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ERCP E-Book

ERCP E-Book

Todd H. Baron | Richard A. Kozarek | David Leslie Carr-Locke

(2018)

Additional Information

Book Details

Abstract

Over the past 40 years, ERCP has become an effective therapeutic modality with diagnostic purposes that are continually improved.. The 3rd Edition of this practical reference helps you make the most of today’s endoscopic retrograde cholangiopancreatography in your practice. You’ll find authoritative, highly illustrated guidance on every aspect of ERCP, including coverage of the latest techniques.

  • Includes new chapters that cover duodenoscope reprocessing; endomicrocopy; EUS-guided endotherapy related to pancreatobiliary disorders; and CT and MRCP related to pancreatobiliary disorders.
  • Contains updated information on radiofrequency ablation for cancer, percutaneous vs. endoscopic drainage, scope cleaning practices, and pancreatic necrosis.

Table of Contents

Section Title Page Action Price
Front Cover cover
Inside Front Cover ifc1
ERCP i
Copyright Page iv
Dedication v
Contributors vi
Foreword xi
Acknowledgment xi
Table Of Contents xiii
Video Contents xv
I General Topics 1
1 Approaching 50 Years 1
ERCP in Its Infancy: 1968 to 1980 1
The Second Decade: 1980 to 1990 4
The Third Decade: 1990 to 2000 4
ERCP in the New Millennium 5
The Future of ERCP 6
Key Points 6
References 6.e1
2 The ERCP Room 7
Evolution of the ERCP Room 7
Staffing for the ERCP Procedure 7
Room Layout 7
Radiologic Imaging Equipment 8
Room Integration Systems 9
Endoscopist Work Area 10
Intraprocedure 10
Preprocedure and Postprocedure Work Area 10
Anesthesia/Sedation Work Area 11
Nursing and Technician Work Area 11
Ergonomics 12
Miscellaneous Issues 13
References 13.e1
3 Radiologic Issues and Radiation Safety During ERCP 14
Fluoroscopic Imaging Systems 14
Radiation Dose Management in Fluoroscopic Procedures 16
Occupational Ionizing Radiation Exposure 17
Creating and Viewing Images 18
Bile Duct Evaluation 20
Pancreatic Duct Evaluation 21
General Imaging Considerations 24
Additional Cancer Risks From Medical Radiation 26
References 29.e1
4 Endoscopes, Guidewires, and Accessories 30
Endoscopes 30
Side-Viewing Endoscopes 30
Forward-Viewing Endoscopes 30
Balloon-Assisted Enteroscopes 30
Echoendoscopes 30
Accessories 30
Standard Cannulation Catheters 31
Sphincterotomes 32
Access Sphincterotomes 32
Guidewires 33
Wire Safety 34
Exchange Assistance Devices (Short-Wire ERCP Systems) 34
Rapid Exchange Biliary System 34
Fusion System 35
V-System 35
Accessories 35
Drainage Devices 35
Plastic Stents 36
Self-Expandable Metal Stents 37
Nasobiliary and Pancreatic Drainage Catheters 37
Tissue Sampling Devices 38
Stricture and Papilla Dilation Devices 38
Stone Extraction Accessories 38
Mechanical Lithotriptors 39
Cholangiopancreatoscopy 39
Intraductal Ultrasound Probes 40
Probe-Based Confocal Laser Endomicroscopy 40
Other Accessories 40
Radiographic Contrast Media Used in ERCP 40
The Use of Carbon Dioxide in ERCP 40
Accessories for Use in Patients With Altered Anatomy 41
Single-Use Versus Reusable Accessories 41
Storage of Accessories 42
Role of the U.S. Food and Drug Administration in Device Evaluation and Monitoring 42
Radiation Exposure 43
References 43.e1
5 Duodenoscope Reprocessing 44
Background 44
History of MDRO in Endoscopy 44
High-Level Disinfection and Reprocessing 45
Reaction From Regulatory Bodies 46
Strategies for Risk Reduction 46
Potential Solutions 47
Conclusions 47
References 48.e1
6 Sedation in ERCP 49
Defining the Continuum of Sedation 49
Defining Sedation-Related Complications (Adverse Events) 50
Risk Assessment 51
Anesthesiologist-Administered Sedation 51
Nonanesthesiologist (Endoscopist)–Administered Sedation 52
Monitoring 52
Room Setup and Considerations for Safety 53
Conclusions 53
References 53.e1
7 Indications for and Contraindications to ERCP 54
Indications for and Contraindications to ERCP 54
Indications for ERCP 55
Special Cases 57
Contraindications to ERCP 57
References 58.e1
8 Adverse Events of ERCP 59
Definitions of Complications, Adverse Events, Unplanned Events, and Other Negative Outcomes 59
Analyses of Adverse Event Rates 59
Overall Adverse Events of ERCP and Sphincterotomy 59
Pancreatitis 60
Patient-Related Risk Factors for Post-ERCP Pancreatitis 61
Technique-Related Risk Factors for Post-ERCP Pancreatitis 61
Specific Techniques to Reduce Risk of Post-ERCP Pancreatitis 62
Pharmacologic Agents 63
Prevention and Treatment of Post-ERCP Pancreatitis 64
Hemorrhage 64
Risk Factors for Hemorrhage After Sphincterotomy 64
Methods to Prevent and Treat Hemorrhage 65
Perforation 65
Cholangitis and Cholecystitis 66
Duodenoscope-Associated Bacterial Infections 66
Long-Term Adverse Events and Sequelae 66
Operator Experience and Adverse Events 66
References 67.e1
9 ERCP Training 68
Training in ERCP 68
Current Status of ERCP Training 68
Learning Curves and Competence in ERCP 69
Toward Competency-Based Medical Education 70
ERCP Training Using Simulation 71
Maintenance of ERCP Skills and Volume for ERCP 72
Quality Measures for Trainees 72
Future Directions 72
Conclusions 73
References 73.e1
Appendix 9.1 The EUS and ERCP Skills Assessment Tool (TEESAT) 74
10 Preparation of the Patient for ERCP 80
Should This Patient Undergo ERCP? 80
When, Where, and With Whom? 80
Evaluation of the Patient Before ERCP 80
History and Physical 80
Laboratory Testing 81
Review of Imaging Studies 81
Preparing the Patient: Day(s) Before ERCP 81
Management of Antithrombotic Agents 81
Antiplatelet Agents 81
Aspirin. 81
Thienopyridines and dual-antiplatelet therapy. 81
Anticoagulants 82
Duration of Fasting 82
Method of Sedation, Proper Personnel, and Patient Monitoring 82
Selecting Sedation for ERCP 82
Proper Personnel 83
Proper Monitoring and Intervention Equipment 83
Preparing the Endoscopy Team 83
Preparing the Patient: the Day of the ERCP 83
Informed Consent 83
Periprocedural Antibiotics 83
Positioning the Patient and Preparing for Radiography 84
Reviewing Intravenous Access and Allergies 84
References 85.e1
11 Principles of Electrosurgery 86
Electrosurgery 86
A Brief History of Electrosurgery and ERCP 86
Basics of Electricity as Applied to Electrosurgery 86
Basics of Electricity 86
The Electrosurgical Unit 87
Monopolar Versus Bipolar Circuits 87
Maximizing Safety 87
Pacemakers 88
Neuromuscular Stimulation 88
Current Leaks 88
Clinical Applications of Electrosurgery in ERCP 88
Types of Current 88
Sphincterotomy 88
Needle-Knife Access Papillotomy and Fistulotomy 89
Electrohydraulic Lithotripsy (see Chapters 19, 46, and 55) 89
Papillectomy 90
Pseudocyst Drainage and Necrosectomy 90
EUS Gallbladder Drainage 91
Radiofrequency Ablation in the Bile Duct 92
References 92.e1
12 Quality Issues and Measures in ERCP 93
Preprocedure Quality Indicators 93
Appropriate Indication 93
Informed Consent 94
Assessment of the Difficulty of the Procedure 95
Prophylactic Antibiotics 95
Endoscopist Experience 95
Intraprocedure Quality Indicators 95
Cannulation Rates 95
Removal of Common Bile Duct Stones 96
Stent Placement for Biliary Obstruction Below the Bifurcation 96
Postprocedure Quality Indicators 96
Comprehensive Documentation 96
Adverse Event Rates 96
Fluoroscopy Duration and Radiation Dose 97
Initiating Quality Measurements 97
Conclusions 98
References 98.e1
13 Medicolegal Issues in ERCP 99
How Often Are Gastroenterologists Sued? 99
How Common Are Lawsuits Involving ERCP? 99
What Are the Key Legal Principles? 99
Duty 100
Breach of Duty 100
Causation 100
Injury 100
Standards of Care and Guidelines 100
Guidelines 100
Who May Be Liable? Not Only the ERCPist 100
Employer Liability 100
Preceptor 100
Proctor 101
Administrator 101
Hospital Liability 101
Summary of Vicarious Liability 101
Informed Consent 101
Material Risks 101
Controversial Areas 102
Exceptions to Informed Consent 102
Informed Refusal 102
Legal Consequences of Failing to Obtain Informed Consent 102
Why Do ERCP Lawsuits Occur? 102
Marginal Indications 102
Poor Communication 102
Poor Endoscopic Technique 102
Sedation/Anesthesia Problems 103
Poor Aftercare 103
Nosocomial Infection 103
Delay in Performing ERCP 103
How to Minimize the Risk of Litigation 103
Levels of Complexity in Training and Practice 103
Certification? 104
Recognizing Higher-Risk Situations 104
Higher-Risk Patients 104
Higher-Risk Procedures 104
The Context of the Procedure 104
Risk-Benefit 104
Professional Behavior 104
Doing Informed Consent Right 105
Documenting the Consent Process: “He Said, She Said” 105
Special Care Needed With “Open Access” and Urgent ERCP 105
Live Teaching Demonstrations 105
Managing Adverse Events 105
When You Are Sued 107
Expert Testimony 107
A Summary of Recommendations 107
Conclusions 107
Acknowledgments 107
References 107.e1
II Techniques 108
14 Cannulation of the Major Papilla 108
Establishing the Duodenal Position 108
Devices and Equipment for Cannulation (See Also Chapter 4) 109
Cannulation Technique 109
Guidewire or Contrast? 109
Papilla Assessment and Basic Technique 111
Small Papilla 113
Periampullary Diverticulum 113
Difficult Cannulation 117
Repeated Cannulation of the Pancreatic Duct Without Biliary Access 117
Needle-Knife Sphincterotomy (See Also Chapter 15) 118
NKS Technique 119
Cannulation of the Pancreatic Duct 121
Quality and Enhancing Outcomes (See Also Chapter 12) 122
References 122.e1
15 Access (Precut) Papillotomy 123
Indication for Precut Papillotomy 123
Precut Accessories 123
Techniques 124
Needle Knife From the Orifice 124
Needle Knife Above the Papillary Orifice (Fistulotomy) 125
Needle Knife With an Insulated Tip 126
Short-Nose Precut Sphincterotomy 127
Transpancreatic Sphincterotomy 127
Unconventional Techniques 127
Use of Pancreatic Stents 128
Adverse Events (see Chapter 8) 129
Pancreatitis 129
Bleeding 130
Perforation 130
Failed Access and Cost 130
Summary 131
References 130.e1
16 Sphincter of Oddi Manometry 132
Method of SOM 132
Sedation 132
Equipment 133
Technical Performance of SOM (Video 16.1) 134
Interpretation Criteria 135
Reproducibility of SOM 136
Adverse Events of SOM 136
Summary 136
References 136.e1
17 Biliary Sphincterotomy 137
Description of the Technique 137
Instruments 137
Procedure 138
EST in Patients With Difficult Anatomy 142
Alternatives to EST 143
Indications 144
Contraindications 145
Adverse Events and Their Management (see Chapter 8) 145
EST-Related Post-ERCP Pancreatitis 145
EST-Related Hemorrhage 146
EST-Related Perforation 146
EST-Related Cholangitis 146
Long-Term Consequences of EST 147
References 147.e1
18 Balloon Dilation of the Native and Postsphincterotomy Papilla 148
EPLBD After EST for Removal of Large Stones 148
Technique of Large-Balloon Dilation of Postsphincterotomy Papilla 148
Adverse Events of EPLBD After EST 149
EPLBD Without Preceding Sphincterotomy (EST) 152
Technique of EPLBD Without Sphincterotomy 152
Adverse Events of EPLBD Without EST 154
Recommendations for Safe and Successful EPLBD 154
EPBD of the Native Papilla 155
Indications for EPBD 155
Adverse Events of EPBD 155
Special Situations 156
Summary 159
References 159.e1
19 Stone Extraction 160
Introduction and Scientific Basis 160
Biliary Stone Disease and Contraindications to ERCP (see Chapter 7) 161
Biliary Stone Disease: Indications and Considerations 161
Contraindications 161
DescriptionS of Techniques 161
Removal of an Impacted Ampullary Stone 161
Balloon Stone Extraction 161
Basket Stone Extraction 162
Mechanical Lithotripsy 164
Intraductal Electrohydraulic Lithotripsy 168
Endoscopic Papillary Balloon Dilation 168
Adverse Events and Their Management (see Chapter 8) 169
Adverse Events of Extraction Balloons 169
Adverse Events of Extraction Baskets 169
Adverse Events of Mechanical Lithotripsy 169
Adverse Events of Intraductal Lithotripsy 170
Relative Cost 170
Conclusions 170
References 170.e1
20 Pancreatic Sphincterotomy 171
Endoscopic Pancreatic Sphincterotomy 171
Preparation 171
Equipment 171
The Endoscopic Technique 172
Pull-Type Sphincterotomy 173
Needle-Knife Sphincterotomy 174
Precut Pancreatic Sphincterotomy 175
Indications for Pancreatic Sphincterotomy 175
Pancreatic Sphincterotomy as Primary Therapy 176
Pancreas Divisum, Sphincter of Oddi Dysfunction, and Recurrent Acute Pancreatitis 176
Chronic Pancreatitis 178
Pancreatic Sphincterotomy as Secondary Therapy 179
Adverse Events of Pancreatic Sphincterotomy 180
The Cost of Pancreatic Sphincterotomy 181
References 181.e1
21 Minor Papilla Cannulation and Sphincterotomy 182
Indications for Minor Papilla Cannulation and Sphincterotomy 182
Sedation, Supplemental Drugs, and ERCP Accessories 182
Sedation 182
Antispasmodic Drugs 182
Supplemental Agents 183
ERCP Accessories 183
Recognition of the Minor Papilla 183
Supplemental Techniques to Identify the Minor Papilla in Difficult Cases 184
Dyeing Solutions 184
Secretin 184
Minor Papilla Cannulation (Video 21.1) 185
Cannulating the Minor Papilla in Difficult Cases 186
Minor Papilla Sphincterotomy 187
Techniques for Minor Papilla Sphincterotomy 187
Sphincterotomy With Pull-Type Sphincterotome 188
Sphincterotomy With Needle Knife Over Pancreatic Stent 189
Sphincterotomy With Wire-Assisted Needle Knife 189
Pull-Type or Needle-Knife Sphincterotome: Pros and Cons 189
Precut Sphincterotomy in Case of Failed Dorsal Duct Cannulation 190
Postprocedural Stenting of the Minor Papilla 191
Repeat Minor Papilla Sphincterotomy 192
Outcomes of Minor Papilla Sphincterotomy 192
Adverse Events (See Chapter 8) 192
References 195.e1
22 Plastic Pancreaticobiliary Stents and Nasopancreaticobiliary Tubes 196
Stent Systems 196
Endoscope Requirements 196
Description of Technique: Biliary 196
Distal Biliary Obstruction 196
Stents for Irretrievable Bile Duct Stones 198
Hilar Biliary Obstruction 200
Nasobiliary Tubes 200
Pancreatic Duct Stent Insertion 201
Nasopancreatic Tubes 202
Drainage of Pancreatic Fluid Collections 202
Indications and Contraindications 202
Biliary Indications 202
Pancreatic Indications 203
Adverse Events 203
Relative Cost 205
References 205.e1
23 Biliary Metal Stent Insertion 206
Indications 206
SEMS for Malignant Biliary Stricture 206
SEMS Versus PS 206
Covered Versus Uncovered SEMS for Malignant Biliary Obstruction 206
Preoperative Use of SEMS in Malignant Biliary Disease 207
SEMS for Benign Biliary Disease 207
Description of Technique 208
Currently Available SEMS 208
Techniques for SEMS Placement 211
Guidewire 211
Stent Size, Positioning, and Sphincterotomy 211
Endoscopic and Fluoroscopic Deployment of SEMS 211
Hilar Strictures 212
Duodenal Obstruction 212
Adverse Events and Their Management 215
Relative Cost 215
References 215.e1
24 Pancreaticobiliary Stent Retrieval 216
Removal of Biliary Stents 216
Plastic Biliary Stents (see Chapter 22) 216
Self-Expandable Metal Stents 216
Indications and Contraindications 217
Timing of Stent Retrieval 218
Techniques 218
Direct Grasping Technique 218
Indirect Grasping Technique 218
Lasso Technique 219
Soehendra Stent Retriever Technique 219
Dilating Balloon Extraction Technique 219
Stent-in-Stent Technique 220
Trimming of SEMS 221
Other Novel Techniques 221
Adverse Events and Management 222
Relative Costs and Choice of Technique 222
Removal of Pancreatic Stents 223
Indications and Contraindications 223
Timing of Stent Retrieval 224
Techniques 224
Adverse Events and Management 226
Relative Costs and Choice of Technique 226
Removal of Lumen-Apposing Metal Stents 226
Indications, Contraindications, and Timing of Stent Retrieval 227
Techniques 228
Summary 229
References 229.e1
25 Papillectomy and Ampullectomy 230
Treatment Options 230
Considerations in FAP 230
Technique (Box 25.1) 231
Initial Endoscopic Assessment 231
Conventional Endoscopy 231
Endoscopic Ultrasonography and Intraductal Endoscopic Ultrasonography 232
Endoscopic Retrograde Cholangiopancreatography 233
Endoscopic Papillectomy 233
Snare Excision 233
Electrosurgical Currents: Cutting Versus Coagulation 234
En Bloc Versus Piecemeal Resection 234
Role of Submucosal Injection 234
Infrequently Performed Novel Techniques 235
Specimen Retrieval and Preparation 235
Preresection Sphincterotomy 235
Postpapillectomy Sphincterotomy 235
Postpapillectomy Stents: Pancreatic and Biliary 235
Adjunctive Therapy and Thermal Ablation 236
Postpapillectomy Surveillance 237
Indications and Contraindications (Box 25.2) 237
Adverse Events and Their Management (Boxes 25.3 and 25.4) 238
Success 239
Relative Cost Savings 239
Subepithelial Lesions 240
Summary 241
References 241.e1
26 Pancreatoscopy 242
Equipment and Technique 242
Video Pancreatoscope 242
Two-Operator “Mother–Baby” Method 242
Single-Operator Cholangiopancreatoscopy 243
Other Techniques 244
Diagnostic Indications 244
Intraductal Papillary Mucinous Neoplasm 244
Indeterminate Pancreatic Duct Strictures (Benign or Malignant) 246
Sampling 247
Therapeutic Indications 247
Intraductal Lithotripsy in Patients With Chronic Pancreatitis 247
Adverse Events and Management 247
Relative Cost 247
Conclusions 248
References 248
27 Cholangioscopy 249
Single-Operator Cholangioscopy 249
Introduction 249
Equipment 249
Technique 249
Clinical Use and Efficacy 249
Intraductal Lithotripsy 249
Clearance of Difficult Biliary Stone Clearance Using FSOC 250
Pancreatic Stone Therapy Using FSOC 251
FSOC Evaluation of Indeterminate Biliary Strictures 252
Reimbursement and Limitations 254
Adverse Events 254
Summary 254
Videocholangioscopy Using the Mother–Baby System 254
Description of the Technique 254
Technique: Diagnostic and Therapeutic 255
Adverse Events and Limitations 255
Videocholangioscopy by the Direct Insertion System 256
Description of the Technique 256
Technique: Diagnostic and Therapeutic 257
Adverse Events and Limitations 258
Acknowledgment 258
References 258.e1
28 Endomicroscopy in the Pancreaticobiliary Tree 259
Confocal Laser Endomicroscopy 259
Technique 259
Diagnostic and Safety Data 259
Optical Coherence Tomography 262
Conclusion 262
References 262.e1
29 ERCP in Children 263
Description of Technique 263
Patient and Family Preparation 263
Procedure Environment 263
Endoscopist 263
Sedation 264
Fluoroscopy (see Chapter 3) 264
Supplemental Medications 264
Endoscopic Equipment 264
Technique 265
Indications and Contraindications (Box 29.1) 265
Diagnostic and Therapeutic Indications 265
Biliary Indications 266
Neonatal Cholestasis 266
Cholelithiasis and Choledocholithiasis 266
Choledochal Anomalies (see also Chapter 35) 266
Biliary Strictures and Leaks 268
Unusual Biliary Infections 274
Sphincter of Oddi Dysmotility (see Chapters 16 and 47) 274
Pancreatic Indications 275
Acute Pancreatitis 275
Chronic Pancreatitis (see Chapter 55) 278
Pancreatic Fluid Collections 278
Adverse Events 278
Relative Costs 281
References 281.e1
30 ERCP in Pregnancy 282
Indication 282
Diagnostic Imaging Modalities 282
Timing 283
Radiation Exposure During ERCP (see Chapter 3) 283
Strategies to Minimize Radiation Risk to the Fetus 284
Positioning, Sedation, and Medications 284
Techniques 285
Outcomes After ERCP During Pregnancy 286
Conclusions 287
References 287.e1
31 ERCP in Surgically Altered Anatomy 288
Surgery That May Affect the Performance or Interpretation of ERCP 288
Esophageal Resection 288
Gastric Resection 288
Billroth I 288
Billroth II 288
Roux-en-Y Gastrectomy 293
Total Gastrectomy 294
Upper GI Bypass Surgery Without Resection 294
Loop Gastrojejunostomy 294
Duodenal Bypass 296
Bariatric Surgery 296
Malabsorptive Jejunoileal Bypass 296
Biliopancreatic Diversion and Duodenal Switch 296
Restrictive Surgery 296
Roux-en-Y Gastric Bypass 298
Pancreatic Resection 299
Conventional Whipple Procedure 299
Pylorus-Preserving Whipple Procedure 301
Pancreaticogastrostomy 301
Other Pancreatic Resective Surgery (see also Chapter 45) 301
Pancreatic Duct Drainage Procedures 301
Puestow Procedure 301
Frey Procedure 302
Duval Procedure 302
Biliary Surgery 302
Choledochoduodenostomy 302
Roux-en-Y Hepaticojejunostomy 302
Cholecystojejunostomy 302
Liver Transplantation (see Chapter 44) 304
Hepaticocutaneous Jejunostomy 304
Endoscopic Techniques Commonly Employed for ERCP in Surgically Altered Anatomy 304
External Rendezvous Procedure 304
Selection of an Anastomotic Limb to Enter 305
Navigation Through the Small Intestine 306
ERCP Accessories 306
Conclusions 306
References 307.e1
32 Endoscopic Ultrasonography–Guided Biliary Drainage 308
Description of Technique 308
Steps and Devices Common to Different EUS-BD Procedures 309
Target Identification Under EUS 309
Needle Access Into the Target Organ 309
Contrast Injection and Guidewire Insertion 310
Puncture Tract Dilation 310
Transmural Stent Placement 313
Specific Considerations for EUS-BD (Therapeutic ESCP) 313
Choice of Approach 313
Transpapillary Drainage 314
Transmural Drainage 317
EUS-guided choledochoduodenostomy. 317
EUS-guided hepaticogastrostomy. 317
Indications and Contraindications 317
Procedural Outcomes and Adverse Events 319
References 320.e1
33 Endoscopic Ultrasound and EUS-Guided Endotherapy 321
Overview 321
Endoscopic Ultrasonography 321
Celiac Nerve Block and Neurolysis 321
Technique 321
Efficacy 322
Adverse Events 322
Drainage of Pancreatic Fluid Collections 322
Technique 323
Efficacy 323
Adverse Events 324
Pancreatic Duct Access and Drainage 324
Technique 324
Biliary Drainage 324
Technique 325
Adverse Events 326
Gallbladder Drainage 326
Technique 326
Efficacy 327
Adverse Events 327
EUS-Guided Ablation and Cancer Therapy 327
Conclusions 327
References 327.e1
III Approach to Clinical Problems 328
34 Pancreaticobiliary Disorders 328
Role of Noninvasive Imaging and EUS Compared With ERCP in Benign Hepatobiliary Diseases 328
Stone Disease 328
Chronic Pancreatitis 330
Role in Diagnosis 330
Pain Management 330
Symptomatic Pancreatic and Peripancreatic Fluid Collections 331
Suspected Pancreaticobiliary Malignancy 332
Conclusions 333
References 334.e1
35 Pancreas Divisum, Biliary Cysts, and Other Congenital Anomalies 335
Ampullary Anomalies 335
Ectopic Major Papilla 335
Anomalous Pancreaticobiliary Junction 335
Biliary Anomalies 335
Variations of Bile Duct Anatomy 335
Biliary Cysts 336
Pancreatic Anomalies 341
Pancreas Divisum 341
Embryology and Terminology 341
Diagnosis 341
Association with Pancreatitis (see also Chapter 52) 341
Incomplete Pancreas Divisum 344
Annular Pancreas 344
References 345.e1
36 Dilated Bile Duct and Pneumobilia 346
Dilated Bile Duct 346
Defining Dilated Bile Ducts 346
Etiology 346
Clinical Evaluation 346
Biochemical Evaluation 347
Imaging 348
Transabdominal Ultrasonography 348
Computed Tomography 348
Magnetic Resonance Imaging 348
Endoscopic Ultrasonography 349
Cholangiography 350
Biliary Scintigraphy 350
Approach to the Dilated Duct 350
Pneumobilia 351
Defining and Imaging Pneumobilia 351
Etiology 352
Clinical Evaluation 352
Approach to the Patient With Pneumobilia 353
References 353.e1
37 The Dilated Pancreatic Duct 354
Background and Definitions 354
Evaluation 354
Clinical 354
Laboratory Evaluation 355
Serum Amylase and Lipase 355
Fecal Fat 355
Fecal Elastase-1 and Chymotrypsin 355
Serum CA 19-9 355
Fluid Carcinoembryonic Antigen 355
Imaging and Endoscopy 355
Treatment 357
Endoscopic Therapy 357
Surgical Therapy 359
Conclusions 360
References 360.e1
38 Ampullary Neoplasia 361
Symptoms and Signs 361
Diagnostic Workup and Evaluation 361
Endoscopy 361
Endoscopic Retrograde Cholangiopancreatography 362
Forceps Biopsy 363
Transabdominal Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging 363
Endoscopic Ultrasonography 363
Intraductal Ultrasonography 364
Colonoscopy 364
Pathology 364
Adenoma 364
Carcinoma 365
Neuroendocrine Tumors 365
Lymphoma 367
Gastrointestinal Stromal Tumor 367
Ampullary Adenomas and FAP Syndrome 367
Pathogenesis of Ampullary Adenoma and FAP Syndrome 367
Treatment 368
Adenomas 368
Carcinomas 371
Conclusions 371
References 371.e1
39 Malignant Biliary Obstruction 372
Epidemiology 372
Natural History 373
Clinical Features and Initial Evaluation 373
Differential Diagnosis of Distal Biliary Malignancies and Imaging Techniques 374
Ampullary Carcinoma 374
Pancreatic Cancer 374
Cholangiocarcinoma 376
Metastatic Disease 376
An Approach to the Management of Patients With Distal Biliary Malignancies 376
Curative Surgery 377
Palliation 377
Endoscopic Stenting 377
Background. 377
Indications for biliary stenting. 378
Plastic stents. 378
Self-expandable metal stents. 379
Stent choices for palliation of malignant biliary obstruction. 381
Percutaneous Approach to Biliary Drainage 382
Surgical Palliation 383
Adjuvant Chemotherapy 383
Summary 384
References 384.e1
40 Malignant Biliary Obstruction of the Hilum and Proximal Bile Ducts 385
Cholangiocarcinoma 385
Risk Factors 385
Anatomy of the Bile Ducts 385
Bismuth-Corlette Classification 385
Diagnostic Evaluation 386
Serologic Testing 386
Cytology 387
Pathology 387
Radiologic Evaluation 388
Endoscopic Evaluation 388
Endoscopic Ultrasonography With Fine-Needle Aspiration 388
Intraductal Ultrasonography 388
Cholangioscopy 388
Confocal Laser Endomicroscopy (see also Chapter 28) 388
Narrow Band Imaging and Chromoendoscopy 389
Management 389
Surgical Resection 389
Preoperative Biliary Drainage 389
Surgical Drainage 390
Biliary Drainage in Patients With Hilar or Proximal Biliary Obstruction 390
General Principles for ERCP in Hilar and Proximal Cholangiocarcinoma 390
Percutaneous versus Endoscopic Biliary Drainage 390
EUS-Guided Biliary Drainage 391
SEMS versus Plastic Stents 391
Local Ablative Techniques 391
Photodynamic Therapy 392
Radiofrequency Ablation 392
Conclusions 392
Acknowledgments 393
References 393.e1
41 Indeterminate Biliary Stricture 394
Historical Features 394
Laboratory Features 394
Noninvasive Cross-Sectional Imaging 395
Invasive Imaging Techniques 395
Tissue Acquisition and Pathologic Investigations 400
Brush Cytology 400
Intraductal Transmucosal Fine-Needle Aspiration 401
Intraductal Forceps Biopsies 401
Ancillary Techniques 402
References 404.e1
42 Endoscopic Approaches to Concomitant Malignant Biliary Obstruction and Gastric Outlet Obstruction 405
Anatomic and Clinical Scenarios 405
Anatomic Scenarios of Biliary and Duodenal Obstruction 405
Clinical Scenarios 408
Results 409
EUS-Guided Gastroenterostomy 409
Technical Approaches 409
Direct EUS-GE 409
Direct Technique With a Non–Cautery-Tip-Assisted LAMS. 409
Direct Technique With an Electrocautery Tip–Assisted LAMS. 410
Balloon-Assisted EUS-GE 411
EUS-Guided Double-Balloon–Occluded Gastrojejunostomy Bypass 411
Indications and Contraindications to EUS-GE 412
Clinical Data on EUS-GE 412
EUS-BD Technical Approaches 412
Rendezvous 412
Direct Transluminal Approach 413
Choledochoduodenostomy. 413
Hepatogastrostomy. 413
Antegrade Stenting 414
Indications for and Contraindications to EUS-BD in Malignant Obstruction 414
Selecting the Optimal Technical Approach to EUS-BD in Malignant Biliary Obstruction With Gastric Outlet Obstruction 414
Clinical Outcome With EUS-Biliary Drainage in Malignant Biliary Obstruction 414
Adverse Events and Their Management 415
EUS-GE 415
EUS-BD 415
Conclusions 416
References 416.e1
43 Benign Biliary Strictures 417
Clinical Features and Diagnosis 417
Endoscopic Technique 417
Outcomes of Endotherapy 418
Postcholecystectomy Strictures 418
Anastomotic Strictures After Liver Transplantation (See Also Chapter 44) 420
Chronic Pancreatitis (See Also Chapter 45) 420
Primary Sclerosing Cholangitis (See Also Chapter 55) 421
Autoimmune Cholangiopathy 421
Conclusions 421
References 421.e1
44 Biliary Surgery Adverse Events, Including Liver Transplantation 422
Laparoscopic Cholecystectomy 422
Bile Leak 425
Biloma 426
Liver Resection 426
Bile Leak 426
Strictures 427
Sump Syndrome After Choledochoduodenostomy 427
Liver Transplantation 427
Strictures 429
Bile Leak 430
Living-Related-Donor Transplants 430
Retained Surgical Stents 430
Summary 431
References 431.e1
45 ERCP and EUS for Acute and Chronic Adverse Events of Pancreatic Surgery and Pancreatic Trauma 432
Pancreaticoduodenectomy (Whipple Operation) With and Without Pylorus Preservation 432
Anatomy 432
Role of Endoscopy in the Management of Adverse Events 432
Biliary Obstruction 434
Bilioenteric Anastomotic Stricture 434
Afferent Limb Obstruction 434
Efferent Limb Obstruction 434
Miscellaneous 434
Other Treatment Options for Biliary and Pancreatic Ductal Obstruction 434
Interventional Radiology and ERCP 434
EUS-Guided Techniques for Biliary Obstruction 435
EUS-Guided Techniques for Pancreatic Duct Obstruction 435
EUS-Guided Rendezvous 435
EUS-guided antegrade drainage. 436
Pancreatic antegrade needle knife. 436
Retained stents. 436
Distal and Central Pancreatectomy 436
Anatomy 436
Adverse Events 437
Role of Endoscopy in Patients With Distal Pancreatectomy 437
Puestow or Longitudinal Pancreatojejunostomy 437
Anatomy 437
Index 539
A 539
B 540
C 541
D 542
E 543
F 544
G 545
H 545
I 545
J 546
K 546
L 546
M 546
N 547
O 547
P 547
Q 550
R 550
S 550
T 552
U 552
V 552
W 552
Z 552
Inside Back Cover ibc1