Additional Information
Book Details
Abstract
This issue of Medical Clinics of North America, guest edited by Robert E. Brannigan, MD, is devoted to Urology. Articles in this outstanding issue include: Prostate Cancer Screening; Treatment Modalities and Outcomes for Prostate Cancer; Kidney, Ureteral, and Bladder Cancer: A Primer for the Internist; Testicular Cancer: Epidemiology, Diagnosis, and Treatment; Urinary Stone Disease: Diagnosis, Medical Therapy, and Surgical Management; Male Voiding Dysfunction, BPH, and Urinary Retention; Female Voiding Dysfunction and Urinary Incontinence; Penile and Urethral Reconstructive Surgery; Male Infertility Diagnosis and Treatment in the Era of IVF/ICSI; Sexual Dysfunction: Behavioral, Medical, and Surgical Therapies; Hypogonadism: Therapeutic Risks, Benefits, and Outcomes; Cutaneous Diseases of the External Genitalia; Urological Emergencies; Telemedicine: Early Experience in the Urology Clinic; and Men’s Health Programs: The Intersection of Internal Medicine and Urology.
Table of Contents
Section Title | Page | Action | Price |
---|---|---|---|
Front Cover | Cover | ||
Urology | i | ||
Copyright | ii | ||
CME Accreditation Page | iii | ||
PROGRAM OBJECTIVE | iii | ||
TARGET AUDIENCE | iii | ||
LEARNING OBJECTIVES | iii | ||
ACCREDITATION | iii | ||
DISCLOSURE OF CONFLICTS OF INTEREST | iii | ||
UNAPPROVED/OFF-LABEL USE DISCLOSURE | iv | ||
TO ENROLL | iv | ||
METHOD OF PARTICIPATION | iv | ||
CME INQUIRIES/SPECIAL NEEDS | iv | ||
Contributors | vii | ||
CONSULTING EDITOR | vii | ||
EDITOR | vii | ||
AUTHORS | vii | ||
Contents | xi | ||
Foreword: Go with the Flow | xi | ||
Preface: Urology and Medicine | xi | ||
Prostate Cancer Screening | xi | ||
Prostate Cancer: A Contemporary Approach to Treatment and Outcomes | xi | ||
Kidney, Ureteral, and Bladder Cancer: A Primer for the Internist | xi | ||
Testicular Cancer: Epidemiology, Diagnosis, and Management | xi | ||
Urinary Stone Disease: Diagnosis, Medical Therapy, and Surgical Management | xii | ||
Cutaneous Lesions of the External Genitalia | xii | ||
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, and Urinary Retention | xii | ||
Female Voiding Dysfunction and Urinary Incontinence | xii | ||
Penile and Urethral Reconstructive Surgery | xiii | ||
Male Infertility Diagnosis and Treatment in the Era of In Vitro Fertilization and Intracytoplasmic Sperm Injection | xiii | ||
Sexual Dysfunction: Behavioral, Medical, and Surgical Treatment | xiii | ||
Hypogonadism: Therapeutic Risks, Benefits, and Outcomes | xiii | ||
Urologic Emergencies | xiii | ||
The Current State of Telemedicine in Urology | xiv | ||
The Intersection of Medicine and Urology: An Emerging Paradigm of Sexual Function, Cardiometabolic Risk, Bone Health, and M ... | xiv | ||
Go with the Flow | xv | ||
REFERENCE | xvi | ||
Urology and Medicine | xvii | ||
REFERENCES | xix | ||
Prostate Cancer Screening | 199 | ||
Key points | 199 | ||
INTRODUCTION | 200 | ||
THE PRE–PROSTATE-SPECIFIC ANTIGEN SCREENING ERA | 200 | ||
Prostate-Specific Antigen as a First-Line Screening Test | 200 | ||
Randomized Clinical Trials of Prostate-Specific Antigen Screening | 200 | ||
US Food and Drug Administration Approval of Prostate-Specific Antigen as an Aid to the Early Detection of Prostate-Specific ... | 201 | ||
THE PROSTATE-SPECIFIC ANTIGEN SCREENING ERA (1991–2008) | 201 | ||
Epidemiologic Impact of Prostate-Specific Antigen Screening | 201 | ||
Enhancements of Prostate-Specific Antigen Tests to Increase Specificity | 201 | ||
Prostate-specific antigen velocity | 201 | ||
Prostate-specific antigen velocity risk count | 202 | ||
Prostate-specific antigen density | 202 | ||
Age-specific median prostate-specific antigen values | 202 | ||
Free-to-total prostate-specific antigen | 202 | ||
Prostate health index | 202 | ||
The 4KScore | 203 | ||
Concerns About Prostate-Specific Antigen Screening | 203 | ||
Politics of Prostate-Specific Antigen Testing: The US Preventive Services Task Force | 203 | ||
2008 TO 2017: THE PROSTATE-SPECIFIC ANTIGEN PROHIBITION ERA | 204 | ||
Criticisms of US Preventive Services Task Force Analysis | 204 | ||
Psychological Effects | 206 | ||
EPILOGUE: 2017 CANCER INTERVENTION AND SURVEILLANCE MODELING NETWORK REANALYSIS OF PROSTATE, LUNG, COLORECTAL, AND OVARIAN ... | 206 | ||
2017—THE FUTURE: PROSTATE-SPECIFIC ANTIGEN SCREENING RENAISSANCE | 206 | ||
US Preventive Services Task Force Backs Away from Total Ban on Prostate-Specific Antigen Testing | 206 | ||
The Burden of Prostate-Specific Antigen–Based Prostate Cancer in the Future | 207 | ||
Author’s Recommendations for Prostate-Specific Antigen Testing | 207 | ||
Prostate Cancer Screening Renaissance | 208 | ||
ACKNOWLEDGMENTS | 208 | ||
REFERENCES | 208 | ||
Prostate Cancer | 215 | ||
Key points | 215 | ||
INTRODUCTION | 215 | ||
OBSERVATION | 216 | ||
Watchful Waiting: Treatment Only for Symptomatic Relief | 216 | ||
Active Surveillance: Disease Monitoring with Treatment on Progression or Patient Preference | 217 | ||
RADICAL PROSTATECTOMY | 218 | ||
Surgery and Oncologic Outcomes | 218 | ||
The Adverse Effects of Surgery | 219 | ||
Lymph Node Dissection During Radical Prostatectomy | 219 | ||
Open Versus Robotic Radical Prostatectomy | 219 | ||
Disease Monitoring and Salvage Treatment Following Surgery | 220 | ||
RADIOTHERAPY | 220 | ||
External Beam Radiotherapy | 221 | ||
Brachytherapy | 221 | ||
Adverse Effects of Radiotherapy | 221 | ||
Disease Monitoring and Salvage Treatment Following Radiotherapy | 222 | ||
ANDROGEN DEPRIVATION THERAPY AND OTHER SYSTEMIC THERAPIES | 222 | ||
The Basics of Androgen Deprivation Therapy | 222 | ||
The Adverse Effects of Androgen Deprivation Therapy | 223 | ||
Second-Generation Androgen Deprivation Therapy | 223 | ||
Chemotherapy for Prostate Cancer | 223 | ||
Immunotherapy for Prostate Cancer | 224 | ||
Bisphosphonates for Patients with Bone Metastases | 224 | ||
FUTURE CONSIDERATIONS | 224 | ||
REFERENCES | 224 | ||
Kidney, Ureteral, and Bladder Cancer | 231 | ||
Key points | 231 | ||
INTRODUCTION | 231 | ||
KIDNEY CANCER: RENAL CELL CARCINOMA | 232 | ||
Patient History | 232 | ||
Pathophysiology | 232 | ||
Physical Examination | 233 | ||
Diagnostic Testing and Imaging Studies | 233 | ||
Differential Diagnosis | 236 | ||
Treatment | 236 | ||
UPPER URINARY TRACT AND BLADDER CANCER: UROTHELIAL CARCINOMA | 238 | ||
Patient History | 239 | ||
Pathophysiology | 239 | ||
Physical Examination | 240 | ||
Diagnostic Testing and Imaging | 240 | ||
Differential Diagnosis | 241 | ||
Treatment of Bladder Urothelial Carcinoma | 243 | ||
Treatment of Upper Tract Urothelial Carcinoma | 243 | ||
SUMMARY | 244 | ||
REFERENCES | 244 | ||
Testicular Cancer | 251 | ||
Key points | 251 | ||
INTRODUCTION AND EPIDEMIOLOGY | 251 | ||
CAUSE AND RISK FACTORS | 251 | ||
SYMPTOMS AND PRESENTATION | 252 | ||
DIAGNOSTIC TESTS | 252 | ||
DIFFERENTIAL DIAGNOSIS | 253 | ||
STAGING | 253 | ||
PATHOLOGY | 253 | ||
Germ Cell Tumors | 253 | ||
Intratubular germ cell neoplasia | 253 | ||
Seminoma | 254 | ||
Nonseminoma | 256 | ||
Gonadal Stromal Tumors | 256 | ||
Leydig cell and Sertoli cell | 256 | ||
Granulosa cell | 256 | ||
Other Tumors | 257 | ||
Lymphoma | 257 | ||
Gonadoblastoma | 257 | ||
INITIAL MANAGEMENT OF A TESTICULAR MASS | 257 | ||
General Considerations | 257 | ||
Fertility Considerations | 257 | ||
Radical Orchiectomy | 257 | ||
SEMINOMA: CLINICAL STAGE IA OR IB | 258 | ||
SEMINOMA: CLINICAL STAGE IIA, IIB, OR IS | 258 | ||
SEMINOMA: CLINICAL STAGE IIC OR III | 259 | ||
NONSEMINOMATOUS GERM CELL TUMOR: CLINICAL STAGE IA/IB | 259 | ||
NONSEMINOMATOUS GERM CELL TUMOR: CLINICAL STAGE IS | 260 | ||
NONSEMINOMATOUS GERM CELL TUMOR: CLINICAL STAGE IIA OR IIB | 260 | ||
NONSEMINOMATOUS GERM CELL TUMOR: CS IIC OR III | 261 | ||
NONSEMINOMATOUS GERM CELL TUMOR: MANAGEMENT OF POSTCHEMOTHERAPY RECURRENCE | 261 | ||
NONSEMINOMATOUS GERM CELL TUMOR: SALVAGE SETTINGS | 261 | ||
Salvage Chemotherapy | 261 | ||
Desperation Retroperitoneal Lymph Node Dissection | 261 | ||
LATE RELAPSES | 262 | ||
TREATMENT-RELATED SEQUELAE | 262 | ||
SUMMARY | 262 | ||
REFERENCES | 262 | ||
Urinary Stone Disease | 265 | ||
Key points | 265 | ||
INTRODUCTION | 265 | ||
DIAGNOSIS | 266 | ||
Presentation | 266 | ||
Clinical Evaluation | 266 | ||
Imaging | 266 | ||
Computed tomography | 266 | ||
Ultrasound | 266 | ||
MRI | 267 | ||
Laboratory Evaluation | 267 | ||
DIETARY AND MEDICAL THERAPY | 267 | ||
Medical Expulsive Therapy for Ureteral Stones | 267 | ||
Urine Volume | 268 | ||
Calcium Stones | 268 | ||
Dietary intervention | 268 | ||
Thiazides | 268 | ||
Citrate | 268 | ||
Allopurinol | 269 | ||
Uric Acid Stones | 269 | ||
Cutaneous Lesions of the External Genitalia | 279 | ||
Key points | 279 | ||
INITIAL EVALUATION | 279 | ||
GENITAL INVOLVEMENT OF SYSTEMIC SKIN DISEASES | 279 | ||
Psoriasis | 280 | ||
Lichen Planus | 280 | ||
Lichen Sclerosus/Balanitis Xerotica Obliterans | 281 | ||
Erythema Multiforme | 282 | ||
Reactive Arthritis (Formerly Reiter Syndrome) | 282 | ||
Fixed Drug Eruption | 282 | ||
NONINFECTIOUS ULCERS | 283 | ||
Behçet Disease | 283 | ||
Pyoderma Gangrenosum | 284 | ||
INFECTIOUS DISORDERS | 284 | ||
Genital Herpes | 284 | ||
Genital Warts/Human Papilloma Virus | 285 | ||
Syphilis | 287 | ||
Chancroid | 289 | ||
Scabies | 289 | ||
Molluscum Contagiosum | 290 | ||
Balanitis and Balanoposthitis | 290 | ||
Cellulitis and Erysipelas | 290 | ||
Fournier Gangrene | 291 | ||
Hidradenitis Suppurativa | 291 | ||
NEOPLASTIC CONDITIONS | 292 | ||
Squamous Cell Carcinoma In Situ/Bowen Disease | 292 | ||
Bowenoid Papulosis | 292 | ||
Squamous Cell Carcinoma | 294 | ||
Verrucous Carcinoma (Buschke-Lowenstein Tumor) | 294 | ||
Kaposi Sarcoma | 295 | ||
Extramammary Paget Disease | 296 | ||
MISCELLANEOUS BENIGN CONDITIONS | 296 | ||
Angiokeratoma of Fordyce | 296 | ||
Pearly Penile Papules | 297 | ||
Zoon Balanitis/Vulvitis | 297 | ||
Median Raphe Cyst | 297 | ||
Epidermoid Cyst | 298 | ||
Vitiligo | 298 | ||
REFERENCES | 298 | ||
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, and Urinary Retention | 301 | ||
Key points | 301 | ||
INTRODUCTION | 301 | ||
VOIDING DYSFUNCTION | 302 | ||
VOIDING DYSFUNCTION AND BENIGN PROSTATIC HYPERPLASIA | 302 | ||
BENIGN PROSTATIC HYPERPLASIA AND URINARY RETENTION | 303 | ||
Acute Urinary Retention | 303 | ||
CHRONIC URINARY RETENTION | 303 | ||
DIAGNOSIS OF VOIDING DYSFUNCTION | 303 | ||
History and Patient-Specific Questionnaires | 304 | ||
Physical Examination | 304 | ||
Laboratory Testing | 304 | ||
Urinalysis | 304 | ||
DIFFERENTIAL DIAGNOSIS | 304 | ||
Infectious Cause | 304 | ||
Obstruction | 305 | ||
Inflammation | 305 | ||
Neoplasm | 306 | ||
Metabolic | 306 | ||
Medication-Induced | 306 | ||
Neurologic | 306 | ||
TREATMENT | 306 | ||
Watchful Waiting | 306 | ||
Medical Therapy | 307 | ||
Phytotherapy | 307 | ||
Alpha-Blockers | 307 | ||
5-Alpha Reductase Inhibitors | 307 | ||
Phosphodiesterase 5 Inhibitors | 308 | ||
Antimuscarinics | 308 | ||
Combination Therapy | 308 | ||
MANAGEMENT | 308 | ||
REFERENCES | 309 | ||
Female Voiding Dysfunction and Urinary Incontinence | 313 | ||
Key points | 313 | ||
NORMAL URINARY CONTINENCE AND VOIDING | 313 | ||
Lower Urinary Health Across the Lifespan in Women | 314 | ||
Urodynamics | 314 | ||
OVERACTIVE BLADDER | 314 | ||
Epidemiology and Impact | 315 | ||
Initial Evaluation: Patient History, Symptoms, and Physical Examination | 315 | ||
Diagnostic testing and imaging | 316 | ||
Management goals | 316 | ||
First-line treatment: behavioral therapies | 316 | ||
Second-line treatment: pharmacologic management | 316 | ||
Third-line treatment: surgical management | 317 | ||
STRESS URINARY INCONTINENCE | 317 | ||
Epidemiology and Impact | 317 | ||
Initial evaluation: patient history, symptoms, and physical examination | 318 | ||
Diagnostic Testing and Imaging | 318 | ||
Management Goals | 318 | ||
Nonsurgical, Conservative Therapies | 318 | ||
Surgical Treatment | 319 | ||
VESICOVAGINAL AND URETEROVAGINAL FISTULAS | 319 | ||
Epidemiology and Impact | 320 | ||
Initial Evaluation: Patient History, Symptoms, and Physical Examination | 320 | ||
Treatment of Fistulas | 320 | ||
SUMMARY | 321 | ||
REFERENCES | 321 | ||
Penile and Urethral Reconstructive Surgery | 325 | ||
Key points | 325 | ||
INTRODUCTION | 325 | ||
URETHRAL DILATION AND DIRECT VISION INTERNAL URETHROTOMY | 326 | ||
Indications/Contraindications | 326 | ||
Patient Preparation | 327 | ||
Approach | 327 | ||
Postprocedure Care | 328 | ||
Reducing Complications | 328 | ||
Outcomes and Evidence | 328 | ||
URETHROPLASTY | 328 | ||
Indications/Contraindications | 328 | ||
Patient Preparation | 329 | ||
Approach | 329 | ||
Postprocedure Care | 330 | ||
Reducing Complications | 330 | ||
Outcomes | 330 | ||
ARTIFICIAL URINARY SPHINCTER IMPLANTATION | 331 | ||
Indications/Contraindications | 331 | ||
Patient Preparation | 331 | ||
Approach | 331 | ||
Postprocedure Care | 332 | ||
Reducing Complications | 332 | ||
Reported Outcomes | 332 | ||
SUMMARY | 333 | ||
REFERENCES | 333 | ||
Male Infertility Diagnosis and Treatment in the Era of In Vitro Fertilization and Intracytoplasmic Sperm Injection | 337 | ||
Key points | 337 | ||
INTRODUCTION | 337 | ||
EVALUATION | 338 | ||
History | 338 | ||
Physical Examination | 339 | ||
Hormonal Evaluation | 339 | ||
Semen Analysis | 340 | ||
Imaging | 341 | ||
TREATMENT | 342 | ||
Medical | 342 | ||
Surgical | 342 | ||
Assisted Reproductive Technologies | 343 | ||
FUTURE CONSIDERATIONS AND SUMMARY | 344 | ||
REFERENCES | 344 | ||
Sexual Dysfunction | 349 | ||
Key points | 349 | ||
INTRODUCTION | 349 | ||
NONPHARMACOLOGIC TREATMENT OPTIONS | 349 | ||
Diet | 350 | ||
Exercise and Physical Activity | 351 | ||
Medication Adjustment | 351 | ||
Tobacco, Alcohol, and Marijuana Use | 351 | ||
PHARMACOLOGIC TREATMENT OPTIONS | 352 | ||
Over-the-Counter and Herbal Supplements | 352 | ||
Arginine | 352 | ||
Ginseng | 352 | ||
Horny goat weed | 352 | ||
Ginkgo biloba | 352 | ||
Phosphodiesterase Type 5 Inhibitors | 352 | ||
Mechanism/pharmacokinetics | 353 | ||
Optimization of use | 353 | ||
Contraindications | 353 | ||
Adverse events | 354 | ||
Vacuum Erection Device | 354 | ||
Intraurethral Suppository | 354 | ||
Intracavernosal (Penile) Injection Therapy | 354 | ||
Adverse events/side effects/contraindications | 355 | ||
SURGICAL TREATMENT OPTIONS | 355 | ||
Noninflatable Implants (Malleable or Semirigid) | 355 | ||
Two-Piece Inflatable Implant | 356 | ||
Three-Piece Inflatable Implant | 356 | ||
Complications of penile prosthesis use | 356 | ||
REFERENCES | 357 | ||
Hypogonadism | 361 | ||
Key points | 361 | ||
INTRODUCTION | 361 | ||
DIAGNOSIS OF HYPOGONADISM | 362 | ||
TREATMENT OF HYPOGONADISM | 364 | ||
TESTOSTERONE THERAPY AND CARDIOVASCULAR RISK | 366 | ||
SUMMARY | 368 | ||
REFERENCES | 368 | ||
Urologic Emergencies | 373 | ||
Key points | 373 | ||
ACUTE URINARY RETENTION | 373 | ||
Clinical Presentation | 373 | ||
Diagnosis | 374 | ||
Treatment | 374 | ||
NEPHROLITHIASIS | 375 | ||
Clinical Presentation | 375 | ||
Diagnosis | 376 | ||
Treatment | 376 | ||
PENILE EMERGENCIES: PARAPHIMOSIS | 376 | ||
Clinical Presentation | 376 | ||
Diagnosis | 377 | ||
Treatment | 377 | ||
PENILE EMERGENCIES: PENILE FRACTURE | 377 | ||
Clinical Presentation | 377 | ||
Diagnosis | 378 | ||
Treatment | 378 | ||
PENILE EMERGENCIES: PRIAPISM | 379 | ||
Clinical Presentation | 379 | ||
Diagnosis | 380 | ||
Treatment | 380 | ||
SCROTAL EMERGENCIES: FOURNIER GANGRENE | 381 | ||
Clinical Presentation | 381 | ||
Diagnosis | 381 | ||
Treatment | 382 | ||
SCROTAL EMERGENCIES: TESTICULAR TORSION | 382 | ||
Clinical Presentation | 382 | ||
Diagnosis | 383 | ||
Treatment | 383 | ||
REFERENCES | 383 | ||
The Current State of Telemedicine in Urology | 387 | ||
Key points | 387 | ||
INTRODUCTION | 387 | ||
CURRENT USE OF TELEMEDICINE | 388 | ||
NECESSARY SYSTEMS AND PROCEDURES | 388 | ||
TECHNIQUES/TYPES OF SERVICES | 389 | ||
Video Visits | 389 | ||
Online Services | 391 | ||
Electronic Consults | 391 | ||
Tele-Rounding | 391 | ||
Tele-Monitoring | 393 | ||
Tele-Mentoring, Tele-Proctoring, and Education | 393 | ||
Tele-Simulation | 393 | ||
REIMBURSEMENT | 394 | ||
TELEMEDICINE IN PRACTICE | 394 | ||
CHALLENGES/LIMITATIONS | 395 | ||
FUTURE CONSIDERATIONS/SUMMARY | 396 | ||
REFERENCES | 396 | ||
The Intersection of Medicine and Urology | 399 | ||
Key points | 399 | ||
WHY MEN’S HEALTH? | 400 | ||
WHO IS THE MEN’S HEALTH DOCTOR: PRIMARY CARE PHYSICIAN, UROLOGIST, OR SUBSPECIALIST? | 400 | ||
ERECTILE DYSFUNCTION AND SUBCLINICAL CARDIOVASCULAR DISEASE: AN INTERSECTION OF MEDICINE AND UROLOGY | 401 | ||
THE TEMPORAL RELATIONSHIP OF ERECTILE DYSFUNCTION, SUBCLINICAL CARDIOVASCULAR DISEASE, AND CLINICAL CARDIOVASCULAR DISEASE | 401 | ||
RECOMMENDATIONS FOR EVALUATION OF CARDIOVASCULAR RISK IN MEN WITH ERECTILE DYSFUNCTION | 402 | ||
AN UPDATE ON TESTOSTERONE REPLACEMENT THERAPY AS ANOTHER EXAMPLE OF THE POTENTIAL OF THE MEN’S HEALTH CENTER | 404 | ||
CHANGES TO THE FOOD AND DRUG ADMINISTRATION LABEL | 404 | ||
STATUS OF PUBLISHED STUDIES LEADING TO ADDITION OF CARDIOVASCULAR RISK WARNING | 404 | ||
REVIEW OF NEW CARDIOVASCULAR STUDIES | 405 | ||
SUMMARY OF CARDIOVASCULAR STUDIES BECAUSE FOOD AND DRUG ADMINISTRATION LABEL CHANGE | 406 | ||
FINAL EXAMPLE OF THE POTENTIAL OF THE MEN’S HEALTH CENTER: OSTEOPOROSIS IS A MEN’S HEALTH CONCERN: INCIDENCE AND GENDER DIS ... | 406 | ||
GAPS IN TREATMENT IN MALE OSTEOPOROSIS ARE SIGNIFICANT | 407 | ||
THE COMPONENTS OF A MEN’S HEALTH CURRICULUM: AN OUTGROWTH OF THE MEN’S HEALTH CENTER | 408 | ||
BUILDING A MEN’S HEALTH CENTER | 409 | ||
THE FUTURE OF MEN’S HEALTH | 409 | ||
REFERENCES | 410 |