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Hybrid PET/MR Imaging, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book

Hybrid PET/MR Imaging, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book

Weili Lin | Sheng-Che Hung | Yueh Z. Lee | Terence Z. Wong

(2017)

Additional Information

Book Details

Abstract

This issue of MRI Clinics of North America focuses on Imaging of the PET/MR Imaging, and articles will include: Principles of PET/MR Imaging; Attenuation Correction of PET/MR Imaging; MR-Derived Improvements in PET Imaging; Neurological Applications of PET/MR; Oncological Applications of PET/MR Imaging on the Head and Neck; Oncological Applications of PET/MR Imaging on GYN/GU; PET/MR Imaging of Multiple Myeloma; Pediatric Nuances of PET/MR Imaging; Cardiac Applications of PET/MR Imaging; Logistics and Practical Considerations of MR Coils for PET/MR; Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment; Practical Clinical Considerations of PET/MR; Incremental value of FDG PET/MR in Assessment of Rectal Cancer, and more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
Hybrid PET/MR Imaging\r i
Copyright\r ii
Contributors iii
CONSULTING EDITORS iii
EDITORS iii
AUTHORS iii
Contents vii
Foreword vii
Preface: Hybrid PET/MR: State-of-the-Art and Future Challenges\r vii
Principles of Simultaneous PET/MR Imaging\r vii
Attenuation Correction of PET/MR Imaging vii
Magnetic Resonance–Derived Improvements in PET Imaging vii
Improved Detection of Small Pulmonary Nodules Through Simultaneous MR/PET Imaging vii
Practical Considerations for Clinical PET/MR Imaging viii
Neurologic Applications of PET/MR Imaging viii
PET–MR Imaging in Head and Neck viii
Cardiac Applications of PET/MR Imaging viii
Applications of PET/MR Imaging in Urogynecologic and Genitourinary Cancers ix
PET/MR Imaging of Multiple Myeloma ix
Pediatric Applications of Hybrid PET/MR Imaging ix
Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment ix
MAGNETIC RESONANCE IMAGING\rCLINICS OF NORTH AMERICA\r x
FORTHCOMING ISSUES x
August 2017 x
November 2017 x
February 2018 x
RECENT ISSUES x
February 2017 x
November 2016 x
August 2016 x
CME Accreditation Page xi
PROGRAM OBJECTIVE xi
TARGET AUDIENCE xi
LEARNING OBJECTIVES xi
ACCREDITATION xi
DISCLOSURE OF CONFLICTS OF INTEREST xi
UNAPPROVED/OFF-LABEL USE DISCLOSURE xi
TO ENROLL xii
METHOD OF PARTICIPATION xii
CME INQUIRIES/SPECIAL NEEDS xii
Foreword xiii
Preface\r xv
Hybrid PET/MR: State-of-the-Art and Future Challenges\r xv
REFERENCES xvi
Principles of Simultaneous PET/MR Imaging 231
Key points 231
INTRODUCTION 231
TECHNICAL ASPECTS THAT MUST BE CONSIDERED FOR INTEGRATING PET AND MR IMAGING 232
Considerations on the PET Side 232
Considerations on the Magnetic Resonance Side 232
INTEGRATED PET/MR IMAGING HARDWARE FOR WHOLE-BODY HUMAN IMAGING 233
Siemens Biograph mMR 233
General Electric SIGNA PET/MR Imaging 233
MAGNETIC RESONANCE-BASED PET ATTENUATION CORRECTION 234
Standard Protocols Approved for Clinical Use 234
Special Considerations 234
Bone imaging 234
Truncation artifacts 234
Metallic implants 235
Lung imaging 235
Magnetic resonance hardware 235
The Potential Added Value of the Time-of-Flight Information 235
PROMISING RESEARCH AND CLINICAL APPLICATIONS 237
Opportunities for Methodologic Cross-Validation and Improvement 237
Opportunities for Synergistic Use of the Multimodal Information 238
Neurology/psychiatry/neuroscience 238
Oncology 238
Cardiology 239
REFERENCES 239
Attenuation Correction of PET/MR Imaging 245
Key points 245
INTRODUCTION 245
ATLAS-BASED APPROACHES 246
Image Registration 247
Voxel-Based Pseudo-Computed Tomography Generation 247
Patch-Based Pseudo-Computed Tomography Generation 247
Machine Learning–Based Pseudo-Computed Tomography Generation 248
Summary 249
DIRECT IMAGING METHODS 250
Direct Imaging with Segmentation Only 250
Direct Imaging Methods with Segmentation and Continuous Linear Attenuation Coefficient Value Conversion 251
Summary 252
SUMMARY 253
REFERENCES 253
Magnetic Resonance–Derived Improvements in PET Imaging 257
Key points 257
INTRODUCTION 257
MAGNETIC RESONANCE–BASED MOTION CORRECTION OF PET IMAGES 258
Cyclic Motion: Respiratory 259
Cyclic Motion: Cardiac 261
Noncyclic Head Motion 262
Noncyclic Gross Body Motion 263
Clinical Impacts of Motion Correction 263
MAGNETIC RESONANCE-GUIDED RESOLUTION IMPROVEMENT OF PET IMAGES 264
Region-Based Partial Volume Correction Methods 264
Postreconstruction MR-Guided Image Corrections 265
MR-Guided PET Reconstruction Methods 267
Evaluation and Clinical Impacts 269
SUMMARY 269
REFERENCES 270
Improved Detection of Small Pulmonary Nodules Through Simultaneous MR/PET Imaging 273
Key points 273
INTRODUCTION 273
LUNG MOTION CORRECTION IN MAGNETIC RESONANCE/PET: PREVIOUS LIMITATIONS 274
Retrospective Motion Correction for Magnetic Resonance/PET Data 274
Prospective Motion Correction for Magnetic Resonance/PET Data 274
METHODS 275
RESULTS 276
DISCUSSION 277
REFERENCES 277
Practical Considerations for Clinical PET/MR Imaging 281
Key points 281
WORKFLOW, PROTOCOLLING, REPORTING AND BILLING 281
MR IMAGING AND RADIATION SAFETY 283
WHOLE-BODY PET/MR IMAGING ACQUISITION 284
Comparison of Whole-Body PET/MR Imaging and PET/Computed Tomography Protocols 284
Sequences 287
Tailoring PET/MR Imaging to the Clinical Application 287
DEDICATED REGIONAL MR IMAGING 290
PET PROTOCOL 290
ARTIFACTS AND PITFALLS 292
SUMMARY 294
REFERENCES 294
Neurologic Applications of PET/MR Imaging 297
Key points 297
INTRODUCTION 297
PET/MR IMAGING PROTOCOLS 298
PET/MR IMAGING BENEFITS AND CHALLENGES 299
APPLICATIONS 300
Oncology 300
Tumor grading and differential diagnosis 301
Tumor extension and treatment planning 302
Treatment follow-up 303
Evaluation of metastatic disease 303
Role of PET/MR imaging in neurooncology 303
Epilepsy 304
Dementia 305
Structural MR imaging 306
Perfusion-weighted imaging 306
Amyloid PET 306
Tau PET 306
18F-FDG PET 307
PET/MR imaging in dementia research 307
CEREBROVASCULAR DISEASE 307
Cerebral Perfusion 307
Carotid Plaque Imaging 307
NEUROLOGIC AND PSYCHIATRIC DISORDERS 307
SUMMARY 308
REFERENCES 308
PET–MR Imaging in Head and Neck 315
Key points 315
INTRODUCTION 315
T-STAGING 316
N-STAGING 317
M-STAGING 318
STANDARDIZED UPTAKE VALUE QUANTITATION 320
ADVANCED MR IMAGING TECHNIQUES 320
DIFFUSION-WEIGHTED IMAGING 320
PERFUSION IMAGING 320
THERAPY RESPONSE ASSESSMENT 321
TREATMENT AND RADIOTHERAPY PLANNING 321
APPLICATION OF NOVEL TRACERS 321
SUMMARY 322
ACKNOWLEDGMENTS 322
REFERENCES 322
Cardiac Applications of PET/MR Imaging 325
Key points 325
INTRODUCTION 325
TECHNICAL CHALLENGES OF PET/MR CARDIOVASCULAR IMAGING 326
Attenuation Correction 326
Motion Correction 327
Optimizing Myocardial PET Signal Uptake 328
PET/MR IN CLINICAL CARDIAC IMAGING 328
PET/Magnetic Resonance Assessment of Myocardial Viability and Infarction 328
PET/Magnetic Resonance in Detecting Myocardial Ischemia 328
PET/Magnetic Resonance in Detecting Atherosclerosis 329
PET/Magnetic Resonance in Other Cardiac Conditions 330
PET/magnetic resonance in cardiac mass assessments 330
Conditions associated with myocardial fibrosis and inflammation 330
PERFORMING A SIMULTANEOUS PET/MAGNETIC RESONANCE CLINICAL EXAMINATION: THE IMAGING PROTOCOL 330
SUMMARY 331
REFERENCES 331
Applications of PET/MR Imaging in Urogynecologic and Genitourinary Cancers 335
Key points 335
APPLICATIONS OF PET/MR IMAGING IN GYNECOLOGIC CANCERS 335
Introduction 335
What Is PET/Magnetic Resonance? 335
What Is the Evidence for, and Ongoing Work on, PET/Magnetic Resonance? 336
How Is PET/Magnetic Resonance Done? Protocolling PET/Magnetic Resonance and Other Issues 337
When Is PET/Magnetic Resonance Used? Current Guidelines and Applications 338
Cervical (and vulvar) cancer 339
Endometrial cancer 339
Ovarian cancer 342
Quantitative Imaging 344
PET/MAGNETIC RESONANCE OF OTHER GENITOURINARY STRUCTURES 344
PET/Magnetic Resonance of the Prostate 344
PET/Magnetic Resonance of the Kidneys and Bladder 345
PET/Magnetic Resonance of the Scrotum and Penis 346
SUMMARY 346
REFERENCES 347
PET/MR Imaging of Multiple Myeloma 351
Key points 351
INTRODUCTION 351
IMAGING WITH FLUORODEOXYGLUCOSE PET AND MAGNETIC RESONANCE: CURRENT RECOMMENDATIONS 352
APPLICATIONS OF PET AND MAGNETIC RESONANCE IMAGING IN PLASMA CELL DYSCRASIAS 353
Staging 355
Prognosis 355
Response to Therapy 357
INTRODUCING PET/MAGNETIC RESONANCE 357
USES OF PET/MAGNETIC RESONANCE IN THE CLINICAL ARENA 359
PERFORMING THE EXAMINATION: BILLING AND WORKFLOW 360
PERFORMING THE EXAMINATION: SCAN PROTOCOL 360
WHEN ARE PET/MAGNETIC RESONANCE USED? 362
SUMMARY 362
REFERENCES 362
Pediatric Applications of Hybrid PET/MR Imaging 367
Key points 367
RADIATION DOSE REDUCTION 367
PET/MR IMAGING TECHNICAL DIFFERENCES IN CHILDREN 368
PET/MR IMAGING WORKFLOW CONSIDERATIONS 370
MR Imaging Sequence Selection 370
Concern for Gadolinium Administration 370
PET Dose Reduction 371
Other PET Agents 371
Siting and Sedation 373
SUMMARY 374
ACKNOWLEDGMENTS 374
REFERENCES 374
Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment 377
Key points 377
INTRODUCTION 377
Radiation Therapy: From Simulation to Treatment Delivery 378
Simulation 378
Contouring 378
Treatment planning 379
Treatment delivery 381
Treatment response evaluation 381
From Anatomic Imaging to Functional Imaging 382
PET/MR IMAGING FOR HALLMARKS OF CANCER RADIOBIOLOGY IN RADIATION THERAPY 383
PET/MR Imaging for Metabolism and Proliferation 384
PET/MR Imaging for Angiogenesis and Hypoxia 392
PET/MR Imaging for Better Characterization of Tumor Heterogeneity 398
PET/MR Imaging for Treatment Assessment and Adaptive Radiotherapy 405
PET/MR IMAGING FOR MR IMAGING-BASED RADIATION TREATMENT PLANNING 414
MR Imaging-Based Treatment Planning 415
Differences Between MR Imaging for Radiology and Radiation Oncology 417
Current Implementation and Challenges 417
PET/MR IMAGING FOR RADIATION THERAPY: CHALLENGES AND FUTURE DIRECTIONS 420
Imaging-Specific Uncertainty 420
System-Specific Uncertainty 421
Process-Specific Uncertainty 421
Optimized PET/MR Imaging Workflow 422
SUMMARY 423
REFERENCES 423
Index 431