Additional Information
Book Details
Abstract
An essential foundation text for residents and pathologists, the third edition of Head and Neck Pathology, a volume in the Foundations in Diagnostic Pathology series, has been fully revised to include recent advances in the field. Featuring a highly templated, easy-to-use format and new information throughout, this practical, affordable resource by Drs. Lester D. R. Thompson and Justin A. Bishop is ideal for study and review as well as everyday clinical practice.
- Inclusion of a wide range of diagnoses in both head and neck and endocrine organ pathology.
- A focus on the specific features of selected non-neoplastic and neoplastic entities, including broad and in-depth differential diagnoses.
- Clinical and Pathologic Features summarized in quick-reference boxes for fast access to information.
- A highly templated format that includes pertinent clinical, imaging, and management/prognostic features; pathologic features; ancillary studies; differential diagnosis; and meaningfully chosen bibliography.
- Over a thousand full-color photographs illustrate important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases.
- Contributions from internationally recognized expert pathologists, keeping you up to date with the latest information in the field.
- New criteria as established by the 2017 World Health Organization Classification of Head and Neck Tumours and the 2017 World Health Organization Classification of Endocrine Organ Tumours.
- A new oropharynx section, separated from the oral cavity.
- Inclusion of unique newly identified molecular information in many tumor entities.
- Coverage of NUT carcinoma, HPV-associated adenoid cystic-like carcinoma, sinonasal renal cell-like adenocarcinoma, SMARCB1 (INI-1) deficient sinonasal carcinoma, biphenotypic sinonasal sarcoma, neuroendocrine carcinomas, oropharyngeal carcinoma, polycystic disease and sclerosing polycystic adenosis, secretory carcinoma, cribriform adenocarcinoma of the minor salivary glands, variants of myoepithelioma, clear cell carcinoma, and changes in gnathic cysts classification.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | cover | ||
| Inside Front Cover | ifc1 | ||
| Half title page | i | ||
| Other books in this series | ii | ||
| Head and Neck Pathology | iii | ||
| Copyright Page | iv | ||
| ■ Contributors | v | ||
| ■ Foreword | vii | ||
| ■ Preface | ix | ||
| ■ Acknowledgments | xi | ||
| Table Of Contents | xiii | ||
| Second Half title page | xv | ||
| 1 Non-Neoplastic Lesions of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx | 1 | ||
| ■ Rhinosinusitis | 1 | ||
| Clinical Features | 1 | ||
| Pathologic Features | 1 | ||
| Gross Findings | 1 | ||
| Microscopic Findings | 2 | ||
| Differential Diagnosis | 2 | ||
| Prognosis and Therapy | 2 | ||
| ■ Sinonasal Inflammatory Polyps | 2 | ||
| Clinical Features | 2 | ||
| Pathologic Features | 3 | ||
| Gross Findings | 3 | ||
| Microscopic Findings | 4 | ||
| Differential Diagnosis | 5 | ||
| Prognosis and Therapy | 6 | ||
| ■ Paranasal Sinus Mucocele | 6 | ||
| Clinical Features | 6 | ||
| Pathologic Features | 7 | ||
| Gross Findings | 7 | ||
| Microscopic Findings | 7 | ||
| Differential Diagnosis | 7 | ||
| Prognosis and Therapy | 7 | ||
| ■ Allergic Fungal Sinusitis | 8 | ||
| Clinical Features | 8 | ||
| Pathologic Features | 8 | ||
| Gross Findings | 8 | ||
| Microscopic Findings | 8 | ||
| Ancillary Studies | 9 | ||
| Differential Diagnosis | 9 | ||
| Prognosis and Therapy | 10 | ||
| ■ Nasal Glial Heterotopia | 10 | ||
| Clinical Features | 10 | ||
| Pathologic Features | 10 | ||
| Gross Findings | 10 | ||
| Microscopic Findings | 11 | ||
| Ancillary Studies | 11 | ||
| Differential Diagnosis | 12 | ||
| Prognosis and Therapy | 12 | ||
| ■ Rhinoscleroma | 12 | ||
| Clinical Features | 12 | ||
| Pathologic Features | 12 | ||
| Gross Findings | 12 | ||
| Microscopic Findings | 13 | ||
| Ancillary Studies | 13 | ||
| Differential Diagnosis | 13 | ||
| Prognosis and Therapy | 14 | ||
| ■ Rhinosporidiosis | 15 | ||
| Clinical Features | 15 | ||
| Pathologic Features | 15 | ||
| Gross Findings | 15 | ||
| Microscopic Findings | 15 | ||
| 2 Benign Neoplasms of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx | 22 | ||
| ■ Sinonasal Papillomas | 22 | ||
| Clinical Features | 22 | ||
| Radiographic Features | 22 | ||
| Pathologic Features | 22 | ||
| Gross Findings | 22 | ||
| Microscopic Findings | 23 | ||
| Exophytic Papilloma | 23 | ||
| Inverted Papilloma | 23 | ||
| Oncocytic Cell Papilloma | 26 | ||
| Ancillary Studies | 28 | ||
| Immunohistochemical Findings | 28 | ||
| Molecular Findings | 28 | ||
| Differential Diagnosis | 29 | ||
| Prognosis and Therapy | 29 | ||
| ■ Lobular Capillary Hemangioma | 29 | ||
| Clinical Features | 29 | ||
| Pathologic Features | 30 | ||
| Gross Findings | 30 | ||
| Microscopic Findings | 30 | ||
| Ancillary Studies | 33 | ||
| Differential Diagnosis | 33 | ||
| Prognosis and Therapy | 33 | ||
| ■ Meningioma | 33 | ||
| Clinical Features | 33 | ||
| Radiographic Features | 33 | ||
| Pathologic Features | 34 | ||
| Gross Findings | 34 | ||
| Microscopic Findings | 34 | ||
| Ancillary Studies | 35 | ||
| Immunohistochemical Findings | 35 | ||
| Differential Diagnosis | 35 | ||
| Prognosis and Therapy | 35 | ||
| ■ Glomangiopericytoma (Sinonasal- Type Hemangiopericytoma) | 35 | ||
| Clinical Features | 36 | ||
| Radiographic Features | 36 | ||
| Pathologic Features | 36 | ||
| Gross Findings | 36 | ||
| Microscopic Findings | 36 | ||
| Ancillary Studies | 38 | ||
| Immunohistochemical Findings | 38 | ||
| Genetic Findings | 38 | ||
| Differential Diagnosis | 38 | ||
| Prognosis and Therapy | 40 | ||
| ■ Nasopharyngeal Angiofibroma | 40 | ||
| Clinical Features | 40 | ||
| Radiographic Features | 42 | ||
| Pathologic Features | 42 | ||
| Gross Findings | 42 | ||
| Microscopic Findings | 43 | ||
| Ancillary Studies | 45 | ||
| Immunohistochemical Findings | 45 | ||
| Differential Diagnosis | 45 | ||
| Prognosis and Therapy | 45 | ||
| ■ Ectopic Pituitary Adenoma | 46 | ||
| Clinical Features | 46 | ||
| Radiographic Features | 46 | ||
| Pathologic Features | 47 | ||
| Microscopic Findings | 47 | ||
| Ancillary Studies | 47 | ||
| Ultrastructural Findings | 47 | ||
| Immunohistochemical Findings | 47 | ||
| Differential Diagnosis | 50 | ||
| Prognosis and Therapy | 50 | ||
| Suggested Readings | 50 | ||
| Suggested Readings | 50.e1 | ||
| Sinonasal Papillomas | 50.e1 | ||
| Lobular Capillary Hemangioma (Pyogenic Granuloma) | 50.e1 | ||
| Meningioma | 50.e1 | ||
| Glomangiopericytoma (Hemangiopericytoma) | 50.e1 | ||
| Nasopharyngeal Angiofibroma | 50.e2 | ||
| Pituitary Adenoma | 50.e2 | ||
| 3 Malignant Neoplasms of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx | 51 | ||
| ■ Squamous Cell Carcinoma | 51 | ||
| Clinical Features | 51 | ||
| Radiographic Features | 52 | ||
| Pathologic Features | 52 | ||
| Gross Findings | 52 | ||
| Microscopic Findings | 53 | ||
| Ancillary Studies | 54 | ||
| Differential Diagnosis | 55 | ||
| Prognosis and Therapy | 56 | ||
| ■ Sinonasal Adenocarcinoma | 57 | ||
| Clinical Features | 57 | ||
| Salivary Gland–Type Adenocarcinoma | 57 | ||
| Non–Salivary Gland–Type Adenocarcinoma | 57 | ||
| Pathologic Features | 58 | ||
| Gross Findings | 58 | ||
| Microscopic Findings | 58 | ||
| Salivary Gland–Type Adenocarcinoma | 58 | ||
| Non–Salivary Gland–Type Adenocarcinoma | 58 | ||
| Intestinal-Type Adenocarcinoma. | 58 | ||
| Nonintestinal-Type Adenocarcinoma. | 58 | ||
| Ancillary Studies | 60 | ||
| Differential Diagnosis | 60 | ||
| Prognosis and Therapy | 60 | ||
| ■ Sinonasal Undifferentiated Carcinoma (SNUC) | 61 | ||
| Clinical Features | 61 | ||
| Pathologic Features | 63 | ||
| Gross Findings | 63 | ||
| Microscopic Findings | 63 | ||
| Ancillary Studies | 63 | ||
| Differential Diagnosis | 63 | ||
| Prognosis and Therapy | 63 | ||
| ■ Nut Carcinoma | 66 | ||
| Clinical Features | 66 | ||
| Pathologic Features | 67 | ||
| Gross Findings | 67 | ||
| Microscopic Findings | 67 | ||
| Ancillary Studies | 68 | ||
| Differential Diagnosis | 68 | ||
| Prognosis and Therapy | 68 | ||
| ■ Nasopharyngeal Carcinoma | 69 | ||
| Clinical Features | 69 | ||
| Radiographic Features | 69 | ||
| Laboratory Studies | 69 | ||
| Pathologic Features | 70 | ||
| Gross Findings | 70 | ||
| Microscopic Findings | 70 | ||
| Nonkeratinizing Squamous Cell Carcinoma | 70 | ||
| Keratinizing Squamous Cell Carcinoma | 71 | ||
| Basaloid Squamous Cell Carcinoma | 71 | ||
| Ancillary Studies | 71 | ||
| Differential Diagnosis | 71 | ||
| Prognosis and Therapy | 72 | ||
| ■ Mucosal Melanoma | 72 | ||
| Clinical Features | 72 | ||
| Pathologic Features | 73 | ||
| Gross Findings | 73 | ||
| Microscopic Findings | 74 | ||
| Ancillary Studies | 74 | ||
| Ultrastructural Findings | 74 | ||
| Immunohistochemical Findings | 74 | ||
| Differential Diagnosis | 74 | ||
| Prognosis and Therapy | 77 | ||
| ■ Olfactory Neuroblastoma | 77 | ||
| Clinical Features | 77 | ||
| Radiographic Features | 77 | ||
| Pathologic Features | 78 | ||
| Gross Findings | 78 | ||
| Microscopic Findings | 78 | ||
| Ancillary Studies | 80 | ||
| Ultrastructural Findings | 80 | ||
| Histochemistry Findings | 80 | ||
| Immunohistochemical Findings | 81 | ||
| Differential Diagnosis | 81 | ||
| Prognosis and Therapy | 81 | ||
| ■ Extranodal NK/T-Cell Lymphoma, Nasal Type | 82 | ||
| Clinical Features | 82 | ||
| Pathologic Features | 83 | ||
| Gross Findings | 83 | ||
| Microscopic Findings | 84 | ||
| Ancillary Studies | 85 | ||
| Histochemical Studies | 85 | ||
| Immunohistochemical Findings | 85 | ||
| Molecular Genetics | 85 | ||
| Differential Diagnosis | 85 | ||
| Prognosis and Therapy | 85 | ||
| ■ Mesenchymal Malignancies | 86 | ||
| Rhabdomyosarcoma | 86 | ||
| Fibrosarcoma | 91 | ||
| Biphenotypic Sinonasal Sarcoma | 92 | ||
| Leiomyosarcoma | 92 | ||
| Angiosarcoma | 94 | ||
| ■ Ewing Sarcoma | 95 | ||
| Clinical Features | 95 | ||
| Pathologic Features | 96 | ||
| Gross Findings | 96 | ||
| Microscopic Findings | 96 | ||
| Ancillary Studies | 96 | ||
| Histochemical Studies | 96 | ||
| Immunohistochemical Findings | 96 | ||
| Molecular Genetics | 96 | ||
| Differential Diagnosis | 96 | ||
| Prognosis and Therapy | 97 | ||
| ■ Teratocarcinosarcoma | 97 | ||
| Clinical Features | 98 | ||
| Pathologic Features | 98 | ||
| Gross Findings | 98 | ||
| Microscopic Findings | 98 | ||
| Ancillary Studies | 99 | ||
| Differential Diagnosis | 100 | ||
| Prognosis and Therapy | 100 | ||
| Suggested Readings | 100 | ||
| Suggested Readings | 100.e1 | ||
| Squamous Cell Carcinoma | 100.e1 | ||
| Sinonasal Adenocarcinoma | 100.e1 | ||
| Sinonasal Undifferentiated Carcinoma | 100.e2 | ||
| NUT Carcinoma | 100.e3 | ||
| Nasopharyngeal Carcinoma | 100.e3 | ||
| Malignant Mucosal Melanoma | 100.e4 | ||
| Olfactory Neuroblastoma | 100.e4 | ||
| Extranodal NK/T-Cell Lymphoma, Nasal Type | 100.e5 | ||
| Rhabdomyosarcoma | 100.e5 | ||
| Biphenotypic Sinonasal Sarcoma | 100.e5 | ||
| Fibrosarcoma | 100.e6 | ||
| Leiomyosarcoma | 100.e6 | ||
| Angiosarcoma | 100.e6 | ||
| Ewing Sarcoma | 100.e6 | ||
| Teratocarcinosarcoma | 100.e6 | ||
| 4 Non-Neoplastic Lesions of the Larynx, Hypopharynx, and Trachea | 101 | ||
| ■ Vocal Cord Polyps and Nodules | 101 | ||
| Clinical Features | 101 | ||
| Pathologic Features | 101 | ||
| Gross Findings | 101 | ||
| Microscopic Findings | 101 | ||
| Differential Diagnosis | 102 | ||
| Prognosis and Therapy | 102 | ||
| ■ Contact Ulcer | 104 | ||
| Clinical Features | 104 | ||
| Pathologic Features | 104 | ||
| Gross Findings | 104 | ||
| Microscopic Findings | 105 | ||
| Differential Diagnosis | 105 | ||
| Prognosis and Therapy | 106 | ||
| ■ Amyloidosis | 107 | ||
| Clinical Features | 107 | ||
| Pathologic Features | 107 | ||
| Gross Findings | 107 | ||
| Microscopic Findings | 107 | ||
| Ancillary Studies | 109 | ||
| Special Stains | 109 | ||
| Immunohistochemical Findings | 109 | ||
| Differential Diagnosis | 109 | ||
| Prognosis and Therapy | 110 | ||
| ■ Cysts of the Larynx (Including Laryngocele) | 110 | ||
| Clinical Features | 110 | ||
| Pathologic Features | 111 | ||
| Gross Findings | 111 | ||
| Microscopic Findings | 111 | ||
| Differential Diagnosis | 114 | ||
| Prognosis and Therapy | 114 | ||
| ■ Reactive Epithelial Changes | 114 | ||
| Clinical Features | 114 | ||
| Pathologic Features | 115 | ||
| Gross Findings | 115 | ||
| Microscopic Findings | 115 | ||
| Ancillary Studies | 120 | ||
| Differential Diagnosis | 121 | ||
| Prognosis and Therapy | 121 | ||
| Suggested Reading | 121 | ||
| Suggested Reading | 121.e1 | ||
| Vocal Cord Polyps and Nodules | 121.e1 | ||
| Contact Ulcer | 121.e1 | ||
| Amyloidosis | 121.e1 | ||
| Cysts of the Larynx (Including Laryngocele) | 121.e1 | ||
| Reactive Epithelial Changes | 121.e1 | ||
| 5 Benign Neoplasms of the Larynx, Hypopharynx, and Trachea | 122 | ||
| ■ Squamous Papillomas | 122 | ||
| Clinical Features | 122 | ||
| Pathologic Features | 123 | ||
| Gross Findings | 123 | ||
| Microscopic Findings | 123 | ||
| Ancillary Studies | 123 | ||
| Differential Diagnosis | 123 | ||
| Prognosis and Therapy | 124 | ||
| ■ Granular Cell Tumor | 125 | ||
| Clinical Features | 126 | ||
| Pathologic Features | 126 | ||
| Gross Findings | 126 | ||
| Microscopic Findings | 126 | ||
| Ancillary Studies | 127 | ||
| Differential Diagnosis | 127 | ||
| Prognosis and Therapy | 129 | ||
| ■ Adult Rhabdomyoma | 129 | ||
| Clinical Features | 129 | ||
| Pathologic Features | 129 | ||
| Gross Findings | 129 | ||
| Microscopic Findings | 129 | ||
| Ancillary Studies | 130 | ||
| Differential Diagnosis | 131 | ||
| Prognosis and Therapy | 131 | ||
| ■ Chondroma | 131 | ||
| Clinical Features | 131 | ||
| Pathologic Features | 131 | ||
| Gross Findings | 131 | ||
| Microscopic Findings | 131 | ||
| Ancillary Studies | 132 | ||
| Differential Diagnosis | 132 | ||
| Prognosis and Therapy | 133 | ||
| ■ Inflammatory Myofibroblastic Tumor | 134 | ||
| Clinical Features | 134 | ||
| Pathologic Features | 134 | ||
| Gross Findings | 134 | ||
| Microscopic Findings | 134 | ||
| Ancillary Studies | 134 | ||
| Differential Diagnosis | 135 | ||
| Prognosis and Therapy | 137 | ||
| Suggested Readings | 137 | ||
| Suggested Readings | 137.e1 | ||
| Squamous Papilloma/Papillomatosis | 137.e1 | ||
| Granular Cell Tumor | 137.e1 | ||
| Adult Rhabdomyoma | 137.e1 | ||
| Chondroma | 137.e1 | ||
| Inflammatory Myofibroblastic Tumor | 137.e1 | ||
| 6 Malignant Neoplasms of the Larynx, Hypopharynx, and Trachea | 138 | ||
| ■ Precursor Squamous Lesions | 138 | ||
| Clinical Features | 138 | ||
| Pathologic Features | 139 | ||
| Gross Findings | 139 | ||
| Microscopic Findings | 139 | ||
| Differential Diagnosis | 142 | ||
| Prognosis and Therapy | 143 | ||
| ■ Squamous Cell Carcinoma | 143 | ||
| Clinical Features | 143 | ||
| Pathologic Features | 143 | ||
| Gross Findings | 143 | ||
| Microscopic Findings | 144 | ||
| Differential Diagnosis | 147 | ||
| Prognosis and Therapy | 148 | ||
| Variants of Squamous Cell Carcinoma | 148 | ||
| Verrucous Squamous Cell Carcinoma | 148 | ||
| Exophytic and Papillary Squamous Cell Carcinoma | 150 | ||
| Spindle Cell Squamous Cell Carcinoma | 153 | ||
| Basaloid Squamous Cell Carcinoma | 160 | ||
| Adenosquamous Carcinoma | 163 | ||
| ■ Neuroendocrine Carcinoma | 164 | ||
| Clinical Features | 164 | ||
| Pathologic Features | 164 | ||
| Gross Findings | 164 | ||
| Microscopic Findings | 164 | ||
| Ancillary Studies | 167 | ||
| Ultrastructural Findings | 167 | ||
| Immunohistochemical Findings | 167 | ||
| Differential Diagnosis | 167 | ||
| Prognosis and Therapy | 168 | ||
| ■ Chondrosarcoma | 168 | ||
| Clinical Features | 169 | ||
| Radiographic Features | 169 | ||
| Pathologic Features | 170 | ||
| Gross Findings | 170 | ||
| Microscopic Findings | 170 | ||
| Differential Diagnosis | 170 | ||
| Prognosis and Therapy | 173 | ||
| ■ Metastatic/Secondary Tumors | 173 | ||
| Clinical Features | 173 | ||
| Pathologic Features | 173 | ||
| Microscopic Findings | 173 | ||
| Differential Diagnosis | 173 | ||
| Prognosis and Treatment | 174 | ||
| Suggested Readings | 174 | ||
| Suggested Readings | 174.e1 | ||
| Precursor Lesions | 174.e1 | ||
| Squamous Cell Carcinoma and Variants | 174.e1 | ||
| Neuroendocrine Carcinoma | 174.e2 | ||
| Chondrosarcoma | 174.e3 | ||
| Metastatic – Secondary Tumors | 174.e3 | ||
| 7 Non-Neoplastic Lesions of the Oral Cavity | 175 | ||
| ■ Fordyce Granules | 175 | ||
| Clinical Features | 175 | ||
| Pathologic Features | 175 | ||
| Differential Diagnosis | 176 | ||
| Prognosis and Therapy | 176 | ||
| ■ Amalgam Tattoo | 176 | ||
| Clinical Features | 176 | ||
| Radiographic Features | 176 | ||
| Pathologic Features | 177 | ||
| Differential Diagnosis | 177 | ||
| Prognosis and Therapy | 177 | ||
| ■ Ectopic Thyroid | 178 | ||
| Clinical Features | 178 | ||
| Radiographic Features | 178 | ||
| Pathologic Features | 178 | ||
| Fine Needle Aspiration | 178 | ||
| Differential Diagnosis | 179 | ||
| Prognosis and Therapy | 179 | ||
| ■ Oral Hairy Leukoplakia | 179 | ||
| Clinical Features | 179 | ||
| Pathologic Features | 179 | ||
| Histochemical Studies | 179 | ||
| Immunohistochemical Findings | 180 | ||
| Molecular Studies | 180 | ||
| Differential Diagnosis | 181 | ||
| Prognosis and Therapy | 181 | ||
| ■ Infections | 181 | ||
| Clinical Features | 181 | ||
| Pathologic Features | 183 | ||
| Candida (Including Median Rhomboid Glossitis) | 183 | ||
| Herpes Simplex Virus 1 | 183 | ||
| Actinomycosis | 183 | ||
| Differential Diagnosis | 184 | ||
| Prognosis and Therapy | 185 | ||
| ■ Oral Lichen Planus | 186 | ||
| Clinical Features | 186 | ||
| Pathologic Features | 186 | ||
| Ancillary Studies | 186 | ||
| Differential Diagnosis | 188 | ||
| Prognosis and Therapy | 188 | ||
| ■ Mucous Membrane Pemphigoid | 188 | ||
| Clinical Features | 188 | ||
| Pathologic Features | 188 | ||
| Ancillary Studies | 189 | ||
| Differential Diagnosis | 190 | ||
| Prognosis and Therapy | 190 | ||
| ■ Pemphigus Vulgaris | 190 | ||
| Clinical Features | 190 | ||
| Pathologic Features | 191 | ||
| Ancillary Studies | 191 | ||
| Differential Diagnosis | 192 | ||
| Prognosis and Therapy | 192 | ||
| ■ Recurrent Aphthous Stomatitis | 192 | ||
| Clinical Features | 192 | ||
| Pathologic Features | 193 | ||
| Differential Diagnosis | 193 | ||
| Prognosis and Therapy | 194 | ||
| ■ Traumatic Ulcerative Granuloma | 194 | ||
| Clinical Features | 194 | ||
| Pathologic Features | 194 | ||
| Differential Diagnosis | 195 | ||
| Prognosis and Therapy | 196 | ||
| Suggested Readings | 196 | ||
| Suggested Readings | 196.e1 | ||
| Fordyce Granules | 196.e1 | ||
| Amalgam Tattoo | 196.e1 | ||
| Ectopic Thyroid | 196.e1 | ||
| Oral Hairy Leukoplakia | 196.e1 | ||
| Infections | 196.e1 | ||
| Oral Lichen Planus | 196.e1 | ||
| Mucous Membrane Pemphigoid | 196.e1 | ||
| Pemphigus Vulgaris | 196.e1 | ||
| Recurrent Aphthous Stomatitis | 196.e2 | ||
| Traumatic Ulcerative Granuloma | 196.e2 | ||
| 8 Benign Neoplasms of the Oral Cavity | 197 | ||
| ■ Fibroma | 197 | ||
| Clinical Features | 197 | ||
| Pathologic Features | 197 | ||
| Gross Findings | 197 | ||
| Microscopic Findings | 197 | ||
| Differential Diagnosis | 198 | ||
| Prognosis and Therapy | 198 | ||
| ■ Squamous Papilloma (Including Verruca and Condyloma) | 200 | ||
| Clinical Features | 200 | ||
| Pathologic Features | 200 | ||
| Gross Findings | 200 | ||
| Microscopic Findings | 200 | ||
| Ancillary Studies | 201 | ||
| Differential Diagnosis | 201 | ||
| Prognosis and Therapy | 203 | ||
| ■ Multifocal Epithelial Hyperplasia | 203 | ||
| Clinical Features | 203 | ||
| Pathologic Features | 203 | ||
| Gross Findings | 203 | ||
| Microscopic Findings | 204 | ||
| Ancillary Studies | 205 | ||
| Differential Diagnosis | 205 | ||
| Prognosis and Therapy | 205 | ||
| ■ Lobular Capillary Hemangioma | 205 | ||
| Clinical Features | 205 | ||
| Pathologic Features | 206 | ||
| Gross Findings | 206 | ||
| Microscopic Findings | 206 | ||
| Ancillary Studies | 207 | ||
| Differential Diagnosis | 207 | ||
| Prognosis and Therapy | 207 | ||
| ■ Peripheral Ossifying Fibroma | 207 | ||
| Clinical Features | 208 | ||
| Pathologic Features | 208 | ||
| Gross Findings | 208 | ||
| Microscopic Findings | 208 | ||
| Differential Diagnosis | 208 | ||
| Prognosis and Therapy | 210 | ||
| ■ Peripheral Giant Cell Granuloma | 210 | ||
| Clinical Features | 210 | ||
| Radiographic Features | 210 | ||
| Pathologic FFeatures | 210 | ||
| Gross Findings | 210 | ||
| Microscopic Findings | 210 | ||
| Differential Diagnosis | 212 | ||
| Prognosis and Therapy | 212 | ||
| ■ Granular Cell Tumor | 212 | ||
| Clinical FFeatures | 212 | ||
| Pathologic FFeatures | 212 | ||
| Gross Findings | 212 | ||
| Microscopic Findings | 212 | ||
| Ancillary Studies | 213 | ||
| Differential Diagnosis | 213 | ||
| Prognosis and Therapy | 214 | ||
| ■ Congenital Granular Cell Epulis | 214 | ||
| Clinical Features | 215 | ||
| Pathologic FFeatures | 215 | ||
| Gross Findings | 215 | ||
| Microscopic Findings | 215 | ||
| Ancillary Studies | 216 | ||
| Differential Diagnosis | 216 | ||
| Prognosis and Therapy | 217 | ||
| ■ Ectomesenchymal Chondromyxoid Tumor | 217 | ||
| Clinical FFeatures | 217 | ||
| Pathologic Features | 217 | ||
| Gross Findings | 217 | ||
| Microscopic Findings | 217 | ||
| Ancillary Studies | 218 | ||
| Differential Diagnosis | 218 | ||
| Prognosis and Therapy | 218 | ||
| Suggested Readings | 218 | ||
| Suggested Readings | 218.e1 | ||
| Fibroma | 218.e1 | ||
| Squamous Papilloma (Including Verruca and Condyloma) | 218.e1 | ||
| Multifocal Epithelial Hyperplasia | 218.e1 | ||
| Lobular Capillary Hemangioma | 218.e1 | ||
| Peripheral Ossifying Fibroma | 218.e1 | ||
| Peripheral Giant Cell Granuloma | 218.e1 | ||
| Granular Cell Tumor | 218.e1 | ||
| Congenital Epulis | 218.e1 | ||
| Ectomesenchymal Chondromyxoid Tumor | 218.e2 | ||
| 9 Malignant Neoplasms of the Oral Cavity | 219 | ||
| ■ Squamous Cell Carcinoma | 219 | ||
| Clinical Features | 219 | ||
| Radiographic Features | 220 | ||
| Pathologic Features | 220 | ||
| Microscopic Findings | 220 | ||
| Ancillary Studies | 222 | ||
| Fine Needle Aspiration | 222 | ||
| Immunohistochemical Findings | 222 | ||
| Differential Diagnosis | 222 | ||
| Prognosis and Therapy | 224 | ||
| ■ Kaposi Sarcoma | 224 | ||
| Clinical Features | 225 | ||
| Pathologic Features | 225 | ||
| Gross Findings | 225 | ||
| Microscopic Findings | 225 | ||
| Ancillary Studies | 226 | ||
| Differential Diagnosis | 226 | ||
| Prognosis and Therapy | 227 | ||
| ■ Oral Mucosal Melanoma | 227 | ||
| Clinical Features | 227 | ||
| Pathologic Features | 228 | ||
| Gross Findings | 228 | ||
| Microscopic Findings | 228 | ||
| Ancillary Studies | 228 | ||
| Differential Diagnosis | 229 | ||
| Prognosis and Therapy | 229 | ||
| Suggested Readings | 229 | ||
| Suggested Readings | 229.e1 | ||
| Squamous Cell Carcinoma | 229.e1 | ||
| Kaposi’s Sarcoma | 229.e1 | ||
| Oral Mucosal Melanoma | 229.e1 | ||
| 10 Malignant Neoplasms of the Oropharynx | 230 | ||
| ■ Squamous Cell Carcinoma | 230 | ||
| Clinical Features | 230 | ||
| Radiographic Features | 231 | ||
| Pathologic Features | 231 | ||
| Gross Findings | 231 | ||
| Microscopic Findings | 231 | ||
| Ancillary Studies | 236 | ||
| Fine Needle Aspiration | 236 | ||
| Immunohistochemical Findings | 236 | ||
| Differential Diagnosis | 236 | ||
| Prognosis and Therapy | 237 | ||
| ■ Small Cell Carcinoma | 237 | ||
| Clinical Features | 237 | ||
| Pathologic Features | 237 | ||
| Gross Findings | 237 | ||
| Microscopic Findings | 239 | ||
| Ancillary Studies | 240 | ||
| Differential Diagnosis | 240 | ||
| Prognosis and Therapy | 240 | ||
| Suggested Readings | 240 | ||
| Suggested Readings | 240.e1 | ||
| Squamous Cell Carcinoma | 240.e1 | ||
| Small Cell Carcinoma | 240.e1 | ||
| 11 Non-Neoplastic Lesions of the Salivary Glands | 241 | ||
| ■ Developmental Lesions, Including Heterotopia and Oncocytosis | 241 | ||
| Clinical Features | 241 | ||
| Pathologic Features | 242 | ||
| Gross Findings | 242 | ||
| Microscopic Findings | 242 | ||
| Ancillary Studies | 243 | ||
| Ultrastructural Findings | 243 | ||
| Histochemical Findings | 243 | ||
| Fine Needle Aspiration | 244 | ||
| Differential Diagnosis | 244 | ||
| Prognosis and Therapy | 244 | ||
| ■ Mucus Retention Cyst, Mucocele, and Sialolithiasis | 244 | ||
| Clinical Features | 244 | ||
| Radiographic Features | 247 | ||
| Pathologic Features | 247 | ||
| Differential Diagnosis | 248 | ||
| Prognosis and Therapy | 248 | ||
| ■ Necrotizing Sialometaplasia | 248 | ||
| Clinical Features | 248 | ||
| Pathologic Features | 249 | ||
| Gross Findings | 249 | ||
| Microscopic Findings | 249 | ||
| Differential Diagnosis | 250 | ||
| Prognosis and Therapy | 251 | ||
| ■ Lymphoepithelial Sialadenitis | 251 | ||
| Clinical Features | 251 | ||
| Pathologic Features | 252 | ||
| Gross Findings | 252 | ||
| Microscopic Findings | 252 | ||
| Ancillary Studies | 252 | ||
| Differential Diagnosis | 252 | ||
| Prognosis and Therapy | 254 | ||
| ■ Lymphoepithelial Cyst | 254 | ||
| Clinical Features | 254 | ||
| Pathologic Features | 254 | ||
| Gross Findings | 254 | ||
| Microscopic Findings | 254 | ||
| Ancillary Studies | 255 | ||
| Differential Diagnosis | 255 | ||
| Prognosis and Therapy | 255 | ||
| ■ Sclerosing Polycystic Adenosis | 257 | ||
| Clinical Features | 257 | ||
| Pathologic Features | 257 | ||
| Gross Findings | 257 | ||
| Microscopic Findings | 257 | ||
| Ancillary Studies | 257 | ||
| Differential Diagnosis | 257 | ||
| Prognosis and Therapy | 258 | ||
| ■ Intercalated Duct Hyperplasia | 258 | ||
| Clinical Features | 259 | ||
| Pathologic Features | 259 | ||
| Gross Findings | 259 | ||
| Microscopic Findings | 259 | ||
| Ancillary Studies | 260 | ||
| Differential Diagnosis | 260 | ||
| Prognosis and Therapy | 260 | ||
| Suggested Readings | 260 | ||
| Suggested Readings | 260.e1 | ||
| Developmental Lesions, Including Heterotopia and Oncocytosis | 260.e1 | ||
| Mucus Retention Cyst, Mucocele, and Sialolithiasis | 260.e1 | ||
| Necrotizing Sialometaplasia | 260.e1 | ||
| Lymphoepithelial Sialadenitis | 260.e1 | ||
| Lymphoepithelial Cyst | 260.e1 | ||
| Sclerosing Polycystic Adenosis | 260.e1 | ||
| Intercalated Duct Hyperplasia | 260.e2 | ||
| 12 Benign Neoplasms of the Salivary Glands | 261 | ||
| ■ Pleomorphic Adenoma | 261 | ||
| Clinical Features | 261 | ||
| Pathologic Features | 261 | ||
| Gross Findings | 261 | ||
| Microscopic Findings | 261 | ||
| Ancillary Studies | 264 | ||
| Immunohistochemical Findings | 264 | ||
| Fine Needle Aspiration | 264 | ||
| Differential Diagnosis | 264 | ||
| Prognosis and Therapy | 264 | ||
| ■ Basal Cell Adenoma | 266 | ||
| Clinical Features | 266 | ||
| Pathologic Features | 266 | ||
| Gross Findings | 266 | ||
| Microscopic Findings | 267 | ||
| Ancillary Studies | 267 | ||
| Immunohistochemical Findings | 267 | ||
| Fine Needle Aspiration | 269 | ||
| Differential Diagnosis | 269 | ||
| Prognosis and Therapy | 269 | ||
| ■ Canalicular Adenoma | 269 | ||
| Clinical Features | 269 | ||
| Pathologic Features | 270 | ||
| Gross Findings | 270 | ||
| Microscopic Findings | 270 | ||
| Ancillary Studies | 272 | ||
| Differential Diagnosis | 272 | ||
| Prognosis and Therapy | 272 | ||
| ■ Oncocytoma | 272 | ||
| Clinical Features | 272 | ||
| Pathologic Features | 272 | ||
| Gross Findings | 272 | ||
| Microscopic Findings | 272 | ||
| Ancillary Studies | 274 | ||
| Histochemical Findings | 274 | ||
| Ultrastructural Findings | 274 | ||
| Fine Needle Aspiration | 274 | ||
| Differential Diagnosis | 274 | ||
| Prognosis and Therapy | 275 | ||
| ■ Warthin Tumor | 275 | ||
| Clinical Features | 276 | ||
| Pathologic Features | 276 | ||
| Gross Findings | 276 | ||
| Microscopic Findings | 276 | ||
| Ancillary Studies | 277 | ||
| Immunohistochemical Findings | 277 | ||
| Fine Needle Aspiration | 277 | ||
| Differential Diagnosis | 277 | ||
| Prognosis and Therapy | 277 | ||
| ■ Sebaceous Adenoma/Lymphadenoma | 279 | ||
| Clinical Features | 279 | ||
| Pathologic Features | 279 | ||
| Gross Findings | 279 | ||
| Microscopic Findings | 279 | ||
| Ancillary Studies | 280 | ||
| Immunohistochemical Findings | 280 | ||
| Fine Needle Aspiration | 281 | ||
| Differential Diagnosis | 281 | ||
| Prognosis and Therapy | 281 | ||
| ■ Hemangioma | 281 | ||
| Clinical Features | 281 | ||
| Pathologic Features | 282 | ||
| Gross Findings | 282 | ||
| Microscopic Findings | 282 | ||
| Ancillary Studies | 282 | ||
| Immunohistochemical Findings | 282 | ||
| Fine Needle Aspiration | 282 | ||
| Differential Diagnosis | 282 | ||
| Prognosis and Therapy | 283 | ||
| Suggested Readings | 283 | ||
| Suggested Readings | 283.e1 | ||
| Pleomorphic Adenoma | 283.e1 | ||
| Basal Cell Adenoma | 283.e1 | ||
| Canalicular Adenoma | 283.e1 | ||
| Oncocytoma | 283.e1 | ||
| Warthin Tumor | 283.e2 | ||
| Sebaceous Adenoma/Lymphadenoma | 283.e2 | ||
| Hemangioma | 283.e2 | ||
| 13 Malignant Neoplasms of the Salivary Glands | 284 | ||
| ■ Mucoepidermoid Carcinoma | 284 | ||
| Clinical Features | 284 | ||
| Pathologic Features | 284 | ||
| Gross Findings | 284 | ||
| Microscopic Findings | 284 | ||
| Tumor Grading | 287 | ||
| Ancillary Studies | 290 | ||
| Immunohistochemical Findings | 290 | ||
| Molecular Findings | 290 | ||
| Fine Needle Aspiration | 290 | ||
| Differential Diagnosis | 291 | ||
| Prognosis and Therapy | 293 | ||
| ■ Acinic Cell Carcinoma | 293 | ||
| Clinical Features | 293 | ||
| Pathologic Features | 294 | ||
| Gross Findings | 294 | ||
| Microscopic Findings | 294 | ||
| Ancillary Studies | 297 | ||
| Ultrastructural Findings | 297 | ||
| Immunohistochemical Findings | 297 | ||
| Fine Needle Aspiration | 297 | ||
| Differential Diagnosis | 297 | ||
| Prognosis and Therapy | 300 | ||
| ■ Adenoid Cystic Carcinoma | 300 | ||
| Clinical Features | 300 | ||
| Pathologic Features | 301 | ||
| Gross Findings | 301 | ||
| Microscopic Findings | 301 | ||
| Ancillary Studies | 305 | ||
| Histochemical and Immunohistochemical Findings | 305 | ||
| Molecular Findings | 305 | ||
| Fine Needle Aspiration | 305 | ||
| Differential Diagnosis | 308 | ||
| Prognosis and Therapy | 309 | ||
| ■ Polymorphous Adenocarcinoma | 309 | ||
| Clinical Features | 309 | ||
| Pathologic Features | 310 | ||
| Gross Findings | 310 | ||
| Microscopic Findings | 310 | ||
| Ancillary Studies | 314 | ||
| Differential Diagnosis | 314 | ||
| Prognosis and Therapy | 317 | ||
| ■ Epithelial-Myoepithelial Carcinoma | 317 | ||
| Clinical Features | 317 | ||
| Pathologic Features | 317 | ||
| Gross Findings | 317 | ||
| Microscopic Findings | 317 | ||
| Ancillary Studies | 319 | ||
| Differential Diagnosis | 322 | ||
| Prognosis and Therapy | 322 | ||
| ■ Secretory Carcinoma (Mammary Analogue Secretory Carcinoma) | 322 | ||
| Clinical Features | 322 | ||
| Pathologic Features | 322 | ||
| Gross Findings | 322 | ||
| Microscopic Findings | 323 | ||
| Tumor Grading | 323 | ||
| Ancillary Studies | 326 | ||
| Immunohistochemical Findings | 326 | ||
| Molecular Findings | 326 | ||
| Fine Needle Aspiration | 326 | ||
| Differential Diagnosis | 326 | ||
| Prognosis and Therapy | 326 | ||
| ■ Salivary Duct Carcinoma | 328 | ||
| Clinical Features | 328 | ||
| Pathologic Features | 328 | ||
| Gross Findings | 328 | ||
| Microscopic Findings | 328 | ||
| Ancillary Studies | 333 | ||
| Immunohistochemical Findings | 333 | ||
| Fine Needle Aspiration | 333 | ||
| Differential Diagnosis | 333 | ||
| Prognosis and Therapy | 333 | ||
| ■ Carcinoma Ex Pleomorphic Adenoma | 335 | ||
| Clinical Features | 335 | ||
| Pathologic Features | 335 | ||
| Gross Findings | 335 | ||
| Microscopic Findings | 336 | ||
| Differential Diagnosis | 340 | ||
| Prognosis and Therapy | 340 | ||
| ■ Extranodal Marginal Zone B-Cell Lymphoma of Salivary Glands | 340 | ||
| Clinical Features | 340 | ||
| Pathologic Features | 341 | ||
| Gross Findings | 341 | ||
| Microscopic Findings | 341 | ||
| Ancillary Studies | 343 | ||
| Differential Diagnosis | 343 | ||
| Prognosis and Therapy | 343 | ||
| ■ Sialoblastoma | 344 | ||
| Clinical Features | 344 | ||
| Pathologic Features | 344 | ||
| Gross Findings | 344 | ||
| Microscopic Findings | 344 | ||
| Ancillary Studies | 346 | ||
| Differential Diagnosis | 346 | ||
| Prognosis and Therapy | 346 | ||
| ■ Uncommon Carcinomas | 346 | ||
| Basal Cell Adenocarcinoma | 346 | ||
| Clear Cell Carcinoma | 348 | ||
| Sebaceous Adenocarcinoma | 351 | ||
| Oncocytic Carcinoma | 354 | ||
| ■ Undifferentiated Carcinomas | 354 | ||
| Small Cell Carcinoma | 354 | ||
| Large Cell Carcinoma | 356 | ||
| Lymphoepithelial Carcinoma | 358 | ||
| ■ Adenocarcinoma, Not Otherwise Specified | 360 | ||
| Clinical Features | 360 | ||
| Pathologic Features | 360 | ||
| Gross Findings | 360 | ||
| Microscopic Findings | 360 | ||
| Ancillary Studies | 362 | ||
| Immunohistochemical Findings | 362 | ||
| Fine Needle Aspiration | 362 | ||
| Differential Diagnosis | 362 | ||
| Prognosis and Therapy | 362 | ||
| Suggested Readings | 362 | ||
| Suggested Readings | 362.e1 | ||
| Mucoepidermoid Carcinoma | 362.e1 | ||
| Acinic Cell Carcinoma | 362.e1 | ||
| Adenoid Cystic Carcinoma | 362.e1 | ||
| Polymorphous Adenocarcinoma | 362.e1 | ||
| Epithelial-Myoepithelial Carcinoma | 362.e2 | ||
| Secretory Carcinoma | 362.e2 | ||
| Salivary Duct Carcinoma | 362.e2 | ||
| Carcinoma ex Pleomorphic Adenoma | 362.e3 | ||
| Extranodal Marginal Zone B-Cell Lymphoma of Salivary Glands | 362.e3 | ||
| Sialoblastoma | 362.e3 | ||
| Uncommon Carcinomas | 362.e4 | ||
| Undifferentiated Carcinomas | 362.e4 | ||
| Adenocarcinoma Not Otherwise Specified | 362.e5 | ||
| 14 Non-Neoplastic Lesions of the Gnathic Bones | 363 | ||
| ■ Osteomyelitis | 363 | ||
| Clinical Features | 363 | ||
| Radiographic Features | 364 | ||
| Pathologic Features | 364 | ||
| Gross Findings | 364 | ||
| Microscopic Findings | 364 | ||
| Differential Diagnosis | 364 | ||
| Prognosis and Therapy | 364 | ||
| ■ Dentigerous Cyst | 366 | ||
| Clinical Features | 366 | ||
| Radiographic Features | 366 | ||
| Pathologic Features | 366 | ||
| Gross Findings | 366 | ||
| Microscopic Findings | 366 | ||
| Differential Diagnosis | 368 | ||
| Prognosis and Therapy | 368 | ||
| ■ Periapical Cyst/Granuloma | 368 | ||
| Clinical Features | 368 | ||
| Radiographic Features | 368 | ||
| Pathologic Features | 368 | ||
| Gross Findings | 368 | ||
| Microscopic Findings | 368 | ||
| Differential Diagnosis | 370 | ||
| Prognosis and Therapy | 370 | ||
| ■ Fibrous Dysplasia | 370 | ||
| Clinical Features | 370 | ||
| Radiographic Features | 370 | ||
| Pathologic Features | 370 | ||
| Gross Findings | 370 | ||
| Microscopic Findings | 370 | ||
| Differential Diagnosis | 371 | ||
| Prognosis and Therapy | 373 | ||
| ■ Osteonecrosis | 373 | ||
| Clinical Features | 373 | ||
| Radiographic Features | 373 | ||
| Pathologic Features | 373 | ||
| Gross Findings | 373 | ||
| Microscopic Findings | 373 | ||
| Differential Diagnosis | 374 | ||
| Prognosis and Therapy | 375 | ||
| ■ Simple (Solitary) Bone Cyst | 375 | ||
| Clinical Features | 375 | ||
| Radiographic Features | 375 | ||
| Pathologic Features | 375 | ||
| Gross Findings | 375 | ||
| Microscopic Findings | 376 | ||
| Differential Diagnosis | 376 | ||
| Prognosis and Therapy | 376 | ||
| ■ Nasopalatine Duct Cyst | 376 | ||
| Clinical Features | 376 | ||
| Radiographic Features | 376 | ||
| Pathologic Features | 377 | ||
| Differential Diagnosis | 377 | ||
| Prognosis and Therapy | 377 | ||
| ■ Tori | 377 | ||
| Clinical Features | 377 | ||
| Radiographic Features | 378 | ||
| Pathologic Features | 378 | ||
| Gross Findings | 378 | ||
| Microscopic Findings | 378 | ||
| Differential Diagnosis | 378 | ||
| Prognosis and Therapy | 378 | ||
| ■ Cherubism | 379 | ||
| Clinical Features | 379 | ||
| Radiographic Features | 379 | ||
| Pathologic Features | 379 | ||
| Gross Findings | 379 | ||
| Microscopic Findings | 380 | ||
| Differential Diagnosis | 380 | ||
| Prognosis and Therapy | 380 | ||
| ■ Cemento-Osseous Dysplasia | 381 | ||
| Clinical Features | 381 | ||
| Radiograhic Features | 381 | ||
| Pathologic Features | 381 | ||
| Gross Findings | 381 | ||
| Microscopic Findings | 381 | ||
| Differential Diagnosis | 381 | ||
| Prognosis and Therapy | 382 | ||
| Suggested Readings | 382 | ||
| Suggested Readings | 382.e1 | ||
| Osteomyelitis | 382.e1 | ||
| Dentigerous Cyst | 382.e1 | ||
| Periapical Cyst/Granuloma | 382.e1 | ||
| Fibrous Dysplasia | 382.e1 | ||
| Osteonecrosis | 382.e2 | ||
| Nasopalatine Duct Cyst | 382.e2 | ||
| Simple Bone Cyst | 382.e2 | ||
| Tori | 382.e2 | ||
| Cherubism | 382.e2 | ||
| Osseous Dysplasia | 382.e3 | ||
| 15 Benign Neoplasms of the Gnathic Bones | 383 | ||
| ■ Ossifying Fibroma | 383 | ||
| Clinical Features | 383 | ||
| Radiographic Features | 383 | ||
| Pathologic Features | 384 | ||
| Gross Findings | 384 | ||
| Microscopic Findings | 384 | ||
| Differential Diagnosis | 384 | ||
| Prognosis and Therapy | 385 | ||
| ■ Juvenile Ossifying Fibroma | 385 | ||
| Clinical Features | 386 | ||
| Radiographic Features | 386 | ||
| Pathologic Features | 386 | ||
| Gross Findings | 386 | ||
| Microscopic Findings | 386 | ||
| Differential Diagnosis | 387 | ||
| Prognosis and Therapy | 388 | ||
| ■ Central Odontogenic Fibroma | 388 | ||
| Clinical Features | 388 | ||
| Radiographic Features | 388 | ||
| Pathologic Features | 388 | ||
| Gross Findings | 388 | ||
| Microscopic Findings | 388 | ||
| Differential Diagnosis | 390 | ||
| Prognosis and Therapy | 390 | ||
| ■ Osteoblastoma | 390 | ||
| Clinical Features | 390 | ||
| Radiographic Features | 390 | ||
| Pathologic Features | 391 | ||
| Gross Findings | 391 | ||
| Microscopic Findings | 391 | ||
| Differential Diagnosis | 391 | ||
| Prognosis and Therapy | 392 | ||
| ■ Osteoid Osteoma | 392 | ||
| Clinical Features | 392 | ||
| Radiographic Features | 392 | ||
| Pathologic Features | 392 | ||
| Gross Findings | 392 | ||
| 16 Malignant Neoplasms of the Gnathic Bones | 417 | ||
| ■ Osteosarcoma | 417 | ||
| Clinical Features | 417 | ||
| Radiographic Features | 417 | ||
| Pathologic Features | 417 | ||
| Gross Findings | 417 | ||
| Microscopic Findings | 418 | ||
| Differential Diagnosis | 419 | ||
| Prognosis and Therapy | 419 | ||
| ■ Chondrosarcoma | 419 | ||
| Clinical Features | 419 | ||
| Radiographic Features | 420 | ||
| Pathologic Features | 420 | ||
| Gross Findings | 420 | ||
| Microscopic Findings | 420 | ||
| Ancillary Studies | 420 | ||
| Differential Diagnosis | 420 | ||
| Prognosis and Therapy | 421 | ||
| ■ Mesenchymal Chondrosarcoma | 421 | ||
| Clinical Features | 422 | ||
| Radiographic Features | 422 | ||
| Pathologic Features | 422 | ||
| Gross Findings | 422 | ||
| Microscopic Findings | 422 | ||
| Ancillary Studies | 422 | ||
| Differential Diagnosis | 423 | ||
| Prognosis and Therapy | 423 | ||
| ■ Ameloblastic Carcinoma | 423 | ||
| Clinical Features | 423 | ||
| Radiographic Features | 423 | ||
| Pathologic Features | 423 | ||
| Gross Findings | 423 | ||
| Microscopic Findings | 423 | ||
| Ancillary Studies | 425 | ||
| Differential Diagnosis | 425 | ||
| Prognosis and Therapy | 425 | ||
| ■ Primary Intraosseous Carcinoma | 425 | ||
| Clinical Features | 425 | ||
| Radiographic Features | 425 | ||
| Pathologic Features | 425 | ||
| Gross Findings | 425 | ||
| Microscopic Findings | 426 | ||
| Differential Diagnosis | 426 | ||
| Prognosis and Therapy | 426 | ||
| ■ Sclerosing Odontogenic Carcinoma | 426 | ||
| Clinical Features | 426 | ||
| Radiographic Features | 426 | ||
| Pathologic Features | 426 | ||
| Gross Findings | 426 | ||
| Microscopic Findings | 427 | ||
| Ancillary Studies | 427 | ||
| Differential Diagnosis | 427 | ||
| Prognosis and Therapy | 428 | ||
| ■ Clear Cell Odontogenic Carcinoma | 428 | ||
| Clinical Features | 428 | ||
| Radiographic Features | 428 | ||
| Pathologic Features | 428 | ||
| Gross Findings | 428 | ||
| Microscopic Findings | 429 | ||
| Ancillary Studies | 429 | ||
| Differential Diagnosis | 429 | ||
| Prognosis and Therapy | 429 | ||
| ■ Ghost Cell Odontogenic Carcinoma | 429 | ||
| Clinical Features | 430 | ||
| Radiographic Features | 430 | ||
| Pathologic Features | 430 | ||
| Gross Findings | 430 | ||
| Microscopic Findings | 430 | ||
| Differential Diagnosis | 430 | ||
| Prognosis and Therapy | 430 | ||
| ■ Odontogenic Sarcoma | 431 | ||
| Clinical Features | 431 | ||
| Radiographic Features | 431 | ||
| Pathologic Features | 432 | ||
| Gross Findings | 432 | ||
| Microscopic Findings | 432 | ||
| Differential Diagnosis | 432 | ||
| Prognosis and Therapy | 432 | ||
| Suggested Readings | 432 | ||
| Suggested Readings | 432.e1 | ||
| Osteosarcoma | 432.e1 | ||
| Chondrosarcoma | 432.e1 | ||
| Mesenchymal Chondrosarcoma | 432.e1 | ||
| Ameloblastic Carcinoma | 432.e1 | ||
| Primary Intraosseous Carcinoma | 432.e1 | ||
| Sclerosing Odontogenic Carcinoma | 432.e2 | ||
| Clear Cell Odontogenic Carcinoma | 432.e2 | ||
| Ghost Cell Odontogenic Carcinoma | 432.e2 | ||
| Odontogenic Carcinosarcoma | 432.e2 | ||
| 17 Non-Neoplastic Lesions of the Ear and Temporal Bone | 433 | ||
| ■ First Branchial Cleft Anomalies | 433 | ||
| Clinical Features | 433 | ||
| Pathologic Features | 434 | ||
| Gross Findings | 434 | ||
| Microscopic Findings | 434 | ||
| Differential Diagnosis | 435 | ||
| Prognosis and Therapy | 436 | ||
| ■ Cystic Chondromalacia | 436 | ||
| Clinical Features | 436 | ||
| Pathologic Features | 437 | ||
| Gross Findings | 437 | ||
| Microscopic Findings | 437 | ||
| Differential Diagnosis | 437 | ||
| Prognosis and Therapy | 438 | ||
| ■ Chondrodermatitis Nodular Helicis | 439 | ||
| Clinical Features | 439 | ||
| Pathologic Features | 439 | ||
| Gross Findings | 439 | ||
| Microscopic Findings | 439 | ||
| Differential Diagnosis | 441 | ||
| Prognosis and Therapy | 441 | ||
| ■ Angiolymphoid Hyperplasia With Eosinophilia | 441 | ||
| Clinical Features | 441 | ||
| Pathologic Features | 442 | ||
| Gross Findings | 442 | ||
| Microscopic Findings | 442 | ||
| Differential Diagnosis | 442 | ||
| Prognosis and Therapy | 444 | ||
| ■ Relapsing Polychondritis | 444 | ||
| Clinical Features | 444 | ||
| Pathologic Features | 445 | ||
| Gross Findings | 445 | ||
| Microscopic Findings | 445 | ||
| Differential Diagnosis | 445 | ||
| Prognosis and Therapy | 446 | ||
| ■ Cholesteatoma | 446 | ||
| Clinical Features | 446 | ||
| Radiographic Features | 447 | ||
| Pathologic Features | 447 | ||
| Gross Findings | 447 | ||
| Microscopic Findings | 447 | ||
| Ancillary Studies | 450 | ||
| Differential Diagnosis | 450 | ||
| Prognosis and Therapy | 450 | ||
| ■ Cholesterol Granuloma | 450 | ||
| Clinical Features | 450 | ||
| Radiographic Features | 450 | ||
| Pathologic Features | 451 | ||
| Gross Findings | 451 | ||
| Microscopic Findings | 451 | ||
| Differential Diagnosis | 451 | ||
| Prognosis and Therapy | 452 | ||
| Suggested Readings | 452 | ||
| Suggested Readings | 452.e1 | ||
| First Branchial Cleft Anomalies | 452.e1 | ||
| Cystic Chondromalacia | 452.e1 | ||
| Chondrodermatitis Nodular Helicis | 452.e1 | ||
| Angiolymphoid Hyperplasia With Eosinophilia | 452.e1 | ||
| Relapsing Polychondritis | 452.e1 | ||
| Cholesteatoma | 452.e1 | ||
| Cholesterol Granuloma | 452.e2 | ||
| 18 Benign Neoplasms of the Ear and Temporal Bone | 453 | ||
| ■ Ceruminous Adenoma | 453 | ||
| Clinical Features | 453 | ||
| Pathologic Features | 453 | ||
| Gross Findings | 453 | ||
| Microscopic Findings | 453 | ||
| Ancillary Studies | 454 | ||
| Differential Diagnosis | 454 | ||
| Prognosis and Therapy | 457 | ||
| ■ Langerhans Cell Histiocytosis | 457 | ||
| Clinical Features | 457 | ||
| Radiographic Features | 457 | ||
| Pathologic Features | 457 | ||
| Gross Findings | 457 | ||
| Microscopic Findings | 457 | ||
| Ancillary Studies | 458 | ||
| Ultrastructural Findings | 458 | ||
| Immunohistochemistry | 458 | ||
| Molecular Findings | 460 | ||
| Differential Diagnosis | 460 | ||
| Prognosis and Therapy | 460 | ||
| ■ Peripheral Nerve Sheath Tumor (Schwannoma) | 460 | ||
| Clinical Features | 461 | ||
| Radiographic Features | 461 | ||
| Pathologic Features | 461 | ||
| Gross Findings | 461 | ||
| Microscopic Findings | 461 | ||
| Ancillary Studies | 462 | ||
| Immunohistochemical Findings | 462 | ||
| Genetic Studies | 462 | ||
| Differential Diagnosis | 462 | ||
| Prognosis and Therapy | 463 | ||
| ■ Paraganglioma | 463 | ||
| Clinical Features | 463 | ||
| Radiographic Features | 464 | ||
| Pathologic Features | 464 | ||
| Gross Findings | 464 | ||
| Microscopic Findings | 464 | ||
| Ancillary Studies | 466 | ||
| Immunohistochemical Findings | 466 | ||
| Genetic Studies | 466 | ||
| Differential Diagnosis | 466 | ||
| Prognosis and Therapy | 467 | ||
| ■ Meningioma | 467 | ||
| Clinical Features | 467 | ||
| Radiographic Features | 468 | ||
| Pathologic Features | 468 | ||
| Gross Findings | 468 | ||
| Microscopic Findings | 468 | ||
| Ancillary Studies | 468 | ||
| Differential Diagnosis | 469 | ||
| Prognosis and Therapy | 470 | ||
| ■ Middle Ear Adenoma (Neuroendocrine Adenoma of the Middle Ear) | 470 | ||
| Clinical Features | 470 | ||
| Pathologic Features | 471 | ||
| Gross Findings | 471 | ||
| Microscopic Findings | 472 | ||
| Ancillary Studies | 472 | ||
| Ultrastructural Findings | 472 | ||
| Histochemical Findings | 474 | ||
| Immunohistochemical Findings | 474 | ||
| Differential Diagnosis | 474 | ||
| Prognosis and Therapy | 474 | ||
| ■ Endolymphatic Sac Tumor | 475 | ||
| Clinical Features | 475 | ||
| Radiographic Features | 475 | ||
| Pathologic Features | 475 | ||
| Gross Findings | 475 | ||
| Microscopic Findings | 476 | ||
| Ancillary Studies | 476 | ||
| Immunohistochemical Findings | 476 | ||
| Genetic Studies | 477 | ||
| Differential Diagnosis | 477 | ||
| Prognosis and Therapy | 477 | ||
| Suggested Readings | 477 | ||
| Suggested Readings | 477.e1 | ||
| Ceruminous Adenoma | 477.e1 | ||
| Langerhans Cell Histiocytosis | 477.e1 | ||
| Peripheral Nerve Sheath Tumor (Schwannoma) | 477.e1 | ||
| Paraganglioma | 477.e1 | ||
| Meningioma | 477.e2 | ||
| Middle Ear Adenoma | 477.e2 | ||
| Endolymphatic Sac Tumor | 477.e2 | ||
| 19 Malignant Neoplasms of the Ear and Temporal Bone | 478 | ||
| ■ Squamous Cell Carcinoma (External Auditory Canal and Middle Ear) | 478 | ||
| Clinical Features | 478 | ||
| Pathologic Features | 478 | ||
| Gross Findings | 478 | ||
| Microscopic Findings | 478 | ||
| Ancillary Studies | 480 | ||
| Differential Diagnosis | 481 | ||
| Prognosis and Therapy | 481 | ||
| ■ Ceruminous Adenocarcinoma | 481 | ||
| Clinical Features | 481 | ||
| Radiographic Features | 481 | ||
| Pathologic Features | 482 | ||
| Ancillary Studies | 483 | ||
| Differential Diagnosis | 483 | ||
| Prognosis and Therapy | 484 | ||
| ■ Metastatic Neoplasms | 484 | ||
| Clinical Features | 484 | ||
| Pathologic Features | 484 | ||
| Ancillary Studies | 487 | ||
| Differential Diagnosis | 487 | ||
| Prognosis and Therapy | 487 | ||
| Suggested Readings | 487 | ||
| Suggested Readings | 487.e1 | ||
| Squamous Cell Carcinoma (External Auditory Canal and Middle Ear) | 487.e1 | ||
| Ceruminous Adenocarcinoma | 487.e1 | ||
| Metastatic Neoplasms | 487.e1 | ||
| 20 Non-Neoplastic Lesions of the Neck (Soft Tissue, Bone, and Lymph Node) | 488 | ||
| ■ Branchial Cleft Anomalies | 488 | ||
| Clinical Features | 488 | ||
| Radiographic Features | 488 | ||
| Pathologic Features | 488 | ||
| Gross Findings | 488 | ||
| Microscopic Findings | 488 | ||
| Ancillary Studies | 489 | ||
| Immunohistochemical Findings | 489 | ||
| Fine Needle Aspiration | 489 | ||
| Differential Diagnosis | 490 | ||
| Prognosis and Therapy | 492 | ||
| ■ Cat Scratch Disease (Granulomatous Inflammation) | 492 | ||
| Clinical Features | 492 | ||
| Pathologic Features | 492 | ||
| Gross Findings | 492 | ||
| Microscopic Findings | 492 | ||
| Ancillary Studies | 493 | ||
| Histochemical Findings | 493 | ||
| Fine Needle Aspiration | 493 | ||
| Immunohistochemical Findings | 493 | ||
| Additional Studies | 494 | ||
| Differential Diagnosis | 494 | ||
| Prognosis and Therapy | 494 | ||
| ■ Bacillary Angiomatosis | 494 | ||
| Clinical Features | 494 | ||
| Pathologic Features | 494 | ||
| Microscopic findings | 494 | ||
| Ancillary Studies | 495 | ||
| Differential Diagnosis | 495 | ||
| Prognosis and Therapy | 495 | ||
| ■ Cervicofacial Actinomycosis | 496 | ||
| Clinical Features | 496 | ||
| Radiographic Features | 496 | ||
| 21 Benign Neoplasms of the Neck (Soft Tissue, Bone, and Lymph Node) | 509 | ||
| ■ Lymphangioma (Cystic Hygroma) | 509 | ||
| Clinical Features | 509 | ||
| Pathologic Features | 509 | ||
| Ancillary Studies | 510 | ||
| Differential Diagnosis | 511 | ||
| Prognosis and Therapy | 511 | ||
| ■ Teratoma | 512 | ||
| Clinical Features | 512 | ||
| Pathologic Features | 513 | ||
| Gross Findings | 513 | ||
| Microscopic Findings | 513 | ||
| Ancillary Studies | 514 | ||
| Differential Diagnosis | 514 | ||
| Prognosis and Therapy | 515 | ||
| ■ Ectopic Hamartomatous Thymoma | 515 | ||
| Clinical Features | 515 | ||
| Pathological Features | 515 | ||
| Gross Findings | 515 | ||
| Microscopic Findings | 516 | ||
| Ancillary Studies | 517 | ||
| Immunohistochemical Findings | 517 | ||
| Differential Diagnosis | 517 | ||
| Prognosis and Therapy | 517 | ||
| ■ Spindle Cell Lipoma/ Pleomorphic Lipoma | 517 | ||
| Clinical Features | 518 | ||
| Pathologic Features | 518 | ||
| Gross Findings | 518 | ||
| Microscopic Findings | 518 | ||
| Ancillary Studies | 520 | ||
| Ultrastructural Findings | 520 | ||
| Immunohistochemical Findings | 520 | ||
| Fine Needle Aspiration | 520 | ||
| Molecular Studies | 520 | ||
| Differential Diagnosis | 520 | ||
| Prognosis and Therapy | 520 | ||
| Suggested Readings | 520 | ||
| Suggested Readings | 520.e1 | ||
| Lymphangioma (Cystic Hygroma) | 520.e1 | ||
| Teratoma | 520.e1 | ||
| Ectopic Hamartomatous Thymoma | 520.e1 | ||
| Spindle Cell Lipoma/Pleomorphic Lipoma | 520.e1 | ||
| 22 Malignant Neoplasms of the Neck (Soft Tissue and Lymph Node) | 521 | ||
| ■ Metastatic Squamous Cell Carcinoma | 521 | ||
| Clinical Features | 521 | ||
| Radiographic Features | 522 | ||
| Pathologic Features | 522 | ||
| Gross Findings | 522 | ||
| Microscopic Findings | 522 | ||
| Ancillary Studies | 524 | ||
| Immunohistochemical and Molecular Findings | 524 | ||
| Fine Needle Aspiration | 527 | ||
| Differential Diagnosis | 527 | ||
| Prognosis and Therapy | 528 | ||
| ■ Metastatic Neoplasm of Unknown Primary | 528 | ||
| Clinical Features | 528 | ||
| Pathologic Features | 529 | ||
| Gross Findings | 529 | ||
| Microscopic Findings | 529 | ||
| Ancillary Studies | 529 | ||
| Histochemical and Immunohistochemical Findings | 529 | ||
| Fine Needle Aspiration | 530 | ||
| Differential Diagnosis | 530 | ||
| Prognosis and Therapy | 530 | ||
| ■ Synovial Sarcoma | 531 | ||
| Clinical Features | 531 | ||
| Radiographic Features | 531 | ||
| Pathologic Features | 532 | ||
| Gross Findings | 532 | ||
| Microscopic Findings | 532 | ||
| Ancillary Studies | 534 | ||
| Immunohistochemical Findings | 534 | ||
| Fine Needle Aspiration | 534 | ||
| Molecular Findings | 536 | ||
| Differential Diagnosis | 536 | ||
| Prognosis and Therapy | 536 | ||
| ■ Chordoma | 537 | ||
| Clinical Features | 537 | ||
| Radiographic Features | 537 | ||
| Pathologic Features | 538 | ||
| Gross Findings | 538 | ||
| Microscopic Findings | 538 | ||
| Ancillary Studies | 538 | ||
| Immunohistochemical Findings | 538 | ||
| Fine Needle Aspiration | 539 | ||
| Molecular Findings | 541 | ||
| Differential Diagnosis | 541 | ||
| Prognosis and Therapy | 541 | ||
| Suggested Readings | 541 | ||
| Suggested Readings | 541.e1 | ||
| Metastatic Squamous Cell Carcinoma | 541.e1 | ||
| Metastatic Neoplasm of Unknown Primary | 541.e1 | ||
| Synovial Sarcoma | 541.e1 | ||
| Chordoma | 541.e1 | ||
| 23 Non-Neoplastic Lesions of the Thyroid Gland | 542 | ||
| ■ Thyroglossal Duct Cyst | 542 | ||
| Clinical Features | 542 | ||
| Radiographic Features | 542 | ||
| Pathologic Features | 542 | ||
| Gross Findings | 542 | ||
| Microscopic Findings | 543 | ||
| Ancillary Studies | 544 | ||
| Fine Needle Aspiration | 544 | ||
| Differential Diagnosis | 544 | ||
| Prognosis and Therapy | 544 | ||
| ■ Thyroid Ectopia and Lingual Thyroid | 546 | ||
| Clinical Features | 546 | ||
| Radiographic Features | 546 | ||
| Pathologic Features | 546 | ||
| Gross Findings | 546 | ||
| Microscopic Findings | 547 | ||
| Ancillary Studies | 547 | ||
| Fine Needle Aspiration | 547 | ||
| Differential Diagnosis | 547 | ||
| Prognosis and Therapy | 548 | ||
| ■ Ultimobranchial Body Remnants (Solid Cell Nests) and Other Intrathyroidal Inclusions | 548 | ||
| Clinical Features | 548 | ||
| Pathologic Features | 548 | ||
| Ancillary Studies | 548 | ||
| Immunohistochemical Findings | 548 | ||
| Differential Diagnosis | 549 | ||
| Prognosis and Therapy | 551 | ||
| ■ Acute Thyroiditis | 551 | ||
| Clinical Features | 551 | ||
| Pathologic Features | 551 | ||
| Gross Findings | 551 | ||
| Microscopic Findings | 551 | ||
| Ancillary Studies | 551 | ||
| Fine Needle Aspiration | 551 | ||
| Differential Diagnosis | 552 | ||
| Prognosis and Therapy | 552 | ||
| ■ Subacute Granulomatous Thyroiditis (De Quervain Thyroiditis) | 552 | ||
| Clinical Features | 553 | ||
| Radiographic Features | 553 | ||
| Laboratory Studies | 553 | ||
| Pathologic Features | 553 | ||
| Gross Findings | 553 | ||
| Microscopic Findings | 553 | ||
| Ancillary Studies | 554 | ||
| Fine Needle Aspiration | 554 | ||
| Differential Diagnosis | 554 | ||
| Prognosis and Therapy | 557 | ||
| ■ Invasive Fibrous Thyroiditis (IgG4-Related Thyroiditis; Riedel Thyroiditis) | 557 | ||
| Clinical Features | 558 | ||
| Radiographic Features | 558 | ||
| Laboratory Studies | 558 | ||
| Pathologic Features | 559 | ||
| Gross Findings | 559 | ||
| Microscopic Findings | 559 | ||
| Ancillary Studies | 561 | ||
| Immunohistochemical Findings | 561 | ||
| Fine Needle Aspiration | 561 | ||
| Differential Diagnosis | 561 | ||
| Prognosis and Therapy | 561 | ||
| ■ Chronic Lymphocytic Thyroiditis (Hashimoto Thyroiditis) | 562 | ||
| Clinical Features | 562 | ||
| Radiographic Features | 562 | ||
| Laboratory Studies | 563 | ||
| Pathologic Features | 563 | ||
| Gross Findings | 563 | ||
| Microscopic Findings | 563 | ||
| Ancillary Studies | 566 | ||
| Immunohistochemical Findings | 566 | ||
| Fine Needle Aspiration | 566 | ||
| Differential Diagnosis | 566 | ||
| Prognosis and Therapy | 567 | ||
| ■ Diffuse Hyperplasia (Graves DISEASE) | 567 | ||
| Clinical Features | 568 | ||
| Radiographic Features | 568 | ||
| Laboratory Studies | 569 | ||
| Pathologic Features | 569 | ||
| Gross Findings | 569 | ||
| Microscopic Findings | 570 | ||
| Ancillary Studies | 571 | ||
| Fine Needle Aspiration | 571 | ||
| Differential Diagnosis | 574 | ||
| Prognosis and Therapy | 574 | ||
| ■ Nodular Hyperplasia (Adenomatoid Nodules, Multinodular Goiter) | 575 | ||
| Clinical Features | 575 | ||
| Radiographic Features | 575 | ||
| Laboratory Studies | 576 | ||
| Pathologic Features | 576 | ||
| Gross Findings | 576 | ||
| Microscopic Findings | 577 | ||
| Ancillary Studies | 582 | ||
| Fine Needle Aspiration | 582 | ||
| Differential Diagnosis | 582 | ||
| Prognosis and Therapy | 583 | ||
| ■ Dyshormonogenetic Goiter | 583 | ||
| Clinical Features | 584 | ||
| Laboratory Studies | 584 | ||
| Pathologic Features | 584 | ||
| Gross Findings | 584 | ||
| Microscopic Findings | 584 | ||
| Ancillary Studies | 586 | ||
| Fine Needle Aspiration | 586 | ||
| Differential Diagnosis | 586 | ||
| Prognosis and Therapy | 586 | ||
| ■ Amyloid Goiter | 586 | ||
| Clinical Features | 587 | ||
| Pathologic Features | 587 | ||
| Gross Findings | 587 | ||
| Microscopic Findings | 587 | ||
| Ancillary Studies | 588 | ||
| Ultrastructural Findings | 588 | ||
| Histochemical Findings | 588 | ||
| Mass Spectrometry | 589 | ||
| Differential Diagnosis | 589 | ||
| Prognosis and Therapy | 589 | ||
| ■ Amiodarone-Induced Thyroid Disease | 589 | ||
| Clinical Features | 590 | ||
| Laboratory Studies | 590 | ||
| Pathologic Features | 590 | ||
| Gross Findings | 590 | ||
| Microscopic Features | 590 | ||
| Differential Diagnosis | 591 | ||
| Prognosis and Therapy | 592 | ||
| Suggested Readings | 592 | ||
| Suggested Readings | 592.e1 | ||
| Thyroglossal Duct Cyst | 592.e1 | ||
| Thyroid Ectopia and Lingual Thyroid | 592.e1 | ||
| Ultimobranchial Body Remnants (Solid Cell Nests) and Other Intrathyroidal Inclusions | 592.e1 | ||
| Acute Thyroiditis | 592.e1 | ||
| Subacute Granulomatous Thyroiditis (de Quervain Thyroiditis) | 592.e1 | ||
| Invasive Fibrous Thyroiditis (IgG4-Related Thyroiditis; Riedel Thyroiditis) | 592.e1 | ||
| Chronic Lymphocytic Thyroiditis (Hashimoto Thyroiditis) | 592.e2 | ||
| Diffuse Hyperplasia (Graves Disease) | 592.e2 | ||
| Adenomatoid Nodules (Multinodular Goiter) | 592.e2 | ||
| Dyshormonogenetic Goiter | 592.e2 | ||
| Amyloid Goiter | 592.e2 | ||
| Amiodarone-Induced Thyroid Disease | 592.e2 | ||
| 24 Benign Neoplasms of the Thyroid Gland | 593 | ||
| ■ Follicular Adenoma | 593 | ||
| Clinical Features | 593 | ||
| Radiographic Features | 593 | ||
| Pathologic Features | 594 | ||
| Gross Findings | 594 | ||
| Microscopic Findings | 594 | ||
| Ancillary Studies | 599 | ||
| Immunohistochemical Findings | 599 | ||
| Fine Needle Aspiration | 602 | ||
| Intraoperative Frozen Section | 602 | ||
| Genetics | 602 | ||
| Differential Diagnosis | 603 | ||
| Prognosis and Therapy | 604 | ||
| ■ Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features | 604 | ||
| Clinical Features | 604 | ||
| Radiographic Features | 604 | ||
| Pathologic Features | 605 | ||
| Gross Findings | 605 | ||
| Microscopic Findings | 605 | ||
| Ancillary Studies | 606 | ||
| Immunohistochemical Findings | 606 | ||
| Fine Needle Aspiration | 607 | ||
| Genetics | 607 | ||
| Differential Diagnosis | 607 | ||
| Prognosis and Therapy | 607 | ||
| ■ Hyalinizing Trabecular Tumor | 608 | ||
| Clinical Features | 608 | ||
| Pathologic Features | 609 | ||
| Gross Findings | 609 | ||
| Microscopic Findings | 609 | ||
| Ancillary Studies | 611 | ||
| Immunohistochemical Findings | 611 | ||
| Fine Needle Aspiration | 611 | ||
| Differential Diagnosis | 613 | ||
| Prognosis and Therapy | 613 | ||
| ■ Teratoma | 613 | ||
| Clinical Features | 613 | ||
| Radiographic Features | 614 | ||
| Pathologic Features | 614 | ||
| Gross Findings | 614 | ||
| Microscopic Findings | 614 | ||
| Ancillary Studies | 615 | ||
| Immunohistochemical Findings | 615 | ||
| Fine Needle Aspiration | 616 | ||
| Differential Diagnosis | 616 | ||
| Prognosis and Therapy | 618 | ||
| Suggested Readings | 618 | ||
| Suggested Readings | 618.e1 | ||
| Follicular Adenoma | 618.e1 | ||
| Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Findings (NIFTP) | 618.e1 | ||
| Hyalinizing Trabecular Tumor | 618.e1 | ||
| Teratoma | 618.e2 | ||
| 25 Malignant Neoplasms of the Thyroid Gland | 619 | ||
| ■ Papillary THYROID Carcinoma | 619 | ||
| Clinical FEATURES | 619 | ||
| Radiographic Features | 620 | ||
| Pathologic FEATURES | 621 | ||
| Gross Findings | 621 | ||
| Microscopic Findings | 621 | ||
| Ancillary Studies | 627 | ||
| Immunohistochemical Findings | 627 | ||
| Fine Needle Aspiration | 628 | ||
| Molecular Findings | 628 | ||
| Differential Diagnosis | 630 | ||
| Prognosis and Therapy | 630 | ||
| ■ Histological Variants of Papillary Carcinoma | 632 | ||
| Encapsulated Variant | 633 | ||
| Follicular Variant | 633 | ||
| Macrofollicular Variant | 634 | ||
| Oncocytic Variant | 635 | ||
| Clear Cell Variant | 637 | ||
| Spindle Cell Variant | 638 | ||
| Diffuse Sclerosing Variant | 638 | ||
| Tall Cell Variant | 639 | ||
| Columnar Cell Variant | 640 | ||
| Solid Variant | 640 | ||
| Cribriform-Morular Variant | 640 | ||
| Hobnail Variant | 643 | ||
| Papillary Carcinoma-Size Variation | 643 | ||
| ■ Follicular Carcinoma | 643 | ||
| Clinical Features | 645 | ||
| Pathologic Features | 645 | ||
| Gross Findings | 645 | ||
| Microscopic Findings | 646 | ||
| Ancillary Studies | 650 | ||
| Immunohistochemical Findings | 650 | ||
| Fine Needle Aspiration | 650 | ||
| Frozen Section | 651 | ||
| Molecular Findings | 651 | ||
| Differential Diagnosis | 651 | ||
| Prognosis and Therapy | 652 | ||
| ■ Undifferentiated Carcinoma | 652 | ||
| Clinical Features | 652 | ||
| Pathologic Features | 654 | ||
| Gross Findings | 654 | ||
| Microscopic Findings | 654 | ||
| Ancillary Studies | 656 | ||
| Immunohistochemical Findings | 656 | ||
| Fine Needle Aspiration | 656 | ||
| Molecular Findings | 656 | ||
| Differential Diagnosis | 656 | ||
| Prognosis and Therapy | 656 | ||
| ■ Medullary THYROID Carcinoma | 656 | ||
| Clinical Features | 658 | ||
| Radiographic Features | 659 | ||
| Pathologic Features | 659 | ||
| Gross Findings | 659 | ||
| Microscopic Findings | 659 | ||
| Ancillary Studies | 666 | ||
| Histochemical and Immunohistochemical Findings | 666 | ||
| Fine Needle Aspiration | 667 | ||
| Molecular Findings | 667 | ||
| Differential Diagnosis | 667 | ||
| Prognosis and Therapy | 667 | ||
| ■ Primary Thyroid Gland Lymphoma | 667 | ||
| Clinical Features | 668 | ||
| Pathologic Features | 669 | ||
| Gross Findings | 669 | ||
| Microscopic Findings | 669 | ||
| Ancillary Studies | 673 | ||
| Immunohistochemical Findings | 673 | ||
| Fine Needle Aspiration | 675 | ||
| Differential Diagnosis | 675 | ||
| Prognosis and Therapy | 676 | ||
| ■ Uncommon Thyroid Neoplasms | 677 | ||
| Mucoepidermoid Carcinoma | 677 | ||
| Squamous Cell Carcinoma | 679 | ||
| Thymic and Related Branchial Pouch Neoplasms | 680 | ||
| Mesenchymal Tumors | 682 | ||
| ■ Metastatic Neoplasms | 687 | ||
| Clinical Features | 687 | ||
| Pathologic Features | 688 | ||
| Gross Findings | 688 | ||
| Microscopic Findings | 689 | ||
| Ancillary Studies | 689 | ||
| Differential Diagnosis | 691 | ||
| Prognosis and Therapy | 691 | ||
| Suggested Readings | 691 | ||
| Suggested Readings | 691.e1 | ||
| Papillary Carcinoma (Including Variants) | 691.e1 | ||
| Follicular Carcinoma | 691.e2 | ||
| Undifferentiated (Anaplastic) Carcinoma | 691.e3 | ||
| Medullary Thyroid Carcinoma | 691.e3 | ||
| Primary Thyroid Lymphoma | 691.e4 | ||
| Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma With Eosinophilia | 691.e4 | ||
| Squamous Cell Carcinoma | 691.e4 | ||
| Spindle Cell Tumor With Thymus-Like Differentiation | 691.e5 | ||
| Carcinoma Showing Thymus-Like Differentiation | 691.e5 | ||
| Mesenchymal Tumors | 691.e5 | ||
| Metastatic Neoplasms | 691.e6 | ||
| 26 Non-Neoplastic Lesions of the Parathyroid Glands | 692 | ||
| ■ General Considerations | 692 | ||
| ■ Primary Chief Cell Hyperplasia | 693 | ||
| Clinical Features | 693 | ||
| Radiographic Features | 693 | ||
| Pathologic Features | 694 | ||
| Gross Findings | 694 | ||
| Microscopic Findings | 694 | ||
| Primary Chief Cell Hyperplasia | 694 | ||
| Water-Clear Cell Hyperplasia | 694 | ||
| Ancillary Studies | 698 | ||
| Differential Diagnosis | 699 | ||
| Prognosis and Therapy | 700 | ||
| ■ Secondary and Tertiary Parathyroid Hyperplasia | 700 | ||
| Clinical Features | 700 | ||
| Pathologic Features | 701 | ||
| Gross Findings | 701 | ||
| Microscopic Findings | 701 | ||
| Differential Diagnosis | 701 | ||
| Prognosis and Therapy | 701 | ||
| Suggested Readings | 702 | ||
| Suggested Readings | 702.e1 | ||
| Primary Chief Cell Hyperplasia | 702.e1 | ||
| Secondary and Tertiary Parathyroid Hyperplasia | 702.e1 | ||
| 27 Benign Neoplasms of the Parathyroid Gland | 703 | ||
| ■ Parathyroid Adenoma | 703 | ||
| Clinical Features | 703 | ||
| Radiographic Features | 704 | ||
| Pathologic Features | 704 | ||
| Gross Findings | 704 | ||
| Microscopic Findings | 704 | ||
| Ancillary Studies | 710 | ||
| Immunohistochemical Findings | 710 | ||
| Histochemistry | 710 | ||
| Fine Needle Aspiration | 710 | ||
| Molecular Findings | 711 | ||
| Differential Diagnosis | 711 | ||
| Prognosis and Therapy | 712 | ||
| Suggested Readings | 712 | ||
| Suggested Readings | 712.e1 | ||
| Parathyroid Adenoma | 712.e1 | ||
| 28 Malignant Neoplasms of the Parathyroid Gland | 713 | ||
| ■ Parathyroid Carcinoma | 713 | ||
| Clinical Features | 713 | ||
| Pathologic Features | 714 | ||
| Gross Findings | 714 | ||
| Microscopic Findings | 714 | ||
| Ancillary Studies | 722 | ||
| Immunohistochemical Findings | 722 | ||
| Molecular Findings | 722 | ||
| Differential Diagnosis | 722 | ||
| Prognosis and Therapy | 724 | ||
| ■ Metastatic Tumors | 725 | ||
| Clinical Features | 726 | ||
| Pathologic Features | 726 | ||
| Gross Findings | 726 | ||
| Microscopic Findings | 726 | ||
| Prognosis and Therapy | 727 | ||
| Suggested Readings | 727 | ||
| Suggested Readings | 727.e1 | ||
| Parathyroid Carcinoma | 727.e1 | ||
| Metastatic Tumors | 727.e1 | ||
| 29 Diseases of the Paraganglia System | 728 | ||
| ■ Paraganglioma | 728 | ||
| Clinical Features | 728 | ||
| Radiographic Features | 730 | ||
| Pathologic Features | 730 | ||
| Gross Findings | 730 | ||
| Microscopic Findings | 731 | ||
| Ancillary Studies | 733 | ||
| Ultrastructural Findings | 733 | ||
| Immunohistochemical Findings | 735 | ||
| Fine Needle Aspiration | 736 | ||
| Differential Diagnosis | 736 | ||
| Middle Ear/Jugulotympanic Paraganglioma | 736 | ||
| Vagal and Carotid Body Tumors | 737 | ||
| Laryngeal Paraganglioma | 738 | ||
| Prognosis and Therapy | 738 | ||
| ■ Malignant Paraganglioma | 739 | ||
| Clinical Features | 739 | ||
| Radiographic Features | 739 | ||
| Pathologic Features | 739 | ||
| Gross Findings | 739 | ||
| Microscopic Findings | 739 | ||
| Ancillary Studies | 740 | ||
| Differential Diagnosis | 740 | ||
| Prognosis and Therapy | 741 | ||
| Suggested Readings | 741 | ||
| Suggested Readings | 741.e1 | ||
| Paraganglioma | 741.e1 | ||
| Malignant Paraganglioma | 741.e1 | ||
| ■ Index | 743 | ||
| A | 743 | ||
| B | 744 | ||
| C | 745 | ||
| D | 747 | ||
| E | 747 | ||
| F | 748 | ||
| G | 749 | ||
| H | 750 | ||
| I | 751 | ||
| J | 751 | ||
| K | 751 | ||
| L | 751 | ||
| M | 752 | ||
| N | 754 | ||
| O | 755 | ||
| P | 756 | ||
| R | 758 | ||
| S | 759 | ||
| T | 761 | ||
| U | 763 | ||
| V | 763 | ||
| W | 763 | ||
| Z | 763 | ||
| Inside Back Cover | ibc1 |