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Book Details
Abstract
This issue of Surgical Pathology Clinics, edited by Dr. John Hart, focuses on Liver Pathology. Topics include--but are not limited to--Hereditary cholestatic disorders; Autoimmunity in the liver; Fibrolamellar carcinoma; Hepatocellular adenoma; Infections/granulomas in the liver; HCV and direct acting antivirals; Lymphomas in the liver; Viral heaptitis; NASH; Drug induced liver injury; PBC and AIH; Liver transplant; Frozen sections of the liver; Hepatocellular carcinoma; and Cholangiocarcinoma.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Liver Pathology | i | ||
| Copyright | ii | ||
| Contributors | iii | ||
| CONSULTING EDITOR | iii | ||
| EDITOR | iii | ||
| AUTHORS | iii | ||
| Contents | v | ||
| Preface: Hepatic Pathology: Evolving Concepts in Diagnosis and Pathogenesis for Medical Diseases and Tumors | v | ||
| Granulomas in the Liver, with a Focus on Infectious Causes | v | ||
| Acute Viral Hepatitis: Beyond A, B, and C | v | ||
| Nonalcoholic Steatohepatitis: Histopathology Basics Within a Broader Context | v | ||
| Chronic Hepatitis C and Direct Acting Antivirals | v | ||
| Recent Advances in the Histopathology of Drug-Induced Liver Injury | vi | ||
| Pathologic Features of Hereditary Cholestatic Diseases | vi | ||
| Primary Biliary Cholangitis and Autoimmune Hepatitis | vi | ||
| Hepatic Adenomas: Classification, Controversies, and Consensus | vi | ||
| Update on Ancillary Testing in the Evaluation of High-Grade Liver Tumors | vii | ||
| Fibrolamellar Carcinoma: What Is New and Why It Matters | vii | ||
| Hepatic Lymphoma Diagnosis | vii | ||
| Cholangiocarcinoma | vii | ||
| Acute, Chronic, and Humoral Rejection: Pathologic Features Under Current Immunosuppressive Regimes | vii | ||
| Frozen Sections of the Liver | viii | ||
| SURGICAL PATHOLOGY CLINICS | ix | ||
| FORTHCOMING ISSUES | ix | ||
| September 2018 | ix | ||
| December 2018 | ix | ||
| March 2019 | ix | ||
| RECENT ISSUES | ix | ||
| March 2018 | ix | ||
| December 2017 | ix | ||
| September 2017 | ix | ||
| Preface: Hepatic Pathology: Evolving Concepts in Diagnosis and Pathogenesis for Medical Diseases and Tumors\r | xi | ||
| Granulomas in the Liver, with a Focus on Infectious Causes | 231 | ||
| ABSTRACT | 231 | ||
| GENERAL CONSIDERATIONS | 231 | ||
| INFECTIOUS CAUSES OF HEPATIC GRANULOMAS | 236 | ||
| BACTERIAL INFECTIONS | 236 | ||
| FUNGAL INFECTIONS | 240 | ||
| PARASITIC INFECTIONS | 241 | ||
| VIRAL INFECTIONS | 242 | ||
| NONINFECTIOUS CAUSES OF HEPATIC GRANULOMAS | 242 | ||
| REFERENCES | 249 | ||
| Acute Viral Hepatitis: Beyond A, B, and C | 251 | ||
| ABSTRACT | 251 | ||
| OVERVIEW | 251 | ||
| HISTOLOGIC FINDINGS IN ACUTE VIRAL HEPATITIS | 252 | ||
| Histologic Clues to the Causative Virus in Acute Hepatitis | 255 | ||
| Hepatitis A | 255 | ||
| Hepatitis E | 256 | ||
| Hepatitis B | 256 | ||
| Hepatitis C | 257 | ||
| OTHER VIRUSES CAUSING ACUTE HEPATITIS | 257 | ||
| Hepatitis D (Delta) Virus | 257 | ||
| Influenza: H1N1 | 258 | ||
| Herpesviruses | 258 | ||
| Epstein-Barr virus | 258 | ||
| Cytomegalovirus | 259 | ||
| Human herpesvirus-6 | 260 | ||
| Herpes zoster | 260 | ||
| Herpes simplex virus types 1 and 2 | 260 | ||
| Adenovirus | 260 | ||
| Icteric Hemorrhagic Fevers | 260 | ||
| Yellow fever | 260 | ||
| Dengue virus | 261 | ||
| Other arboviruses: zika and chikungunya virus | 263 | ||
| Ebola and Marburg viruses | 263 | ||
| Hantavirus | 263 | ||
| SUMMARY | 263 | ||
| REFERENCES | 264 | ||
| Nonalcoholic Steatohepatitis | 267 | ||
| ABSTRACT | 267 | ||
| OVERVIEW | 267 | ||
| EPIDEMIOLOGY | 268 | ||
| PATHOGENESIS | 268 | ||
| MICROSCOPIC FEATURES | 268 | ||
| STEATOSIS | 268 | ||
| LOBULAR INFLAMMATION | 270 | ||
| BALLOONING AND MALLORY-DENK BODIES | 270 | ||
| FIBROSIS | 272 | ||
| OTHER IMPORTANT HISTOPATHOLOGIC LESIONS SEEN IN NONALCOHOLIC FATTY LIVER DISEASE | 275 | ||
| PEDIATRIC NONALCOHOLIC FATTY LIVER DISEASE | 275 | ||
| TWO HISTOPATHOLOGIC SCORING SYSTEMS FOR NONALCOHOLIC FATTY LIVER DISEASE: THE NAFLD ACTIVITY SCORE AND THE STEATOSIS, ACTIV ... | 275 | ||
| DIFFERENTIAL DIAGNOSIS | 277 | ||
| ALCOHOL-ASSOCIATED LIVER DISEASE AND ALCOHOLIC STEATOHEPATITIS | 280 | ||
| WILSON DISEASE | 281 | ||
| DRUG-ASSOCIATED STEATOHEPATITIS AND CHEMOTHERAPY-ASSOCIATED STEATOHEPATITIS | 281 | ||
| NONALCOHOLIC FATTY LIVER DISEASE WITH CONCURRENT DISEASE | 281 | ||
| PROGNOSIS AND TREATMENT | 281 | ||
| SUMMARY | 282 | ||
| REFERENCES | 283 | ||
| Chronic Hepatitis C and Direct Acting Antivirals | 287 | ||
| ABSTRACT | 287 | ||
| HEPATITIS C VIRUS OVERVIEW | 287 | ||
| RISK FACTORS FOR HEPATITIS C VIRUS | 288 | ||
| DIRECTLY ACTING ANTIVIRAL THERAPY | 289 | ||
| HISTOLOGIC EXAMINATION FOR HEPATITIS C VIRUS | 291 | ||
| HISTOLOGIC FINDINGS IN ACUTE HEPATITIS C VIRUS HEPATITIS | 292 | ||
| HISTOLOGIC FINDINGS IN CHRONIC HEPATITIS C VIRUS HEPATITIS | 292 | ||
| SUMMARY | 295 | ||
| REFERENCES | 295 | ||
| Recent Advances in the Histopathology of Drug-Induced Liver Injury | 297 | ||
| ABSTRACT | 297 | ||
| OVERVIEW | 297 | ||
| EVALUATION OF THE LIVER BIOPSY | 298 | ||
| RECENT REPORTS OF HISTOLOGIC INJURY PATTERNS IN DRUG-INDUCED LIVER INJURY | 299 | ||
| HERBALS AND DIETARY SUPPLEMENTS | 302 | ||
| IMMUNOMODULATING AGENTS AND DRUG-INDUCED AUTOIMMUNE HEPATITIS | 304 | ||
| TEMOZOLOMIDE AND VANISHING BILE DUCT SYNDROME | 307 | ||
| THE PATHOLOGIST’S ROLE IN THE EVALUATION OF SUSPECTED DRUG-INDUCED LIVER INJURY | 307 | ||
| REFERENCES | 309 | ||
| Pathologic Features of Hereditary Cholestatic Diseases | 313 | ||
| ABSTRACT | 313 | ||
| OVERVIEW | 313 | ||
| CYSTIC FIBROSIS | 314 | ||
| PATHOLOGY | 314 | ||
| ALPHA-1-ANTITRYPSIN DEFICIENCY | 315 | ||
| PATHOLOGY | 316 | ||
| DISORDERS OF BILE CANALICULAR TRANSPORTERS (FAMILIAL INTRAHEPATIC CHOLESTASIS AND RELATED DISORDERS) | 316 | ||
| PATHOGENESIS | 316 | ||
| CLINICAL MANIFESTATIONS | 318 | ||
| Progressive Familial Intrahepatic Cholestasis | 318 | ||
| Manifestations of Milder Disease | 319 | ||
| PATHOLOGY: SEVERE DISEASE IN INFANTS AND CHILDREN | 319 | ||
| ATP8B1 Deficiency | 319 | ||
| ABCB11 Deficiency | 319 | ||
| ABCB4 Deficiency | 319 | ||
| PATHOLOGY: MILDER DISEASE IN ADULTS | 319 | ||
| BILE ACID SYNTHETIC DISORDERS | 323 | ||
| ALAGILLE SYNDROME | 323 | ||
| PATHOGENESIS | 323 | ||
| PATHOLOGY | 323 | ||
| ACKNOWLEDGMENTS | 325 | ||
| REFERENCES | 325 | ||
| Primary Biliary Cholangitis and Autoimmune Hepatitis | 329 | ||
| ABSTRACT | 329 | ||
| OVERVIEW | 329 | ||
| PRIMARY BILIARY CHOLANGITIS | 330 | ||
| OVERVIEW OF PRIMARY BILIARY CHOLANGITIS | 330 | ||
| CLINICAL FEATURES OF PRIMARY BILIARY CHOLANGITIS | 330 | ||
| MICROSCOPIC FEATURES OF PRIMARY BILIARY CHOLANGITIS | 330 | ||
| DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF PRIMARY BILIARY CHOLANGITIS | 332 | ||
| Autoimmune Cholangitis | 333 | ||
| Autoimmune Hepatitis | 333 | ||
| Primary Sclerosing Cholangitis | 333 | ||
| Large Duct Obstruction | 333 | ||
| Ascending Cholangitis | 333 | ||
| Drug-Induced Liver Injury | 334 | ||
| Various Causes of Granuloma Formation | 335 | ||
| Various Causes of Cholestasis | 336 | ||
| Various Causes of Duct Loss/Ductopenia | 336 | ||
| TREATMENT AND PROGNOSIS OF PRIMARY BILIARY CHOLANGITIS | 337 | ||
| AUTOIMMUNE HEPATITIS | 339 | ||
| OVERVIEW OF AUTOIMMUNE HEPATITIS | 339 | ||
| CLINICAL FEATURES OF AUTOIMMUNE HEPATITIS | 339 | ||
| MICROSCOPIC FEATURES OF AUTOIMMUNE HEPATITIS | 340 | ||
| DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF AUTOIMMUNE HEPATITIS | 342 | ||
| Primary Biliary Cholangitis | 343 | ||
| Chronic Viral Hepatitis | 343 | ||
| Wilson Disease | 343 | ||
| IgG4-Related Sclerosing Cholangitis | 343 | ||
| Drug-Induced Liver Injury | 344 | ||
| Autoimmune Hepatitis–Like Disease in the Transplanted Liver | 345 | ||
| PROGNOSIS OF AUTOIMMUNE HEPATITIS | 346 | ||
| REFERENCES | 347 | ||
| Hepatic Adenomas | 351 | ||
| ABSTRACT | 351 | ||
| OVERVIEW | 351 | ||
| DEFINITION | 351 | ||
| HEPATIC ADENOMA-LIKE NODULES IN CIRRHOTIC LIVERS | 352 | ||
| CLINICAL FINDINGS | 352 | ||
| CLINICAL MANAGEMENT | 352 | ||
| DIAGNOSTIC APPROACH | 352 | ||
| GENERAL OVERVIEW OF HEPATIC ADENOMA SUBTYPES | 354 | ||
| SUBTYPE DETERMINATION | 355 | ||
| HNF1-ALPHA–INACTIVATED ADENOMA | 355 | ||
| INFLAMMATORY ADENOMA | 356 | ||
| BETA-CATENIN–ACTIVATED ADENOMA | 357 | ||
| UNCLASSIFIED ADENOMAS | 359 | ||
| NEWLY REPORTED SUBTYPES | 359 | ||
| OTHER SUBTYPES | 360 | ||
| AN EXPANDED ADENOMA CLASSIFICATION SCHEMA | 361 | ||
| MALIGNANT TRANSFORMATION | 362 | ||
| REFERENCES | 364 | ||
| Update on Ancillary Testing in the Evaluation of High-Grade Liver Tumors | 367 | ||
| ABSTRACT | 367 | ||
| OVERVIEW | 367 | ||
| STAINS TO DETERMINE LIVER ORIGIN | 368 | ||
| THE UREA CYCLE STAINS: ARGINASE-1 AND HEPATOCYTE IN PARAFFIN 1 | 368 | ||
| STAINS WITH A CANALICULAR PATTERN: BILE SALT EXPORT PUMP, CLUSTER OF DIFFERENTIATION 10, AND POLYCLONAL CARCINOEMBRYONIC AN ... | 369 | ||
| GLYPICAN-3 | 369 | ||
| IN SITU HYBRIDIZATION FOR ALBUMIN | 369 | ||
| SPECIFIC SITUATIONS | 370 | ||
| SCIRRHOUS HEPATOCELLULAR CARCINOMA | 370 | ||
| FIBROLAMELLAR CARCINOMA | 371 | ||
| CHOLANGIOCARCINOMA VERSUS HEPATOCELLULAR CARCINOMA | 371 | ||
| ALBUMIN IN SITU HYBRIDIZATION IN CHOLANGIOCARCINOMA | 372 | ||
| SUMMARY | 373 | ||
| REFERENCES | 373 | ||
| Fibrolamellar Carcinoma | 377 | ||
| ABSTRACT | 377 | ||
| OVERVIEW | 377 | ||
| GROSS FEATURES | 379 | ||
| MICROSCOPIC FEATURES | 379 | ||
| DIFFERENTIAL DIAGNOSIS | 381 | ||
| DIAGNOSIS | 381 | ||
| MOLECULAR PATHOLOGY OF FIBROLAMELLAR CARCINOMA | 383 | ||
| ARE THERE MIXED FIBROLAMELLAR-HEPATOCELLULAR CARCINOMAS? | 384 | ||
| FIBROLAMELLAR CARCINOMA IS DISTINCT FROM CONVENTIONAL HEPATOCELLULAR CARCINOMA | 385 | ||
| PROGNOSIS | 385 | ||
| REFERENCES | 385 | ||
| Hepatic Lymphoma Diagnosis | 389 | ||
| ABSTRACT | 389 | ||
| OVERVIEW | 389 | ||
| NON-HODGKIN B-CELL LYMPHOMAS | 391 | ||
| DIFFUSE LARGE B-CELL LYMPHOMA | 391 | ||
| BURKITT LYMPHOMA | 393 | ||
| B-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA | 393 | ||
| CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA | 393 | ||
| HAIRY CELL LEUKEMIA | 393 | ||
| FOLLICULAR LYMPHOMA | 393 | ||
| MANTLE CELL LYMPHOMA | 393 | ||
| EXTRANODAL MARGINAL ZONE LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID TISSUE | 394 | ||
| MATURE T-CELL NEOPLASMS | 395 | ||
| PERIPHERAL T-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED | 395 | ||
| HEPATOSPLENIC T-CELL LYMPHOMA | 395 | ||
| IMMUNODEFICIENCY-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS: POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS | 395 | ||
| HODGKIN LYMPHOMAS | 397 | ||
| CLASSIC HODGKIN LYMPHOMA | 397 | ||
| NODULAR LYMPHOCYTE–PREDOMINANT HODGKIN LYMPHOMA | 397 | ||
| LYMPHOMA MIMICS: NODULAR LYMPHOID LESION | 398 | ||
| EPSTEIN-BARR VIRUS-POSITIVE HEPATIC LYMPHOID INFILTRATES | 398 | ||
| REFERENCES | 400 | ||
| Cholangiocarcinoma | 403 | ||
| ABSTRACT | 403 | ||
| OVERVIEW | 403 | ||
| CLASSIFICATION SCHEMES | 404 | ||
| CLASSIFICATION BY ANATOMIC LOCATION | 404 | ||
| CLASSIFICATION BY MACROSCOPIC GROWTH PATTERN | 406 | ||
| CLASSIFICATION BY MICROSCOPIC FEATURES | 406 | ||
| CLASSIFICATION BY CELL OF ORIGIN | 408 | ||
| INTRAHEPATIC CHOLANGIOCARCINOMA | 409 | ||
| HISTOLOGIC SUBTYPES | 409 | ||
| IMMUNOHISTOCHEMICAL AND MOLECULAR CHARACTERISTICS | 409 | ||
| DIFFERENTIAL DIAGNOSIS | 411 | ||
| Combined Hepatocellular Carcinoma and Cholangiocarcinoma | 415 | ||
| Other Histologic Mimics of Intrahepatic Cholangiocarcinoma | 415 | ||
| GROSSING AND STAGING INTRAHEPATIC CHOLANGIOCARCINOMA | 416 | ||
| EXTRAHEPATIC CHOLANGIOCARCINOMA | 416 | ||
| IMMUNOHISTOCHEMICAL AND MOLECULAR CHARACTERISTICS | 418 | ||
| DIFFERENTIAL DIAGNOSIS | 419 | ||
| GROSSING AND STAGING EXTRAHEPATIC CHOLANGIOCARCINOMA | 421 | ||
| PRECURSOR LESIONS | 421 | ||
| PROGNOSIS, TREATMENT, AND POTENTIAL TARGETS | 425 | ||
| REFERENCES | 425 | ||
| Acute, Chronic, and Humoral Rejection | 431 | ||
| ABSTRACT | 431 | ||
| OVERVIEW | 431 | ||
| CURRENT STRATEGIES OF IMMUNOSUPPRESSION FOR LIVER TRANSPLANTATION | 432 | ||
| IMMUNOSUPPRESSIVE AGENTS | 432 | ||
| STRATEGIES AND PROTOCOLS | 432 | ||
| IMMUNE TOLERANCE | 433 | ||
| T-CELL–MEDIATED REJECTION (ACUTE CELLULAR REJECTION) | 434 | ||
| CLINICAL AND LABORATORY ASPECTS | 434 | ||
| TYPICAL HISTOLOGIC FEATURES | 434 | ||
| GRADING T-CELL–MEDIATED REJECTION | 434 | ||
| UNUSUAL FORMS OF T-CELL–MEDIATED REJECTION | 435 | ||
| Late-Onset Acute Rejection | 435 | ||
| Central Perivenulitis | 436 | ||
| Plasma Cell-Rich Rejection | 437 | ||
| Hepatitic Rejection | 437 | ||
| Idiopathic Posttransplant Hepatitis | 438 | ||
| DIFFERENTIAL DIAGNOSIS | 438 | ||
| TREATMENT AND PROGNOSIS | 440 | ||
| CHRONIC REJECTION | 442 | ||
| CLINICAL AND LABORATORY ASPECTS | 442 | ||
| HISTOLOGIC FEATURES | 442 | ||
| STAGING CHRONIC REJECTION | 444 | ||
| DIFFERENTIAL DIAGNOSIS | 445 | ||
| TREATMENT AND PROGNOSIS | 446 | ||
| ANTIBODY-MEDIATED REJECTION (HUMORAL REJECTION) | 446 | ||
| CLINICAL AND LABORATORY ASPECTS | 446 | ||
| HISTOLOGIC FEATURES | 448 | ||
| C4D IMMUNOHISTOCHEMISTRY | 448 | ||
| DIFFERENTIAL DIAGNOSIS | 450 | ||
| TREATMENT AND PROGNOSIS | 450 | ||
| REFERENCES | 450 | ||
| Frozen Sections of the Liver | 453 | ||
| ABSTRACT | 453 | ||
| OVERVIEW | 453 | ||
| SURGICAL RESECTION OF ADENOCARCINOMA | 453 | ||
| COLORECTAL CANCER METASTASES | 453 | ||
| INTRAHEPATIC CHOLANGIOCARCINOMA | 454 | ||
| Distinguishing Adenocarcinoma from Primary Hepatic Bile Duct Lesions | 454 | ||
| BILE DUCT HAMARTOMA | 456 | ||
| BILE DUCT ADENOMA (PERIBILIARY GLAND HAMARTOMA) | 456 | ||
| BENIGN DUCTULAR REACTIONS ASSOCIATED WITH BILE DUCT OBSTRUCTION AND CHOLECYSTITIS | 456 | ||
| SURGICAL RESECTION OF PRIMARY HEPATIC TUMORS | 459 | ||
| DISTINGUISHING HEPATOCELLULAR CARCINOMA FROM OTHER HEPATOCELLULAR LESIONS | 459 | ||
| Intrahepatic Cholangiocarcinoma | 459 | ||
| Cavernous Hemangioma | 460 | ||
| Epithelioid Hemangioendothelioma | 460 | ||
| DISTINGUISHING HEPATOCELLULAR CARCINOMA FROM METASTASES | 460 | ||
| Gastrointestinal Endocrine Tumors | 461 | ||
| Renal Cell Carcinoma | 462 | ||
| Adrenal Cortical Carcinoma | 462 | ||
| Malignant Melanoma | 462 | ||
| Gastrointestinal Stromal Tumor | 463 | ||
| Angiomyolipoma | 463 | ||
| DONOR LIVER EVALUATION | 463 | ||
| SUMMARY | 465 | ||
| REFERENCES | 465 |