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BOOK
Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas, An Issue of Surgical Pathology Clinics, E-Book
(2017)
Additional Information
Book Details
Abstract
This issue of Surgical Pathology Clinics, edited by Rhonda K. Yantiss, will focus on Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas. Topics in this issue include, but are not limited to: Other forms of esophagitis; Diagnosis and management of Barrett-related neoplasia in the modern era; Patterns of gastric injury; Practical approach to the flat duodenal biopsy specimen; Chronic colitis in biopsy samples; Mucosal biopsy following bone marrow transplantation; The many faces of medication-related injury in the GI tract; The differential diagnosis of acute colitis: Clues to a specific diagnosis; Problematic colorectal polyps; Persistent problems in colorectal cancer reporting; Emerging concepts in gastric neoplasia; Immunohistochemistry pitfalls; Molecular testing in the modern era, and Lymphoproliferative diseases of the gut.
Table of Contents
Section Title | Page | Action | Price |
---|---|---|---|
Front Cover | Cover | ||
Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas\r | i | ||
Copyright\r | ii | ||
Contributors | iii | ||
CONSULTING EDITOR | iii | ||
EDITOR | iii | ||
AUTHORS | iii | ||
Contents | v | ||
Preface | v | ||
Other Forms of Esophagitis: It Is Not Gastroesophageal Reflux Disease, So Now What Do I Do? | v | ||
Diagnosis and Management of Barrett-Related Neoplasia in the Modern Era | v | ||
Patterns of Gastric Injury: Beyond Helicobacter pylori | v | ||
Practical Approach to the Flattened Duodenal Biopsy | v | ||
Chronic Colitis in Biopsy Samples: Is It Inflammatory Bowel Disease or Something Else? | vi | ||
The Differential Diagnosis of Acute Colitis: Clues to a Specific Diagnosis | vi | ||
The Many Faces of Medication-Related Injury in the Gastrointestinal Tract | vi | ||
Mucosal Biopsy After Bone Marrow Transplantation | vi | ||
Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders | vii | ||
Problematic Colorectal Polyps: Is It Cancer and What Do I Need to Do About It? | vii | ||
Persistent Problems in Colorectal Cancer Reporting | vii | ||
Immunohistochemical Pitfalls: Common Mistakes in the Evaluation of Lynch Syndrome | vii | ||
Molecular Testing of Colorectal Cancer in the Modern Era: What Are We Doing and Why? | viii | ||
Lymphoproliferative Diseases of the Gut: A Survival Guide for the General Pathologist | viii | ||
SURGICAL PATHOLOGY CLINICS\r | ix | ||
FORTHCOMING ISSUES | ix | ||
March 2018 | ix | ||
June 2018 | ix | ||
September 2018 | ix | ||
RECENT ISSUES | ix | ||
September 2017 | ix | ||
June 2017 | ix | ||
March 2017 | ix | ||
Preface | xi | ||
Other Forms of Esophagitis | 765 | ||
ABSTRACT | 765 | ||
OVERVIEW | 765 | ||
EOSINOPHILIC ESOPHAGITIS | 765 | ||
CLINICAL AND ENDOSCOPIC FEATURES | 765 | ||
MICROSCOPIC FEATURES AND DIAGNOSIS | 766 | ||
DIFFERENTIAL DIAGNOSIS | 767 | ||
PROGNOSIS | 767 | ||
LYMPHOCYTIC ESOPHAGITIS | 768 | ||
CLINICAL AND ENDOSCOPIC FEATURES | 768 | ||
MICROSCOPIC FEATURES AND DIAGNOSIS | 768 | ||
ASSOCIATIONS AND PROPOSED CAUSES | 769 | ||
DIFFERENTIAL DIAGNOSIS | 769 | ||
PROGNOSIS | 770 | ||
SLOUGHING ESOPHAGITIS (ESOPHAGITIS DISSECANS SUPERFICIALIS) | 770 | ||
CLINICAL AND ENDOSCOPIC FEATURES | 770 | ||
MICROSCOPIC FEATURES AND DIAGNOSIS | 770 | ||
DIFFERENTIAL DIAGNOSIS | 771 | ||
PROGNOSIS | 771 | ||
MEDICATION-INDUCED ESOPHAGEAL INJURY | 771 | ||
CLINICAL AND ENDOSCOPIC FEATURES | 771 | ||
MICROSCOPIC FEATURES AND DIAGNOSIS | 772 | ||
PROGNOSIS | 772 | ||
INFECTIOUS ESOPHAGITIS | 773 | ||
HERPES ESOPHAGITIS | 773 | ||
Diagnosis and Management of Barrett-Related Neoplasia in the Modern Era | 781 | ||
ABSTRACT | 781 | ||
OVERVIEW | 781 | ||
CLASSIFICATION OF DYSPLASIA IN BARRETT ESOPHAGUS | 782 | ||
BARRETT ESOPHAGUS: NEGATIVE FOR DYSPLASIA | 783 | ||
BARRETT ESOPHAGUS: INDEFINITE FOR DYSPLASIA | 783 | ||
BARRETT ESOPHAGUS: LOW-GRADE DYSPLASIA | 783 | ||
BARRETT ESOPHAGUS: HIGH-GRADE DYSPLASIA | 784 | ||
INTRAMUCOSAL CARCINOMA | 785 | ||
VARIANT DYSPLASIA PATTERNS | 786 | ||
ROLE OF IMMUNOLABELING | 789 | ||
TREATMENT AND POST-TREATMENT CHANGES | 790 | ||
EVALUATION OF ENDOSCOPIC MUCOSAL RESECTION SPECIMENS | 792 | ||
FOLLOW-UP OF BARRETT ESOPHAGUS PATIENTS | 797 | ||
PROGNOSTICATION | 798 | ||
SUMMARY | 799 | ||
REFERENCES | 799 | ||
Patterns of Gastric Injury | 801 | ||
ABSTRACT | 801 | ||
OVERVIEW | 801 | ||
GASTRITIS WITH PROMINENT INFLAMMATORY INFILTRATES IN THE LAMINA PROPRIA | 802 | ||
GASTRITIS WITH LYMPHOPLASMACYTIC INFLAMMATION | 802 | ||
Autoimmune Gastritis | 802 | ||
Syphilitic Gastritis | 802 | ||
GASTRITIS WITH PROMINENT INFLAMMATION AND SUBEPITHELIAL COLLAGEN DEPOSITION | 803 | ||
Collagenous Gastritis | 803 | ||
GASTRITIS WITH PREDOMINANTLY LYMPHOCYTIC INFLAMMATION | 806 | ||
Epstein-Barr Virus–Associated Gastritis | 806 | ||
Lymphomatoid Gastropathy (Natural Killer Cell Enteropathy) | 806 | ||
GASTRITIS WITH INTRAEPITHELIAL LYMPHOCYTOSIS | 806 | ||
Lymphocytic Gastritis | 806 | ||
GASTRITIS WITH EOSINOPHIL-RICH INFLAMMATION | 806 | ||
Eosinophilic Gastritis and Gastroenteritis | 806 | ||
GASTRITIS WITH PREDOMINANTLY NEUTROPHILIC INFLAMMATION | 810 | ||
Acute Suppurative (Phlegmonous) Gastritis | 810 | ||
Emphysematous Gastritis | 810 | ||
Doxycycline-Induced Gastritis | 811 | ||
GASTRITIS WITH GRANULOMATOUS INFLAMMATION | 811 | ||
CROHN'S DISEASE | 811 | ||
SARCOIDOSIS | 811 | ||
INFECTIOUS GASTRITIS | 812 | ||
GASTRITIS WITH LIMITED LAMINA PROPRIA INFLAMMATION | 812 | ||
GASTRITIS WITH VIRAL INCLUSIONS | 812 | ||
Cytomegalovirus-Associated Gastritis | 812 | ||
Herpes Simplex Virus–Associated Gastritis | 812 | ||
GASTRITIS WITH HEMORRHAGE AND/OR NECROSIS | 813 | ||
Caustic Gastritis | 813 | ||
Ulcero-Hemorrhagic Gastritis | 813 | ||
REACTIVE (CHEMICAL) GASTROPATHY | 814 | ||
GASTRITIS WITH INCREASED APOPTOSIS AND/OR ATYPICAL MITOTIC FIGURES | 816 | ||
Graft-Versus-Host Disease | 816 | ||
Drug-Induced Gastritis Due to Colchicine and Taxol | 816 | ||
Chemoradiation-Induced Gastritis | 817 | ||
GASTRITIS CHARACTERIZED BY CRYSTAL OR PIGMENT DEPOSITION | 817 | ||
IRON PILL GASTRITIS | 817 | ||
GASTRIC MUCOSAL CALCINOSIS | 817 | ||
LANTHANUM CARBONATE | 820 | ||
KAYEXALATE IN SORBITOL | 820 | ||
REFERENCES | 820 | ||
Practical Approach to the Flattened Duodenal Biopsy | 823 | ||
ABSTRACT | 823 | ||
A SYSTEMATIC APPROACH TO DUODENAL BIOPSIES | 823 | ||
CELIAC DISEASE: HISTOLOGY, REPORTING, SPECIAL SITUATIONS, DIFFERENTIAL DIAGNOSIS | 825 | ||
HISTOLOGY | 825 | ||
SPECIAL SITUATIONS IN CELIAC DISEASE | 826 | ||
Ultra-short Celiac Disease | 826 | ||
Collagenous Sprue | 826 | ||
Treated Celiac Disease | 828 | ||
Refractory Celiac Disease | 829 | ||
DIFFERENTIAL DIAGNOSIS | 830 | ||
Tropical Sprue | 830 | ||
Common Variable Immunodeficiency | 832 | ||
Autoimmune Enteropathy | 832 | ||
Medication Injury | 832 | ||
Small Intestinal Bacterial Overgrowth | 835 | ||
Inflammatory Bowel Disease | 835 | ||
THE PATHOLOGY REPORT | 835 | ||
REFERENCES | 838 | ||
Chronic Colitis in Biopsy Samples | 841 | ||
ABSTRACT | 841 | ||
OVERVIEW | 841 | ||
NORMAL COLON HISTOLOGY | 842 | ||
INFLAMMATORY BOWEL DISEASE | 842 | ||
ULCERATIVE COLITIS | 842 | ||
CROHN COLITIS | 847 | ||
INDETERMINATE COLITIS | 853 | ||
EFFECT OF TREATMENT ON INFLAMMATORY BOWEL DISEASE | 853 | ||
DIFFERENTIAL DIAGNOSIS OF CHRONIC COLITIS | 853 | ||
THE NONDISTORTING, NONULCERATING COLITIDES | 855 | ||
CHRONIC COLITIDES WITH VARIABLE HISTOLOGIC FEATURES | 857 | ||
Diverticular Disease–Associated Colitis | 857 | ||
Diversion Colitis | 858 | ||
Drug-Associated Chronic Colitis | 858 | ||
Infection and Unclassified Colitides | 859 | ||
SUMMARY | 860 | ||
REFERENCES | 861 | ||
The Differential Diagnosis of Acute Colitis: Clues to a Specific Diagnosis | 863 | ||
ABSTRACT | 863 | ||
OVERVIEW | 863 | ||
HISTOLOGY OF THE NORMAL COLONIC MUCOSA | 864 | ||
HISTOLOGIC PATTERNS ASSOCIATED WITH ACUTE COLITIS | 864 | ||
ACUTE COLITIS (ACUTE SELF-LIMITED COLITIS) | 865 | ||
HISTOPATHOLOGY | 866 | ||
DIFFERENTIAL DIAGNOSIS OF ACUTE COLITIS AND INFLAMMATORY BOWEL DISEASE | 866 | ||
INFECTIOUS CAUSES OF ACUTE COLITIS WITH SPECIAL HISTOLOGIC PATTERNS | 868 | ||
FOCAL ACTIVE COLITIS | 873 | ||
HISTOPATHOLOGY | 874 | ||
ACUTE COLITIS WITH ISCHEMIC FEATURES | 874 | ||
PSEUDOMEMBRANOUS COLITIS | 875 | ||
HISTOPATHOLOGY | 877 | ||
DIFFERENTIAL DIAGNOSIS | 877 | ||
HEMORRHAGIC COLITIS | 877 | ||
HISTOPATHOLOGY | 878 | ||
ACUTE ISCHEMIC COLITIS | 878 | ||
HISTOPATHOLOGY | 882 | ||
SUMMARY | 883 | ||
REFERENCES | 883 | ||
The Many Faces of Medication-Related Injury in the Gastrointestinal Tract | 887 | ||
ABSTRACT | 887 | ||
OVERVIEW | 887 | ||
CHEMOTHERAPEUTIC AGENTS | 888 | ||
IMMUNOMODULATORS AND TARGETED AGENTS | 889 | ||
ANTIBIOTICS | 890 | ||
BISPHOSPHONATES | 892 | ||
IRON | 893 | ||
RESINS | 895 | ||
SARTANS | 896 | ||
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS | 900 | ||
IMMUNOSUPRESSIVE AGENTS | 902 | ||
SUMMARY | 906 | ||
REFERENCES | 906 | ||
Mucosal Biopsy After Bone Marrow Transplantation | 909 | ||
ABSTRACT | 909 | ||
OVERVIEW | 909 | ||
GRAFT-VERSUS-HOST DISEASE | 910 | ||
CLINICAL FEATURES | 910 | ||
PATHOGENESIS OF GRAFT-VERSUS-HOST DISEASE | 910 | ||
MORPHOLOGIC FEATURES OF GRAFT-VERSUS-HOST DISEASE | 910 | ||
GRADING OF GRAFT-VERSUS-HOST DISEASE | 911 | ||
PATHOLOGIC FEATURES OF CHRONIC GRAFT-VERSUS-HOST DISEASE | 913 | ||
REPORTING GRAFT-VERSUS-HOST DISEASE | 914 | ||
DIFFERENTIAL DIAGNOSIS OF GASTROINTESTINAL GRAFT-VERSUS-HOST DISEASE | 915 | ||
CHEMOTHERAPY-INDUCED INJURY | 916 | ||
MYCOPHENOLATE MOFETIL (CELLCEPT) | 916 | ||
PROTON PUMP INHIBITOR EFFECT | 921 | ||
BOWEL PREPARATION | 921 | ||
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS | 921 | ||
CORD COLITIS | 921 | ||
INFECTION | 922 | ||
CYTOMEGALOVIRUS | 922 | ||
ADENOVIRUS | 923 | ||
STRONGYLOIDES STERCORALIS | 923 | ||
IDIOPATHIC ESOPHAGEAL ULCERS | 925 | ||
NEUTROPENIC ENTEROCOLITIS | 925 | ||
SUMMARY | 927 | ||
REFERENCES | 927 | ||
Emerging Concepts in Gastric Neoplasia | 931 | ||
ABSTRACT | 931 | ||
OVERVIEW | 931 | ||
HEREDITARY DIFFUSE GASTRIC CANCER | 932 | ||
CDH1 GERMLINE MUTATION | 932 | ||
CTNNA1 GERMLINE MUTATION | 937 | ||
OTHER MUTATIONS DESCRIBED IN HEREDITARY DIFFUSE GASTRIC CANCER | 937 | ||
FAMILIAL INTESTINAL GASTRIC CANCER | 937 | ||
GASTRIC POLYPOSIS AND GASTRIC CANCER PREDISPOSITION | 937 | ||
BACKGROUND | 937 | ||
FUNDIC GLAND POLYPOSIS SYNDROMES | 938 | ||
GAPPS (Gastric Adenocarcinoma and Proximal Polyposis of the Stomach)-Related Gastric Polyposis and Cancer | 938 | ||
Familial Adenomatous Polyposis and Gastric Fundic Gland Polyposis | 938 | ||
MUTYH-Associated Polyposis and Gastric Fundic Gland Polyposis | 938 | ||
GASTRIC HAMARTOMATOUS POLYPOSIS | 938 | ||
Peutz-Jeghers Syndrome | 938 | ||
Juvenile Polyposis | 940 | ||
Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome (Including Cowden Syndrome) | 940 | ||
OTHER HEREDITARY CANCER SYNDROMES IN WHICH GASTRIC CANCER RISK IS INCREASED | 940 | ||
LYNCH SYNDROME AND GASTRIC CANCER RISK | 940 | ||
LI-FRAUMENI SYNDROME AND GASTRIC CANCER RISK | 941 | ||
HEREDITARY BREAST AND OVARIAN CANCER AND GASTRIC CANCER RISK | 941 | ||
SUMMARY | 942 | ||
REFERENCES | 943 | ||
Problematic Colorectal Polyps | 947 | ||
ABSTRACT | 947 | ||
OVERVIEW | 947 | ||
EPITHELIAL MISPLACEMENT VERSUS ADENOCARCINOMA | 948 | ||
MANAGEMENT OF MALIGNANT COLORECTAL POLYPS | 955 | ||
REFERENCES | 959 | ||
Persistent Problems in Colorectal Cancer Reporting | 961 | ||
ABSTRACT | 961 | ||
OVERVIEW | 961 | ||
ASSIGNING TUMOR STAGE TO LOCALLY ADVANCED CANCERS | 962 | ||
DEFINITIONS OF TUMOR STAGE (PT) | 962 | ||
DEFINITION OF SEROSAL PENETRATION (PT4A) | 962 | ||
FEATURES OF SEROSAL PENETRATION AT THE TIME OF GROSS EXAMINATION | 963 | ||
HISTOLOGIC FEATURES OF SEROSAL PENETRATION | 963 | ||
USE OF ANCILLARY TESTS TO FACILITATE DETECTION OF SEROSAL PENETRATION | 966 | ||
STAGING REGIONAL LYMPH NODES | 966 | ||
DEFINITIONS OF LYMPH NODE STAGE (PN) | 966 | ||
GROSS EXAMINATION OF REGIONAL LYMPH NODES | 966 | ||
MICROMETASTASES AND ISOLATED TUMOR CELLS | 968 | ||
ACELLULAR MUCIN IN LYMPH NODES FROM TREATMENT-NAÏVE PATIENTS | 969 | ||
TUMOR DEPOSITS IN PERICOLORECTAL SOFT TISSUE | 970 | ||
PROGNOSTIC IMPORTANCE OF RESPONSE TO NEOADJUVANT THERAPY | 974 | ||
SUMMARY | 974 | ||
REFERENCES | 975 | ||
Immunohistochemical Pitfalls | 977 | ||
ABSTRACT | 977 | ||
OVERVIEW | 977 | ||
MISMATCH REPAIR PROTEIN IMMUNOHISTOCHEMISTRY AND MICROSATELLITE INSTABILITY | 978 | ||
DIAGNOSTIC ALGORITHM FOR SCREENING NEWLY DIAGNOSED COLORECTAL CANCER FOR LYNCH SYNDROME | 978 | ||
USUAL AND UNUSUAL STAINING PATTERNS OF MISMATCH REPAIR PROTEINS | 981 | ||
REPORTING AND INTERPRETATION PITFALLS FOR MISMATCH REPAIR PROTEIN IMMUNOHISTOCHEMISTRY | 981 | ||
MISMATCH REPAIR-DEFICIENT COLORECTAL CANCERS | 987 | ||
COMMONLY ENCOUNTERED MISTAKES IN INTERPRETING MISMATCH REPAIR PROTEIN EXPRESSION USING IMMUNOHISTOCHEMISTRY | 989 | ||
SUMMARY | 1002 | ||
REFERENCES | 1004 | ||
Molecular Testing of Colorectal Cancer in the Modern Era | 1009 | ||
ABSTRACT | 1009 | ||
OVERVIEW | 1009 | ||
ESTABLISHED BIOMARKERS | 1010 | ||
MICROSATELLITE INSTABILITY | 1010 | ||
MLH1 PROMOTER HYPERMETHYLATION | 1011 | ||
RAS MUTATIONS | 1012 | ||
BRAF V600E MUTATION | 1012 | ||
EMERGING BIOMARKERS | 1014 | ||
PIK3CA MUTATIONS | 1014 | ||
HER2 GENETIC ALTERATIONS | 1014 | ||
PRACTICAL CONSIDERATIONS | 1015 | ||
APPROACHES TO GENOTYPING | 1015 | ||
TYPE OF SPECIMEN | 1015 | ||
SUMMARY | 1016 | ||
REFERENCES | 1016 | ||
Lymphoproliferative Diseases of the Gut | 1021 | ||
ABSTRACT | 1021 | ||
OVERVIEW | 1021 | ||
GASTROINTESTINAL LYMPHOID TISSUE | 1022 | ||
SPECIFIC GASTROINTESTINAL LYMPHOMAS | 1024 | ||
B-CELL LYMPHOMAS | 1024 | ||
Diffuse Large B-Cell Lymphoma | 1024 | ||
Mucosa-Associated Lymphoid Tissue Lymphoma | 1026 | ||
Follicular lymphoma | 1028 | ||
Mantle Cell Lymphoma | 1029 | ||
Burkitt Lymphoma | 1031 | ||
T-CELL LYMPHOMAS | 1032 | ||
Enteropathy-Associated T-Cell Lymphoma | 1032 | ||
Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type | 1033 | ||
GENERAL APPROACH TO GASTROINTESTINAL LYMPHOMA DIAGNOSIS | 1034 | ||
SUMMARY | 1036 | ||
REFERENCES | 1036 |