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Slatter's Fundamentals of Veterinary Ophthalmology E-Book

Slatter's Fundamentals of Veterinary Ophthalmology E-Book

David Maggs | Paul Miller | Ron Ofri

(2017)

Additional Information

Book Details

Abstract

Learn to recognize, diagnose, and manage a wide range of common ocular conditions with Slatter’s Fundamentals of Veterinary Ophthalmology, 6th Edition. This thoroughly updated text provides the latest, most practical information on structure and function of the eye, the ophthalmic examination and diagnostic techniques, medical and surgical management of ocular disease, and management of ocular emergencies. Enhanced and logically organized coverage includes dogs, cats, horses, livestock, birds, and exotic pets. In addition, over 1,000 color photos and illustrations accurately depict ocular conditions encountered in practice and demonstrate diagnostic and surgical techniques. Edited by three of the most revered authorities in the field of veterinary ophthalmology, this reference is an essential aid to successful veterinary practice and education.

  • Clinical Tips boxes such as "The Controversy Remains", "Did You Know?", "Look Again", and "Note" offer helpful practice advice and facts.
  • UPDATED Additional species added to the exotics chapter include birds, small mammals, and others.
  • A team of internationally respected veterinary ophthalmologists provide comprehensive, clinical expertise in all areas needed to evaluate, diagnose, manage, and monitor a patient with ophthalmic disease.
  • Practical, clinically focused coverage provides a one-stop diagnostic guide to ophthalmic disease in small and large animals including dogs, cats, horses, livestock (cows, sheep, goats), birds, and exotic pets.
  • Chapters on equine, livestock, and exotic pet ophthalmology written by specialists in these fields for the most clinically relevant coverage.
  • NEW! Chapter on ophthalmic surgical techniques describes instrument and suture choice, patient positioning, surgical preparation, and general techniques.
  • NEW! Additional drawings depict ophthalmic surgeries.
  • NEW! In-depth equine and livestock ophthalmology content
  • NEW! Suggested reading lists included at the end of each chapter.

Table of Contents

Section Title Page Action Price
Front Cover cover
Slatter's Fundamentals of Veterinary Ophthalmology i
Copyright Page iv
CONTRIBUTORS v
Dedication vii
PREFACE AND ACKNOWLEDGMENTS ix
Table Of Contents xi
1 The Eye and Vision 1
Evolution of the Eye 1
Development of the Eye 1
Basic Anatomy of the Eye 2
Fundamentals of Vision 4
Luminance 4
Motion 6
Depth Perception 7
Texture (Visual Acuity) 8
Optical Factors in Visual Acuity 9
Retinal Factors in Visual Acuity 12
Estimates of Visual Acuity 13
Color Vision 14
Central Visual Pathways 16
Suggested Reading 16
2 The Ophthalmic Examination and Diagnostic Testing 18
Collecting a Complete Ophthalmic History 18
The Ophthalmic Examination Procedure 19
Assessment From a Distance, Retropulsion, and Behavioral Visual Testing 21
Neuroophthalmic Testing 21
Menace Response 22
Palpebral Reflex 22
Oculocephalic Reflexes 22
Assessment of Pupil Symmetry Using Retroillumination 23
Pupillary Light Reflexes 23
The Swinging Flashlight Test 24
Dazzle Reflex 24
Examination of the Anterior Segment 24
Eyelids 27
Conjunctiva 27
Third Eyelid 27
Nasolacrimal Apparatus 28
Sclera 28
Clinical Differentiation of Episcleral and Conjunctival Hyperemia (or “Injection”) 29
Cornea 30
Anterior Chamber 30
Iris and Pupil 31
Lens 31
Ophthalmoscopy 32
Indirect Ophthalmoscopy 33
Direct Ophthalmoscopy 34
Monocular Indirect Ophthalmoscopy 35
Examination of the Posterior Segment 35
Vitreous 35
The Fundus 35
Additional Diagnostic Testing 36
Three Essential Tests in Most Ophthalmic Patients 36
Tear Film Testing 36
Assessment of Basal and Reflex Aqueous Tear Production (STT-1) 37
Assessment of Basal Aqueous Tear Production (STT-2 and the Phenol Red Thread Test) 37
Assessment of Tear Film Stability 37
Tonometry 38
Indentation Tonometry 38
Applanation Tonometry 39
Rebound Tonometry 39
Normal Intraocular Pressure 40
Application of Ocular Stains (Fluorescein, Rose Bengal, and Lissamine Green) 40
Fluorescein 40
Rose Bengal and Lissamine Green 42
Additional Diagnostic Testing in General Practice 43
Ocular Surface Sampling 43
Cytologic Samples 43
Microbiological Samples 44
Assessment of the Nasolacrimal Apparatus (Jones Test and Nasolacrimal Flushing) 44
Ultrasonography 46
Radiography 47
Additional Diagnostic Testing Typically Done in Specialty Practice 47
Gonioscopy 47
Electroretinography and Visual Evoked Potentials 47
Retinoscopy 48
Computed Tomography and Magnetic Resonance Imaging 48
Suggested Reading 49
Ophthalmic Examination Techniques 49
Tear Testing 49
Tonometry 50
Ocular Surface Sampling 50
Retinoscopy 50
Diagnostic Imaging 50
Other Diagnostic Techniques 50
3 Ophthalmic Medications and Therapeutics 51
Routes of Ocular Drug Administration 51
Topical Formulations 52
Solutions, Suspensions, and Gels (“Eye Drops”) 54
Ointments 54
Subconjunctival, Sub-Tenon’s, Peribulbar, and Retrobulbar Injections 55
Systemic Drug Administration 56
Antibacterial Drugs 57
Selection and Administration of Antibiotics 57
Penicillins 58
Cephalosporins 59
Chloramphenicol 60
Aminoglycosides 60
Neomycin 60
Gentamicin and Tobramycin 60
Amikacin 61
Cyclic Polypeptides 61
Bacitracin 61
Polymyxin B 61
Tetracyclines 61
Azithromycin 61
Sulfonamides 62
Fluoroquinolones 62
Enrofloxacin, Orbifloxacin, and Pradofloxacin 62
Ciprofloxacin, Ofloxacin, Moxifloxacin, Gatifloxacin, and Others 62
Fusidic Acid 63
Antifungal Drugs 63
Natamycin 63
Azoles 63
Amphotericin B 64
Antiviral Drugs 64
Idoxuridine 64
Ganciclovir 65
Penciclovir and Famciclovir 65
Trifluridine (Trifluorothymidine) 65
Cidofovir 66
Vidarabine 66
Acyclovir and Valacyclovir 66
Lysine 67
Interferons 67
Antiparasitic Agents 67
Intraocular Inflammation and Mechanisms of Action of Antiinflammatory Agents 67
Corticosteroids 68
Indications for Corticosteroid Use 68
Ophthalmic Corticosteroids 69
Cautions and Contraindications With Corticosteroid Use 69
Nonsteroidal Antiinflammatory Drugs 70
Indications for NSAID Use 71
Ophthalmic NSAIDs 71
Cautions and Contraindications With NSAID Use 71
Mast Cell Stabilizers and Antihistamines 72
4 Principles of Ophthalmic Surgery 89
Introduction 89
Instruments, Suture Materials, and Sutures 89
Basic Instruments for Extraocular Procedures 91
Instruments for Handling of 7/0 Suture and Smaller 93
Instrument and Suture Handling for Ophthalmic Surgeries 95
Additional Supplies for Ophthalmic Surgeries 96
Anesthesia of the Ophthalmic Patient 97
Preparation of the Surgical Site for Ophthalmic Surgeries 97
Positioning for Ophthalmic Surgeries 98
Surgical Exposure for Ophthalmic Surgeries 99
General Principles During Surgery 99
Postoperative Considerations 100
Postoperative Corneal Protection 100
General Postoperative Management and Recovery of the Ophthalmic Patient 100
Suggested Reading 100
5 Diseases of the Orbit 101
Embryology 101
Anatomy 101
Orbital Bones 101
Extraocular Muscles 102
Lacrimal Gland, Base of Third Eyelid, and Ventral Orbital Fat Pad 103
Orbital Blood Vessels 103
Orbital Nerves 104
Orbital Fascia 104
Structures Surrounding the Orbit 105
Pathological Mechanisms 107
Exophthalmos 107
Enophthalmos 109
Strabismus 109
Diagnostic Methods 109
History 109
Physical Examination 109
Hematology and Serum Biochemistry 110
Diagnostic Imaging 110
Ultrasonography 110
Radiography 111
Advanced Imaging Techniques 111
Fine-Needle Aspiration, Biopsy, and Orbitotomy 112
Orbital Diseases 112
Orbital Cellulitis, Abscessation, and Foreign Body 113
Clinical signs. 114
Workup and treatment. 114
Cystic Orbital and Periocular Lesions 115
Zygomatic Mucocele 115
Clinical signs. 115
Treatment. 115
Neoplasia 116
Clinical signs. 116
Treatment. 117
Feline Restrictive Orbital Myofibroblastic Sarcoma 118
Periorbital Fractures 119
Treatment. 119
Orbital Emphysema 119
Masticatory Muscle Myositis 120
Extraocular Muscle Myositis 120
Proptosis of the Globe 120
Surgical Procedures 120
Enucleation 120
Indications. 120
Lateral Subconjunctival Enucleation Technique 122
Insertion of an Intraorbital Prosthesis 122
Transpalpebral Enucleation–Exenteration Technique 122
Exenteration 124
Ocular Prostheses 124
Intrascleral Prosthesis 124
Systemic Causes of Orbital Disease in the Dog and Cat 124
Suggested Reading 125
6 Diseases of the Eyelids 127
Embryology, Anatomy, and Physiology 127
Eyelid Opening and Closing 128
General Pathologic Responses 129
Premature or Delayed Opening of the Eyelids in Neonates 129
Eyelid Agenesis (Coloboma) 131
Prominent Nasal Skin Folds 131
Disorders of the Cilia 132
Clinical Signs of Cilia Disorders 133
Treatment of Distichiasis 134
Cryoepilation 134
Electroepilation 135
Treatment of Ectopic Cilia 135
Treatment of Trichiasis 136
Entropion 136
Clinical Signs of Entropion 137
Treatment of Entropion 137
Temporary “Tacking” Techniques 138
Wedge Resection 139
Hotz-Celsus Procedure 139
Combined Hotz-Celsus and Lateral Wedge Resection 140
Lateral Arrowhead Procedure and Tenotomy for Lateral Entropion 140
Medial Canthoplasty for Lower Medial Entropion and Brachycephalic Ocular Syndrome 141
Upper Eyelid Entropion 142
Ectropion 142
Treatment of Ectropion 143
Wedge Resection 143
“V-to-Y” Blepharoplasty 143
Eyelid Injuries 143
Treatment of Eyelid Injuries 144
Nonneoplastic Disorders of the Meibomian and Other Eyelid Glands 144
Chalazia 144
Hordeolum and Meibomian Adenitis 145
Eyelid Neoplasia 146
Squamous Cell Carcinoma 148
Meibomian Adenoma 149
Feline Multiple Apocrine Hidrocystoma 149
Viral Papillomatosis 149
Mast Cell Tumors 149
Histiocytoma 150
Histiocytosis 150
Skin Diseases Affecting the Eyelids 150
Skin Disease Presenting With Periocular Alopecia as the Major Clinical Sign 151
Skin Disease Presenting With Erythema, Scales, and Crusts as the Major Clinical Sign 152
Skin Disease Presenting With Periocular Pruritus as the Major Clinical Sign 153
Skin Disease Presenting With Eyelid Margin Hyperpigmentation as the Major Clinical Sign 154
Skin Disease Presenting With Eyelid Margin Depigmentation as the Major Clinical Sign 154
Skin Disease Presenting With Eyelid Margin Erosion or Ulceration as the Major Clinical Sign 155
Skin Disease Presenting With Blepharitis as the Major Clinical Sign 155
Skin Disease Presenting With Periocular Papules as the Major Clinical Sign 155
Skin Disease Presenting With Solitary Nodules as the Major Clinical Sign 156
Suggested Reading 156
Disorders of the Cilia and Meibomian Glands 156
Entropion/Ectropion 156
Eyelid Neoplasia 157
Skin Diseases Affecting the Eyelids 157
7 Diseases of the Conjunctiva 158
Embryology, Anatomy, and Physiology 158
Conjunctival Wound Healing 159
Clinical Signs of Conjunctival Disease 159
Conjunctival Hyperemia 160
Chemosis (Conjunctival Edema) 160
Ocular Discharge 160
Conjunctival Ulceration 160
Conjunctival Swelling, Thickening, or Mass Formation 160
Pruritus 161
Conjunctivitis 162
Classification 162
Differential Diagnosis 162
Diagnostic Methods 162
Bacterial Culturing 162
Conjunctival Scrapings 163
Conjunctival Biopsy 163
General Treatment Considerations for Conjunctivitis 163
Antibiotics 164
Corticosteroids 165
Cleansing Agents and Warm-Packing 165
Topical Mast Cell Stabilizers and Antihistamines 165
Vasoconstrictive Agents 165
Bacterial Conjunctivitis 165
Chlamydial Conjunctivitis 165
Treatment 166
Mycoplasmal Conjunctivitis 166
Viral Conjunctivitis 166
Feline Viral Conjunctivitis 166
Diagnostic testing. 168
Treatment of herpetic disease in cats. 168
Canine Viral Conjunctivitis 171
Treatment of herpetic disease in dogs. 172
Mycotic Conjunctivitis 172
Parasitic Conjunctivitis 172
Leishmaniasis 172
Onchocerciasis 172
Immune-Mediated Conjunctivitis 173
Allergic Conjunctivitis 173
Treatment. 173
Feline Epitheliotropic Mastocytic Conjunctivitis 173
Other Conjunctival Disorders 174
Drug Plaques 174
Conjunctival Lacerations 174
Ligneous Conjunctivitis 174
Lipogranulomatous Conjunctivitis 174
Conjunctival Neoplasia 175
Conjunctival Dermoid 175
Canine Conjunctival Papillomatosis 175
Canine Mast Cell Tumors 175
Canine and Feline Conjunctival Vascular Tumors 175
Canine and Feline Melanocytic Tumors 176
Canine Transmissible Venereal Tumors 176
Suggested Reading 176
Diagnostic Testing 176
Chlamydia and Mycoplasma 176
Viral Conjunctivitis and Antiviral Drugs 177
Lysine and the Interferons 177
Parasitic Conjunctivitis 177
Other Conjunctivitides 177
Conjunctival Neoplasia 177
8 Diseases of the Third Eyelid 178
Embryology, Anatomy, and Physiology 178
Placement of Third Eyelid Flaps 179
Examination of the Third Eyelid 179
Clinical Signs of Third Eyelid Disease 179
Structural Abnormalities of the Third Eyelid 180
Lack of Pigment on the Leading Edge of the Third Eyelid 180
Scrolling of the Third Eyelid 180
Treatment 180
Hyperplastic Lymphoid Follicles on the Bulbar Surface of the Third Eyelid 180
Prolapse of the Gland of the Third Eyelid (“Cherry Eye”) 181
Treatment 182
Complications Following Third Eyelid Gland Replacement 182
Neoplasms Affecting the Third Eyelid 183
Trauma to the Third Eyelid 183
Inflammatory Disorders of the Third Eyelid 184
Foreign Bodies and Parasites Under the Third Eyelid 184
Suggested Reading 185
Anatomy and Physiology 185
Scrolled and Everted Third Eyelid Cartilage 185
Inflammatory Disorders of the Third Eyelid 185
Neoplasia of the Third Eyelid 185
Prolapsed Gland of the Third Eyelid 185
Other Third Eyelid Surgeries 185
9 Diseases of the Lacrimal System 186
Introduction 186
Embryology, Anatomy, Physiology, and Examination 186
Embryology 186
Anatomy 187
Physiology 188
Tear Film 188
The lipid layer. 189
The aqueous–mucin layer. 189
Blinking, Evaporation, and Nasolacrimal Drainage 189
Tear Film Examination Methods 190
Disorders of the Lacrimal Secretory System 191
Quantitative Keratoconjunctivitis Sicca 191
Etiology 191
Congenital keratoconjunctivitis sicca. 191
Autoimmune keratoconjunctivitis sicca. 192
Neurogenic keratoconjunctivitis sicca. 192
Endocrinologic diseases. 192
Systemic infectious diseases. 192
Toxic or drug-induced keratoconjunctivitis sicca. 192
Other causes of secondary keratoconjunctivitis sicca. 193
Clinical Features 193
Mucoid or mucopurulent ocular discharge. 193
Blepharospasm. 193
Conjunctival hyperemia. 193
Corneal vascularization and pigmentation. 193
Dry and lusterless cornea. 193
Dry ipsilateral nostril. 193
Corneal ulceration. 194
Reduced vision. 194
Diagnosis 194
Medical Treatment 194
Nonspecific topical treatment for quantitative keratoconjunctivitis sicca 195
Eyewash and removal of excess mucus. 195
Artificial tears (lacrimomimetics). 195
Specific topical and systemic treatment for quantitative keratoconjunctivitis sicca (lacrimostimulants). 197
Immunomodulating agents. 197
Pilocarpine. 197
Reducing ocular surface inflammation. 197
Controlling secondary infection. 198
Other medications. 198
Follow-up and reevaluation protocol. 198
Surgical Treatment of Quantitative Keratoconjunctivitis Sicca 198
Parotid duct transposition. 198
Preoperative considerations. 198
Surgical preparation. 198
Surgery. 199
Intraoperative complications. 199
Postoperative treatment. 199
Success rate and postoperative complications. 199
Lacrimal punctal occlusion. 201
Cyclosporine A subconjunctival implants. 201
Qualitative Keratoconjunctivitis Sicca 202
Etiology 202
Clinical Presentation 202
Diagnosis 202
Treatment 203
Mucin-deficiency keratoconjunctivitis sicca treatment. 203
Lipid-deficiency keratoconjunctivitis sicca treatment. 203
Neoplasia of the Lacrimal Glands 203
Nasolacrimal Drainage System 203
Examination Methods 204
Congenital Disorders of the Nasolacrimal Drainage System 205
Congenital Punctal Atresia or Micropunctum 205
Diagnosis. 205
Treatment. 205
Displacement of the Puncta and Canaliculus 206
10 Diseases of the Cornea and Sclera 213
Embryology, Anatomy, and Physiology 213
Cornea 213
Sclera 215
Normal Corneal Healing 216
Epithelium 216
Stroma 216
Endothelium and Descemet’s Membrane 216
Effects of Corticosteroids on Corneal Healing 217
Pathologic Responses 217
Stromal Malacia (or “Melting”) 218
Corneal Edema 219
Corneal Vascularization 220
Corneal Fibrosis 222
Corneal Melanosis 222
Stromal Infiltration With White Blood Cells 223
Anterior Stromal Deposition of Lipid and/or Mineral 224
Corneal Ulcers in All Species 225
Common Causes of Corneal Ulceration 226
Simple Versus Complicated Ulcers 227
General Principles of Corneal Ulcer Treatment 228
Antibiotics 228
Atropine 229
Analgesic and Antiinflammatory Agents 229
Prevention of Self-Trauma 230
Temporary Tarsorrhaphy Versus Third Eyelid Flap 230
Treatment of Uncomplicated (Simple) Corneal Ulcers 230
Treatment of Deep Corneal Ulcers and Descemetoceles 231
Medical Treatment of Deep Ulcers 232
Protease Inhibitors 232
Surgical Treatment of Deep Ulcers 233
Cyanoacrylate Adhesives (Tissue Glue) 235
Treatment of Indolent Corneal Ulcers in Dogs 235
Corneal Trauma and Foreign Bodies 238
Corneal Lacerations 238
Removal of Corneal Foreign Bodies 240
Epithelial Inclusion Cysts 240
Corneal Diseases Seen Most Commonly in Dogs 241
Corneal Lipid/Mineral Dystrophy 241
Corneal Endothelial Dystrophy 241
Superficial Punctate Keratitis 242
Pigmentary Keratitis/Keratopathy 242
“Pannus” or Chronic Immune-Mediated Superficial Keratoconjunctivitis 243
Canine Herpesvirus 244
Infectious Canine Hepatitis 245
Corneal Diseases Seen Most Commonly in Cats 245
Feline Herpetic Keratitis 245
Feline Eosinophilic Keratoconjunctivitis 246
Feline Corneal Sequestration 247
Acute Bullous Keratopathy 247
Ulcerative Mycoplasmal Keratitis 248
Mycobacterial Keratitis 248
“Florida Keratopathy” or “Florida Spots” or “Tropical Keratopathy” 249
Congenital Corneal Diseases 249
Dermoid 249
Persistent Pupillary Membranes 249
Corneal Epithelial Dysmaturation or “Puppy Dystrophy” 249
Scleral and Limbal Disorders 250
Colobomatous Defects 250
Scleritis and Episcleritis 250
Scleral Trauma 251
Limbal Neoplasia 251
Suggested Reading 252
Anatomy 252
Pathologic Responses 252
Corneal Ulcers and Trauma 252
Corneal Diseases Specific to Dogs 252
Corneal Diseases Specific to Cats 253
Scleral and Limbal Disorders 253
11 Diseases of the Uvea 254
Anatomy and Physiology 254
Iris 254
Ciliary Body 256
Choroid 257
Blood–Ocular Barrier 258
Pathologic Reactions 259
Definitions 259
Immune Mechanisms 259
Congenital Uveal Abnormalities 261
Abnormalities of the Pupil 261
Persistent Pupillary Membrane 261
Coloboma 262
Anterior Segment Dysgenesis 262
Disorders of Pigmentation 263
Heterochromia 263
Waardenburg Syndrome 263
Iris Nevi 263
Uveitis 263
Sequelae of Uveitis 264
Posterior Synechiae 264
Peripheral Anterior Synechiae 265
Cataract 265
Glaucoma 265
Retinal Detachment 265
Atrophy 265
Preiridal Fibrovascular Membranes 265
Cyclitic Membranes 265
Diagnosis of Uveitis 265
General Therapeutic Principles 266
1. Make an Etiologic Diagnosis 266
2. Control Inflammation 266
Corticosteroids. 266
Nonsteroidal antiinflammatory drugs. 268
Immunosuppressive agents. 268
3. Prevent Undesirable Sequelae 268
Mydriatics and cycloplegics. 268
Antiglaucoma drugs. 268
4. Relieve Pain 268
Specific Forms of Uveitis 268
Infectious Uveitis 268
Immune-Mediated Uveitis 268
Uveodermatologic syndrome. 269
Lens-induced uveitis. 269
Leakage through the intact lens capsule. 269
Penetrating lens injuries. 269
Uveitis associated with dental disease. 270
Pigmentary uveitis of golden retrievers. 270
Feline uveitis. 270
Toxic uveitis. 271
Trauma 271
Traumatic Uveitis 271
Iris Prolapse 271
Signs 271
Hyphema 272
Etiologic Factors 272
Diagnosis 272
Treatment 272
Additional Therapy for Mild Hyphema 272
Additional Therapy for Severe Hyphema 272
Uveal Cysts and Neoplasms 273
Uveal Cysts 273
Primary Tumors 273
Adenoma and Adenocarcinoma 273
Canine Uveal Melanocytoma and Melanoma 274
Clinical signs. 274
Treatment. 274
Ocular Melanosis of Cairn Terriers 274
Feline Diffuse Iris Melanoma 275
Primary Feline Ocular Sarcomas 276
Secondary Tumors 276
Lymphosarcoma 276
Miscellaneous Disorders 276
Iris Hypoplasia 276
Iris Atrophy 276
Primary or Senile Iris Atrophy 276
Secondary Iris Atrophy 277
Suggested Reading 277
12 The Glaucomas 279
Aqueous Production and Drainage 279
Balancing Aqueous Production and Outflow 280
Causes of Variations in Intraocular Pressure 281
Diurnal Variation 281
Age 281
Blood Flow 281
Drugs 281
Ocular Inflammation 281
Diagnostic Methods 281
Tonometry 281
Ophthalmoscopy 281
Gonioscopy 281
Clinical Signs 281
Increased Intraocular Pressure 283
Pain, Blepharospasm, and Altered Behavior 283
Engorged Episcleral Vessels 284
Corneal and Scleral Changes 284
Edema 284
Buphthalmos and Descemet’s Streaks 284
Changes in Anterior Chamber Depth 285
Fixed Dilated Pupil 285
Lens Changes 285
Fundus Changes 286
Impaired Vision 286
Optic Disc Cupping 287
Retinal Degeneration 287
Classification 289
Pathogenesis 292
Primary Open-Angle Glaucoma 292
Primary Angle-Closure Glaucoma 292
Secondary Glaucomas 295
Obstruction of the Iridocorneal Angle 295
Pupillary Block 295
Ciliary Body–Vitreous–Lens Block 296
Combined-Mechanism Glaucoma 296
Treatment 296
Emergency Treatment of Acute Glaucoma 297
Long-Term Management of Glaucoma 298
Surgical Therapy for Glaucoma 299
Surgery to Increase Aqueous Humor Outflow 300
Surgery to Reduce Aqueous Humor Production 300
Cyclocryotherapy 300
Laser Cyclophotocoagulation 301
Combined Procedures 301
Lens Luxation 302
Glaucoma Secondary to Uveitis 302
Glaucoma Secondary to Intraocular Neoplasia 302
Absolute Glaucoma 302
Evisceration With Intrascleral Prosthesis 303
Enucleation 303
Feline Glaucoma 303
Suggested Reading 304
13 Diseases of the Lens 306
Anatomy and Physiology 306
Embryology 306
Gross Anatomy and Function 306
Lens Components 309
Capsule 309
Lens Epithelium 309
Lens Fibers 309
Metabolism and Composition 310
Nuclear Sclerosis 311
Congenital Anomalies 312
Cataract 312
Molecular and Cellular Pathogenesis of Cataracts 312
Classification 313
Degree of Opacity and Maturation 315
Lens-Induced Uveitis 316
Causes of Cataracts 316
Hereditary Cataracts 316
Diabetic Cataracts 317
Senile Cataracts 319
Secondary and Acquired Cataracts 319
Cataracts secondary to ocular disease. 319
Traumatic cataracts. 319
Nutritional cataracts. 320
Cataracts secondary to infection. 321
Cataracts secondary to radiation and toxicity. 321
Developmental Cataracts 322
Diagnosis of Cataracts 322
History 322
Clinical Signs 323
Genetic Testing 323
Treatment of Cataract 323
Medical Therapy 323
Surgical Case Selection 324
Surgical Correction 325
Discission and aspiration. 325
Intracapsular extraction. 325
Extracapsular extraction. 325
Phacoemulsification. 325
Postoperative Vision and Intraocular Lens Implantation 325
Medical Care, Complications, and Prognosis 326
Lens Luxation 327
Etiology 327
Clinical Signs and Progression 328
Treatment 331
Suggested Reading 332
14 Diseases of the Vitreous 334
Anatomy and Physiology 334
Embryology and Anatomy 334
Composition 335
Function 337
Pathologic Reactions 337
Principles of Diagnosis and Treatment of Vitreal Disorders 337
Diagnosis 337
Hyalocentesis and Intravitreal Injections 338
Drug Delivery 339
Surgical Procedures 339
Vitrectomy 339
Advanced Vitreoretinal Surgical Techniques 339
Congenital and Developmental Abnormalities (Persistent Fetal Vasculature) 340
Persistent Hyaloid Artery 340
Persistent Tunica Vasculosa Lentis 340
Persistent Hyperplastic Tunica Vasculosa Lentis/Persistent Hyperplastic Primary Vitreous 340
Acquired Disorders 341
Vitreous Hemorrhage 341
Inflammation and Infection 341
Vitreous Degeneration 342
Vitreous Opacities (Floaters) 342
Asteroid Hyalosis and Synchysis Scintillans 342
Vitreous Mass 342
Role of the Vitreous in the Pathogenesis of Ocular Diseases 343
Vitreous and Lens Luxation 343
Retinal Detachment 344
Aqueous Humor Misdirection Syndrome 344
Canine Ocular Gliovascular Syndrome 344
Suggested Reading 345
15 Diseases of the Retina 347
Embryology and Cellular Anatomy 347
Embryology 347
Cellular Anatomy 347
Retinal Pigment Epithelium 350
Blood Supply 351
Physiology and Biochemistry 352
Rods and Cones 352
Visual Photopigments 356
Photochemistry 356
Dark and Light Adaptation 357
Normal Ophthalmoscopic Variations (Applied Anatomy) 357
Sensory Neuroretina 357
Tapetum 357
Nontapetal Fundus 359
Optic Disc (Optic Nerve Head, Optic Papilla) 360
Myelination of Nerve Fiber Layer 361
Blood Vessels 361
Ophthalmoscopic Signs of Fundic Diseases and Their Underlying Pathologic Mechanisms 362
Primary Photoreceptor Disease 362
Inflammations 363
Retina–Choroid Interaction 363
Reactions of Pigment Epithelium 363
Perivascular Cuffing 364
Gliosis 364
Retinal Hemorrhages 364
Retinal Detachment 367
Retina–Optic Nerve Interaction 367
Ischemia 367
Congenital Retinal Disorders 368
Retinal Dysplasia 368
Collie Eye Anomaly 369
Coloboma 371
Retinopathy 371
Inherited Retinopathies 371
Classification of Inherited Retinopathies 371
Age of onset. 371
Affected cells. 371
Mode of inheritance. 372
Genetic and molecular pathogenesis. 372
Clinical Signs 372
Progressive loss of vision. 372
Tapetal hyperreflectivity. 372
Changes in retinal vasculature. 372
Additional clinical signs. 373
Additional Diagnostic Testing 373
Referral. 373
Electroretinography. 373
Genetic testing. 374
Treatment 375
Specific Forms of Inherited Retinopathy 376
Day Blindness (Achromatopsia, Hemeralopia) 376
Retinal Pigment Epithelium Dystrophy 376
Congenital Stationary Night Blindness 377
Canine Multifocal Retinopathy 377
Retinal Dystrophy in Briards 378
Inherited Retinal Degenerations in Cats 378
Retinopathies Associated With Storage Diseases 378
Acquired Retinopathies 379
Retinopathy Secondary to Infectious Diseases 379
Clinical signs of chorioretinitis. 379
Treatment. 379
Chorioretinal scarring. 380
Retinopathy Secondary to Cardiovascular Diseases 381
Sudden Acquired Retinal Degeneration Syndrome 382
Feline Central Retinal Degeneration 383
Toxic Retinopathies 384
Ivermectin toxicity. 384
Enrofloxacin toxicity in cats. 384
Retinal Detachment 385
Etiologic Factors 385
Signs 386
Therapy 387
Suggested Reading 388
16 Neuroophthalmic Diseases 390
Cranial Nerves of Ophthalmic Significance 390
Optic Nerve (Cranial Nerve [CN] II) 390
Decussation and Visual Field Projections in the Visual Cortex 390
Oculomotor Nerve (CN III) 391
Trochlear Nerve (CN IV) 391
Trigeminal Nerve (CN V) 391
Abducens Nerve (CN VI) 392
Facial Nerve (CN VII) 392
Autonomic Innervation of the Eye and Adnexa 393
Sympathetic Innervation 394
Parasympathetic Innervation 396
Neuroophthalmic Examination 396
Vision 397
Menace Response 397
Tracking Moving Objects 399
Maze Test 399
Visual Placing Reflex 400
Pupil Size and the Pupillary Light Reflex 400
Testing the Pupillary Light Reflex 400
Additional Tests 401
Swinging Flashlight Test 401
Dazzle Reflex 401
Electrophysiology 401
Imaging 401
Lesions in Patients With Visual and/or PLR Deficits 402
Lesions in Blind Patients With Normal Pupillary Light Reflex 402
Lesions in Blind Patients With Abnormal Pupillary Light Reflex 403
Pupils in Patients With an Intracranial Lesion 405
Lesions Causing Pupillary Light Reflex Abnormalities in Visual Patients 406
Cavernous Sinus and Orbital Fissure Syndromes 406
Additional Causes of Pupillary Light Reflex Abnormalities 407
Diseases of the Autonomic Nervous System 407
Horner’s Syndrome 407
Clinical signs. 407
Etiologic factors. 408
Diagnosis. 409
Treatment. 409
Dysautonomia (Key–Gaskell Syndrome) 410
Clinical signs. 410
Diagnosis. 410
Demonstration of parasympathetic denervation. 410
Demonstration of sympathetic denervation. 410
Treatment. 410
Extraocular Muscles and Lesions Causing Strabismus 411
Function of the Extraocular Muscles 411
Lesions Causing Strabismus 411
Strabismus Caused by Disorders of the Vestibular System 412
Strabismus Caused by Lesions in Innervation of the Extraocular Muscles 412
Oculomotor paralysis. 412
Trochlear paralysis. 413
Abducens paralysis. 413
Consequences and Treatment of Strabismus 413
Lesions of Additional Cranial Nerves 414
Facial Nerve Paralysis 414
Causes of Facial Nerve Paralysis and Other Associated Signs 414
Diagnosis and Treatment 415
Trigeminal Nerve Dysfunction 416
Lesions Causing Eyelid Abnormalities 416
Protrusion of the Third Eyelid 416
Horner’s Syndrome 416
Tetanus 416
Haw’s Syndrome 417
Dysautonomia 417
Nonneurogenic Causes 417
Abnormalities of the Palpebral Fissure 417
Innervation of the Upper Eyelid 417
Lesions Increasing the Size of the Palpebral Opening 417
Lesions Causing Ptosis 417
The Vestibular System and Nystagmus 418
Physiologic Vestibular Nystagmus 418
Signs of Vestibular Disease 418
Eye Position in Vestibular Disease 418
Loss of Physiologic Nystagmus 419
Pathologic Nystagmus 419
Causes of Vestibular Disease 419
Otitis Media and Otitis Interna 419
Idiopathic Vestibular Disease (Feline Vestibular Syndrome, Idiopathic Benign Vestibular Disease, Old Dog Vestibular Disease) 420
Central Disorders 420
Congenital and Neonatal Nystagmus 420
Diseases of the Central Visual Pathways 420
Diseases of the Optic Nerve 420
Congenital Anomalies 420
Aplasia and hypoplasia. 420
Colobomas. 420
Optic Neuritis 421
Etiologic factors. 421
Clinical signs. 422
Differential diagnosis. 422
Treatment and Prognosis. 422
Neoplasms 423
Clinical signs. 423
Diagnosis and treatment. 424
Optic Neuropathy 424
Etiologic factors. 424
Clinical signs. 424
Treatment. 424
Papilledema 424
Clinical signs. 425
Diseases of the Optic Chiasm 425
Postchiasma Diseases 426
Unilateral Disease 426
Neoplastic lesions. 426
Traumatic lesions. 426
Unilateral infectious lesions. 426
Feline ischemic encephalopathy. 426
Bilateral Disease 427
Space-occupying lesions. 427
Metabolic diseases. 427
Ischemic necrosis of cerebrum. 428
Distemper. 428
Hydrocephalus. 428
Additional Neuroophthalmic Diseases 428
Granulomatous Meningoencephalitis 428
Storage Diseases 428
Cerebellar Disease 429
Systemic Diseases 430
Suggested Reading 430
17 Ophthalmic Emergencies 432
Basic Materials Required to Address Ocular Emergencies 432
Basic Diagnostic Instruments and Supplies 432
Surgical Instruments 432
Medications 432
Proptosis of the Globe 432
Prognosis 433
Avulsion of Extraocular Muscles 433
Hyphema 433
Pupils 433
Skull Conformation 433
Postoperative Therapy 433
Severe Ocular and Adnexal Contusions and Concussion 435
Common Clinical Signs Associated With Ocular Trauma 435
Penetrating/Perforating Injuries of the Globe 436
Lid Lacerations 437
Treatment 437
Important Facts 437
Corneal Lacerations 437
Severe Corneal Ulceration 438
Glaucoma 438
Interim Therapy 439
Hyphema 439
Acute Anterior Uveitis 439
Acute Anterior Lens Luxation 440
Sudden Blindness 440
Suggested Reading 441
18 Equine Ophthalmology 442
Ocular Examination 442
Treating the Equine Eye 445
Supplies Needed to Place an SPL 445
Protecting the Equine Eye 446
Eyelid and Nictitans Disease 446
Squamous Cell Carcinoma 447
Equine Sarcoid 448
Nasolacrimal Disease 448
Conjunctival Disease 449
Equine Viral Conjunctivitis 449
Parasitic Conjunctivitis 449
Equine Conjunctival Angiosarcoma 449
Corneal Disease 450
Uncomplicated Corneal Ulcers 450
Corneal Lacerations 450
Complicated Corneal Ulcers 451
Equine Fungal Keratitis 452
Stromal Abscess 454
Nonhealing Ulcers 455
Equine Eosinophilic Keratoconjunctivitis 456
Calcific Band Keratopathy 457
Nonulcerative Keratitis 457
Friesian Stromal Loss 457
Endotheliitis 457
Corneal Squamous Cell Carcinoma 457
Uveal Disease 458
Uveal Cysts 459
Uveitis 460
Equine Recurrent Uveitis 461
Pathogenesis 461
Diagnosis 461
Treatment 461
Outcome 463
Lens Disease 463
Glaucoma 464
Chorioretinal Disease 466
Ocular Manifestation of Systemic Disease 467
Orbital Disease 467
Enucleation 468
Suggested Reading 469
19 Livestock Ophthalmology 471
Ophthalmic Examination 471
Ophthalamic Medication Administration 473
Orbital Anatomy and Nerve Blocks 473
Transpalpebral Enucleation Surgical Technique 474
Bovine Ophthalmology 475
Congenital Abnormalities 475
Orbital Disease 475
Orbital Neoplasia 475
Orbital Inflammation 476
Dexamethasone-Induced Exophthalmos 476
Eyelid Diseases 476
Entropion 476
Eyelid Trauma 476
Blepharitis 477
Nasolacrimal System Diseases 477
Conjunctival and Corneal Diseases 477
Dermoids 477
Infectious Bovine Keratoconjunctivitis 478
Ocular Squamous Cell Carcinoma 480
Etiology 480
Clinical Signs 480
Diagnosis 482
Treatment 482
Uvea 482
Congenital Disorders of Uvea 482
Uveitis 482
Uveal Tumors 483
Glaucoma 483
Cataracts 484
Diseases of the Fundus 484
Congenital Diseases 484
Acquired Diseases 484
Ophthalmic Diseases of Sheep and Goats 485
Eyelid Diseases 485
Entropion 485
Eyelid Coloboma 485
Blepharitis 485
Conjunctival and Corneal Diseases 486
Infectious Keratoconjunctivitis 486
Uveitis 488
Glaucoma 488
Cataracts 488
Diseases of the Fundus 488
Ophthalmic Diseases of Pigs 488
Anatomy 488
Congenital Abnormalities 488
Eyelid Diseases 489
Entropion 489
Blepharitis 489
Conjunctival and Corneal Diseases 490
Uvea 490
Congenital Disorders of Uvea 490
Uveitis 490
Cataracts 490
Diseases of the Fundus 491
Ocular Manifestations of Systemic Diseases in Livestock Animals 491
Infectious Diseases 491
Bacterial Diseases 491
Listeriosis. 491
Thromboembolic meningoencephalitis. 491
Mannheimia (pasteurella) pneumonia. 491
Tuberculosis. 491
Septicemia. 492
Viral Diseases 492
Arthrogryposis–hydranencephaly. 492
Bluetongue. 492
Infectious bovine rhinotracheitis. 492
Malignant catarrhal fever. 493
Bovine viral diarrhea. 493
Protozoal Diseases 493
Babesiosis. 493
Trypanosomiasis. 493
Toxoplasma gondii infection. 493
Anaplasma phagocytophilum. 493
Besnoitia. 493
Other Infectious Diseases 493
Scrapie. 493
Miscellaneous Diseases 494
Hypovitaminosis A 494
Polioencephalomalacia 494
Toxic Plants 494
Suggested Reading 495
20 Exotic Pet and Avian Ophthalmology 496
Ophthalmic Examination and Diagnostic Testing 496
Rabbits 498
Ophthalmic Anatomy 498
Orbital Disease 498
Adnexal Disease 499
Conjunctival Disease 500
Nasolacrimal Disease 501
Corneal Disease 501
Cataract 502
Glaucoma 503
Guinea Pigs 503
Ophthalmic Anatomy 503
Adnexal Disease 503
Corneal Disease 504
Conjunctival Disease 504
Cataract 504
Heterotopic Bone 505
Chinchillas 505
Ophthalmic Anatomy 505
Ophthalmic Disease 505
Hamsters 506
Ophthalmic Anatomy 506
Orbital Diseases of the Globe and Orbit 506
Entropion 506
Corneal and Conjunctival Disease 506
Cataracts 507
Glaucoma 507
Mice and Rats 507
Ophthalmic Anatomy 507
Exophthalmos 507
Diseases of the Lacrimal System and Conjunctiva 507
Corneal Disease 508
Cataract 508
Diseases of the Fundus 508
Ferrets 508
Ophthalmic Anatomy 508
Orbital Disease 509
Conjunctival Disease 509
Cataract 509
Avian Species 510
Ophthalmic Anatomy 510
Ophthalmic Disease 511
Trauma 511
Conjunctival Disease 511
Lizards, Turtles, Tortoises, and Crocodilians 513
Ophthalmic Anatomy 513
Ophthalmic Disease 514
Snakes 515
Ophthalmic Anatomy 515
Diseases of the Spectacle 515
Amphibians 517
Appendix Breed Predisposition to Eye Disorders 523
Dogs 523
Afghan Hound 523
Airedale 523
Akbash 523
Akita 523
Alaskan Malamute 523
American Bulldog 523
American Cocker Spaniel 523
American Eskimo Dog 524
American Hairless (Rat) Terrier 524
American Pit Bull Terrier 524
American Staffordshire Terrier 524
American Water Spaniel 524
Australian Cattle Dog (Queensland Heeler or Blue Heeler) 524
Australian Shepherd 524
Australian Terrier 524
Basenji 524
Basset Hound 524
Beagle 524
Bearded Collie 524
Bedlington Terrier 525
Belgian Malinois 525
Belgian Sheepdog (Belgian Shepherd—Groenendael) 525
Belgian Tervuren 525
Bernese Mountain Dog 525
Bichon Frise 525
Black and Tan Coonhound 525
Bloodhound 525
Border Collie 525
Border Terrier 525
Borzoi 525
Boston Terrier 525
Bouvier des Flandres 526
Boxer 526
Boykin Spaniel 526
Briard 526
Brittany Spaniel 526
Brussels Griffon 526
Bull Mastiff 526
Bull Terrier 526
Cairn Terrier 526
Cane Corso 526
Cardigan Welsh Corgi 526
Cavalier King Charles Spaniel 527
Chesapeake Bay Retriever 527
Chihuahua 527
Chinese Crested 527
Chow Chow 527
Clumber Spaniel 527
Collie (Rough and Smooth) 527
Coonhound 527
Corgi 527
Coton de Tulear 527
Curly Coated Retriever 527
Dachshund (All Varieties) 528
Dalmatian 528
Dandie Dinmont Terrier 528
Doberman Pinscher 528
Dogue de Bordeaux (French Mastiff) 528
English Bulldog 528
English Cocker Spaniel 528
English Setter 528
English Springer Spaniel 528
English Toy Spaniel (King Charles, Prince Charles, Ruby, Blenheim) 529
Entlebucher 529
Field Spaniel 529
Flat Coated Retriever 529
Fox Terrier (Smooth) 529
Fox Terrier (Wirehaired) 529
French Bulldog 529
German Shepherd 529
German Shorthaired Pointer 529
German Wirehaired Pointer 529
Giant Schnauzer 529
Golden Retriever 529
Gordon Setter 530
Great Dane 530
Great Pyrenees 530
Greater Swiss Mountain Dog 530
Greyhound 530
Havanese 530
Irish Setter 530
Irish Water Spaniel 530
Irish Wolfhound 530
Italian Greyhound 530
Jack Russell Terrier 531
Jagdterrier 531
Japanese Chin 531
Keeshond 531
Kerry Blue Terrier 531
Komondor 531
Kuvasz 531
Labrador Retriever 531
Lakeland Terrier 531
Lancashire Heelers 531
Leonberger 531
Lhasa Apso 531
Löwchen 532
Maltese Terrier 532
Manchester Terrier 532
Mastiff 532
Miniature Australian Shepherd 532
Miniature Bull Terrier 532
Miniature Pinscher 532
Miniature Schnauzer 532
Newfoundland 532
Norfolk Terrier 532
Norwegian Buhund 532
Norwegian Elkhound 532
Norwich Terrier 532
Nova Scotia Duck Tolling Retriever 533
Old English Sheepdog 533
Papillon 533
Parson Russell Terrier 533
Patterdale Terrier 533
Pekingese 533
Pembroke Welsh Corgi 533
Perro de Presa Canario 533
Petit Basset Griffon Vendéen 533
Pointer 533
Polish Lowland Sheepdog 533
Pomeranian 533
Poodle (All Varieties) 533
Portuguese Water Dog 534
Pug 534
Puli 534
Queensland Blue Heeler 534
Rat Terrier 534
Redbone Coonhound 534
Rhodesian Ridgeback 534
Rottweiler 534
Saint Bernard 534
Saluki 534
Samoyed 534
Schipperke 535
Scottish Terrier 535
Sealyham Terrier 535
Shar-Pei 535
Shetland Sheepdog (Sheltie) 535
Shiba Inu 535
Shih Tzu 535
Siberian Husky 535
Silky Terrier 535
Skye Terrier 535
Smooth Fox Terrier 535
Soft-Coated Wheaten Terrier 535
Spinone Italiano 536
Spitz 536
Staffordshire Bull Terrier 536
Standard Schnauzer 536
Sussex Spaniel 536
Swedish Vallhund 536
Tenterfield Terrier 536
Tibetan Spaniel 536
Tibetan Terrier 536
Toy Fox Terrier 536
Toy Havanese 536
Vizsla 536
Volipino Italiano 536
Weimaraner 536
Welsh Springer Spaniel 536
Welsh Terrier 536
West Highland White Terrier 537
Whippet 537
Wire Fox Terrier 537
Yorkshire Terrier 537
Cats 537
Abyssinian 537
Albinotic Felidae 537
Birman 537
Burmese 537
Domestic Shorthair 537
Himalayan 537
Korat 537
Manx 537
Persian 537
Siamese 537
Cattle 537
Angus 537
Ayrshire 537
Beef Master 537
Brahman 537
Brown Swiss 537
Charolais 538
Devon 538
Friesian (Holstein) 538
German Brown 538
German Fleckvieh 538
German Spotted 538
Guernsey 538
Hereford 538
Jersey 538
Romagnola 538
Shorthorn 538
Simmental 538
Sheep 538
Corriedale 538
Hampshire Downs 538
New Zealand Romney 538
Piebald 538
Shropshire 538
Southdown 538
South Hampshire 538
Suffolk 538
Horses 538
Appaloosa 538
Arabian 538
Belgian 538
Clydesdale 538
Friesian 538
Haflinger 538
Lipizzaner 539
Morgan 539
Quarter Horse 539
Rocky Mountain Horse 539
Shire 539
Thoroughbred 539
Goat 539
Angora 539
Pigs 539
Miniature Swine 539
Pot-Bellied 539
Yorkshire 539
Glossary 540
A 540
B 540
C 540
D 541
E 542
F 542
G 542
H 542
I 543
J 543
K 543
L 543
M 543
N 543
O 544
P 544
R 545
S 545
T 545
U 546
V 546
W 546
X 546
Z 546
Index 547
A 547
B 548
C 548
D 551
E 552
F 553
G 554
H 554
I 555
J 556
K 556
L 556
M 557
N 558
O 558
P 559
R 560
S 561
T 563
U 564
V 564
W 564
X 565
Y 565
Z 565