP IT UP! ix
?RE-THINK ix
?AS YOU AGE ix
?SUM IT UP! ix
END-OF-CHAPTER FEATURES ix
Summary Outline ix
Review Your Knowledge ix
Go Figure ix
ANSWERS TO REVIEW YOUR KNOWLEDGE AND GO FIGURE QUESTIONS ix
GLOSSARY ix
STUDY GUIDE ix
Contents x
1 - Introduction to the Human Body 1
ANATOMY AND PHYSIOLOGY: WHAT THEY ARE 1
WHAT’S IT MEAN? 1
WHY DO I NEED TO KNOW THIS? 2
THE BODY’S LEVELS OF ORGANIZATION 2
MAJOR ORGAN SYSTEMS 2
HOMEOSTASIS: STAYING THE SAME 6
ANATOMICAL TERMS: TALKING ABOUT THE BODY 6
ANATOMICAL POSITION 6
RELATIVE POSITIONS 6
PLANES OF THE BODY 7
REGIONAL TERMS 8
CAVITIES OF THE BODY 9
DORSAL CAVITY 10
VENTRAL CAVITY 10
THORACIC CAVITY 10
ABDOMINOPELVIC CAVITY 10
Division into Quadrants 11
Division into Regions 11
Other Cavities 11
2 - Basic Chemistry 15
MATTER, ELEMENTS, AND ATOMS 15
MATTER 15
ELEMENTS 16
ATOMS 16
ATOMIC STRUCTURE 16
OTHER CHARACTERISTICS OF ATOMS 16
ELECTRON SHELLS 18
CHEMICAL BONDS 18
IONIC BONDS 18
COVALENT BONDS 18
HYDROGEN BONDS 18
POLARITY 19
IONS 20
CATIONS, ANIONS, AND ELECTROLYTES 20
ION FORMATION 20
IONIZATION 20
MOLECULES AND COMPOUNDS 21
MOLECULES 21
COMPOUNDS 21
SOME IMPORTANT COMPOUNDS AND MOLECULES 21
WATER 21
OXYGEN 21
CARBON DIOXIDE 22
CHEMICAL REACTIONS 22
ACIDS AND BASES 22
ACIDS 23
BASES 23
NEUTRALIZATION OF ACIDS AND BASES 23
MEASUREMENT: THE PH SCALE 23
READING THE PH SCALE 23
PH OF BODY FLUIDS 23
ENERGY 24
FORMS OF ENERGY 25
CONVERSION OF ENERGY 25
ENERGY TRANSFER: THE ROLE OF ADENOSINE TRIPHOSPHATE 25
MIXTURES, SOLUTIONS, SUSPENSIONS, AND PRECIPITATES 25
MIXTURES 26
SOLUTIONS 26
SUSPENSIONS 26
PRECIPITATES 27
3 - CELLS 30
TYPICAL CELL 30
CELL MEMBRANE 31
INSIDE THE CELL 31
NUCLEUS 31
CYTOPLASM 32
Cytoplasmic Gel 32
CYTOPLASMIC ORGANELLES 34
Mitochondria 34
Ribosomes 34
Endoplasmic Reticulum 34
Golgi Apparatus 34
Lysosomes 35
Cytoskeleton 35
Centrioles 35
ON THE CELL MEMBRANE 35
MICROVILLI 35
CILIA 36
FLAGELLA 36
MOVEMENT ACROSS THE CELL MEMBRANE 36
PASSIVE TRANSPORT MECHANISMS 36
DIFFUSION 36
FACILITATED DIFFUSION 38
OSMOSIS 38
TONICITY 39
Isotonic Solution 39
Hypotonic Solution 39
Hypertonic Solutions 39
FILTRATION 39
ACTIVE TRANSPORT MECHANISMS 40
ACTIVE TRANSPORT PUMPS 40
ENDOCYTOSIS 40
EXOCYTOSIS 40
CELL DIVISION 40
CELL CYCLE 41
INTERPHASE 41
MITOSIS 42
CELL DIFFERENTIATION 43
STEM CELLS 43
ORDER, DISORDER, AND DEATH 43
4 - CELL METABOLISM 48
METABOLISM 48
CARBOHYDRATES 48
MONOSACCHARIDES 48
DISACCHARIDES 49
POLYSACCHARIDES 49
USES OF GLUCOSE 50
THE BREAKDOWN OF GLUCOSE 50
THE MAKING OF GLUCOSE 51
LIPIDS (FATS) 52
USES OF LIPIDS 52
MAKING FAT 54
PROTEINS 54
AMINO ACIDS 54
USES OF PROTEINS 55
BREAKDOWN OF PROTEIN AND THE PROBLEM WITH AMMONIA 55
Formation of Urea 55
PROTEIN SYNTHESIS AND DNA 56
DNA STRUCTURE 56
THE GENETIC CODE 56
Reading the Code 57
Copying the Code: mRNA 57
mRNA as Copycat 58
STEPS IN PROTEIN SYNTHESIS 58
5 - Microbiology Basics 65
WHAT IS DISEASE? 65
TYPES OF PATHOGENS 66
MICROORGANISMS (MICROBES) 66
OTHER (MULTICELLULAR) DISEASE-CAUSING ORGANISMS 69
LABORATORY IDENTIFICATION OF PATHOGENS 69
THE SPREAD OF INFECTION 70
PORTALS OF ENTRY AND EXIT 70
HOW PATHOGENS SPREAD 71
PERSON-TO-PERSON CONTACT 71
ENVIRONMENT-TO-PERSON CONTACT 71
“TINY ANIMAL”-TO-PERSON CONTACT 71
FIVE GERM-LADEN STORIES 71
DR. SEMMELWEIS SCREAMS, “WASH THOSE MITTS!” 72
FLORA AND HER VAGINAL ITCH 74
RICK, NICK, AND THE SICK TICK 75
WHY TYPHOID MARY NEEDED TO LOSE HER GALLBLADDER 75
A POX NEWS ALERT! 75
6 - Tissues and Membranes 78
EPITHELIAL TISSUE 78
Where Is It Found? 78
What Does It Do? 78
What Is It Like? 78
Classification 79
Simple Epithelia 79
Stratified Epithelia 80
Glandular Epithelia 82
Connective Tissue 82
Where Is It Found? 82
What Does It Look Like? 82
Connective Tissue Cells 82
Types of Connective Tissue 83
Loose Connective Tissue 83
Dense Fibrous Connective Tissue 83
Cartilage 85
Types of Cartilage 86
Bone 86
Blood and Lymph 86
Nervous Tissue 86
Neurons 86
Muscle Tissue 86
Skeletal Muscle 86
Smooth Muscle 86
Cardiac Muscle 86
Tissue Repair 88
Membranes 88
Classification of Membranes 88
Epithelial Membranes 88
Cutaneous Membrane 88
Mucous Membranes 88
Serous Membranes 89
7 - INTEGUMENTARY SYSTEM AND BODY TEMPERATURE 94
STRUCTURE OF THE SKIN 95
LAYERS OF THE SKIN 95
EPIDERMIS 95
DERMIS 96
THE SKIN TELLS A STORY 96
SUBCUTANEOUS LAYER 97
THE SKIN, DRUGS, AND CHEMICALS 97
SKIN COLOR 97
ACCESSORY STRUCTURES OF THE SKIN 98
HAIR 98
NAILS 100
GLANDS 100
BODY TEMPERATURE 102
HEAT PRODUCTION 102
HEAT LOSS 102
REGULATION 102
NEWBORNS AND BODY TEMPERATURE 103
WHEN SKIN IS BURNED 104
ESCHAR 106
A NOTE ABOUT SKIN CARE 106
8 - SKELETAL SYSTEM 112
ARRANGEMENT AND FUNCTIONSOF BONES 112
THE SKELETAL SYSTEM: WHAT IT DOES 112
MANY SIZES AND SHAPES OF BONES 112
BONE TISSUE AND BONE FORMATION 114
COMPACT AND SPONGY BONE 114
LONG BONES 116
OSSIFICATION 116
OSSIFICATION OF FLAT BONES: INTRAMEMBRANOUS OSSIFICATION 116
OSSIFICATION OF LONG BONES: ENDOCHONDRAL OSSIFICATION 116
GROWING BONES 117
GROWING TALLER 117
The “What-Ifs” of the Epiphyseal Disc 117
GROWING THICKER AND WIDER 117
BUMPS AND GROOVES 117
BROKEN BONES 118
DIVISIONS OF THE SKELETAL SYSTEM 118
AXIAL SKELETON 118
SKULL 118
Cranium 118
Facial Bones 120
Sinuses 122
How the Skull Bones Are Held Together 122
The Infant Skull 122
Hyoid Bone 123
Bones of the Middle Ear 123
VERTEBRAL COLUMN 123
The Back and Its Stack of Bones 123
Two Special Vertebrae: Atlas (C1) and Axis (C2) 124
Characteristics of Vertebrae 124
SOME VERTEBRAL COLUMN CONCERNS 124
Curvatures 125
THORACIC CAGE 126
Sternum 126
Ribs 126
Lines and Angles 126
APPENDICULAR SKELETON 128
SHOULDER GIRDLE 128
Clavicle 128
Scapula 128
UPPER LIMBS 128
Humerus 128
Radius 128
Ulna 128
Hand 128
Pelvic Girdle 130
Pelvis 130
Coxal Bone 130
LOWER LIMBS 130
Femur 130
Patella 132
Tibia and Fibula 132
Foot 132
JOINTS (ARTICULATIONS) 134
JOINT CLASSIFICATION 134
IMMOVABLE JOINTS 134
SLIGHTLY MOVABLE JOINTS 134
FREELY MOVABLE JOINTS 134
NAMING JOINTS 135
MOVING SYNOVIAL JOINTS 135
HINGE JOINT 136
BALL-AND-SOCKET JOINT 136
PIVOT JOINT 136
SADDLE JOINT 137
GLIDING JOINT 137
CONDYLOID JOINT 137
CLINICALLY “BIG” SYNOVIAL JOINTS 137
KNEE 137
SHOULDER 137
ELBOW 137
HIP 137
9 - Muscular System 143
TYPES AND FUNCTIONS OF MUSCLES 143
SKELETAL MUSCLE 143
SMOOTH MUSCLE 143
CARDIAC MUSCLE 144
STRUCTURE OF THE WHOLE MUSCLE 145
MUSCLE 145
LAYERS OF CONNECTIVE TISSUE 145
MUSCLE ATTACHMENTS 146
STRUCTURE AND FUNCTION OF A SINGLE MUSCLE FIBER 146
HOW MUSCLES CONTRACT 146
SLIDING FILAMENT MECHANISM 146
THE ROLE OF CALCIUM AND ADENOSINE TRIPHOSPHATE 147
SKELETAL MUSCLES AND NERVES 148
SOMATIC MOTOR NEURON 148
THE MOTOR UNIT 148
THE NEUROMUSCULAR JUNCTION 148
THE STIMULATED MUSCLE MEMBRANE 148
DISORDERS OF THE NEUROMUSCULAR JUNCTION 149
Myasthenia Gravis 149
Neuromuscular Blockade Caused by Curare 149
Effects of Neurotoxins on Muscle Function 149
MUSCLE RESPONSES 151
ENERGY SOURCE FOR MUSCLE CONTRACTION 152
MUSCLE FATIGUE 153
MUSCLE TERMS 153
ORIGIN AND INSERTION 153
PRIME MOVER, SYNERGIST, AND ANTAGONIST 153
MUSCLE OVERUSE AND UNDERUSE TERMS 153
HYPERTROPHY 153
ATROPHY 153
CONTRACTURE 153
HOW SKELETAL MUSCLES ARE NAMED 154
SIZE 154
SHAPE 154
ORIENTATION OF FIBERS 154
LOCATION 154
NUMBER OF ORIGINS 154
ORIGIN AND INSERTION 154
MUSCLE ACTION 154
MUSCLES FROM HEAD TO TOE 154
MUSCLES OF THE HEAD 154
FACIAL MUSCLES 154
CHEWING MUSCLES 160
MUSCLES OF THE NECK 161
STERNOCLEIDOMASTOID 161
TRAPEZIUS 161
MUSCLES OF THE TRUNK 161
MUSCLES INVOLVED IN BREATHING 161
MUSCLES THAT FORM THE ABDOMINAL WALL 161
MUSCLES THAT MOVE THE VERTEBRAL COLUMN 162
MUSCLES THAT FORM THE PELVIC FLOOR 162
MUSCLES OF THE SHOULDER (PECTORAL) GIRDLE AND ARM 162
MUSCLES THAT MOVE THE FOREARM 163
MUSCLES THAT MOVE THE WRIST, HAND, AND FINGERS 163
THE CARPAL TUNNEL 164
MUSCLES THAT MOVE THE THIGH, LEG, AND FOOT 164
MUSCLES THAT MOVE THE FEMUR (THIGH BONE) 164
MUSCLES THAT MOVE THE LEG 165
MUSCLES THAT MOVE THE FOOT 165
10 - Nervous System: Nervous Tissue and Brain 173
THE NERVOUS SYSTEM: STRUCTURE AND FUNCTION 173
DIVISIONS OF THE NERVOUS SYSTEM 173
FUNCTIONS OF THE NERVOUS SYSTEM 173
SENSORY FUNCTION 173
INTEGRATIVE FUNCTION 173
MOTOR FUNCTION 174
CELLS THAT MAKE UP THE NERVOUS SYSTEM 174
NEUROGLIA 174
NEURON 175
PARTS OF A NEURON 176
Three Parts 176
The Axon: A Special Structure 176
WHITE MATTER VERSUS GRAY MATTER 177
THE NEURON CARRYING INFORMATION 177
THE NERVE IMPULSE: WHAT IT IS 177
THE NERVE IMPULSE: WHAT CAUSES IT 177
RESTING MEMBRANE POTENTIAL 178
DEPOLARIZATION 179
REPOLARIZATION 179
THE NERVE IMPULSE: WHAT CAUSES IT TO MOVE 180
THE NERVE IMPULSE: WHAT CAUSES IT TO MOVE QUICKLY 181
SYNAPSE ACROSS NEURONS 181
PARTS OF A SYNAPSE 181
EVENTS AT THE SYNAPSE 182
BRAIN: STRUCTURE AND FUNCTION 183
CEREBRUM 183
GRAY ON THE OUTSIDE, WHITE ON THE INSIDE 183
MARKINGS OF THE CEREBRUM 184
LOBES OF THE CEREBRUM 185
Frontal Lobe 185
Parietal Lobe 187
Temporal Lobe 187
Occipital Lobe 187
FUNCTIONS INVOLVING MANY CEREBRAL LOBES 187
Speech Area 187
ASSOCIATION AREAS 187
PATCHES OF GRAY 187
DIENCEPHALON 188
BRAIN STEM 188
MIDBRAIN 188
PONS 188
MEDULLA OBLONGATA 189
Vomiting Center 189
CEREBELLUM 189
STRUCTURES ACROSS DIVISIONS OF THE BRAIN 190
LIMBIC SYSTEM: THE EMOTIONAL BRAIN 190
RETICULAR FORMATION 190
Reticular Activating System (RAS): Wakefulness, Sleep, and Coma 190
Stages of Sleep 190
MEMORY AREAS 191
PROTECTING THE CENTRAL NERVOUS SYSTEM 191
BONE: FIRST LAYER OF PROTECTION 191
MENINGES: SECOND LAYER OF PROTECTION 191
CEREBROSPINAL FLUID: THIRD LAYER OF PROTECTION 191
BLOOD–BRAIN BARRIER: FOURTH LAYER OF PROTECTION 193
11 - Nervous System: Spinal Cord and Peripheral Nerves 201
WHAT THE SPINAL CORD IS 201
LOCATION AND SIZE 201
GRAY ON THE INSIDE, WHITE ON THE OUTSIDE 201
GRAY MATTER 201
WHITE MATTER 202
Decussation 203
WHAT THE SPINAL CORD DOES 204
REFLEXES 204
WHAT REFLEXES ARE 204
THE REFLEX ARC 205
MANY, MANY REFLEXES 205
OUCH! THE WITHDRAWAL REFLEX 205
Organ Reflexes 206
PERIPHERAL NERVOUS SYSTEM 207
NERVES 207
CLASSIFYING THE PERIPHERAL NERVOUS SYSTEM 207
STRUCTURAL CLASSIFICATION OF THE PERIPHERAL NERVOUS SYSTEM 207
Cranial Nerves 207
SPINAL NERVES ATTACHED TO THE SPINAL CORD 210
Names and Numbers of Spinal Nerves 211
Spinal Nerve Plexuses 211
What a Dermatome Is 212
FUNCTIONAL CLASSIFICATION OF THE PERIPHERAL NERVOUS SYSTEM 215
12 - Autonomic Nervous System 219
AUTONOMIC (VISCERAL) REFLEXES 219
WHAT THEY DO 219
PATHWAY 219
ORGANIZATION AND FUNCTION OF THE AUTONOMIC NERVOUS SYSTEM 220
DIVISION OF THE AUTONOMIC NERVOUS SYSTEM 220
SYMPATHETIC NERVOUS SYSTEM: FIGHT OR FLIGHT 220
PARASYMPATHETIC NERVOUS SYSTEM: FEED AND BREED 221
AUTONOMIC TERMINOLOGY AND PHARMACOLOGY 221
AUTONOMIC TONE AND VASOMOTOR TONE 222
AUTONOMIC NERVOUS SYSTEM NEURONS 222
NUMBERS AND GANGLIA 222
NEURONS OF THE SYMPATHETIC NERVOUS SYSTEM 223
NEURONS OF THE PARASYMPATHETIC NERVOUS SYSTEM 223
RUNNING WITH CRANIAL NERVES 224
Oculomotor Nerve (CN III) 224
Facial Nerve (CN Vll) 224
Glossopharyngeal Nerve (CN lX) 224
Vagus Nerve (CN X) 224
NAMING FIBERS AND NEUROTRANSMITTERS 224
NEUROTRANSMITTERS: TERMINATION OF ACTIVITY 225
RECEPTORS OF THE AUTONOMIC NERVOUS SYSTEM 225
CHOLINERGIC RECEPTORS 225
ADRENERGIC RECEPTORS 226
AUTONOMIC TERMINOLOGY: “DOING” AUTONOMIC PHARMACOLOGY 227
13 - SENSORY SYSTEM 232
RECEPTORS AND SENSATION 232
CELLS THAT DETECT STIMULI 232
SENSATION AND PERCEPTION 233
EXPERIENCING A SENSATION 233
FOUR COMPONENTS 233
TWO CHARACTERISTICS OF SENSATION 233
THE GENERAL SENSES 234
PAIN 234
TOUCH AND PRESSURE 236
TEMPERATURE 236
PROPRIOCEPTION 237
THE SPECIAL SENSES 237
SENSE OF SMELL: THE NOSE 237
WHAT A SMELL CAN TELL 237
SENSE OF TASTE: THE TONGUE 238
SOME TASTEFUL COMMENTS 238
SENSE OF SIGHT: THE EYE 239
VISUAL ACCESSORY ORGANS 239
Eyebrows 239
Eyelids 239
Conjunctiva 240
Eyelashes 240
Lacrimal Apparatus 240
Extrinsic Eye Muscles 241
THE EYEBALL 241
Layers of the Eyeball 241
Cavities and Fluids 243
MUSCLES OF THE EYE 243
Extrinsic Eye Muscles 243
Intrinsic Eye Muscles 244
PATHWAY OF LIGHT 245
REFRACTION AND ACCOMMODATION 245
STIMULATION OF THE PHOTORECEPTORS 247
Night Vision 247
Color Vision 247
INFORMING THE BRAIN: THE VISUAL PATHWAY 247
VISION LOSS—WHEN ALL IS NOT RIGHT 248
SENSE OF HEARING: THE EAR 249
STRUCTURE OF THE EAR 249
External Ear 249
Middle Ear 250
Inner Ear 250
HEARING HAPPENS WHEN… 251
HEARING DOESN’T HAPPEN WHEN… 251
SENSE OF BALANCE: THE EAR 251
STATIC EQUILIBRIUM 251
DYNAMIC EQUILIBRIUM 252
14 - ENDOCRINE SYSTEM 260
ENDOCRINE GLANDS 260
CLASSIFICATION OF HORMONES 260
TARGETS 262
HORMONE RECEPTORS 262
CONTROL OF HORMONE SECRETION 263
FEEDBACK LOOPS 263
BIORHYTHMS 263
CONTROL BY THE CENTRAL NERVOUS SYSTEM 263
PITUITARY GLAND AND THE HYPOTHALAMUS 264
ANTERIOR PITUITARY GLAND 264
GROWTH HORMONE 264
PROLACTIN 267
TROPIC HORMONES 267
POSTERIOR PITUITARY GLAND 267
ANTIDIURETIC HORMONE 267
OXYTOCIN 267
THYROID GLAND 268
THYROID FOLLICLE 268
WHAT THYROID HORMONES (T3 AND T4) DO 268
REGULATION OF SECRETION 269
THE NEED FOR IODINE 269
SYNTHESIS OF THYROID HORMONE 269
IODINE DEFICIENCY 269
CALCITONIN 269
PARATHYROID GLANDS 270
PTH DEFICIENCY AND HYPOCALCEMIC TETANY 270
ADRENAL GLANDS 271
ADRENAL MEDULLA 271
ADRENAL CORTEX 273
GLUCOCORTICOIDS 273
Control of Cortisol Secretion 273
MINERALOCORTICOIDS 273
SEX HORMONES 273
NEGATIVE FEEDBACK…AGAIN 273
PANCREAS 274
INSULIN 274
SECRETION AND EFFECTS 274
GLUCAGON 276
GONADS 277
THYMUS GLAND 277
PINEAL GLAND 277
OTHER HORMONES 277
ORGAN-SPECIFIC HORMONES 277
PROSTAGLANDINS 277
ADIPOSE TISSUE HORMONES 277
Heart and Blood Vessels 277
Diabetes Mellitus 277
Cancer 278
Joint Disease 278
15 - BLOOD 284
COMPOSITION OF BLOOD 285
CHARACTERISTICS 285
BLOOD HAS TWO PARTS 285
ORIGIN OF BLOOD CELLS 286
HEMOPOIESIS AND RED BONE MARROW 286
BONE MARROW WOES: TOO LITTLE, TOO MUCH 286
BONE MARROW DEPRESSION 286
BONE MARROW OVERACTIVITY 286
BLOOD CELLS 287
RED BLOOD CELLS 287
SHAPE AND CONTENTS 288
HEMOGLOBIN 288
WHY BLOOD CHANGES ITS COLOR 289
WHAT IS ESSENTIAL FOR HEMOGLOBIN PRODUCTION? 289
REGULATION OF RBC PRODUCTION 290
REMOVAL AND BREAKDOWN OF RED BLOOD CELLS 290
RECYCLE! 290
WHITE BLOOD CELLS 291
TYPES OF WHITE BLOOD CELLS 292
GRANULOCYTES 292
AGRANULOCYTES 293
GOOD NEWS, BAD NEWS 294
PLATELETS 294
BLOOD COUNTS 294
DIFFERENTIAL COUNT 294
HEMOSTASIS: PREVENTION OF BLOOD LOSS 294
BLOOD VESSEL SPASM 294
FORMATION OF A PLATELET PLUG 294
BLOOD COAGULATION 294
FORMATION OF THE BLOOD CLOT 295
CLOT RETRACTION 295
CLOT BUSTING: FIBRINOLYSIS 295
PREVENTION OF EXCESSIVE CLOT FORMATION 297
Natural Mechanisms 297
Use of Medications That Prevent Excessive Clot Formations 297
BLOOD TYPES 298
ANTIGENS AND BLOOD TYPES 298
ANTIBODIES AND BLOOD TYPE 298
ANTIGEN–ANTIBODY INTERACTION 298
COMPATIBILITY AND INCOMPATIBILITY OF BLOOD TYPES 298
RH CLASSIFICATION SYSTEM 300
16 - ANATOMY OF THE HEART 308
FUNCTION, LOCATION, AND SIZE OF THE HEART 308
LAYERS AND COVERING OF THE HEART 309
ENDOCARDIUM 310
MYOCARDIUM 310
EPICARDIUM 310
PERICARDIUM 310
A DOUBLE PUMP AND TWO CIRCULATIONS 311
THE HEART’S CHAMBERS AND GREAT VESSELS 312
RIGHT ATRIUM 312
RIGHT VENTRICLE 313
LEFT ATRIUM 313
LEFT VENTRICLE 313
GREAT VESSELS OF THE HEART 313
HEART VALVES 313
ATRIOVENTRICULAR VALVES 313
SEMILUNAR VALVES 314
PULMONIC VALVE 314
AORTIC VALVE 314
HEART SOUNDS 315
PATHWAY OF BLOOD FLOW THROUGH THE HEART 315
BLOOD SUPPLY TO THE MYOCARDIUM 315
ISCHEMIA AND INFARCTION 316
CARDIAC ENZYMES AND LEAKY CELLS 317
CARDIAC CONDUCTION SYSTEM 318
PARTS OF THE CARDIAC CONDUCTION SYSTEM 318
SINOATRIAL NODE 318
ATRIAL CONDUCTING FIBERS 318
ATRIOVENTRICULAR NODE 318
HIS-PURKINJE SYSTEM 318
AUTOMATICITY AND RHYTHMICITY 319
NORMAL, SLOW, AND SLOWER 319
ELECTROCARDIOGRAM 319
17 - Function of the Heart 325
THE COORDINATED AND ADAPTABLE PUMP 325
CARDIAC CYCLE 325
AUTONOMIC CONTROL OF THE HEART 326
WHY THE AUTONOMIC NERVOUS SYSTEM? 326
AUTONOMIC WIRING 326
AUTONOMIC FIRING 327
Sympathetic Stimulation 327
Parasympathetic (Vagus Nerve) Stimulation 327
CARDIAC OUTPUT AND VENOUS RETURN 328
Heart Rate 328
Stroke Volume 329
How to Change Stroke Volume 329
CHANGING CARDIAC OUTPUT 330
HEART TALK 331
HEART TALK: CLINICAL TERMS 331
END-DIASTOLIC VOLUME 331
PRELOAD 331
EJECTION FRACTION 331
AFTERLOAD 331
INOTROPIC EFFECT 331
CHRONOTROPIC EFFECT 332
DROMOTROPIC EFFECT 332
HEART TALK: RECEPTOR LANGUAGE 332
BETA1-ADRENERGIC RECEPTOR ACTIVATION 332
BETA1-ADRENERGIC RECEPTOR BLOCKADE 332
MUSCARINIC (CHOLINERGIC) RECEPTOR ACTIVATION 333
MUSCARINIC (CHOLINERGIC) RECEPTOR BLOCKADE 333
THE FAILING HEART: WHEN THE HEART CAN’T PUMP 333
LEFT HEART FAILURE 333
BACKWARD FAILURE 333
FORWARD FAILURE 333
RIGHT HEART FAILURE 334
18 - ANATOMY OF THE BLOOD VESSELS AND SPECIAL CIRCULATIONS 342
CIRCLES, CIRCUITS, AND CIRCULATIONS 342
BLOOD VESSELS 343
NAMING THE BLOOD VESSELS 343
ARTERIES 343
CAPILLARIES 343
VEINS 343
BLOOD VESSEL WALLS: THE LAYERED LOOK 343
BLOOD VESSELS: WHAT THEY DO 345
ARTERIES 345
ARTERIOLES 345
CAPILLARIES 345
VEINS AND VENULES 345
MAJOR ARTERIES OF THE SYSTEMIC CIRCULATION 346
AORTA 346
BRANCHES OF THE AORTA 347
BRANCHES OF THE ASCENDING AORTA 347
BRANCHES OF THE AORTIC ARCH 347
BRANCHES OF THE DESCENDING AORTA (THORACIC AORTA) 347
BRANCHES OF THE DESCENDING AORTA (ABDOMINAL AORTA) 347
MAJOR VEINS OF THE SYSTEMIC CIRCULATION 349
VENAE CAVAE 349
VEINS THAT EMPTY INTO THE SUPERIOR VENA CAVA 349
VEINS THAT EMPTY INTO THE INFERIOR VENA CAVA 350
SPECIAL CIRCULATIONS 351
BLOOD SUPPLY TO THE HEAD AND BRAIN 351
ARTERIES OF THE HEAD AND NECK 351
VENOUS DRAINAGE OF THE HEAD AND BRAIN 353
BLOOD SUPPLY TO THE LIVER AND THE HEPATIC PORTAL CIRCULATION 353
HEPATIC BLOOD VESSELS 353
FETAL CIRCULATION 353
PULSE 356
WHAT IS A PULSE? 356
WHAT CAN YOU LEARN ABOUT A PATIENT BY FEELING THE PULSE? 356
19 - Functions of the Blood Vessels 361
BLOOD VESSELS DELIVER 361
BLOOD VESSELS REGULATE BLOOD PRESSURE 361
BLOOD PRESSURE: NORMAL AND ABNORMAL 362
BLOOD PRESSURE IN DIFFERENT BLOOD VESSELS 362
WHAT DETERMINES BLOOD PRESSURE? 362
HEART AND BLOOD PRESSURE 362
BLOOD VESSELS AND BLOOD PRESSURE 363
HOW BLOOD PRESSURE STAYS WITHIN NORMAL LIMITS 365
RAPIDLY ACTING MECHANISMS 365
SLOWER-ACTING MECHANISMS AND LONG-TERM REGULATION OF BLOOD PRESSURE 367
BLOOD VESSELS ACT AS EXCHANGE VESSELS 367
WHAT IS AN EXCHANGE VESSEL? 367
WHY CAPILLARIES ARE GOOD EXCHANGE VESSELS 367
THIN CAPILLARY WALLS 368
MILLIONS OF CAPILLARIES 368
SLOW VELOCITY OF BLOOD FLOW 368
CAPILLARY FORCES: EXCHANGE 368
EXCHANGE INVOLVING DIFFUSION 368
EXCHANGE INVOLVING FILTRATION-OSMOSIS 368
MECHANISMS OF EDEMA FORMATION 368
Heart Failure 368
Severe Burn 369
Kidney Disease 369
Blocked Lymphatic Drainage 370
BLOOD VESSELS DISTRIBUTE BLOOD 370
BLOOD VESSELS REGULATE BODY TEMPERATURE 370
20 - LYMPHATIC SYSTEM 376
LYMPH: WHAT IT IS, WHERE IT COMES FROM 376
LYMPHATIC VESSELS 376
WHAT CAUSES LYMPH TO MOVE? 377
LYMPHATIC TISSUE 378
LYMPHATIC ORGANS 378
LYMPH NODES 378
THYMUS GLAND 379
SPLEEN 379
LYMPHATIC NODULES 381
TONSILS 381
MALT 381
PEYER’S PATCHES 381
APPENDIX 381
21 - Immune System 385
CLASSIFICATION OF THE IMMUNE SYSTEM 385
NONSPECIFIC IMMUNITY 385
FIRST LINE OF DEFENSE 386
SECOND LINE OF DEFENSE 387
Phagocytosis 387
Inflammation 388
Fever 388
Protective Proteins 389
Natural Killer Cells 389
SPECIFIC IMMUNITY: THIRD LINE OF DEFENSE 389
ANTIGENS 390
SELF AND NONSELF: IS THAT ME? 390
LYMPHOCYTES 390
Why the Names “T” and “B” Cells? 390
T-Cell Activation and Cell-Mediated Immunity 391
B-Cell Activation and Antibody-Mediated Immunity 392
ANTIBODIES 392
What Antibodies Are 392
What Antibodies Do 393
Remember Me? Primary and Secondary Responses 393
TYPES OF IMMUNITY 394
GENETIC IMMUNITY 394
ACQUIRED IMMUNITY 394
NATURALLY ACQUIRED IMMUNITY 394
ARTIFICIALLY ACQUIRED IMMUNITY 395
OTHER IMMUNE RESPONSES 396
ALLERGIC REACTIONS 396
22 - Respiratory System 403
STRUCTURE: ORGANS OF THE RESPIRATORY SYSTEM 403
UPPER AND LOWER RESPIRATORY TRACTS 403
NOSE AND NASAL CAVITIES 404
PHARYNX 405
LARYNX 405
WHERE AND WHAT IS YOUR VOICEBOX? 405
VOCAL CORDS 407
TRUE OR FALSE 407
DOWN THE WRONG WAY 407
TRACHEA 408
WHERE IT SITS AND WHERE IT SPLITS 408
KEEPING IT OPEN 408
BRONCHIAL TREE: BRONCHI, BRONCHIOLES, AND ALVEOLI 408
BRONCHI 408
BRONCHIOLES 410
ALVEOLI 410
LUNGS 410
RIGHT AND LEFT 410
PLEURAL MEMBRANES 411
PLEURA 411
PLEURAL CAVITY: A POTENTIAL SPACE 411
COLLAPSED AND EXPANDED LUNGS 411
WHY LUNGS COLLAPSE 411
ELASTIC RECOIL 411
SURFACE TENSION 411
WHY LUNGS EXPAND 412
SAYING IT ANOTHER WAY: COMPLIANCE 414
RESPIRATORY FUNCTION 414
THREE STEPS IN RESPIRATION 414
STEP 1: VENTILATION OR BREATHING 415
What It Is 415
Boyle’s Law: Pressure and Volume 415
Boyle’s Law and Breathing 416
The Muscles of Respiration 416
Nerves That Supply the Respiratory Muscles 417
STEP 2: EXCHANGE OF OXYGEN AND CARBON DIOXIDE 419
Why the Lungs Are Good Gas Exchangers 419
Partial Pressures and the Diffusion of Gases 419
STEP 3: TRANSPORT OF OXYGEN AND CARBON DIOXIDE 420
Oxygen Transport 420
Carbon Dioxide Transport 420
AMOUNTS OF AIR 421
LUNG VOLUMES 421
LUNG CAPACITIES 422
DEAD SPACE 422
CONTROL OF BREATHING 422
NEURAL CONTROL OF BREATHING 423
CHEMICAL CONTROL OF BREATHING 424
23 - Digestive System 432
OVERVIEW OF THE DIGESTIVE SYSTEM 433
DIGESTION AND ABSORPTION 433
LAYERS AND MEMBRANES OF THE DIGESTIVE TRACT 434
MUCOSA 434
SUBMUCOSA 434
MUSCLE LAYER 434
SEROSA 435
INNERVATION OF THE DIGESTIVE TRACT 435
STRUCTURES AND ORGANS 435
MOUTH 435
TEETH 435
TONGUE 437
SALIVARY GLANDS 437
OTHER STRUCTURES WITHIN THE MOUTH 437
PHARYNX 437
ESOPHAGUS 438
STOMACH 438
WHAT IT DOES 438
REGIONS OF THE STOMACH 439
MUSCLES OF THE STOMACH 440
GLANDS OF THE STOMACH 440
VOMITING 440
SMALL INTESTINE 440
LOCATION AND PARTS 440
SEGMENTS OF THE SMALL INTESTINE 441
THE WALL OF THE SMALL INTESTINE AND ABSORPTION 441
Peristalsis and Absorption in the Small Intestine 441
LARGE INTESTINE 442
SEGMENTS OF THE LARGE INTESTINE 442
FUNCTIONS OF THE LARGE INTESTINE 443
Peristalsis and Absorption 443
Inside the Gut: Microbiota. Inside the gut and throughout the much-maligned waste there is a lot going on. Your gut microbiota (... 444
Intestinal Gas 444
ACCESSORY DIGESTIVE ORGANS 445
LIVER 445
WHAT THE LIVER DOES 445
BLOOD SUPPLY TO THE LIVER 447
Blood Supply and the Hepatic Portal System 447
LIVER LOBULES 447
BILE 447
BILIARY TREE 447
GALLBLADDER 448
PANCREAS 448
DIGESTION AND ABSORPTION 449
CARBOHYDRATES AND CARBOHYDRATE-SPLITTING ENZYMES 449
PROTEINS AND PROTEIN-SPLITTING ENZYMES 449
FATS, BILE, AND FAT-SPLITTING ENZYMES 450
NUTRITION: CONCEPTS TO KNOW 453
CARBOHYDRATES 453
PROTEINS 454
FATS (LIPIDS) 454
VITAMINS 454
MINERALS 455
HEALTH AND A BALANCED DIET 456
A BALANCED DIET 456
POORLY BALANCED DIET AND DISEASE 456
APPETITE CONTROL AND THE COUCH POTATO 456
24 - Urinary System 463
EXCRETION 463
ORGANS OF EXCRETION 463
URINARY SYSTEM ORGANS 463
URINARY SYSTEM TERMS 464
KIDNEYS 465
LOCATION 465
STRUCTURE 465
BLOOD SUPPLY 465
NERVE SUPPLY 465
FUNCTIONS OF THE KIDNEYS 465
URINE MAKING: THE NEPHRON UNIT 465
STRUCTURES 465
RENAL TUBULES 466
RENAL BLOOD VESSELS (VASCULAR STRUCTURES) 466
URINE FORMATION 466
GLOMERULAR FILTRATION 466
Why Filtration Occurs 466
What Substances Are Filtered 466
TUBULAR REABSORPTION 468
TUBULAR SECRETION 468
HORMONES THAT WORK ON THE KIDNEYS 468
ALDOSTERONE 468
ANTIDIURETIC HORMONE 470
NATRIURETIC PEPTIDES 470
PARATHYROID HORMONE AND CALCITONIN 471
COMPOSITION OF URINE 471
UREMIA AND DIALYSIS 472
YOUR PLUMBING 473
URETERS 473
URINARY BLADDER 473
URINATION 475
URETHRA 475
AN AUTONOMIC MOMENT 476
25 - WATER, ELECTROLYTE, AND ACID–BASE BALANCE 482
BODY FLUIDS: DISTRIBUTION AND COMPOSITION 482
FLUID COMPARTMENTS 482
COMPOSITION OF BODY FLUIDS 483
WATER BALANCE 483
WATER INTAKE 483
WATER OUTPUT 483
WATER IMBALANCES 484
DEHYDRATION 484
EDEMA 484
WHY DOES FLUID SHIFT? 485
FLUID SPACING—IN OTHER WORDS 485
DAILY WEIGHTS AND FLUID BALANCE 485
ELECTROLYTE BALANCE 485
QUICK REFERENCE: ELECTROLYTES 485
MOST IMPORTANT IONS 486
SODIUM (NA+) 486
POTASSIUM (K+) 486
CALCIUM (CA2+) 486
MAGNESIUM (MG2+) 486
CHLORIDE (CL−) 487
BICARBONATE (HCO3−) 487
OTHER IONS 487
ACID–BASE BALANCE 487
QUICK REFERENCE: ACIDS AND BASES 487
WHERE THE ACID COMES FROM 487
HOW THE BODY REGULATES PH 487
BUFFERS 488
LUNGS 488
RESPIRATORY ACTIVITY AS THE CAUSE OF CHANGES IN PH 489
RESPIRATORY ACTIVITY AS THE CORRECTION FOR CHANGES IN PH 489
KIDNEYS 490
ACID–BASE IMBALANCES 490
ACIDOSIS 490
ALKALOSIS 491
26 - Reproductive Systems 496
MALE REPRODUCTIVE SYSTEM 496
TESTES 496
LOCATION, LOCATION, LOCATION 498
LOBULES 498
SPERM CELLS 498
GENITAL DUCTS 499
EPIDIDYMIS 499
VAS DEFERENS AND EJACULATORY DUCTS 499
URETHRA 500
ACCESSORY GLANDS 500
SEMINAL VESICLES 500
PROSTATE GLAND 500
BULBOURETHRAL GLANDS 500
SEMEN 500
EXTERNAL GENITALS 500
MALE SEXUAL RESPONSE: ERECTION, EMISSION, EJACULATION, AND ORGASM 501
MALE SEX HORMONES 501
EFFECTS OF TESTOSTERONE 501
HORMONAL CONTROL OF MALE REPRODUCTION 501
FEMALE REPRODUCTIVE SYSTEM 502
OVARIES 502
EGG DEVELOPMENT: THE OVARIAN FOLLICLE 502
OVULATION 502
OVARIAN HORMONES 502
Estrogen 504
Progesterone 504
GENITAL TRACT 504
FALLOPIAN TUBES 504
Tube Troubles 504
UTERUS 504
VAGINA 505
EXTERNAL GENITALS 505
FEMALE SEXUAL RESPONSE 506
HORMONAL CONTROL OF THE REPRODUCTIVE CYCLES 506
TWO REPRODUCTIVE CYCLES 507
OVARIAN CYCLE 507
Follicular Phase 507
Luteal Phase 507
UTERINE CYCLE 509
Menstrual Phase 509
Proliferative Phase 509
Secretory Phase 509
IMPLANTATION: KEEPING THE CORPUS LUTEUM ALIVE 509
MENARCHE, MENSES, AND MENOPAUSE 510
FEMALE BREAST AND LACTATION 510
STRUCTURE OF A BREAST: THE MAMMARY GLANDS 510
HORMONES OF LACTATION…GOT MILK? 510
METHODS OF BIRTH CONTROL 510
27 - Human Development and Heredity 519
FERTILIZATION 519
WHEN FERTILIZATION OCCURS 519
WHERE FERTILIZATION OCCURS 520
HOW FERTILIZATION OCCURS 520
HUMAN DEVELOPMENT 520
PRENATAL DEVELOPMENT 520
EARLY EMBRYONIC PERIOD 520
FROM ZYGOTE TO BLASTOCYST … OR FROM ZYGOTE TO EGGPLANT 520
SEEING DOUBLE: TWINS 522
EMBRYONIC PERIOD 522
EXTRAEMBRYONIC MEMBRANES 522
PLACENTA 522
Formation of the Placenta 522
Functions of the Placenta 524
HOOK UP: THE UMBILICAL CORD 524
ORGANOGENESIS 524
BE CAREFUL: TERATOGENS 524
FETAL PERIOD 526
CHANGES IN THE MOTHER’S BODY DURING PREGNANCY 527
BIRTH 528
POSTNATAL CHANGES AND DEVELOPMENTAL STAGES 529
IMMEDIATE ADJUSTMENTS 529
DEVELOPMENT AS A LIFELONG PROCESS 529
HEREDITY 529
DNA, GENES, AND CHROMOSOMES 530
GENETIC ART: THE KARYOTYPE 530
DOMINANT, RECESSIVE, AND CODOMINANT GENES 531
TOO MANY OR TOO FEW CHROMOSOMES 532
GENETIC EXPRESSION 532
GENETIC MUTATIONS 532
IT’S A BOY; IT’S A GIRL: HOW THE SEX OF THE CHILD IS DETERMINED 532
XS AND YS 532
SEX DETERMINATION: A MALE THING 532
SEX-LINKED TRAITS 532
CONGENITAL AND HEREDITARY DISEASE 533
Answers to Review Your Knowledge and Go Figure Questions 537
Chapter 1: Introduction to the Human Body 537
Matching: Regional Terms 537
Glossary 541
A 541
B 542
C 542
D 544
E 544
F 545
G 545
H 546
I 546
J 547
K 547
L 547
M 547
N 548
O 548
P 549
Q 550
R 550
S 551
T 552
U 552
V 552
W 553
Z 553
Index 554
A 554
B 555
C 556
D 558
E 559
F 560
G 560
H 561
I 562
J 563
K 563
L 563
M 564
N 565
O 566
P 566
Q 568
R 568
S 568
T 570
U 571
V 571
W 572
X 572
Y 572
Z 572