BOOK
Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas, An Issue of Surgical Pathology Clinics, E-Book
(2017)
Additional Information
Book Details
Abstract
This issue of Surgical Pathology Clinics, edited by Rhonda K. Yantiss, will focus on Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas. Topics in this issue include, but are not limited to: Other forms of esophagitis; Diagnosis and management of Barrett-related neoplasia in the modern era; Patterns of gastric injury; Practical approach to the flat duodenal biopsy specimen; Chronic colitis in biopsy samples; Mucosal biopsy following bone marrow transplantation; The many faces of medication-related injury in the GI tract; The differential diagnosis of acute colitis: Clues to a specific diagnosis; Problematic colorectal polyps; Persistent problems in colorectal cancer reporting; Emerging concepts in gastric neoplasia; Immunohistochemistry pitfalls; Molecular testing in the modern era, and Lymphoproliferative diseases of the gut.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas\r | i | ||
| Copyright\r | ii | ||
| Contributors | iii | ||
| CONSULTING EDITOR | iii | ||
| EDITOR | iii | ||
| AUTHORS | iii | ||
| Contents | v | ||
| Preface | v | ||
| Other Forms of Esophagitis: It Is Not Gastroesophageal Reflux Disease, So Now What Do I Do? | v | ||
| Diagnosis and Management of Barrett-Related Neoplasia in the Modern Era | v | ||
| Patterns of Gastric Injury: Beyond Helicobacter pylori | v | ||
| Practical Approach to the Flattened Duodenal Biopsy | v | ||
| Chronic Colitis in Biopsy Samples: Is It Inflammatory Bowel Disease or Something Else? | vi | ||
| The Differential Diagnosis of Acute Colitis: Clues to a Specific Diagnosis | vi | ||
| The Many Faces of Medication-Related Injury in the Gastrointestinal Tract | vi | ||
| Mucosal Biopsy After Bone Marrow Transplantation | vi | ||
| Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders | vii | ||
| Problematic Colorectal Polyps: Is It Cancer and What Do I Need to Do About It? | vii | ||
| Persistent Problems in Colorectal Cancer Reporting | vii | ||
| Immunohistochemical Pitfalls: Common Mistakes in the Evaluation of Lynch Syndrome | vii | ||
| Molecular Testing of Colorectal Cancer in the Modern Era: What Are We Doing and Why? | viii | ||
| Lymphoproliferative Diseases of the Gut: A Survival Guide for the General Pathologist | viii | ||
| SURGICAL PATHOLOGY CLINICS\r | ix | ||
| FORTHCOMING ISSUES | ix | ||
| March 2018 | ix | ||
| June 2018 | ix | ||
| September 2018 | ix | ||
| RECENT ISSUES | ix | ||
| September 2017 | ix | ||
| June 2017 | ix | ||
| March 2017 | ix | ||
| Preface | xi | ||
| Other Forms of Esophagitis | 765 | ||
| ABSTRACT | 765 | ||
| OVERVIEW | 765 | ||
| EOSINOPHILIC ESOPHAGITIS | 765 | ||
| CLINICAL AND ENDOSCOPIC FEATURES | 765 | ||
| MICROSCOPIC FEATURES AND DIAGNOSIS | 766 | ||
| DIFFERENTIAL DIAGNOSIS | 767 | ||
| PROGNOSIS | 767 | ||
| LYMPHOCYTIC ESOPHAGITIS | 768 | ||
| CLINICAL AND ENDOSCOPIC FEATURES | 768 | ||
| MICROSCOPIC FEATURES AND DIAGNOSIS | 768 | ||
| ASSOCIATIONS AND PROPOSED CAUSES | 769 | ||
| DIFFERENTIAL DIAGNOSIS | 769 | ||
| PROGNOSIS | 770 | ||
| SLOUGHING ESOPHAGITIS (ESOPHAGITIS DISSECANS SUPERFICIALIS) | 770 | ||
| CLINICAL AND ENDOSCOPIC FEATURES | 770 | ||
| MICROSCOPIC FEATURES AND DIAGNOSIS | 770 | ||
| DIFFERENTIAL DIAGNOSIS | 771 | ||
| PROGNOSIS | 771 | ||
| MEDICATION-INDUCED ESOPHAGEAL INJURY | 771 | ||
| CLINICAL AND ENDOSCOPIC FEATURES | 771 | ||
| MICROSCOPIC FEATURES AND DIAGNOSIS | 772 | ||
| PROGNOSIS | 772 | ||
| INFECTIOUS ESOPHAGITIS | 773 | ||
| HERPES ESOPHAGITIS | 773 | ||
| Diagnosis and Management of Barrett-Related Neoplasia in the Modern Era | 781 | ||
| ABSTRACT | 781 | ||
| OVERVIEW | 781 | ||
| CLASSIFICATION OF DYSPLASIA IN BARRETT ESOPHAGUS | 782 | ||
| BARRETT ESOPHAGUS: NEGATIVE FOR DYSPLASIA | 783 | ||
| BARRETT ESOPHAGUS: INDEFINITE FOR DYSPLASIA | 783 | ||
| BARRETT ESOPHAGUS: LOW-GRADE DYSPLASIA | 783 | ||
| BARRETT ESOPHAGUS: HIGH-GRADE DYSPLASIA | 784 | ||
| INTRAMUCOSAL CARCINOMA | 785 | ||
| VARIANT DYSPLASIA PATTERNS | 786 | ||
| ROLE OF IMMUNOLABELING | 789 | ||
| TREATMENT AND POST-TREATMENT CHANGES | 790 | ||
| EVALUATION OF ENDOSCOPIC MUCOSAL RESECTION SPECIMENS | 792 | ||
| FOLLOW-UP OF BARRETT ESOPHAGUS PATIENTS | 797 | ||
| PROGNOSTICATION | 798 | ||
| SUMMARY | 799 | ||
| REFERENCES | 799 | ||
| Patterns of Gastric Injury | 801 | ||
| ABSTRACT | 801 | ||
| OVERVIEW | 801 | ||
| GASTRITIS WITH PROMINENT INFLAMMATORY INFILTRATES IN THE LAMINA PROPRIA | 802 | ||
| GASTRITIS WITH LYMPHOPLASMACYTIC INFLAMMATION | 802 | ||
| Autoimmune Gastritis | 802 | ||
| Syphilitic Gastritis | 802 | ||
| GASTRITIS WITH PROMINENT INFLAMMATION AND SUBEPITHELIAL COLLAGEN DEPOSITION | 803 | ||
| Collagenous Gastritis | 803 | ||
| GASTRITIS WITH PREDOMINANTLY LYMPHOCYTIC INFLAMMATION | 806 | ||
| Epstein-Barr Virus–Associated Gastritis | 806 | ||
| Lymphomatoid Gastropathy (Natural Killer Cell Enteropathy) | 806 | ||
| GASTRITIS WITH INTRAEPITHELIAL LYMPHOCYTOSIS | 806 | ||
| Lymphocytic Gastritis | 806 | ||
| GASTRITIS WITH EOSINOPHIL-RICH INFLAMMATION | 806 | ||
| Eosinophilic Gastritis and Gastroenteritis | 806 | ||
| GASTRITIS WITH PREDOMINANTLY NEUTROPHILIC INFLAMMATION | 810 | ||
| Acute Suppurative (Phlegmonous) Gastritis | 810 | ||
| Emphysematous Gastritis | 810 | ||
| Doxycycline-Induced Gastritis | 811 | ||
| GASTRITIS WITH GRANULOMATOUS INFLAMMATION | 811 | ||
| CROHN'S DISEASE | 811 | ||
| SARCOIDOSIS | 811 | ||
| INFECTIOUS GASTRITIS | 812 | ||
| GASTRITIS WITH LIMITED LAMINA PROPRIA INFLAMMATION | 812 | ||
| GASTRITIS WITH VIRAL INCLUSIONS | 812 | ||
| Cytomegalovirus-Associated Gastritis | 812 | ||
| Herpes Simplex Virus–Associated Gastritis | 812 | ||
| GASTRITIS WITH HEMORRHAGE AND/OR NECROSIS | 813 | ||
| Caustic Gastritis | 813 | ||
| Ulcero-Hemorrhagic Gastritis | 813 | ||
| REACTIVE (CHEMICAL) GASTROPATHY | 814 | ||
| GASTRITIS WITH INCREASED APOPTOSIS AND/OR ATYPICAL MITOTIC FIGURES | 816 | ||
| Graft-Versus-Host Disease | 816 | ||
| Drug-Induced Gastritis Due to Colchicine and Taxol | 816 | ||
| Chemoradiation-Induced Gastritis | 817 | ||
| GASTRITIS CHARACTERIZED BY CRYSTAL OR PIGMENT DEPOSITION | 817 | ||
| IRON PILL GASTRITIS | 817 | ||
| GASTRIC MUCOSAL CALCINOSIS | 817 | ||
| LANTHANUM CARBONATE | 820 | ||
| KAYEXALATE IN SORBITOL | 820 | ||
| REFERENCES | 820 | ||
| Practical Approach to the Flattened Duodenal Biopsy | 823 | ||
| ABSTRACT | 823 | ||
| A SYSTEMATIC APPROACH TO DUODENAL BIOPSIES | 823 | ||
| CELIAC DISEASE: HISTOLOGY, REPORTING, SPECIAL SITUATIONS, DIFFERENTIAL DIAGNOSIS | 825 | ||
| HISTOLOGY | 825 | ||
| SPECIAL SITUATIONS IN CELIAC DISEASE | 826 | ||
| Ultra-short Celiac Disease | 826 | ||
| Collagenous Sprue | 826 | ||
| Treated Celiac Disease | 828 | ||
| Refractory Celiac Disease | 829 | ||
| DIFFERENTIAL DIAGNOSIS | 830 | ||
| Tropical Sprue | 830 | ||
| Common Variable Immunodeficiency | 832 | ||
| Autoimmune Enteropathy | 832 | ||
| Medication Injury | 832 | ||
| Small Intestinal Bacterial Overgrowth | 835 | ||
| Inflammatory Bowel Disease | 835 | ||
| THE PATHOLOGY REPORT | 835 | ||
| REFERENCES | 838 | ||
| Chronic Colitis in Biopsy Samples | 841 | ||
| ABSTRACT | 841 | ||
| OVERVIEW | 841 | ||
| NORMAL COLON HISTOLOGY | 842 | ||
| INFLAMMATORY BOWEL DISEASE | 842 | ||
| ULCERATIVE COLITIS | 842 | ||
| CROHN COLITIS | 847 | ||
| INDETERMINATE COLITIS | 853 | ||
| EFFECT OF TREATMENT ON INFLAMMATORY BOWEL DISEASE | 853 | ||
| DIFFERENTIAL DIAGNOSIS OF CHRONIC COLITIS | 853 | ||
| THE NONDISTORTING, NONULCERATING COLITIDES | 855 | ||
| CHRONIC COLITIDES WITH VARIABLE HISTOLOGIC FEATURES | 857 | ||
| Diverticular Disease–Associated Colitis | 857 | ||
| Diversion Colitis | 858 | ||
| Drug-Associated Chronic Colitis | 858 | ||
| Infection and Unclassified Colitides | 859 | ||
| SUMMARY | 860 | ||
| REFERENCES | 861 | ||
| The Differential Diagnosis of Acute Colitis: Clues to a Specific Diagnosis | 863 | ||
| ABSTRACT | 863 | ||
| OVERVIEW | 863 | ||
| HISTOLOGY OF THE NORMAL COLONIC MUCOSA | 864 | ||
| HISTOLOGIC PATTERNS ASSOCIATED WITH ACUTE COLITIS | 864 | ||
| ACUTE COLITIS (ACUTE SELF-LIMITED COLITIS) | 865 | ||
| HISTOPATHOLOGY | 866 | ||
| DIFFERENTIAL DIAGNOSIS OF ACUTE COLITIS AND INFLAMMATORY BOWEL DISEASE | 866 | ||
| INFECTIOUS CAUSES OF ACUTE COLITIS WITH SPECIAL HISTOLOGIC PATTERNS | 868 | ||
| FOCAL ACTIVE COLITIS | 873 | ||
| HISTOPATHOLOGY | 874 | ||
| ACUTE COLITIS WITH ISCHEMIC FEATURES | 874 | ||
| PSEUDOMEMBRANOUS COLITIS | 875 | ||
| HISTOPATHOLOGY | 877 | ||
| DIFFERENTIAL DIAGNOSIS | 877 | ||
| HEMORRHAGIC COLITIS | 877 | ||
| HISTOPATHOLOGY | 878 | ||
| ACUTE ISCHEMIC COLITIS | 878 | ||
| HISTOPATHOLOGY | 882 | ||
| SUMMARY | 883 | ||
| REFERENCES | 883 | ||
| The Many Faces of Medication-Related Injury in the Gastrointestinal Tract | 887 | ||
| ABSTRACT | 887 | ||
| OVERVIEW | 887 | ||
| CHEMOTHERAPEUTIC AGENTS | 888 | ||
| IMMUNOMODULATORS AND TARGETED AGENTS | 889 | ||
| ANTIBIOTICS | 890 | ||
| BISPHOSPHONATES | 892 | ||
| IRON | 893 | ||
| RESINS | 895 | ||
| SARTANS | 896 | ||
| NONSTEROIDAL ANTI-INFLAMMATORY DRUGS | 900 | ||
| IMMUNOSUPRESSIVE AGENTS | 902 | ||
| SUMMARY | 906 | ||
| REFERENCES | 906 | ||
| Mucosal Biopsy After Bone Marrow Transplantation | 909 | ||
| ABSTRACT | 909 | ||
| OVERVIEW | 909 | ||
| GRAFT-VERSUS-HOST DISEASE | 910 | ||
| CLINICAL FEATURES | 910 | ||
| PATHOGENESIS OF GRAFT-VERSUS-HOST DISEASE | 910 | ||
| MORPHOLOGIC FEATURES OF GRAFT-VERSUS-HOST DISEASE | 910 | ||
| GRADING OF GRAFT-VERSUS-HOST DISEASE | 911 | ||
| PATHOLOGIC FEATURES OF CHRONIC GRAFT-VERSUS-HOST DISEASE | 913 | ||
| REPORTING GRAFT-VERSUS-HOST DISEASE | 914 | ||
| DIFFERENTIAL DIAGNOSIS OF GASTROINTESTINAL GRAFT-VERSUS-HOST DISEASE | 915 | ||
| CHEMOTHERAPY-INDUCED INJURY | 916 | ||
| MYCOPHENOLATE MOFETIL (CELLCEPT) | 916 | ||
| PROTON PUMP INHIBITOR EFFECT | 921 | ||
| BOWEL PREPARATION | 921 | ||
| NONSTEROIDAL ANTI-INFLAMMATORY DRUGS | 921 | ||
| CORD COLITIS | 921 | ||
| INFECTION | 922 | ||
| CYTOMEGALOVIRUS | 922 | ||
| ADENOVIRUS | 923 | ||
| STRONGYLOIDES STERCORALIS | 923 | ||
| IDIOPATHIC ESOPHAGEAL ULCERS | 925 | ||
| NEUTROPENIC ENTEROCOLITIS | 925 | ||
| SUMMARY | 927 | ||
| REFERENCES | 927 | ||
| Emerging Concepts in Gastric Neoplasia | 931 | ||
| ABSTRACT | 931 | ||
| OVERVIEW | 931 | ||
| HEREDITARY DIFFUSE GASTRIC CANCER | 932 | ||
| CDH1 GERMLINE MUTATION | 932 | ||
| CTNNA1 GERMLINE MUTATION | 937 | ||
| OTHER MUTATIONS DESCRIBED IN HEREDITARY DIFFUSE GASTRIC CANCER | 937 | ||
| FAMILIAL INTESTINAL GASTRIC CANCER | 937 | ||
| GASTRIC POLYPOSIS AND GASTRIC CANCER PREDISPOSITION | 937 | ||
| BACKGROUND | 937 | ||
| FUNDIC GLAND POLYPOSIS SYNDROMES | 938 | ||
| GAPPS (Gastric Adenocarcinoma and Proximal Polyposis of the Stomach)-Related Gastric Polyposis and Cancer | 938 | ||
| Familial Adenomatous Polyposis and Gastric Fundic Gland Polyposis | 938 | ||
| MUTYH-Associated Polyposis and Gastric Fundic Gland Polyposis | 938 | ||
| GASTRIC HAMARTOMATOUS POLYPOSIS | 938 | ||
| Peutz-Jeghers Syndrome | 938 | ||
| Juvenile Polyposis | 940 | ||
| Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome (Including Cowden Syndrome) | 940 | ||
| OTHER HEREDITARY CANCER SYNDROMES IN WHICH GASTRIC CANCER RISK IS INCREASED | 940 | ||
| LYNCH SYNDROME AND GASTRIC CANCER RISK | 940 | ||
| LI-FRAUMENI SYNDROME AND GASTRIC CANCER RISK | 941 | ||
| HEREDITARY BREAST AND OVARIAN CANCER AND GASTRIC CANCER RISK | 941 | ||
| SUMMARY | 942 | ||
| REFERENCES | 943 | ||
| Problematic Colorectal Polyps | 947 | ||
| ABSTRACT | 947 | ||
| OVERVIEW | 947 | ||
| EPITHELIAL MISPLACEMENT VERSUS ADENOCARCINOMA | 948 | ||
| MANAGEMENT OF MALIGNANT COLORECTAL POLYPS | 955 | ||
| REFERENCES | 959 | ||
| Persistent Problems in Colorectal Cancer Reporting | 961 | ||
| ABSTRACT | 961 | ||
| OVERVIEW | 961 | ||
| ASSIGNING TUMOR STAGE TO LOCALLY ADVANCED CANCERS | 962 | ||
| DEFINITIONS OF TUMOR STAGE (PT) | 962 | ||
| DEFINITION OF SEROSAL PENETRATION (PT4A) | 962 | ||
| FEATURES OF SEROSAL PENETRATION AT THE TIME OF GROSS EXAMINATION | 963 | ||
| HISTOLOGIC FEATURES OF SEROSAL PENETRATION | 963 | ||
| USE OF ANCILLARY TESTS TO FACILITATE DETECTION OF SEROSAL PENETRATION | 966 | ||
| STAGING REGIONAL LYMPH NODES | 966 | ||
| DEFINITIONS OF LYMPH NODE STAGE (PN) | 966 | ||
| GROSS EXAMINATION OF REGIONAL LYMPH NODES | 966 | ||
| MICROMETASTASES AND ISOLATED TUMOR CELLS | 968 | ||
| ACELLULAR MUCIN IN LYMPH NODES FROM TREATMENT-NAÏVE PATIENTS | 969 | ||
| TUMOR DEPOSITS IN PERICOLORECTAL SOFT TISSUE | 970 | ||
| PROGNOSTIC IMPORTANCE OF RESPONSE TO NEOADJUVANT THERAPY | 974 | ||
| SUMMARY | 974 | ||
| REFERENCES | 975 | ||
| Immunohistochemical Pitfalls | 977 | ||
| ABSTRACT | 977 | ||
| OVERVIEW | 977 | ||
| MISMATCH REPAIR PROTEIN IMMUNOHISTOCHEMISTRY AND MICROSATELLITE INSTABILITY | 978 | ||
| DIAGNOSTIC ALGORITHM FOR SCREENING NEWLY DIAGNOSED COLORECTAL CANCER FOR LYNCH SYNDROME | 978 | ||
| USUAL AND UNUSUAL STAINING PATTERNS OF MISMATCH REPAIR PROTEINS | 981 | ||
| REPORTING AND INTERPRETATION PITFALLS FOR MISMATCH REPAIR PROTEIN IMMUNOHISTOCHEMISTRY | 981 | ||
| MISMATCH REPAIR-DEFICIENT COLORECTAL CANCERS | 987 | ||
| COMMONLY ENCOUNTERED MISTAKES IN INTERPRETING MISMATCH REPAIR PROTEIN EXPRESSION USING IMMUNOHISTOCHEMISTRY | 989 | ||
| SUMMARY | 1002 | ||
| REFERENCES | 1004 | ||
| Molecular Testing of Colorectal Cancer in the Modern Era | 1009 | ||
| ABSTRACT | 1009 | ||
| OVERVIEW | 1009 | ||
| ESTABLISHED BIOMARKERS | 1010 | ||
| MICROSATELLITE INSTABILITY | 1010 | ||
| MLH1 PROMOTER HYPERMETHYLATION | 1011 | ||
| RAS MUTATIONS | 1012 | ||
| BRAF V600E MUTATION | 1012 | ||
| EMERGING BIOMARKERS | 1014 | ||
| PIK3CA MUTATIONS | 1014 | ||
| HER2 GENETIC ALTERATIONS | 1014 | ||
| PRACTICAL CONSIDERATIONS | 1015 | ||
| APPROACHES TO GENOTYPING | 1015 | ||
| TYPE OF SPECIMEN | 1015 | ||
| SUMMARY | 1016 | ||
| REFERENCES | 1016 | ||
| Lymphoproliferative Diseases of the Gut | 1021 | ||
| ABSTRACT | 1021 | ||
| OVERVIEW | 1021 | ||
| GASTROINTESTINAL LYMPHOID TISSUE | 1022 | ||
| SPECIFIC GASTROINTESTINAL LYMPHOMAS | 1024 | ||
| B-CELL LYMPHOMAS | 1024 | ||
| Diffuse Large B-Cell Lymphoma | 1024 | ||
| Mucosa-Associated Lymphoid Tissue Lymphoma | 1026 | ||
| Follicular lymphoma | 1028 | ||
| Mantle Cell Lymphoma | 1029 | ||
| Burkitt Lymphoma | 1031 | ||
| T-CELL LYMPHOMAS | 1032 | ||
| Enteropathy-Associated T-Cell Lymphoma | 1032 | ||
| Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type | 1033 | ||
| GENERAL APPROACH TO GASTROINTESTINAL LYMPHOMA DIAGNOSIS | 1034 | ||
| SUMMARY | 1036 | ||
| REFERENCES | 1036 |