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Urology, An Issue of Medical Clinics of North America, E-Book

Urology, An Issue of Medical Clinics of North America, E-Book

Robert E. Brannigan

(2018)

Additional Information

Book Details

Abstract

This issue of Medical Clinics of North America, guest edited by Robert E. Brannigan, MD, is devoted to Urology. Articles in this outstanding issue include: Prostate Cancer Screening; Treatment Modalities and Outcomes for Prostate Cancer; Kidney, Ureteral, and Bladder Cancer: A Primer for the Internist; Testicular Cancer: Epidemiology, Diagnosis, and Treatment; Urinary Stone Disease: Diagnosis, Medical Therapy, and Surgical Management; Male Voiding Dysfunction, BPH, and Urinary Retention; Female Voiding Dysfunction and Urinary Incontinence; Penile and Urethral Reconstructive Surgery; Male Infertility Diagnosis and Treatment in the Era of IVF/ICSI; Sexual Dysfunction: Behavioral, Medical, and Surgical Therapies; Hypogonadism: Therapeutic Risks, Benefits, and Outcomes; Cutaneous Diseases of the External Genitalia; Urological Emergencies; Telemedicine: Early Experience in the Urology Clinic; and Men’s Health Programs: The Intersection of Internal Medicine and Urology.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Urology i
Copyright ii
CME Accreditation Page iii
PROGRAM OBJECTIVE iii
TARGET AUDIENCE iii
LEARNING OBJECTIVES iii
ACCREDITATION iii
DISCLOSURE OF CONFLICTS OF INTEREST iii
UNAPPROVED/OFF-LABEL USE DISCLOSURE iv
TO ENROLL iv
METHOD OF PARTICIPATION iv
CME INQUIRIES/SPECIAL NEEDS iv
Contributors vii
CONSULTING EDITOR vii
EDITOR vii
AUTHORS vii
Contents xi
Foreword: Go with the Flow xi
Preface: Urology and Medicine xi
Prostate Cancer Screening xi
Prostate Cancer: A Contemporary Approach to Treatment and Outcomes xi
Kidney, Ureteral, and Bladder Cancer: A Primer for the Internist xi
Testicular Cancer: Epidemiology, Diagnosis, and Management xi
Urinary Stone Disease: Diagnosis, Medical Therapy, and Surgical Management xii
Cutaneous Lesions of the External Genitalia xii
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, and Urinary Retention xii
Female Voiding Dysfunction and Urinary Incontinence xii
Penile and Urethral Reconstructive Surgery xiii
Male Infertility Diagnosis and Treatment in the Era of In Vitro Fertilization and Intracytoplasmic Sperm Injection xiii
Sexual Dysfunction: Behavioral, Medical, and Surgical Treatment xiii
Hypogonadism: Therapeutic Risks, Benefits, and Outcomes xiii
Urologic Emergencies xiii
The Current State of Telemedicine in Urology xiv
The Intersection of Medicine and Urology: An Emerging Paradigm of Sexual Function, Cardiometabolic Risk, Bone Health, and M ... xiv
Go with the Flow xv
REFERENCE xvi
Urology and Medicine xvii
REFERENCES xix
Prostate Cancer Screening 199
Key points 199
INTRODUCTION 200
THE PRE–PROSTATE-SPECIFIC ANTIGEN SCREENING ERA 200
Prostate-Specific Antigen as a First-Line Screening Test 200
Randomized Clinical Trials of Prostate-Specific Antigen Screening 200
US Food and Drug Administration Approval of Prostate-Specific Antigen as an Aid to the Early Detection of Prostate-Specific ... 201
THE PROSTATE-SPECIFIC ANTIGEN SCREENING ERA (1991–2008) 201
Epidemiologic Impact of Prostate-Specific Antigen Screening 201
Enhancements of Prostate-Specific Antigen Tests to Increase Specificity 201
Prostate-specific antigen velocity 201
Prostate-specific antigen velocity risk count 202
Prostate-specific antigen density 202
Age-specific median prostate-specific antigen values 202
Free-to-total prostate-specific antigen 202
Prostate health index 202
The 4KScore 203
Concerns About Prostate-Specific Antigen Screening 203
Politics of Prostate-Specific Antigen Testing: The US Preventive Services Task Force 203
2008 TO 2017: THE PROSTATE-SPECIFIC ANTIGEN PROHIBITION ERA 204
Criticisms of US Preventive Services Task Force Analysis 204
Psychological Effects 206
EPILOGUE: 2017 CANCER INTERVENTION AND SURVEILLANCE MODELING NETWORK REANALYSIS OF PROSTATE, LUNG, COLORECTAL, AND OVARIAN ... 206
2017—THE FUTURE: PROSTATE-SPECIFIC ANTIGEN SCREENING RENAISSANCE 206
US Preventive Services Task Force Backs Away from Total Ban on Prostate-Specific Antigen Testing 206
The Burden of Prostate-Specific Antigen–Based Prostate Cancer in the Future 207
Author’s Recommendations for Prostate-Specific Antigen Testing 207
Prostate Cancer Screening Renaissance 208
ACKNOWLEDGMENTS 208
REFERENCES 208
Prostate Cancer 215
Key points 215
INTRODUCTION 215
OBSERVATION 216
Watchful Waiting: Treatment Only for Symptomatic Relief 216
Active Surveillance: Disease Monitoring with Treatment on Progression or Patient Preference 217
RADICAL PROSTATECTOMY 218
Surgery and Oncologic Outcomes 218
The Adverse Effects of Surgery 219
Lymph Node Dissection During Radical Prostatectomy 219
Open Versus Robotic Radical Prostatectomy 219
Disease Monitoring and Salvage Treatment Following Surgery 220
RADIOTHERAPY 220
External Beam Radiotherapy 221
Brachytherapy 221
Adverse Effects of Radiotherapy 221
Disease Monitoring and Salvage Treatment Following Radiotherapy 222
ANDROGEN DEPRIVATION THERAPY AND OTHER SYSTEMIC THERAPIES 222
The Basics of Androgen Deprivation Therapy 222
The Adverse Effects of Androgen Deprivation Therapy 223
Second-Generation Androgen Deprivation Therapy 223
Chemotherapy for Prostate Cancer 223
Immunotherapy for Prostate Cancer 224
Bisphosphonates for Patients with Bone Metastases 224
FUTURE CONSIDERATIONS 224
REFERENCES 224
Kidney, Ureteral, and Bladder Cancer 231
Key points 231
INTRODUCTION 231
KIDNEY CANCER: RENAL CELL CARCINOMA 232
Patient History 232
Pathophysiology 232
Physical Examination 233
Diagnostic Testing and Imaging Studies 233
Differential Diagnosis 236
Treatment 236
UPPER URINARY TRACT AND BLADDER CANCER: UROTHELIAL CARCINOMA 238
Patient History 239
Pathophysiology 239
Physical Examination 240
Diagnostic Testing and Imaging 240
Differential Diagnosis 241
Treatment of Bladder Urothelial Carcinoma 243
Treatment of Upper Tract Urothelial Carcinoma 243
SUMMARY 244
REFERENCES 244
Testicular Cancer 251
Key points 251
INTRODUCTION AND EPIDEMIOLOGY 251
CAUSE AND RISK FACTORS 251
SYMPTOMS AND PRESENTATION 252
DIAGNOSTIC TESTS 252
DIFFERENTIAL DIAGNOSIS 253
STAGING 253
PATHOLOGY 253
Germ Cell Tumors 253
Intratubular germ cell neoplasia 253
Seminoma 254
Nonseminoma 256
Gonadal Stromal Tumors 256
Leydig cell and Sertoli cell 256
Granulosa cell 256
Other Tumors 257
Lymphoma 257
Gonadoblastoma 257
INITIAL MANAGEMENT OF A TESTICULAR MASS 257
General Considerations 257
Fertility Considerations 257
Radical Orchiectomy 257
SEMINOMA: CLINICAL STAGE IA OR IB 258
SEMINOMA: CLINICAL STAGE IIA, IIB, OR IS 258
SEMINOMA: CLINICAL STAGE IIC OR III 259
NONSEMINOMATOUS GERM CELL TUMOR: CLINICAL STAGE IA/IB 259
NONSEMINOMATOUS GERM CELL TUMOR: CLINICAL STAGE IS 260
NONSEMINOMATOUS GERM CELL TUMOR: CLINICAL STAGE IIA OR IIB 260
NONSEMINOMATOUS GERM CELL TUMOR: CS IIC OR III 261
NONSEMINOMATOUS GERM CELL TUMOR: MANAGEMENT OF POSTCHEMOTHERAPY RECURRENCE 261
NONSEMINOMATOUS GERM CELL TUMOR: SALVAGE SETTINGS 261
Salvage Chemotherapy 261
Desperation Retroperitoneal Lymph Node Dissection 261
LATE RELAPSES 262
TREATMENT-RELATED SEQUELAE 262
SUMMARY 262
REFERENCES 262
Urinary Stone Disease 265
Key points 265
INTRODUCTION 265
DIAGNOSIS 266
Presentation 266
Clinical Evaluation 266
Imaging 266
Computed tomography 266
Ultrasound 266
MRI 267
Laboratory Evaluation 267
DIETARY AND MEDICAL THERAPY 267
Medical Expulsive Therapy for Ureteral Stones 267
Urine Volume 268
Calcium Stones 268
Dietary intervention 268
Thiazides 268
Citrate 268
Allopurinol 269
Uric Acid Stones 269
Cutaneous Lesions of the External Genitalia 279
Key points 279
INITIAL EVALUATION 279
GENITAL INVOLVEMENT OF SYSTEMIC SKIN DISEASES 279
Psoriasis 280
Lichen Planus 280
Lichen Sclerosus/Balanitis Xerotica Obliterans 281
Erythema Multiforme 282
Reactive Arthritis (Formerly Reiter Syndrome) 282
Fixed Drug Eruption 282
NONINFECTIOUS ULCERS 283
Behçet Disease 283
Pyoderma Gangrenosum 284
INFECTIOUS DISORDERS 284
Genital Herpes 284
Genital Warts/Human Papilloma Virus 285
Syphilis 287
Chancroid 289
Scabies 289
Molluscum Contagiosum 290
Balanitis and Balanoposthitis 290
Cellulitis and Erysipelas 290
Fournier Gangrene 291
Hidradenitis Suppurativa 291
NEOPLASTIC CONDITIONS 292
Squamous Cell Carcinoma In Situ/Bowen Disease 292
Bowenoid Papulosis 292
Squamous Cell Carcinoma 294
Verrucous Carcinoma (Buschke-Lowenstein Tumor) 294
Kaposi Sarcoma 295
Extramammary Paget Disease 296
MISCELLANEOUS BENIGN CONDITIONS 296
Angiokeratoma of Fordyce 296
Pearly Penile Papules 297
Zoon Balanitis/Vulvitis 297
Median Raphe Cyst 297
Epidermoid Cyst 298
Vitiligo 298
REFERENCES 298
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, and Urinary Retention 301
Key points 301
INTRODUCTION 301
VOIDING DYSFUNCTION 302
VOIDING DYSFUNCTION AND BENIGN PROSTATIC HYPERPLASIA 302
BENIGN PROSTATIC HYPERPLASIA AND URINARY RETENTION 303
Acute Urinary Retention 303
CHRONIC URINARY RETENTION 303
DIAGNOSIS OF VOIDING DYSFUNCTION 303
History and Patient-Specific Questionnaires 304
Physical Examination 304
Laboratory Testing 304
Urinalysis 304
DIFFERENTIAL DIAGNOSIS 304
Infectious Cause 304
Obstruction 305
Inflammation 305
Neoplasm 306
Metabolic 306
Medication-Induced 306
Neurologic 306
TREATMENT 306
Watchful Waiting 306
Medical Therapy 307
Phytotherapy 307
Alpha-Blockers 307
5-Alpha Reductase Inhibitors 307
Phosphodiesterase 5 Inhibitors 308
Antimuscarinics 308
Combination Therapy 308
MANAGEMENT 308
REFERENCES 309
Female Voiding Dysfunction and Urinary Incontinence 313
Key points 313
NORMAL URINARY CONTINENCE AND VOIDING 313
Lower Urinary Health Across the Lifespan in Women 314
Urodynamics 314
OVERACTIVE BLADDER 314
Epidemiology and Impact 315
Initial Evaluation: Patient History, Symptoms, and Physical Examination 315
Diagnostic testing and imaging 316
Management goals 316
First-line treatment: behavioral therapies 316
Second-line treatment: pharmacologic management 316
Third-line treatment: surgical management 317
STRESS URINARY INCONTINENCE 317
Epidemiology and Impact 317
Initial evaluation: patient history, symptoms, and physical examination 318
Diagnostic Testing and Imaging 318
Management Goals 318
Nonsurgical, Conservative Therapies 318
Surgical Treatment 319
VESICOVAGINAL AND URETEROVAGINAL FISTULAS 319
Epidemiology and Impact 320
Initial Evaluation: Patient History, Symptoms, and Physical Examination 320
Treatment of Fistulas 320
SUMMARY 321
REFERENCES 321
Penile and Urethral Reconstructive Surgery 325
Key points 325
INTRODUCTION 325
URETHRAL DILATION AND DIRECT VISION INTERNAL URETHROTOMY 326
Indications/Contraindications 326
Patient Preparation 327
Approach 327
Postprocedure Care 328
Reducing Complications 328
Outcomes and Evidence 328
URETHROPLASTY 328
Indications/Contraindications 328
Patient Preparation 329
Approach 329
Postprocedure Care 330
Reducing Complications 330
Outcomes 330
ARTIFICIAL URINARY SPHINCTER IMPLANTATION 331
Indications/Contraindications 331
Patient Preparation 331
Approach 331
Postprocedure Care 332
Reducing Complications 332
Reported Outcomes 332
SUMMARY 333
REFERENCES 333
Male Infertility Diagnosis and Treatment in the Era of In Vitro Fertilization and Intracytoplasmic Sperm Injection 337
Key points 337
INTRODUCTION 337
EVALUATION 338
History 338
Physical Examination 339
Hormonal Evaluation 339
Semen Analysis 340
Imaging 341
TREATMENT 342
Medical 342
Surgical 342
Assisted Reproductive Technologies 343
FUTURE CONSIDERATIONS AND SUMMARY 344
REFERENCES 344
Sexual Dysfunction 349
Key points 349
INTRODUCTION 349
NONPHARMACOLOGIC TREATMENT OPTIONS 349
Diet 350
Exercise and Physical Activity 351
Medication Adjustment 351
Tobacco, Alcohol, and Marijuana Use 351
PHARMACOLOGIC TREATMENT OPTIONS 352
Over-the-Counter and Herbal Supplements 352
Arginine 352
Ginseng 352
Horny goat weed 352
Ginkgo biloba 352
Phosphodiesterase Type 5 Inhibitors 352
Mechanism/pharmacokinetics 353
Optimization of use 353
Contraindications 353
Adverse events 354
Vacuum Erection Device 354
Intraurethral Suppository 354
Intracavernosal (Penile) Injection Therapy 354
Adverse events/side effects/contraindications 355
SURGICAL TREATMENT OPTIONS 355
Noninflatable Implants (Malleable or Semirigid) 355
Two-Piece Inflatable Implant 356
Three-Piece Inflatable Implant 356
Complications of penile prosthesis use 356
REFERENCES 357
Hypogonadism 361
Key points 361
INTRODUCTION 361
DIAGNOSIS OF HYPOGONADISM 362
TREATMENT OF HYPOGONADISM 364
TESTOSTERONE THERAPY AND CARDIOVASCULAR RISK 366
SUMMARY 368
REFERENCES 368
Urologic Emergencies 373
Key points 373
ACUTE URINARY RETENTION 373
Clinical Presentation 373
Diagnosis 374
Treatment 374
NEPHROLITHIASIS 375
Clinical Presentation 375
Diagnosis 376
Treatment 376
PENILE EMERGENCIES: PARAPHIMOSIS 376
Clinical Presentation 376
Diagnosis 377
Treatment 377
PENILE EMERGENCIES: PENILE FRACTURE 377
Clinical Presentation 377
Diagnosis 378
Treatment 378
PENILE EMERGENCIES: PRIAPISM 379
Clinical Presentation 379
Diagnosis 380
Treatment 380
SCROTAL EMERGENCIES: FOURNIER GANGRENE 381
Clinical Presentation 381
Diagnosis 381
Treatment 382
SCROTAL EMERGENCIES: TESTICULAR TORSION 382
Clinical Presentation 382
Diagnosis 383
Treatment 383
REFERENCES 383
The Current State of Telemedicine in Urology 387
Key points 387
INTRODUCTION 387
CURRENT USE OF TELEMEDICINE 388
NECESSARY SYSTEMS AND PROCEDURES 388
TECHNIQUES/TYPES OF SERVICES 389
Video Visits 389
Online Services 391
Electronic Consults 391
Tele-Rounding 391
Tele-Monitoring 393
Tele-Mentoring, Tele-Proctoring, and Education 393
Tele-Simulation 393
REIMBURSEMENT 394
TELEMEDICINE IN PRACTICE 394
CHALLENGES/LIMITATIONS 395
FUTURE CONSIDERATIONS/SUMMARY 396
REFERENCES 396
The Intersection of Medicine and Urology 399
Key points 399
WHY MEN’S HEALTH? 400
WHO IS THE MEN’S HEALTH DOCTOR: PRIMARY CARE PHYSICIAN, UROLOGIST, OR SUBSPECIALIST? 400
ERECTILE DYSFUNCTION AND SUBCLINICAL CARDIOVASCULAR DISEASE: AN INTERSECTION OF MEDICINE AND UROLOGY 401
THE TEMPORAL RELATIONSHIP OF ERECTILE DYSFUNCTION, SUBCLINICAL CARDIOVASCULAR DISEASE, AND CLINICAL CARDIOVASCULAR DISEASE 401
RECOMMENDATIONS FOR EVALUATION OF CARDIOVASCULAR RISK IN MEN WITH ERECTILE DYSFUNCTION 402
AN UPDATE ON TESTOSTERONE REPLACEMENT THERAPY AS ANOTHER EXAMPLE OF THE POTENTIAL OF THE MEN’S HEALTH CENTER 404
CHANGES TO THE FOOD AND DRUG ADMINISTRATION LABEL 404
STATUS OF PUBLISHED STUDIES LEADING TO ADDITION OF CARDIOVASCULAR RISK WARNING 404
REVIEW OF NEW CARDIOVASCULAR STUDIES 405
SUMMARY OF CARDIOVASCULAR STUDIES BECAUSE FOOD AND DRUG ADMINISTRATION LABEL CHANGE 406
FINAL EXAMPLE OF THE POTENTIAL OF THE MEN’S HEALTH CENTER: OSTEOPOROSIS IS A MEN’S HEALTH CONCERN: INCIDENCE AND GENDER DIS ... 406
GAPS IN TREATMENT IN MALE OSTEOPOROSIS ARE SIGNIFICANT 407
THE COMPONENTS OF A MEN’S HEALTH CURRICULUM: AN OUTGROWTH OF THE MEN’S HEALTH CENTER 408
BUILDING A MEN’S HEALTH CENTER 409
THE FUTURE OF MEN’S HEALTH 409
REFERENCES 410