BOOK
Principles of Pulmonary Medicine E-Book
Steven E. Weinberger | Barbara A. Cockrill | Jess Mandel
(2017)
Additional Information
Book Details
Abstract
With an emphasis on the pathophysiologic basis of pulmonary disease, Principles of Pulmonary Medicine, 7th Edition, by Drs. Steven E Weinberger, Barbara A Cockrill, and Jess Mandel, provides a superbly illustrated introduction to this fast-changing field. This essential text employs a concise and understandable approach, integrating clinical topics with underlying physiologic, pathophysiologic, and basic science concepts critical for medical students, trainees, and those looking for a practical update on both acute and chronic pulmonary diseases
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | cover | ||
| Inside Front Cover | ifc1 | ||
| Principles of Pulmonary Medicine | i | ||
| Copyright Page | iv | ||
| Dedication | v | ||
| Introduction to the Seventh Edition | vii | ||
| Table Of Contents | ix | ||
| Online Contents | xi | ||
| 1 Pulmonary Anatomy and Physiology | 1 | ||
| Abstract | 1.e1 | ||
| Keywords | 1.e1 | ||
| Anatomy | 1 | ||
| Physiology | 3 | ||
| Mechanical Aspects of the Lungs and Chest Wall | 3 | ||
| Ventilation | 5 | ||
| Circulation | 7 | ||
| Diffusion | 8 | ||
| Oxygen Transport | 8 | ||
| Carbon Dioxide Transport | 11 | ||
| Ventilation-Perfusion Relationships | 12 | ||
| Abnormalities in Gas Exchange | 15 | ||
| Hypoxemia | 15 | ||
| Hypercapnia | 17 | ||
| References | 18 | ||
| 2 Presentation of the Patient with Pulmonary Disease | 19 | ||
| Abstract | 19.e1 | ||
| Keywords | 19.e1 | ||
| Dyspnea | 19 | ||
| Cough | 23 | ||
| Evaluation and Management of Cough | 25 | ||
| Hemoptysis | 26 | ||
| Chest Pain | 27 | ||
| References | 28 | ||
| Dyspnea | 28 | ||
| Cough | 28 | ||
| Hemoptysis | 28 | ||
| Chest Pain | 29 | ||
| 3 Evaluation of the Patient With Pulmonary Disease | 30 | ||
| Abstract | 30.e1 | ||
| Keywords | 30.e1 | ||
| Evaluation on a Macroscopic Level | 30 | ||
| Physical Examination | 30 | ||
| Chest Radiography | 34 | ||
| Computed Tomography | 37 | ||
| Magnetic Resonance Imaging | 42 | ||
| Radionuclide Lung Scanning | 43 | ||
| Perfusion and Ventilation Scanning | 43 | ||
| Positron Emission Tomography (Fluorodeoxyglucose Scanning) | 45 | ||
| Pulmonary Angiography | 45 | ||
| Ultrasonography | 46 | ||
| Bronchoscopy | 46 | ||
| Evaluation on a Microscopic Level | 48 | ||
| Obtaining Specimens | 49 | ||
| Processing Specimens | 50 | ||
| Assessment on a Functional Level | 52 | ||
| Pulmonary Function Tests | 52 | ||
| Lung Volumes | 52 | ||
| Flow Rates | 53 | ||
| Diffusing Capacity | 54 | ||
| Interpretation of Normality in Pulmonary Function Testing | 55 | ||
| Patterns of Pulmonary Function Impairment | 55 | ||
| Other Tests | 57 | ||
| Arterial Blood Gases | 58 | ||
| Pulse Oximetry | 60 | ||
| Exercise Testing | 61 | ||
| References | 62 | ||
| Physical Examination | 62 | ||
| Chest Roentgenography | 62 | ||
| Computed Tomography | 62 | ||
| Magnetic Resonance Imaging | 62 | ||
| Lung Scanning | 62 | ||
| Pulmonary Angiography | 62 | ||
| Ultrasound | 63 | ||
| Bronchoscopy | 63 | ||
| Obtaining and Processing Specimens | 63 | ||
| Assessment on a Functional Level | 63 | ||
| 4 Anatomic and Physiologic Aspects of Airways | 65 | ||
| Abstract | 65.e1 | ||
| Keywords | 65.e1 | ||
| Structure | 65 | ||
| Neural Control of Airways | 68 | ||
| Function | 70 | ||
| Airway Resistance | 70 | ||
| Maximal Expiratory Effort | 71 | ||
| References | 74 | ||
| 5 Asthma | 75 | ||
| Abstract | 75.e1 | ||
| Keywords | 75.e1 | ||
| Etiology and Pathogenesis | 75 | ||
| Predisposition to Asthma | 76 | ||
| Genetics | 76 | ||
| Acquired (Environmental) Factors | 76 | ||
| Airway Inflammation, Cytokine Mediators, and Bronchial Hyperresponsiveness | 77 | ||
| Asthma Phenotypes | 79 | ||
| Common Provocative Stimuli | 79 | ||
| Allergen Exposure | 79 | ||
| Histamine | 80 | ||
| Leukotrienes | 80 | ||
| Late-Phase Asthmatic Response | 80 | ||
| Inhaled Irritants | 82 | ||
| Respiratory Tract Infection | 82 | ||
| Exercise | 82 | ||
| Pathology | 82 | ||
| Pathophysiology | 83 | ||
| Clinical Features | 84 | ||
| Diagnostic Approach | 85 | ||
| Treatment | 87 | ||
| Bronchodilators | 87 | ||
| Antiinflammatory Drugs | 89 | ||
| Agents With Specific Targeted Action | 89 | ||
| Bronchial Thermoplasty | 90 | ||
| Management Strategy | 90 | ||
| References | 91 | ||
| Reviews | 91 | ||
| Etiology and Pathogenesis | 91 | ||
| Clinical Features and Diagnostic Approach | 91 | ||
| Treatment | 92 | ||
| 6 Chronic Obstructive Pulmonary Disease | 93 | ||
| Abstract | 93.e1 | ||
| Keywords | 93.e1 | ||
| Etiology and Pathogenesis | 94 | ||
| Smoking | 95 | ||
| Environmental and Indoor Pollution | 96 | ||
| Infection | 97 | ||
| Genetic Factors | 97 | ||
| Pathology | 98 | ||
| Pathophysiology | 98 | ||
| Functional Abnormalities in Airways Disease | 99 | ||
| Functional Abnormalities in Emphysema | 102 | ||
| Mechanisms of Abnormal Gas Exchange | 102 | ||
| Pulmonary Hypertension | 104 | ||
| COPD Phenotypes | 104 | ||
| Clinical Features | 105 | ||
| Diagnostic Approach and Assessment | 106 | ||
| Treatment | 107 | ||
| References | 110 | ||
| Reviews | 110 | ||
| Etiology and Pathogenesis | 110 | ||
| Clinical Features | 111 | ||
| Treatment | 111 | ||
| 7 Miscellaneous Airway Diseases | 113 | ||
| Abstract | 113.e1 | ||
| Keywords | 113.e1 | ||
| Bronchiectasis | 113 | ||
| Etiology and Pathogenesis | 113 | ||
| Pathology | 114 | ||
| Pathophysiology | 115 | ||
| Clinical Features | 115 | ||
| Diagnostic Approach | 116 | ||
| Treatment | 116 | ||
| Cystic Fibrosis | 118 | ||
| Etiology and Pathogenesis | 118 | ||
| Pathology | 120 | ||
| Pathophysiology | 120 | ||
| Clinical Features | 120 | ||
| Diagnostic Approach | 121 | ||
| Treatment | 122 | ||
| Upper Airway Disease | 122 | ||
| Etiology | 123 | ||
| Pathophysiology | 123 | ||
| Clinical Features | 123 | ||
| Diagnostic Approach | 124 | ||
| Treatment | 124 | ||
| References | 124 | ||
| Bronchiectasis | 124 | ||
| Cystic Fibrosis | 125 | ||
| Upper Airway Disease | 125 | ||
| 8 Anatomic and Physiologic Aspects of the Pulmonary Parenchyma | 126 | ||
| Abstract | 126.e1 | ||
| Keywords | 126.e1 | ||
| Anatomy | 126 | ||
| Physiology | 129 | ||
| References | 131 | ||
| Anatomy | 131 | ||
| Physiology | 131 | ||
| 9 Overview of Diffuse Parenchymal Lung Diseases | 132 | ||
| Abstract | 132.e1 | ||
| Keywords | 132.e1 | ||
| Pathology | 134 | ||
| Pathology of Idiopathic Interstitial Pneumonias | 135 | ||
| End-Stage Diffuse Parenchymal Lung Disease | 138 | ||
| Pathogenesis | 138 | ||
| Pathophysiology | 140 | ||
| Decreased Compliance | 141 | ||
| Decrease in Lung Volumes | 141 | ||
| Impairment of Diffusion | 141 | ||
| Abnormalities in Small Airways Function | 142 | ||
| Disturbances in Gas Exchange | 142 | ||
| Pulmonary Hypertension | 142 | ||
| Clinical Features | 142 | ||
| Diagnostic Approach | 143 | ||
| References | 144 | ||
| 10 Diffuse Parenchymal Lung Diseases Associated With Known Etiologic Agents | 145 | ||
| Abstract | 145.e1 | ||
| Keywords | 145.e1 | ||
| Diseases Caused by Inhaled Inorganic Dusts | 145 | ||
| Silicosis | 146 | ||
| Coal Worker’s Pneumoconiosis | 146 | ||
| Asbestosis | 148 | ||
| Berylliosis | 150 | ||
| Hypersensitivity Pneumonitis | 151 | ||
| Drug-Induced Parenchymal Lung Disease | 153 | ||
| Radiation-Induced Lung Disease | 155 | ||
| References | 156 | ||
| Diseases Caused by Inhaled Inorganic Dusts | 156 | ||
| Hypersensitivity Pneumonitis | 157 | ||
| Drug-Induced Parenchymal Lung Disease | 157 | ||
| Radiation-Induced Lung Disease | 157 | ||
| 11 Diffuse Parenchymal Lung Diseases of Unknown Etiology | 158 | ||
| Abstract | 158.e1 | ||
| Keywords | 158.e1 | ||
| Idiopathic Pulmonary Fibrosis | 158 | ||
| Other Idiopathic Interstitial Pneumonias | 161 | ||
| Pulmonary Parenchymal Involvement Complicating Connective Tissue Disease | 163 | ||
| Sarcoidosis | 164 | ||
| Miscellaneous Disorders Involving the Pulmonary Parenchyma | 169 | ||
| Pulmonary Langerhans Cell Histiocytosis | 169 | ||
| Lymphangioleiomyomatosis | 170 | ||
| Goodpasture Syndrome | 171 | ||
| Granulomatosis with Polyangiitis | 172 | ||
| Chronic Eosinophilic Pneumonia | 173 | ||
| Pulmonary Alveolar Proteinosis | 174 | ||
| References | 174 | ||
| Idiopathic Pulmonary Fibrosis | 174 | ||
| Other Idiopathic Interstitial Pneumonias | 175 | ||
| Pulmonary Parenchymal Involvement Complicating Connective Tissue Disease | 175 | ||
| Sarcoidosis | 176 | ||
| Miscellaneous Disorders Involving the Pulmonary Parenchyma | 176 | ||
| 12 Anatomic and Physiologic Aspects of the Pulmonary Vasculature | 177 | ||
| Abstract | 177.e1 | ||
| Keywords | 177.e1 | ||
| Anatomy | 177 | ||
| Physiology | 178 | ||
| Pulmonary Vascular Resistance | 178 | ||
| Distribution of Pulmonary Blood Flow | 180 | ||
| Pulmonary Vascular Response to Hypoxia | 181 | ||
| Other Aspects of Pulmonary Vascular Physiology | 182 | ||
| References | 183 | ||
| 13 Pulmonary Embolism | 184 | ||
| Abstract | 184.e1 | ||
| Keywords | 184.e1 | ||
| Etiology and Pathogenesis | 184 | ||
| Pathology | 185 | ||
| Pathophysiology | 186 | ||
| Clinical Features | 187 | ||
| Diagnostic Evaluation | 188 | ||
| Treatment | 191 | ||
| References | 192 | ||
| General Reviews | 192 | ||
| Specific Aspects | 193 | ||
| 14 Pulmonary Hypertension | 194 | ||
| Abstract | 194.e1 | ||
| Keywords | 194.e1 | ||
| Pathogenesis | 195 | ||
| Pathology | 197 | ||
| Pathophysiology | 197 | ||
| Clinical Features | 199 | ||
| Diagnostic Features | 199 | ||
| Specific Disorders Associated With Pulmonary Hypertension | 201 | ||
| Idiopathic Pulmonary Arterial Hypertension and Related Disorders (Group 1 PAH) | 201 | ||
| Pulmonary Hypertension Owing to Left Heart Disease (Group 2 PH) | 202 | ||
| Pulmonary Hypertension Owing to Lung Disease and/or Hypoxia (Group 3 PH) | 203 | ||
| Chronic Thromboembolic Pulmonary Hypertension (Group 4 PH) | 203 | ||
| Pulmonary Hypertension With Unclear Multifactorial Mechanisms (Group 5 PH) | 204 | ||
| References | 204 | ||
| General Reviews | 204 | ||
| Pulmonary Arterial Hypertension and Related Disorders | 204 | ||
| Pulmonary Hypertension Related to Lung Disease | 205 | ||
| Chronic Thromboembolic Pulmonary Hypertension | 205 | ||
| Pulmonary Hypertension Associated With Left Heart Disease | 205 | ||
| Pulmonary Hypertension Associated With Multifactorial Mechanisms | 205 | ||
| 15 Pleural Disease | 206 | ||
| Abstract | 206.e1 | ||
| Keywords | 206.e1 | ||
| Anatomy | 206 | ||
| Physiology | 207 | ||
| Pleural Effusion | 209 | ||
| Pathogenesis of Pleural Fluid Accumulation | 209 | ||
| Etiology of Pleural Effusion | 210 | ||
| Transudative Pleural Fluid | 210 | ||
| Exudative Pleural Fluid | 211 | ||
| Clinical Features | 212 | ||
| Diagnostic Approach | 212 | ||
| Treatment | 214 | ||
| Pneumothorax | 215 | ||
| Etiology and Pathogenesis | 215 | ||
| Pathophysiology | 216 | ||
| Clinical Features | 217 | ||
| Diagnostic Approach | 217 | ||
| Treatment | 218 | ||
| References | 220 | ||
| General Reviews | 220 | ||
| Pleural Effusion | 220 | ||
| Pneumothorax | 220 | ||
| 16 Mediastinal Disease | 221 | ||
| Abstract | 221.e1 | ||
| Keywords | 221.e1 | ||
| Anatomic Features | 221 | ||
| Mediastinal Masses | 223 | ||
| Etiology | 223 | ||
| Anterior Mediastinal Masses | 223 | ||
| Middle Mediastinal Masses | 224 | ||
| Posterior Mediastinal Masses | 224 | ||
| Clinical Features | 224 | ||
| Diagnostic Approach | 224 | ||
| Treatment | 225 | ||
| Pneumomediastinum | 226 | ||
| Etiology and Pathogenesis | 226 | ||
| Pathophysiology | 226 | ||
| Clinical Features | 226 | ||
| Diagnostic Approach | 227 | ||
| Treatment | 227 | ||
| References | 227 | ||
| 17 Anatomic and Physiologic Aspects of Neural, Muscular, and Chest Wall Interactions with the Lungs | 229 | ||
| Abstract | 229.e1 | ||
| Keywords | 229.e1 | ||
| Respiratory Control | 229 | ||
| Organization of Respiratory Control | 230 | ||
| The Respiratory Generator | 230 | ||
| Input from Other Regions of the Central Nervous System | 231 | ||
| Chemoreceptors | 231 | ||
| Input from Other Receptors | 232 | ||
| Ventilatory Response to Hypercapnia and Hypoxia | 233 | ||
| Ventilatory Response to Other Stimuli | 235 | ||
| Respiratory Muscles | 235 | ||
| References | 237 | ||
| Respiratory Control | 237 | ||
| Respiratory Muscles | 238 | ||
| 18 Disorders of Ventilatory Control | 239 | ||
| Abstract | 239.e1 | ||
| Keywords | 239.e1 | ||
| Primary Neurologic Disease | 239 | ||
| Presentation with Hyperventilation | 239 | ||
| Presentation with Hypoventilation | 240 | ||
| Abnormal Patterns of Breathing | 240 | ||
| Cheyne-Stokes Breathing | 240 | ||
| Control Abnormalities Secondary to Lung Disease | 242 | ||
| Sleep Apnea Syndrome | 243 | ||
| Types | 243 | ||
| Clinical Features | 243 | ||
| Pathophysiology | 244 | ||
| Treatment | 246 | ||
| References | 246 | ||
| Primary Neurologic Disease | 246 | ||
| Cheyne-Stokes Breathing | 246 | ||
| Control Abnormalities Secondary to Lung Disease | 247 | ||
| Sleep Apnea Syndrome | 247 | ||
| 19 Disorders of the Respiratory Pump | 248 | ||
| Abstract | 248.e1 | ||
| Keywords | 248.e1 | ||
| Neuromuscular Disease Affecting the Muscles of Respiration | 248 | ||
| Specific Diseases | 248 | ||
| Pathophysiology and Clinical Consequences | 250 | ||
| Diaphragmatic Disease | 250 | ||
| Diaphragmatic Fatigue | 251 | ||
| Unilateral Diaphragmatic Paralysis | 252 | ||
| Bilateral Diaphragmatic Paralysis | 253 | ||
| DISORDERS Affecting the Chest Wall | 254 | ||
| Kyphoscoliosis | 254 | ||
| Obesity | 255 | ||
| References | 257 | ||
| Neuromuscular Disease Affecting The Muscles Of Respiration | 257 | ||
| Diaphragmatic Disease | 258 | ||
| Diseases Affecting the Chest Wall | 258 | ||
| 20 Lung Cancer | 259 | ||
| Abstract | 259.e1 | ||
| Key words | 259.e1 | ||
| Etiology and Pathogenesis | 260 | ||
| Smoking | 260 | ||
| Occupational Factors | 261 | ||
| Genetic Factors | 261 | ||
| Parenchymal Scarring | 262 | ||
| Miscellaneous Factors | 262 | ||
| Concepts of Lung Cancer Pathogenesis | 263 | ||
| Pathology | 263 | ||
| Squamous Cell Carcinoma | 264 | ||
| Small Cell Carcinoma | 265 | ||
| Adenocarcinoma | 266 | ||
| Large Cell Carcinoma | 268 | ||
| References | 268 | ||
| Etiology and Pathogenesis | 268 | ||
| Pathology | 268 | ||
| 21 Lung Cancer | 270 | ||
| Abstract | 270.e1 | ||
| Keywords | 270.e1 | ||
| Clinical Features | 270 | ||
| Symptoms Relating to Primary Lung Lesion | 271 | ||
| Symptoms Relating to Nodal and Distant Metastasis | 271 | ||
| Paraneoplastic Syndromes | 271 | ||
| Diagnostic Approach | 272 | ||
| Macroscopic Evaluation | 272 | ||
| Staging of Lung Cancer | 274 | ||
| Microscopic and Molecular Evaluation | 275 | ||
| Functional Assessment | 275 | ||
| Screening for Lung Cancer | 276 | ||
| Principles of Therapy | 276 | ||
| Treatment of Non–Small Cell Lung Cancer | 276 | ||
| Treatment of Small Cell Lung Cancer | 277 | ||
| Restoration of Airway Patency | 278 | ||
| Bronchial Carcinoid Tumors | 278 | ||
| Malignant Mesothelioma | 278 | ||
| Solitary Pulmonary Nodule | 281 | ||
| References | 282 | ||
| Lung Cancer: General Reviews and Clinical Aspects | 282 | ||
| Lung Cancer: Diagnostic Approaches | 283 | ||
| Lung Cancer: Treatment | 283 | ||
| Bronchial Carcinoids | 283 | ||
| Malignant Mesothelioma | 284 | ||
| Solitary Pulmonary Nodule | 284 | ||
| 22 Lung Defense Mechanisms | 285 | ||
| Abstract | 285.e1 | ||
| Keywords | 285.e1 | ||
| Physical or Anatomic Factors | 286 | ||
| Antimicrobial Peptides | 287 | ||
| Phagocytic and Inflammatory Cells | 288 | ||
| Pulmonary Alveolar Macrophages | 288 | ||
| Dendritic Cells | 289 | ||
| Polymorphonuclear Leukocytes | 290 | ||
| Natural Killer Cells | 290 | ||
| Adaptive Immune Responses | 290 | ||
| Humoral Immune Mechanisms | 291 | ||
| Cellular Immune Mechanisms | 292 | ||
| Failure of Respiratory Defense Mechanisms | 292 | ||
| Impairment of Physical Clearance | 292 | ||
| Impairment of Antimicrobial Peptides | 293 | ||
| Impairment of Phagocytic and Inflammatory Cells | 293 | ||
| Defects in the Adaptive Immune System | 294 | ||
| Augmentation of Respiratory Defense Mechanisms | 295 | ||
| References | 295 | ||
| Pulmonary Host Defenses | 295 | ||
| Augmentation of Respiratory Defense Mechanisms | 296 | ||
| 23 Pneumonia | 297 | ||
| Abstract | 297.e1 | ||
| Keywords | 297.e1 | ||
| Etiology and Pathogenesis | 298 | ||
| Bacteria | 299 | ||
| Viruses | 300 | ||
| Mycoplasma | 300 | ||
| Pathology | 301 | ||
| Pathophysiology | 301 | ||
| Clinical Features | 302 | ||
| Diagnostic Approach | 303 | ||
| Therapeutic Approach: General Principles and Antibiotic Susceptibility | 306 | ||
| Initial Management Strategies Based on Clinical Setting of Pneumonia | 307 | ||
| Community-Acquired Pneumonia | 307 | ||
| Nosocomial (Hospital-Acquired) Pneumonia | 309 | ||
| Intrathoracic Complications of Pneumonia | 310 | ||
| Lung Abscess | 310 | ||
| Empyema | 310 | ||
| Respiratory Infections Associated With Bioterrorism | 310 | ||
| Anthrax | 311 | ||
| Plague | 311 | ||
| Tularemia | 311 | ||
| References | 312 | ||
| General Articles | 312 | ||
| Pneumonia Caused by Specific Organisms | 312 | ||
| Respiratory Infections Associated With Bioterrorism | 313 | ||
| 24 Tuberculosis and Nontuberculous Mycobacteria | 314 | ||
| Abstract | 314.e1 | ||
| Keywords | 314.e1 | ||
| Etiology and Pathogenesis | 315 | ||
| Definitions | 316 | ||
| Pathology | 317 | ||
| Pathophysiology | 317 | ||
| Clinical Manifestations | 318 | ||
| Diagnostic Approach | 318 | ||
| Principles of Therapy | 321 | ||
| Nontuberculous Mycobacteria | 322 | ||
| References | 323 | ||
| General Reviews | 323 | ||
| Pathogenesis | 323 | ||
| Clinical Manifestations and Diagnostic Approach | 324 | ||
| Treatment | 324 | ||
| Nontuberculous Mycobacteria | 324 | ||
| 25 Miscellaneous Infections Caused by Fungi and Pneumocystis | 325 | ||
| Abstract | 325.e1 | ||
| Keywords | 325.e1 | ||
| Fungal Infections | 325 | ||
| Histoplasmosis | 325 | ||
| Types of Infection | 326 | ||
| Coccidioidomycosis | 327 | ||
| Blastomycosis | 328 | ||
| Aspergillosis | 329 | ||
| Allergic Bronchopulmonary Aspergillosis | 329 | ||
| Aspergilloma | 330 | ||
| Invasive Aspergillosis | 331 | ||
| Chronic Necrotizing Pulmonary Aspergillosis | 331 | ||
| Cryptococcosis | 331 | ||
| Other Fungi | 332 | ||
| Pneumocystis Infection | 332 | ||
| References | 334 | ||
| Fungal Infections (General References) | 334 | ||
| Histoplasmosis | 335 | ||
| Coccidioidomycosis | 335 | ||
| Blastomycosis | 335 | ||
| Aspergillosis | 335 | ||
| Pneumocystis Infection | 336 | ||
| 26 Pulmonary Complications in the Immunocompromised Host | 337 | ||
| Abstract | 337.e1 | ||
| Keywords | 337.e1 | ||
| Acquired Immunodeficiency Syndrome | 338 | ||
| Etiology and Pathogenesis | 338 | ||
| Infectious Complications of Acquired Immunodeficiency Syndrome | 339 | ||
| Pneumocystis jiroveci Pneumonia | 339 | ||
| Mycobacterial Infection | 340 | ||
| Other Bacterial Infection | 341 | ||
| Viral Infection | 341 | ||
| Fungal Infection | 342 | ||
| Noninfectious Complications of Acquired Immunodeficiency Syndrome | 342 | ||
| Neoplastic Disease | 342 | ||
| Inflammatory Disease | 343 | ||
| Pulmonary Vascular Disease | 343 | ||
| Diagnostic Evaluation of Pulmonary Infiltrates in Acquired Immunodeficiency Syndrome | 344 | ||
| Pulmonary Complications in Non–HIV Immunocompromised Patients | 344 | ||
| Organ Transplant Recipients | 344 | ||
| Solid Organ Transplantation | 344 | ||
| Hematopoietic Stem Cell Transplantation | 345 | ||
| Treatment of Inflammatory Conditions | 345 | ||
| Primary Immunodeficiencies | 346 | ||
| Diagnostic Evaluation of Pulmonary Infiltrates in Non–HIV Immunocompromised Patients | 346 | ||
| References | 348 | ||
| Infectious Pulmonary Complications of HIV Infection | 348 | ||
| Noninfectious Complications of HIV Infection | 348 | ||
| Pulmonary Disease Associated With Non-HIV Immunodeficiency | 348 | ||
| 27 Classification and Pathophysiologic Aspects of Respiratory Failure | 350 | ||
| Abstract | 350.e1 | ||
| Keywords | 350.e1 | ||
| Definition of Respiratory Failure | 351 | ||
| Classification of Acute Respiratory Failure | 351 | ||
| Hypoxemic Type | 351 | ||
| Hypercapnic/Hypoxemic Type | 352 | ||
| Presentation of Gas Exchange Failure | 352 | ||
| Pathogenesis of Gas Exchange Abnormalities | 353 | ||
| Hypoxemic Respiratory Failure | 353 | ||
| Hypercapnic/Hypoxemic Respiratory Failure | 353 | ||
| Clinical and Therapeutic Aspects of Hypercapnic/Hypoxemic Respiratory Failure | 354 | ||
| References | 355 | ||
| General | 355 | ||
| Respiratory Failure in Obstructive Lung Disease | 356 | ||
| Respiratory Failure in Neuromuscular and Chest Wall Disease | 356 | ||
| 28 Acute Respiratory Distress Syndrome | 357 | ||
| Abstract | 357.e1 | ||
| Keywords | 357.e1 | ||
| Physiology of Fluid Movement in Alveolar Interstitium | 358 | ||
| Two Mechanisms of Fluid Accumulation | 359 | ||
| Etiology | 360 | ||
| Inhaled Injurious Agents | 360 | ||
| Injury via Pulmonary Circulation | 362 | ||
| Pathogenesis | 362 | ||
| Pathology | 363 | ||
| Pathophysiology | 364 | ||
| Effects on Gas Exchange | 364 | ||
| Changes in Pulmonary Vasculature | 365 | ||
| Effects on Mechanical Properties of the Lungs | 365 | ||
| Clinical Features | 365 | ||
| Diagnostic Approach | 366 | ||
| Treatment | 367 | ||
| References | 368 | ||
| General Reviews | 368 | ||
| Pathogenesis | 369 | ||
| Treatment | 369 | ||
| 29 Management of Respiratory Failure | 370 | ||
| Abstract | 370.e1 | ||
| Keywords | 370.e1 | ||
| Goals and Principles Underlying Supportive Therapy | 371 | ||
| Hypoxemic Respiratory Failure | 371 | ||
| Hypercapnic Respiratory Failure | 372 | ||
| Reducing Work of Breathing | 373 | ||
| Mechanical Ventilation | 373 | ||
| Pressure-Limited Ventilation | 373 | ||
| Volume-Cycled Ventilation | 374 | ||
| Positive End-Expiratory Pressure | 376 | ||
| Other Ventilatory Strategies | 376 | ||
| Discontinuation of Ventilatory Support | 377 | ||
| Noninvasive Ventilatory Support for Acute Respiratory Failure | 377 | ||
| Complications of Intubation and Mechanical Ventilation | 377 | ||
| Selected Aspects of Therapy for Chronic Respiratory Failure | 380 | ||
| Chronic Ventilatory Support | 380 | ||
| Lung Transplantation | 380 | ||
| References | 381 | ||
| Mechanical Ventilation | 381 | ||
| Chronic Ventilatory Support | 382 | ||
| Lung Transplantation | 383 | ||
| A Sample Problems Using Respiratory Equations | 384 | ||
| Answers | 385 | ||
| B Pulmonary Function Tests: Guidelines for Interpretation and Sample Problems | 386 | ||
| Analysis of Pulmonary Function Tests | 386 | ||
| Answers | 389 | ||
| C Arterial Blood Gases: Guidelines for Interpretation and Sample Problems | 390 | ||
| Analysis of Acid-Base Status | 390 | ||
| Analysis of Oxygenation | 391 | ||
| Sample Problems | 392 | ||
| Answers | 392 | ||
| Index | 394 | ||
| A | 394 | ||
| B | 395 | ||
| C | 396 | ||
| D | 398 | ||
| E | 399 | ||
| F | 400 | ||
| G | 400 | ||
| H | 400 | ||
| I | 401 | ||
| J | 402 | ||
| K | 402 | ||
| L | 402 | ||
| M | 403 | ||
| N | 404 | ||
| O | 404 | ||
| P | 404 | ||
| Q | 407 | ||
| R | 407 | ||
| S | 407 | ||
| T | 408 | ||
| U | 409 | ||
| V | 409 | ||
| W | 410 | ||
| X | 410 | ||
| Y | 410 | ||
| Z | 410 | ||
| Inside Back Cover | ibc1 |