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Book Details
Abstract
Gain a deeper understanding of oral health with the definitive text in oral histology. Written by Dr. Antonio Nanci, a world-renowned leader in cell biology, the new ninth edition of Ten Cate’s Oral Histology covers all the latest research and trends in oral histology, embryology, physiology, oral biology, and postnatal growth and development that is essential to success in oral health! Considered to be the standard in the field, this renowned text uses straightforward explanations and detailed, full-color micrographs, images, and illustrations to help you better understand even the most complex topics.
- Detailed histological and structural images help you differentiate the structures.
- Medical approach to histology helps you understand underlying biological events, and oral tissue repair and regeneration.
- Full-color format helps bring oral histology to life.
- Learning resources on the Evolve website include multiple-choice review questions with instant feedback, and interactive drag-and-drop exercises.
- NEW! Full-color micrographs, images, and 3D art enhance your understanding of key oral histology concepts.
- NEW! Commentary boxes highlight new and innovative research topics from leaders in the field.
- NEW! Updated content — including additional content on the nervous system in chapter four — has been added to keep you up to date with the latest information in the field.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | cover | ||
| Ten Cate's Oral Histology | i | ||
| Copyright Page | ii | ||
| Dedication | iii | ||
| Contributors | iv | ||
| Preface | v | ||
| Acknowledgments | v | ||
| Table Of Contents | vi | ||
| 1 Structure of the Oral Tissues | 1 | ||
| Chapter Outline | 1 | ||
| The Tooth | 1 | ||
| Enamel | 1 | ||
| Dentin | 1 | ||
| Pulp | 2 | ||
| Supporting Tissues of the Tooth | 3 | ||
| Periodontal Ligament | 3 | ||
| Cementum | 3 | ||
| Oral Mucosa | 3 | ||
| Salivary Glands | 4 | ||
| Bones of the Jaw | 5 | ||
| Temporomandibular Joint | 5 | ||
| Hard Tissue Formation | 6 | ||
| The Organic Matrix in Hard Tissues | 6 | ||
| Mineral | 6 | ||
| Mineralization | 6 | ||
| Crystal Growth | 8 | ||
| Alkaline Phosphatase | 8 | ||
| Transport of Mineral Ions to Mineralization Sites | 9 | ||
| Hard Tissue Degradation | 10 | ||
| Summary | 10 | ||
| 2 General Embryology | 12 | ||
| Chapter Outline | 12 | ||
| Germ Cell Formation and Fertilization | 12 | ||
| Prenatal Development | 12 | ||
| Induction, Competence, and Differentiation | 13 | ||
| Formation of the Three-Layered Embryo | 14 | ||
| Formation of the Neural Tube and Fate of the Germ Layers | 17 | ||
| Folding of the Embryo | 17 | ||
| The Neural Crest | 18 | ||
| Recommended Reading | 22 | ||
| 3 Embryology of the Head, Face, and Oral Cavity | 23 | ||
| Chapter Outline | 23 | ||
| Neural Crest Cells and Head Formation | 23 | ||
| Branchial (Pharyngeal) Arches and the Primitive Mouth | 26 | ||
| Fate of Grooves and Pouches | 26 | ||
| Anatomy of an Arch | 27 | ||
| Fusion of Processes | 28 | ||
| Formation of the Face | 28 | ||
| Formation of the Secondary Palate | 29 | ||
| Formation of the Tongue | 34 | ||
| Development of the Skull | 36 | ||
| Development of the Mandible and Maxilla | 36 | ||
| Mandible | 36 | ||
| Maxilla | 38 | ||
| Common Features of Jaw Development | 39 | ||
| Development of the Temporomandibular Joint | 39 | ||
| Congenital Defects | 39 | ||
| Recommended Reading | 40 | ||
| 4 Basic Concepts on the Cell, Extracellular Matrix, and Neural Elements | 41 | ||
| Chapter Outline | 41 | ||
| The Cell Membrane | 41 | ||
| Cytoskeleton | 42 | ||
| Intercellular Junctions | 42 | ||
| Epithelium–Connective Tissue Interface | 46 | ||
| Fibroblasts | 46 | ||
| Cellular Organization | 47 | ||
| Contraction and Motility | 47 | ||
| Junctions | 47 | ||
| Heterogeneity | 47 | ||
| Aging | 50 | ||
| Secretory Products of Fibroblasts | 50 | ||
| Collagens | 50 | ||
| Collagen Synthesis and Assembly | 54 | ||
| Inherited Diseases Involving Collagens | 54 | ||
| Elastin | 54 | ||
| Proteoglycans | 54 | ||
| Glycoproteins | 58 | ||
| Growth Factors and Cytokines | 58 | ||
| Extracellular Matrix Degradation | 58 | ||
| Summary | 59 | ||
| Organization and Physiology of the Nervous System | 60 | ||
| The Nervous System | 60 | ||
| Cells of the Nervous System | 61 | ||
| Electrophysiologic Features of Nervous System Cells | 63 | ||
| The Resting Membrane Potential | 63 | ||
| The Action Potential | 64 | ||
| Propagation of the Action Potential | 64 | ||
| Synaptic Transmission | 65 | ||
| Recommended Reading | 67 | ||
| 5 Development of the Tooth and Its Supporting Tissues | 68 | ||
| Chapter Outline | 68 | ||
| Primary Epithelial Band | 68 | ||
| Dental Lamina | 68 | ||
| Vestibular Lamina | 71 | ||
| Initiation of the Tooth | 71 | ||
| Tooth Type Determination | 74 | ||
| Instructive Signals for Patterning | 75 | ||
| Regionalization of Oral and Dental Ectoderm | 76 | ||
| Bud Stage | 76 | ||
| Bud-to-Cap Transition | 76 | ||
| Cap Stage | 77 | ||
| Signaling Centers | 78 | ||
| Bell Stage | 79 | ||
| Fine Structure of the Enamel Organ at the Very Early Bell Stage | 80 | ||
| Dental Papilla and Follicle | 80 | ||
| Breakup of the Dental Lamina and Crown Pattern Determination | 80 | ||
| Nerve and Vascular Supply During Early Development | 82 | ||
| Vascular Supply | 82 | ||
| Nerve Supply | 83 | ||
| Formation of the Permanent Dentition | 83 | ||
| Hard Tissue Formation | 84 | ||
| Root Formation | 85 | ||
| Tooth Eruption | 86 | ||
| Formation of Supporting Tissues | 86 | ||
| Recommended Reading | 90 | ||
| 6 Bone | 91 | ||
| Chapter Outline | 91 | ||
| Gross Bone Histology | 91 | ||
| Bone Cells | 91 | ||
| Osteoblasts | 92 | ||
| Osteocytes | 100 | ||
| Osteoclasts | 100 | ||
| Regulation of Bone Cell Formation | 103 | ||
| Bone Development and Formation | 105 | ||
| Endochondral Bone Formation | 105 | ||
| Intramembranous Bone Formation | 110 | ||
| Sutural Bone Growth | 112 | ||
| Bone Turnover (Remodeling) | 112 | ||
| Recommended Reading | 117 | ||
| 7 Enamel: Composition, Formation, and Structure | 118 | ||
| Chapter Outline | 118 | ||
| Physical Characteristics of Enamel | 118 | ||
| Structure of Enamel | 118 | ||
| Amelogenesis | 122 | ||
| Light Microscopy of Amelogenesis | 125 | ||
| Electron Microscopy of Amelogenesis | 128 | ||
| Presecretory Stage | 128 | ||
| Morphogenetic Phase | 128 | ||
| Differentiation Phase | 128 | ||
| Secretory Stage | 131 | ||
| Maturation Stage | 133 | ||
| Transitional Phase | 135 | ||
| Maturation Proper | 140 | ||
| Ameloblast Secretory Products | 141 | ||
| Mineral Pathway and Mineralization | 147 | ||
| Regulation of pH During Enamel Formation | 147 | ||
| Structural and Organizational Features of Enamel | 147 | ||
| Rod Interrelationships | 147 | ||
| Striae of Retzius | 148 | ||
| Cross Striations | 149 | ||
| Bands of Hunter and Schreger | 149 | ||
| Gnarled Enamel | 151 | ||
| Enamel Tufts and Lamellae | 151 | ||
| Dentinoenamel Junction and Enamel Spindles | 151 | ||
| Enamel Surface | 151 | ||
| Age Changes | 152 | ||
| Defects of Amelogenesis | 152 | ||
| Clinical Implications | 154 | ||
| Fluoridation | 154 | ||
| Acid Etching | 155 | ||
| Recommended Reading | 156 | ||
| 8 Dentin-Pulp Complex | 157 | ||
| Chapter Outline | 157 | ||
| Basic Structure of Dentin | 157 | ||
| Composition, Formation, and Structure of Dentin | 157 | ||
| Types of Dentin | 160 | ||
| Primary Dentin | 160 | ||
| Secondary Dentin | 160 | ||
| Tertiary Dentin | 160 | ||
| Pattern of Dentin Formation | 160 | ||
| Dentinogenesis | 161 | ||
| Odontoblast Differentiation | 161 | ||
| Formation of Mantle Dentin | 162 | ||
| Vascular Supply | 163 | ||
| Control of Mineralization | 164 | ||
| Pattern of Mineralization | 164 | ||
| Formation of Root Dentin | 165 | ||
| Secondary and Tertiary Dentinogenesis | 165 | ||
| Histology of Dentin | 167 | ||
| Dentinal Tubules | 167 | ||
| Peritubular Dentin | 170 | ||
| Sclerotic Dentin | 170 | ||
| Intertubular Dentin | 172 | ||
| Interglobular Dentin | 172 | ||
| Incremental Growth Lines | 173 | ||
| Granular Layer of Tomes | 174 | ||
| Pulp | 175 | ||
| Odontoblasts | 175 | ||
| Fibroblasts | 182 | ||
| Undifferentiated Ectomesenchymal Cells | 182 | ||
| Dental Pulp Stem Cells | 182 | ||
| Inflammatory Cells | 183 | ||
| Matrix and Ground Substance | 183 | ||
| Vasculature and Lymphatic Supply | 183 | ||
| Innervation of the Dentin-Pulp Complex | 185 | ||
| Dentin Sensitivity | 186 | ||
| Pulp Stones | 190 | ||
| Age Changes | 191 | ||
| Response to Environmental Stimuli | 192 | ||
| Recommended Reading | 192 | ||
| 9 Periodontium | 193 | ||
| Chapter Outline | 193 | ||
| Cementum | 193 | ||
| Biochemical Composition | 193 | ||
| Initiation of Cementum Formation | 194 | ||
| Origin of Periodontal Cells and Differentiation of Cementoblasts | 194 | ||
| Molecular Factors Regulating Cementogenesis | 196 | ||
| Bone Morphogenetic Proteins | 196 | ||
| Epithelial Factors | 197 | ||
| Major Matrix Proteins With Cell Adhesion Motifs | 197 | ||
| Gla Proteins | 198 | ||
| Transcription Factors | 198 | ||
| Wnt Signaling | 199 | ||
| Other Factors | 199 | ||
| Cementum Varieties | 199 | ||
| Acellular Extrinsic Fiber Cementum (Primary Cementum) | 199 | ||
| Cellular Intrinsic Fiber Cementum (Secondary Cementum) | 202 | ||
| Acellular Afibrillar Cementum | 203 | ||
| Distribution of Cementum Varieties Along the Root | 204 | ||
| Cementoenamel Junction | 204 | ||
| Attachment of Cementum Onto Dentin | 204 | ||
| Alveolar Process | 205 | ||
| Periodontal Ligament | 206 | ||
| Fibroblasts | 208 | ||
| Epithelial Cells | 210 | ||
| Undifferentiated Mesenchymal Cells | 210 | ||
| Stem Cells | 210 | ||
| Bone and Cementum Cells | 210 | ||
| Fibers | 210 | ||
| Elastic Fibers | 212 | ||
| Ground Substance | 213 | ||
| Blood Supply | 213 | ||
| Nerve Supply | 213 | ||
| Adaptation to Functional Demand | 215 | ||
| Recommended Reading | 217 | ||
| 10 Physiologic Tooth Movement | 218 | ||
| Chapter Outline | 218 | ||
| Preeruptive Tooth Movement | 218 | ||
| Eruptive Tooth Movement | 220 | ||
| Histologic Features | 220 | ||
| Mechanisms of Eruptive Tooth Movement | 220 | ||
| Root Formation | 220 | ||
| Bone Remodeling | 221 | ||
| Dental Follicle | 221 | ||
| Periodontal Ligament | 221 | ||
| Molecular Determinants of Tooth Eruption | 221 | ||
| Posteruptive Tooth Movement | 222 | ||
| Accommodation for Growth | 222 | ||
| Compensation for Occlusal Wear | 222 | ||
| Accommodation for Interproximal Wear | 222 | ||
| Anterior Component of Occlusal Force | 222 | ||
| Contraction of the Transseptal Ligament | 222 | ||
| Soft Tissue Pressures | 222 | ||
| Shedding of Teeth | 222 | ||
| Odontoclast | 223 | ||
| Pressure | 224 | ||
| Pattern of Shedding | 225 | ||
| Abnormal Tooth Movement | 227 | ||
| Orthodontic Tooth Movement | 228 | ||
| Recommended Reading | 235 | ||
| 11 Salivary Glands | 236 | ||
| Chapter Outline | 236 | ||
| Functions of Saliva | 236 | ||
| Protection | 236 | ||
| Buffering | 236 | ||
| Pellicle Formation | 236 | ||
| Maintenance of Tooth Integrity | 237 | ||
| Antimicrobial Action | 237 | ||
| Tissue Repair | 237 | ||
| Digestion | 238 | ||
| Taste | 238 | ||
| Anatomy | 238 | ||
| Development | 238 | ||
| Structure | 238 | ||
| Secretory Cells | 240 | ||
| Serous Cells | 241 | ||
| Mucous Cells | 241 | ||
| Formation and Secretion of Saliva | 243 | ||
| Macromolecular Components | 243 | ||
| Fluid and Electrolytes | 244 | ||
| Other Mechanisms Modulating Saliva Secretion | 245 | ||
| Myoepithelial Cells | 246 | ||
| Ducts | 246 | ||
| Intercalated Ducts | 246 | ||
| Striated Ducts | 247 | ||
| Excretory Ducts | 247 | ||
| Ductal Modification of Saliva | 254 | ||
| Connective Tissue | 254 | ||
| Nerve Supply | 255 | ||
| Blood Supply | 255 | ||
| Summary of Salivary Gland Structure | 255 | ||
| Histology of the Major Salivary Glands | 256 | ||
| Parotid Gland | 256 | ||
| Submandibular Gland | 257 | ||
| Sublingual Gland | 257 | ||
| Histology of the Minor Salivary Glands | 257 | ||
| Clinical Considerations | 258 | ||
| Age Changes | 258 | ||
| Diseases | 258 | ||
| Dry Mouth (Xerostomia) | 258 | ||
| Recommended Reading | 259 | ||
| 12 Oral Mucosa | 260 | ||
| Chapter Outline | 260 | ||
| Definition of the Oral Mucosa | 260 | ||
| Functions of the Oral Mucosa | 260 | ||
| Protection | 260 | ||
| Sensation | 261 | ||
| Secretion | 261 | ||
| Thermal Regulation | 261 | ||
| Boundaries of the Oral Mucosa | 261 | ||
| Clinical Features | 261 | ||
| Component Tissues and Glands | 262 | ||
| Oral Epithelium | 263 | ||
| Epithelial Proliferation | 264 | ||
| Epithelial Maturation | 264 | ||
| Keratinization | 264 | ||
| Nonkeratinization | 266 | ||
| Ultrastructure of the Epithelial Cell | 267 | ||
| Cellular Events in Maturation | 268 | ||
| Keratinized Epithelium | 269 | ||
| Nonkeratinized Epithelium | 270 | ||
| Permeability and Absorption | 270 | ||
| Nonkeratinocytes in the Oral Epithelium | 270 | ||
| Melanocytes and Oral Pigmentation | 271 | ||
| Langerhans Cells | 271 | ||
| Merkel Cells | 272 | ||
| Inflammatory Cells | 272 | ||
| Junction of the Epithelium and Lamina Propria | 272 | ||
| Lamina Propria | 273 | ||
| Cells | 274 | ||
| Fibroblasts | 274 | ||
| Macrophages | 274 | ||
| Mast Cells | 275 | ||
| Inflammatory Cells | 275 | ||
| Fibers and Ground Substance | 276 | ||
| Collagen | 276 | ||
| Elastic Fibers | 276 | ||
| Ground Substance | 276 | ||
| Blood Supply | 276 | ||
| Nerve Supply | 276 | ||
| Structural Variations | 278 | ||
| Masticatory Mucosa | 278 | ||
| Lining Mucosa | 282 | ||
| Specialized Mucosa | 282 | ||
| Fungiform Papillae | 282 | ||
| Filiform Papillae | 282 | ||
| Foliate Papillae | 283 | ||
| Circumvallate Papillae | 283 | ||
| Junctions in the Oral Mucosa | 283 | ||
| Mucocutaneous Junction | 283 | ||
| Mucogingival Junction | 283 | ||
| Dentogingival Junction | 283 | ||
| Connective Tissue Component | 285 | ||
| Col | 286 | ||
| Blood Supply | 286 | ||
| Nerve Supply | 286 | ||
| Development of the Oral Mucosa | 287 | ||
| Age Changes | 287 | ||
| Recommended Reading | 288 | ||
| 13 The Mastication Apparatus | 289 | ||
| Chapter Outline | 289 | ||
| Classification of Joints | 289 | ||
| Fibrous Joints | 289 | ||
| Cartilaginous Joints | 289 | ||
| Synovial Joints | 289 | ||
| Type of Joint | 289 | ||
| Development of the Joint | 290 | ||
| Bones of the Joint | 290 | ||
| Cartilage Associated With the Joint | 290 | ||
| Capsule, Ligaments, and Disk of the Joint | 299 | ||
| Synovial Membrane | 300 | ||
| Muscle Contraction | 302 | ||
| Motor Unit | 302 | ||
| Muscle Spindle | 303 | ||
| Golgi Tendon Organ | 303 | ||
| Muscles of Mastication | 303 | ||
| Biomechanics of the Joint | 304 | ||
| Innervation of the Joint | 305 | ||
| Blood Supply to the Joint | 309 | ||
| Recommended Reading | 309 | ||
| 14 Facial Growth and Development | 310 | ||
| Chapter Outline | 310 | ||
| Basic Concepts of Facial Growth | 310 | ||
| Size Increases and Remodeling | 310 | ||
| Displacement Process | 310 | ||
| Mandibular Condyle and Growth | 311 | ||
| Facial Types | 312 | ||
| Facial Profiles | 314 | ||
| Epigenetics and Malocclusion | 314 | ||
| Curve of Occlusion | 315 | ||
| Male and Female Faces | 315 | ||
| Age-Related Changes | 318 | ||
| Recommended Reading | 319 | ||
| 15 Repair and Regeneration of Oral Tissues | 320 | ||
| Chapter Outline | 320 | ||
| Wound Healing in Oral Mucosa | 320 | ||
| Initial Response to Wounding: Hemostasis | 320 | ||
| Inflammatory Cell Activation, Migration, and Function | 321 | ||
| Reparative Phase | 321 | ||
| Wound Contraction and Scarring | 322 | ||
| Wound Healing at the Dentogingival Junction | 323 | ||
| Repair of Enamel | 324 | ||
| Repair of the Dentin-Pulp Complex | 324 | ||
| Dental Caries | 326 | ||
| Cavity Preparation | 327 | ||
| Repair After Tooth Extraction | 328 | ||
| Alterations to the Periodontal Connective Tissues With the Development of Periodontal Inflammation | 329 | ||
| Repair of the Periodontium | 329 | ||
| Mechanisms of Repair and Regeneration of Periodontal Connective Tissues | 329 | ||
| Stem Cells | 331 | ||
| New Perspectives | 332 | ||
| Recommended Reading | 334 | ||
| Index | 335 | ||
| A | 335 | ||
| B | 335 | ||
| C | 336 | ||
| D | 336 | ||
| E | 337 | ||
| F | 338 | ||
| G | 338 | ||
| H | 338 | ||
| I | 339 | ||
| J | 339 | ||
| K | 339 | ||
| L | 339 | ||
| M | 339 | ||
| N | 340 | ||
| O | 340 | ||
| P | 341 | ||
| R | 342 | ||
| S | 342 | ||
| T | 343 | ||
| U | 344 | ||
| V | 344 | ||
| W | 344 | ||
| X | 344 | ||
| Y | 344 | ||
| Z | 344 | ||
| Evolve pages_Endsheet2 | 347 |