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Practice of Clinical Echocardiography E-Book

Practice of Clinical Echocardiography E-Book

Catherine M. Otto

(2016)

Additional Information

Book Details

Abstract

The new edition of Practice of Clinical Echocardiography provides expert guidance on interpreting echocardiographic images and Doppler flow data. Designed for those already equipped with a mastery of basic principles, this definitive reference shows you how to apply these findings to your daily clinical decision making. Each chapter focuses on a specific disease process with technical details of qualitative and quantitative interpretation of echocardiographic images and Doppler flow data.

  • Disease-oriented chapters emphasize the role of echocardiography in clinical decision making and prediction of clinical outcomes.
  • New chapters cover emerging technologies, including transcatheter procedures for structural heart disease.
  • Numerous images illustrate findings, while diagrams explain pathophysiology and flow charts guide clinical practice.
  • Each chapter includes a summary box with a practical approach to echo data acquisition, measurement, and interpretation.

Table of Contents

Section Title Page Action Price
Front Cover Cover
IFC ES1
THE PRACTICE OF CLINICAL ECHOCARDIOGRAPHY i
THE PRACTICE OF CLINICAL ECHOCARDIOGRAPHY iii
Copyright iv
CONTRIBUTORS v
PREFACE xi
ACKNOWLEDGMENTS xiii
CONTENTS xv
GLOSSARY xvii
I - Advanced Principles for the Echocardiographer 1
1 - The Diagnostic Echocardiography Laboratory: Structure, Standards, and Quality Improvement 3
QUALITY IN CONTEXT 3
STRUCTURE AND STANDARDS 3
LABORATORY STRUCTURE 3
QUALITY IMPROVEMENT 9
PATIENT SELECTION AND APPROPRIATE USE CRITERIA 9
REPRODUCIBILITY AND VARIABILITY 11
ECHOCARDIOGRAPHY OUTSIDE THE ECHOCARDIOGRAPHY LABORATORY 13
QUALITY IN AN ERA OF HEALTH CARE REFORM 14
REFERENCES 16
2 - 3D Echocardiography: Principles of Image Acquisition, Display, and Analysis 18
ULTRASOUND IMAGING SYSTEM FUNCTION 18
RESOLUTION IN 3D ECHO 20
SPATIAL RESOLUTION 20
TEMPORAL RESOLUTION 21
Single-Beat or Multibeat Acquisition 21
Parallel Beamforming 21
Interpolation of Images or Image Sectors 22
Frame Reordering 22
Virtual Array 23
Multiline Transmission 23
High-Pulse Repetition Frequency 23
RELATIONSHIP BETWEEN SPATIAL AND TEMPORAL RESOLUTION 24
3D ECHO DATA ACQUISITION 24
2D IMAGE OPTIMIZATION 24
3D ACQUISITION MODES 24
Simultaneous Multiplane Mode 24
Pyramidal Size 26
“Zoom” 26
Narrow Sector 26
Wide Sector 26
COLOR FLOW DOPPLER 26
CHALLENGES WITH 3D ECHO ACQUISITION 27
Temporal Versus Spatial Resolution 27
ECG-Gating and Breath-Hold 27
3D IMAGE OPTIMIZATION 27
GAIN 27
BRIGHTNESS 27
SMOOTHING 27
COLORIZATION 27
3D IMAGE DISPLAY 28
DATA SET CROPPING 28
Autocrop 29
Box Crop 29
Plane Crop 29
Two-Plane Crop 30
POSTACQUISITION DISPLAY 30
Volume Rendering 30
Surface Rendering 30
2D Tomographic Slices 30
3D ECHO ANALYSIS 31
MULTIPLANAR RECONSTRUCTION 31
MODELING 31
COLOR DOPPLER 31
3D ECHO ACQUISITION AND ANALYSIS PROTOCOLS 32
LEFT VENTRICLE 32
Acquisition 32
Presentation 32
Analysis 32
Limitations 32
RIGHT VENTRICLE 33
II - The Left Ventricle 105
7 - Quantitative Evaluation of Left Ventricular Structure, Wall Stress, and Systolic Function 107
DEFINITIONS AND THEORETICAL CONSIDERATIONS 108
ASSESSMENT OF LEFT VENTRICULAR MASS, VOLUME, AND GEOMETRY 111
M-MODE ECHOCARDIOGRAPHY 111
Mass 111
Volume 113
Relative Wall Thickness 113
TWO-DIMENSIONAL ECHOCARDIOGRAPHY 115
Mass 115
Geometry 116
Doppler Echocardiography 117
ASSESSMENT OF LEFT VENTRICULAR SYSTOLIC FUNCTION 117
EJECTION FRACTION 119
Hemodynamic Determinants of the Ejection Fraction 119
FRACTIONAL SHORTENING AND RELATED INDICES 120
STRESS-SHORTENING RELATIONS 120
Midwall Stress-Shortening Analysis 121
PRESSURE-VOLUME ANALYSIS 122
POTENTIAL LIMITATIONS 123
REFERENCES 126
8 - Myocardial Mechanics: Velocities, Strain, Strain Rate, Cardiac Synchrony, and Twist 128
VELOCITY AND DISPLACEMENT IMAGING 128
VELOCITIES BY COLOR DOPPLER 128
VELOCITIES BY PULSED DOPPLER 128
DISPLACEMENT IMAGING 129
DEFORMATION IMAGING 131
BASIC CONCEPTS 131
STRAIN AND STRAIN RATE BY TISSUE DOPPLER IMAGING 132
PHYSICAL PRINCIPLES OF SPECKLE TRACKING ECHOCARDIOGRAPHY 132
STRAIN AND STRAIN RATE BY SPECKLE TRACKING ECHOCARDIOGRAPHY 133
LEFT VENTRICULAR ROTATION AND TWIST 133
LIMITATIONS OF VELOCITY AND STRAIN IMAGING 134
ANGLE DEPENDENCY 134
INADEQUATE TRACKING 134
NOISE REDUCTION VERSUS SPATIAL AND TEMPORAL RESOLUTION 134
MOVEMENT OF SAMPLE VOLUME RELATIVE TO MYOCARDIUM 135
REVERBERATIONS 135
LOAD DEPENDENCY 136
LIMITATIONS OF LEFT VENTRICULAR ROTATION AND TWIST 136
TRANSMURAL STRAIN GRADIENT 136
INTERVENDOR VARIABILITY IN STRAIN 136
NORMAL LV PHYSIOLOGY 136
SYSTOLIC VELOCITIES 137
DIASTOLIC VELOCITIES 137
MYOCARDIAL ISCHEMIA 138
CARDIAC SYNCHRONY 139
MECHANISMS OF LEFT VENTRICULAR INTRAVENTRICULAR DYSSYNCHRONY 139
EFFECT OF LEFT BUNDLE BRANCH BLOCK ON LEFT VENTRICULAR FUNCTION 141
DYSSYNCHRONY AND RISK OF VENTRICULAR ARRHYTHMIAS 141
STRAIN IMAGING IN SUBCLINICAL LEFT VENTRICULAR DYSFUNCTION 142
RIGHT VENTRICULAR FUNCTION 143
REFERENCES 144
9 - Left Ventricular Diastolic Function 147
BASIC PRINCIPLES 147
PHYSIOLOGY OF DIASTOLIC FUNCTION 147
EFFECT OF AGING ON DIASTOLIC FUNCTION 148
MITRAL INFLOW PATTERN 150
PULMONARY VENOUS FLOW 152
COLOR M-MODE DOPPLER 152
TISSUE DOPPLER IMAGING 152
ASSESSMENT OF LEFT VENTRICULAR FILLING PRESSURE: E/E′ RATIO 153
ASSESSMENT OF DIASTOLIC FUNCTION IN SPECIAL CIRCUMSTANCES 154
SINUS TACHYCARDIA 154
ATRIAL FIBRILLATION 154
MITRAL REGURGITATION 154
SUPPORTIVE ECHOCARDIOGRAPHIC FINDINGS OF DIASTOLIC DYSFUNCTION 155
LEFT ATRIAL ENLARGEMENT AND ABNORMAL LEFT ATRIAL FUNCTION 155
PULMONARY HYPERTENSION 156
EVALUATION OF DIASTOLIC FUNCTION IN THE CLINICAL SETTING 156
GRADING OF LEFT VENTRICULAR DIASTOLIC FUNCTION 156
ESTIMATION OF LEFT VENTRICULAR FILLING PRESSURES 157
NEW TECHNOLOGIES FOR THE ASSESSMENT OF DIASTOLIC FUNCTION 158
DIASTOLIC STRESS ECHOCARDIOGRAPHY 158
STRAIN 159
LEFT VENTRICULAR TWIST AND TORSION 161
ACKNOWLEDGEMENTS 161
REFERENCES 163
10 - Digital Image Processing and Automated Image Analysis in Echocardiography 166
DIGITAL IMAGE PROCESSING AND AUTOMATED ANALYSIS:DEFINITION AND MOTIVATION 166
DIGITAL IMAGE STORAGE, COMMUNICATION, AND COMPRESSION 167
DIGITAL IMAGES 167
STORAGE FORMATS AND IMAGE COMMUNICATION 167
Digital Imaging and Communications in Medicine 167
General-Purpose Formats 167
IMAGE COMPRESSION 167
MEDICAL IMAGE PROCESSING 167
IMAGE ENHANCEMENT: LEVEL MANIPULATIONS, FILTERING 167
IMAGE INTERPRETATION: THE INTERPRETATION PYRAMID 168
Cardiac Image Interpretation 168
Rules for a Well-Behaved Automated Border Detection Method 169
AUTOMATED BORDER DETECTION IN ECHOCARDIOGRAPHY 169
PROBLEMS AND PITFALLS 169
PRACTICAL CONSIDERATIONS 170
Acquisition and Image Quality 170
Contour Definitions and Consistency 170
Choice of Detection Technique 170
OVERVIEW OF AUTOMATED BORDER DETECTION METHODS 170
FEATURE-DRIVEN METHODS 170
STRUCTURE-BASED METHOD: TISSUE TRACKING 170
OBJECT-BASED METHODS: GEOMETRIC MODELING 173
PATTERN MATCHING 173
3D ACTIVE SURFACE DETECTION 174
POPULATION MODEL–BASED METHOD: ACTIVE APPEARANCE MODELS 177
CLASSIFICATION AND AUTOMATED LOCALIZATION 178
COMPARISON BETWEEN AUTOMATED BORDER DETECTION METHODS 178
FUTURE PROMISE: INTELLIGENT ULTRASOUND SYSTEMS 178
REFERENCES 180
III - Ischemic Heart Disease 183
11 - The Role of Echocardiographic Evaluation in Patients Presenting with Acute Chest Pain to the Emergency Department 185
BACKGROUND AND PRINCIPLES 185
ECHOCARDIOGRAPHY AND THE PHYSIOLOGY OF ACUTE ISCHEMIA 185
TECHNICAL ASPECTS OF ECHO 186
IMAGE ACQUISITION 186
CLINICAL APPLICATIONS 187
TRIAGE OF PATIENTS WITH CHEST PAIN 187
STRAIN IMAGING 188
STRESS ECHOCARDIOGRAPHY 189
USE OF MYOCARDIAL CONTRAST 191
ASSESSMENT OF THE NEED FOR URGENT CORONARY ANGIOGRAPHY 191
RISK STRATIFICATION AND LONG-TERM OUTCOMES 192
POINT OF CARE CARDIAC ULTRASOUND IN THE EMERGENCY DEPARTMENT 193
USE OF ECHOCARDIOGRAPHY IN CHEST PAIN UNITS AND CLINICAL ALGORITHMS 194
COST EFFECTIVENESS 194
EVALUATION OF NONISCHEMIC CAUSES OF CHEST PAIN 195
AORTIC DISSECTION 195
PULMONARY EMBOLUS 195
PERICARDITIS 195
AORTIC STENOSIS 195
LIMITATIONS 195
ISCHEMIA EVALUATION 195
IMAGE QUALITY 196
PERSONNEL AVAILABILITY 197
SUMMARY 197
REFERENCES 198
12 - Echocardiography in the Coronary Care Unit: Management of Acute Myocardial Infarction, Detection of Complications, and Prognosti... 200
APPLICABLE MODES OF ECHOCARDIOGRAPHY IN THECORONARY CARE UNIT 200
ECHOCARDIOGRAPHY IN THE DIAGNOSIS AND LOCALIZATION OF ACUTE MYOCARDIAL INFARCTION 201
DIAGNOSTIC ROLE OF ECHOCARDIOGRAPHY 201
LOCALIZATION OF INFARCTION 201
RIGHT VENTRICULAR INFARCTION 203
DETECTING COMPLICATIONS OF ACUTE MYOCARDIAL INFARCTION 204
HEMODYNAMIC ASSESSMENT OF MYOCARDIAL INFARCTION USING DOPPLER ECHOCARDIOGRAPHY 204
POSTINFARCTION PERICARDIAL EFFUSION 204
ACUTE MITRAL REGURGITATION 204
VENTRICULAR SEPTAL RUPTURE 205
RUPTURE OF THE VENTRICULAR FREE WALL 208
PSEUDOANEURYSM 208
INFARCT EXPANSION AND TRUE ANEURYSM FORMATION 208
LEFT VENTRICULAR THROMBUS 209
RISK STRATIFICATION AFTER MYOCARDIAL INFARCTION 210
LEFT VENTRICULAR SYSTOLIC FUNCTION 210
REGIONAL WALL MOTION SCORE 211
LEFT VENTRICULAR DIASTOLIC FUNCTION 211
LEFT ATRIAL VOLUME 212
LEFT VENTRICULAR REMODELING 212
STRESS ECHOCARDIOGRAPHY 213
CORONARY FLOW RESERVE 213
MITRAL REGURGITATION 213
REFERENCES 215
13 - Stress Echocardiography for Coronary Ischemia 218
PHYSIOLOGIC AND PATHOPHYSIOLOGIC PRINCIPLES 218
THE ISCHEMIC CASCADE 218
DETERMINANTS OF MYOCARDIAL OXYGEN DEMAND AND SUPPLY 219
INDICATIONS AND CONTRAINDICATIONS FOR STRESS ECHOCARDIOGRAPHY 219
INDICATIONS 219
Use of Exercise Stress Echocardiography to Assess Preoperative Risk in Noncardiac Surgery 223
CONTRAINDICATIONS 223
COST-EFFECTIVENESS 223
STRESS PROTOCOLS 223
GENERAL CONSIDERATIONS 223
EQUIPMENT AND PERSONNEL 224
PATIENT PREPARATION 224
EXERCISE STRESS TESTING 225
EXERCISE STRESS PROTOCOLS 225
Treadmill Protocols 225
Bicycle Protocols 225
Handgrip 225
EXERCISE STRESS ECHOCARDIOGRAPHY WITH MEDICAL THERAPY 225
OUTCOME ASSESSMENT OF STRESS ECHOCARDIOGRAPHY 225
Symptoms, Angina, and Perceived Effort 225
Heart Rate 226
Heart Rate Recovery 226
Blood Pressure 227
Functional Capacity 227
Electrocardiographic Changes 227
Echocardiographic Imaging 227
Duke Treadmill Score 228
Other Important Stress Echocardiographic Outcomes 228
TERMINATION OF STRESS ECHOCARDIOGRAPHY 231
ACCURACY OF EXERCISE STRESS ECHOCARDIOGRAPHY 231
SENSITIVITY, SPECIFICITY, AND PROGNOSTIC VALUE 232
FUTURE DEVELOPMENTS 235
STRAIN ECHOCARDIOGRAPHY 235
3D ECHOCARDIOGRAPHY 237
REFERENCES 241
14 - NONEXERCISE STRESS ECHOCARDIOGRAPHY FOR DIAGNOSIS OF CORONARY ARTERY DISEASE 243
PHARMACOLOGIC STRESS ECHOCARDIOGRAPHY IN CURRENT CLINICAL PRACTICE 254
DOBUTAMINE STRESS ECHOCARDIOGRAPHY 244
DIPYRIDAMOLE STRESS ECHOCARDIOGRAPHY 245
ERGONOVINE 245
PACING STRESS ECHOCARDIOGRAPHY 245
DIAGNOSTIC ACCURACY OF NONEXERCISE STRESS ECHOCARDIOGRAPHY FOR DIAGNOSING SIGNIFICANT CORONARY ARTERY DISEASE 245
ASSESSMENT OF MYOCARDIAL VIABILITY 247
NEW TECHNIQUES IN STRESS ECHOCARDIOGRAPHY 252
THREE-DIMENSIONAL STRESS ECHOCARDIOGRAPHY 252
CORONARY FLOW VELOCITY RESERVE 253
TISSUE DOPPLER IMAGING AND TWO-DIMENSIONAL SPECKLE TRACKING STRAIN ECHOCARDIOGRAPHY 253
REFERENCES 257
IV - Valvular Heart Disease 259
15 - Aortic Stenosis: Disease Severity, Progression, and Timing of Intervention 261
VALVE MORPHOLOGY 262
HEMODYNAMIC SEVERITY 263
AORTIC VELOCITY AND MEAN PRESSURE GRADIENT 263
CONTINUITY EQUATION AORTIC VALVE AREA 264
Left Ventricular Outflow Tract Velocity 264
Left Ventricular Outflow Tract Diameter 265
STROKE VOLUME INDEX 265
VELOCITY RATIO 265
TRANSESOPHAGEAL ECHOCARDIOGRAPHY PLANIMETRY VALVE AREA 266
CLINICAL CHALLENGES IN ASSESSMENT OF AORTIC STENOSIS SEVERITY 268
MEASUREMENT PRECISION AND VARIABILITY 268
EFFECT OF TRANSAORTIC FLOW 268
ANATOMIC VERSUS EFFECTIVE AORTIC VALVE AREA 269
PRESSURE RECOVERY 269
DISCORDANCE BETWEEN DIFFERENT MEASURES OF AORTIC STENOSIS SEVERITY 270
ADJUSTMENT FOR BODY SIZE 270
CONCURRENT HYPERTENSION 270
LEFT VENTRICULAR CHANGES IN AORTIC STENOSIS 270
LEFT VENTRICULAR HYPERTROPHY AND REMODELING 270
DIASTOLIC FUNCTION 270
SYSTOLIC FUNCTION 270
STROKE VOLUME INDEX 271
LONGITUDINAL FUNCTION 271
ASSOCIATED FINDINGS 271
AORTIC REGURGITATION 271
CONCOMITANT SUBVALVULAR OBSTRUCTION 271
MITRAL ANNULAR CALCIFICATION AND MITRAL REGURGITATION 271
CORONARY ARTERY DISEASE 273
PULMONARY HYPERTENSION 273
ALTERNATIVE DIAGNOSTIC MODALITIES 273
EXERCISE STRESS TESTING 273
CARDIAC CATHETERIZATION 273
Gradients 273
Aortic Valve Area 273
COMPUTED TOMOGRAPHY 273
CARDIAC MAGNETIC RESONANCE IMAGING 274
CLINICAL APPROACH 274
PROGNOSTIC VALUE 274
STRATEGIES TO MITIGATE OR HALT PROGRESSION 274
Timing of Aortic Valve Replacement 276
SYMPTOMATIC PATIENTS 278
ASYMPTOMATIC PATIENTS 278
LOW-GRADIENT AORTIC STENOSIS WITH REDUCED EJECTION FRACTION (STAGE D2) 278
LOW-GRADIENT AORTIC STENOSIS WITH PRESERVED EJECTION FRACTION (STAGE D3) 279
PATIENTS WITH INDICATIONS FOR OTHER CARDIAC SURGERY 282
ACKNOWLEDGMENT 282
REFERENCES 284
16 - Transcatheter Aortic Valve Implantation: Role of Echocardiography in Patient Selection, Procedural Planning and Monitoring, and Monitoring, and Evaluation of Outcomes. 287
SEVERITY OF AORTIC STENOSIS 287
HIGH-RISK ASSESSMENT 288
SPECIFIC ASSOCIATED CONDITIONS 288
Bicuspid Aortic Valve 288
Mitral Regurgitation 288
Left Ventricular Hypertrophy and Obstruction 289
Ascending Aortic Aneurysm 289
Exuberant Aortic Atheroma 289
Intracardiac Masses 289
PLANNING OF THE PROCEDURE 289
MEASURING THE AORTIC ANNULUS AND PROSTHESIS SIZING 289
DISTANCE BETWEEN PLANE OF AORTIC ANNULUS AND CORONARY OSTIA 291
BASAL SEPTAL HYPERTROPHY 291
AORTIC VALVE CALCIFICATION 291
GUIDING THE PROCEDURE—INTRAPROCEDURAL COMPLICATIONS 292
TRANSESOPHAGEAL GUIDANCE 292
Before Implantation 292
Balloon Valvuloplasty 292
Prosthesis Positioning and Deployment 292
IS TRANSESOPHAGEAL ECHOCARDIOGRAPHY MANDATORY DURING TRANSCATHETER AORTIC VALVE IMPLANTATION? 293
IMMEDIATE COMPLICATIONS 294
Annulus Rupture 294
Pericardial Effusion and Tamponade 294
Coronary Obstruction and Myocardial Infarction 294
Prosthesis Malposition and Malfunction and Severe Aortic Regurgitation 294
Acute Mitral Regurgitation 295
Cardiogenic Shock 295
SHORT-TERM AND MIDTERM OUTCOME 295
HEMODYNAMIC PERFORMANCE OF IMPLANTED PROSTHESIS 295
PARAVALVULAR REGURGITATION 296
THROMBOSIS 298
ENDOCARDITIS 299
PROSTHESIS DEGENERATION 300
CONCLUSION 300
REFERENCES 301
17 - Aortic Valve Regurgitation: Quantitation of Disease Severity and Timing of Surgical Intervention 303
ETIOLOGY 303
LEAFLET ABNORMALITIES 303
AORTIC ROOT ABNORMALITIES 305
AORTIC REGURGITATION SEVERITY 305
COLOR DOPPLER ECHOCARDIOGRAPHY 305
Semiquantitative Methods 306
Quantitative Methods 306
PULSED WAVE DOPPLER 308
CONTINUOUS WAVE DOPPLER 308
Deceleration Time of Regurgitant Flow 308
INTEGRATING DOPPLER INDEXES OF SEVERITY 309
ALTERNATIVE APPROACHES 309
LEFT VENTRICLE SIZE AND SYSTOLIC FUNCTION 310
DIMENSIONS AND CONTRACTILE FUNCTION OF THE LEFT VENTRICLE 310
CONTRACTILE RESERVE EVALUATION 310
AORTIC ROOT AND ASCENDING AORTA EVALUATION 310
AORTIC VALVE AND ROOT FUNCTION 311
NATURAL HISTORY AND SERIAL TESTING IN CHRONIC AORTIC REGURGITATION 312
MANAGEMENT AND TIMING OF SURGERY 312
MEDICAL TREATMENT 312
INDICATIONS FOR SURGERY 313
Symptomatic Patients with Left Ventricular Dysfunction 314
Symptomatic Patients with Normal Left Ventricular Systolic Function 314
Asymptomatic Patients with Reduced Ejection Fraction 314
Asymptomatic Patients with Normal Ejection Fraction 314
Concomitant Aortic Root Disease 314
SELECTING AND GUIDING SURGICAL TREATMENT 314
ROLE OF ECHOCARDIOGRAPHY 314
SURGICAL IMPLICATIONS 315
RESULTS OF SURGERY AND FOLLOW-UP 316
ACUTE AORTIC REGURGITATION 316
ACUTE TYPE A AORTIC DISSECTION 317
INFECTIVE ENDOCARDITIS 317
OTHER UNCOMMON CAUSES OF ACUTE AORTIC REGURGITATION 318
SUMMARY AND FUTURE PERSPECTIVES 318
REFERENCES 320
18 - Mitral Regurgitation: Valve Anatomy, Regurgitant Severity, and Timing of Intervention 322
ANATOMY AND PATHOPHYSIOLOGY 322
MITRAL VALVE ANATOMY 322
Embryology and Components of the Mitral Valve 322
Mitral Annulus 322
Mitral Leaflets 322
Chordae Tendineae and Papillary Muscles 323
MECHANISM OF MITRAL REGURGITATION 323
Primary Mitral Regurgitation 323
Secondary Mitral Regurgitation 325
Carpentier Classification Nomenclature 329
Mitral Regurgitation Mechanisms Summary 329
QUANTITATION OF MITRAL REGURGITATION 329
COLOR DOPPLER METHODS 329
Distal Jet Area Method 329
Vena Contracta Width Method 330
Proximal Isovelocity Surface Area Method 331
Geometric Factors That Influence the Proximal Isovelocity Surface Area Method 332
Technical Factors 332
Different Reference Values for Effective Regurgitant Orifice Area based on the Cause of Mitral Regurgitation 333
VOLUMETRIC METHODS USING PULSED DOPPLER 333
SUPPORTIVE ECHO AND DOPPLER DATA 333
Pulmonary Venous Flow Pattern: Systolic Flow Reversal 333
Holosystolic versus Nonholosystolic Mitral Regurgitation 334
Peak E Wave Velocity 334
Continuous Wave Doppler Pattern 334
Valve Morphology and Left-Sided Chamber Size 334
ROLE OF THREE-DIMENSIONAL ECHOCARDIOGRAPHY 334
IMPORTANCE OF HEMODYNAMIC AND PHYSIOLOGIC FACTORS 334
Summary of Approach to Grading Mitral Regurgitation: Importance of Integrative Method 334
Integrative Approach to Quantitation of Mitral Regurgitation Severity 335
TIMING OF SURGICAL INTERVENTION 335
DISEASE COURSE 335
TIMING OF INTERVENTION 336
Therapy for Primary Mitral Regurgitation 336
Therapy for Secondary Mitral Regurgitation 337
CLINICAL CORRELATES 337
REFERENCES 340
19 - Transesophageal Echocardiography for Surgical Repair of Mitral Regurgitation 343
THE TEAM APPROACH TO ECHOCARDIOGRAPHY-GUIDED MITRAL REPAIR 343
ESSENTIAL ANATOMY 344
MITRAL VALVE DISEASE 344
DEGENERATIVE (MYXOMATOUS) DISEASE 345
INFECTIVE ENDOCARDITIS 345
RHEUMATIC DISEASE 347
RADIATION NECROSIS 347
DYSTROPHIC CALCIFICATION 347
PAPILLARY MUSCLE RUPTURE 347
SECONDARY VALVE DISEASE 347
TRANSESOPHAGEAL IMAGING OF THE MITRAL VALVE 348
STANDARD MULTIPLANE IMAGING 348
PRINCIPLES OF AXIAL IMAGING 349
THREE-DIMENSIONAL IMAGING 349
PREREPAIR TRANSESOPHAGEAL ECHOCARDIOGRAPHY 349
DEGENERATIVE DISEASE 356
ENDOCARDITIS 356
RHEUMATIC DISEASE 356
PAPILLARY MUSCLE RUPTURE 356
SECONDARY DISEASE 356
DISEASE COMBINATIONS 356
SURGICAL TECHNIQUES OF IMAGE-GUIDED MITRAL REPAIR 358
DEGENERATIVE DISEASE 358
ENDOCARDITIS 366
RHEUMATIC DISEASE 366
PAPILLARY MUSCLE RUPTURE 366
SECONDARY DISEASE 366
POSTREPAIR TRANSESOPHAGEAL ECHOCARDIOGRAPHY 366
LEAFLET STRUCTURE AND FUNCTION 366
RESIDUAL MITRAL REGURGITATION 367
NEW MITRAL STENOSIS 367
VENTRICULAR DYSFUNCTION 367
SYSTOLIC ANTERIOR MOTION 367
REFERENCES 371
20 - Transcatheter Mitral Valve Repair: Role of Echocardiography in Patient Selection, Procedural Guidance, and Evaluation of Outcome 374
PERCUTANEOUS THERAPIES FOR MITRAL REGURGITATION 374
OVERVIEW 374
EDGE-TO-EDGE MITRAL VALVE REPAIR 376
USE OF ECHOCARDIOGRAPHY IN PATIENT SELECTION 376
DETERMINING THE CAUSE OF MITRAL REGURGITATION 376
DEGENERATIVE MITRAL REGURGITATION 377
FUNCTIONAL MITRAL REGURGITATION 378
MIXED MITRAL REGURGITATION 379
DETERMINING MITRAL REGURGITATION SEVERITY 379
MODERATE TO SEVERE MITRAL REGURGITATION 380
SEVERE MITRAL REGURGITATION 380
ECHOCARDIOGRAPHIC MARKERS TO DETERMINE SUITABILITY FOR EDGE-TO-EDGE MITRAL VALVE REPAIR 382
PROCEDURAL GUIDANCE 382
TRANSSEPTAL PUNCTURE 382
NAVIGATION IN THE LEFT ATRIUM 382
GUIDING CATHETER AND DELIVERY SYSTEM STEERING 382
DEVICE ALIGNMENT TO THE MITRAL VALVE 383
DEVICE ADVANCEMENT INTO LEFT VENTRICLE 383
LEAFLET GRASPING 384
DEVICE RELEASE AND DETERMINATION OF RESIDUAL MITRAL REGURGITATION 384
CONSIDERATION FOR ADDITIONAL CLIPS 384
RETRIEVAL OF DELIVERY CATHETERS 384
ATRIAL SEPTAL DEFECT CHECK 384
EVALUATION OF POSSIBLE COMPLICATIONS 384
EVALUATION OF OUTCOMES 385
ALTERNATIVE IMAGING TECHNIQUES 386
RECENT ADVANCES AND FUTURE DIRECTIONS 387
REFERENCES 393
21 - Mitral Stenosis: Patient Selection, Hemodynamic Results, Complications, and Long-Term Outcome with Balloon Mitral Commissurotomy 395
BASIC PRINCIPLES AND ECHOCARDIOGRAPHIC APPROACH 395
DIAGNOSIS 396
EVALUATION OF SEVERITY 396
ASSESSMENT OF HEMODYNAMIC CONSEQUENCES 397
ASSESSMENT OF CONSEQUENCES ON THE LEFT ATRIUM 397
ASSESSMENT OF VALVE ANATOMY 397
MITRAL REGURGITATION 398
ASSOCIATED LESIONS 398
THROMBOEMBOLIC COMPLICATIONS 399
USE OF THE DIFFERENT ECHOCARDIOGRAPHIC TECHNIQUES 399
TECHNIQUE, QUANTITATION, AND DATA ANALYSIS 399
BEFORE BALLOON MITRAL COMMISSUROTOMY 399
Valve Function 399
Valve Anatomy 399
Exercise Echocardiography 400
DURING BALLOON MITRAL COMMISSUROTOMY 400
EARLY AFTER BALLOON MITRAL COMMISSUROTOMY 401
DURING FOLLOW-UP 402
RESULTS OF BALLOON MITRAL COMMISSUROTOMY 403
Failure and Complications 403
Immediate Results 403
Late Results 404
The Elderly 407
Young Patients 407
Pregnant Women 407
IMPLICATIONS FOR PATIENT SELECTION 407
Contraindications 407
Choice of Procedure 408
Timing of the Procedure 409
RESEARCH APPLICATIONS 410
Stress Echocardiography 410
Evaluation of Atrioventricular Compliance 411
Evaluation of Valve Anatomy 411
POTENTIAL LIMITATIONS, FUTURE DIRECTIONS 411
ALTERNATE APPROACHES 412
REFERENCES 413
22 - Endocarditis: The Role of Echocardiography in Diagnosis and Clinical Decision-Making 416
BASIC PRINCIPLES AND ECHOCARDIOGRAPHIC APPROACH 416
TECHNICAL DETAILS, QUANTITATION, AND DATA ANALYSIS 417
DIAGNOSIS OF ENDOCARDITIS 421
GENERAL CONSIDERATIONS 421
EVALUATION OF PATIENTS WITH BACTEREMIA 424
EVALUATION OF PATIENTS WITH PROSTHETIC VALVES 424
EVALUATION OF PATIENTS WITH CARDIAC IMPLANTABLE ELECTRONIC DEVICES 425
UTILITY IN MANAGEMENT 425
UTILITY IN FOLLOW-UP 428
RESEARCH APPLICATIONS 429
POTENTIAL LIMITATIONS AND FUTURE DIRECTIONS 429
ALTERNATE APPROACHES 429
REFERENCES 431
23 - Fluid Dynamics of Prosthetic Valves 433
PRINCIPLES OF FLUID DYNAMICS 433
CONSERVATION OF MASS 433
MECHANICAL ENERGY 434
BERNOULLI’S EQUATION 435
THE CONTROL VOLUME ENERGY ANALYSIS 435
MECHANISMS OF MECHANICAL ENERGY LOSS 436
Viscous Losses 436
Turbulent Losses 436
Valvular Regurgitation 436
MECHANICAL ENERGY CONVERSION AND LOSS IN A STENOSIS 436
APPLICATIONS OF FLUID DYNAMICS TO PROSTHETIC HEART VALVES 437
PRESSURE DROP 437
DOPPLER GRADIENT 438
EFFECTIVE ORIFICE AREA 438
REGURGITANT VOLUME 439
MECHANICAL ENERGY LOSSES 440
NOVEL ENERGY LOSS PARAMETERS 441
IN VIVO EVALUATION OF PROSTHETIC VALVES 441
HEMODYNAMICS OF NATIVE VALVES 441
HEMODYNAMICS OF SPECIFIC PROSTHETIC VALVE DESIGNS 443
MECHANICAL VALVES 445
BIOPROSTHETIC VALVES 445
TRANSCATHETER VALVES 445
Antegrade Flow Fields 448
Normal Regurgitant Flow 448
FUTURE DIRECTIONS 450
ACKNOWLEDGMENTS 451
REFERENCES 453
24 - Echocardiographic Recognition and Quantitation of Prosthetic Valve Dysfunction 455
PROSTHETIC VALVE COMPLICATIONS AND DYSFUNCTION 455
PROSTHESIS-PATIENT MISMATCH 455
PROSTHETIC VALVE THROMBOSIS AND PANNUS 455
STRUCTURAL VALVE DETERIORATION 457
INFECTIVE ENDOCARDITIS 457
BASIC PRINCIPLES FOR DOPPLER ECHOCARDIOGRAPHIC EVALUATION OF PROSTHETIC VALVE FUNCTION 457
TIMING OF ECHOCARDIOGRAPHIC FOLLOW-UP 457
CLINICAL DATA 457
RECOGNITION AND QUANTITATION OF PROSTHETIC VALVE STENOSIS 457
LEAFLET MORPHOLOGY AND MOBILITY 457
QUANTITATIVE PARAMETERS 459
Transprosthetic Velocity and Gradient 459
Transprosthetic Jet Contour and Acceleration Time 460
Effective Orifice Area 461
Doppler Velocity Index 464
RECOGNITION AND QUANTITATION OF PROSTHETIC VALVE REGURGITATION 465
PROSTHETIC AORTIC VALVE REGURGITATION 465
Parameters of the Severity of Prosthetic Aortic Valve Regurgitation 466
Color Doppler Parameters 467
Spectral Doppler Parameters 468
Quantitative Parameters 468
Integrative, Multiparametric Approach for the Evaluation of Prosthetic Aortic Valve Regurgitation 469
PROSTHETIC MITRAL VALVE REGURGITATION 470
Imaging Considerations 470
Parameters of the Severity of Prosthetic Mitral Valve Regurgitation 470
INDIRECT SIGNS AND CONSEQUENCES OF PROSTHETIC VALVE REGURGITATION 471
ROLE OF STRESS ECHOCARDIOGRAPHY 471
PROSTHETIC RIGHT HEART VALVES 471
PROSTHETIC TRICUSPID VALVE STENOSIS 471
PROSTHETIC TRICUSPID VALVE REGURGITATION 471
PROSTHETIC PULMONIC VALVES 472
INTERPRETATION OF DOPPLER ECHOCARDIOGRAPHIC DATA 472
HIGH TRANSPROSTHETIC GRADIENTS 472
Prosthetic Aortic Valves 472
Prosthetic Mitral Valves 473
LOW FLOW STATES 473
PERIOPERATIVE EVALUATION 474
DOPPLER ECHOCARDIOGRAPHY FOR THE MANAGEMENT OF SPECIFIC PROSTHETIC VALVE–RELATED COMPLICATIONS 475
PROSTHETIC VALVE THROMBOSIS 475
PROSTHETIC VALVE ENDOCARDITIS 476
SUMMARY 477
REFERENCES 479
V - Cardiomyopathies and Pericardial Disease 481
25 - Dilated Cardiomyopathy: The Role of Echocardiography in Diagnosis and Patient Management 483
CLASSIFICATION OF DILATED CARDIOMYOPATHY 483
EPIDEMIOLOGY 483
CLINICAL PRESENTATION 483
ECHOCARDIOGRAPHIC FEATURES OF DILATED CARDIOMYOPATHY 485
LEFT VENTRICULAR SYSTOLIC FUNCTION 485
TISSUE DOPPLER IMAGING, STRAIN, AND STRAIN RATE 486
LEFT VENTRICULAR SYSTOLIC FUNCTION AND PROGNOSIS 487
LEFT VENTRICULAR SIZE AND SHAPE 490
LEFT VENTRICULAR DIASTOLIC FUNCTION 490
SECONDARY MITRAL REGURGITATION 491
LEFT VENTRICULAR CONTRACTILE RESERVE 491
RIGHT-SIDED INVOLVEMENT 492
FAMILIAL SCREENING 492
OTHER CARDIAC CONDITIONS THAT APPEAR SIMILAR TO DILATED CARDIOMYOPATHY 494
LEFT VENTRICULAR NONCOMPACTION 494
STRESS-INDUCED CARDIOMYOPATHY 494
MYOCARDITIS 495
CARDIAC RESYNCHRONIZATION THERAPY 496
INTRAVENTRICULAR DYSSYNCHRONY 496
M-mode 497
Tissue Doppler Imaging 497
Speckle Tracking Imaging 497
Three-Dimensional Echocardiography 497
INTERVENTRICULAR DELAY 497
RESPONSE TO CRT 498
CHANGES IN DIASTOLIC FUNCTION WITH CARDIAC RESYNCHRONIZATION THERAPY 499
MANAGEMENT OF NONRESPONDERS 500
TARGETED LEFT VENTRICULAR LEAD PLACEMENT 500
GUIDELINES AND CARDIAC RESYNCHRONIZATION THERAPY 500
HEART FAILURE RISK SCORES 500
REFERENCES 502
26 - Hypertrophic Cardiomyopathy: Echocardiography in Diagnosis and Management of Patients 505
GENETICS 505
Diagnosis 506
DIAGNOSTIC CRITERIA 506
FAMILY SCREENING 507
DIFFERENTIAL DIAGNOSIS 507
MIMICS OF HYPERTROPHIC CARDIOMYOPATHY 507
STORAGE DISEASES 508
ATHLETE’S HEART 508
SEPTAL HYPERTROPHY IN THE ELDERLY 508
LEFT VENTRICULAR HYPERTROPHY 509
DISTRIBUTION AND PATTERNS OF HYPERTROPHY 509
TECHNICAL FACTORS 511
LEFT VENTRICULAR OUTFLOW TRACT OBSTRUCTION 511
PATHOPHYSIOLOGY 511
MITRAL LEAFLET SYSTOLIC ANTERIOR MOTION 511
DOPPLER ASSESSMENT 511
TECHNICAL ASPECTS 513
MITRAL REGURGITATION 513
STRESS TESTING AND OTHER METHODS OF PROVOCATION 514
Types of Exercise in Patients with HCM 516
Other methods of provocation 517
HYPERTROPHIC CARDIOMYOPATHY SUBTYPES 517
ASYMMETRIC APICAL HYPERTROPHIC CARDIOMYOPATHY 517
MIDVENTRICULAR OBSTRUCTION AND APICAL ANEURYSMS 518
HYPERTROPHIC CARDIOMYOPATHY OF THE ELDERLY 518
DIASTOLIC DYSFUNCTION 519
FACTORS CONTRIBUTING TO IMPAIRED DIASTOLIC FUNCTION 519
ASSESSMENT OF DIASTOLIC FUNCTION 519
ASYNCHRONOUS RELAXATION 520
LEFT ATRIAL SIZE AND FUNCTION 521
NEWER ECHOCARDIOGRAPHIC TECHNIQUES 522
STRAIN IMAGING 522
THREE-DIMENSIONAL ECHOCARDIOGRAPHY 522
MANAGEMENT OF LEFT VENTRICULAR OUTFLOW TRACT OBSTRUCTION 523
SURGICAL MYECTOMY 523
Role of Intraoperative Echocardiography 523
Outcomes after Myectomy 524
SEPTAL ETHANOL ABLATION 524
COMPARISON OF TREATMENT STRATEGIES 526
ECHOCARDIOGRAPHIC PREDICTORS OF CLINICAL OUTCOME 527
REFERENCES 531
27 - Restrictive Cardiomyopathy: Diagnosis and Prognostic Implications 534
DEFINITION AND PATHOPHYSIOLOGY 534
2D ECHOCARDIOGRAPHIC AND DOPPLER FEATURES 535
M-MODE IMAGING 535
2D IMAGING 535
SPECTRAL DOPPLER IMAGING 537
FINDINGS 537
Mitral Inflow Pulsed Wave Doppler 538
Pulmonary Vein Pulsed Wave Doppler 539
Tissue Doppler of the Mitral Annulus 539
Color M-Mode 539
Tissue Doppler and Longitudinal Strain 539
Limitations and Pitfalls of Pulsed Wave Doppler and Color M-Mode 539
2D SPECKLE TRACKING STRAIN IMAGING 539
SPECIFIC RESTRICTIVE CARDIOMYOPATHIES 539
AMYLOIDOSIS 540
Definition 540
Cardiac Features 540
Clinical Presentation 540
Echo Doppler 541
Magnetic Resonance Imaging 541
Nuclear Imaging 541
IDIOPATHIC RESTRICTIVE CARDIOMYOPATHY 542
HYPEREOSINOPHILIC SYNDROME AND ENDOMYOCARDIAL FIBROSIS 542
HEMOCHROMATOSIS 544
SARCOIDOSIS 544
STORAGE DISORDERS63 545
Gaucher Disease 545
Glycogen Storage Disorder: Pompe Disease 545
Fabry Disease 546
DRUG-INDUCED RESTRICTIVE CARDIOMYOPATHY 547
POSTRADIATION CARDIOMYOPATHY 547
OTHER CAUSES OF RESTRICTIVE CARDIOMYOPATHY 547
DIFFERENTIATING BETWEEN RESTRICTIVE CARDIOMYOPATHY AND CONSTRICTIVE PERICARDITIS 548
REFERENCES 553
28 - Pericardial Disease 556
PERICARDIAL ANATOMY AND FUNCTION 556
ANATOMY OF THE PERICARDIUM 556
PERICARDIAL FLUID 556
FUNCTIONS OF THE PERICARDIUM 556
PERICARDIAL PRESSURE AND NORMAL RESPIRATORY EFFECTS ON HEMODYNAMICS 557
PATHOPHYSIOLOGIC PRINCIPLES IN COMPRESSIVE PERICARDIAL DISEASE 558
ECHOCARDIOGRAPHIC EVALUATION FOR PERICARDIAL DISEASE 558
CONSTRICTIVE PERICARDITIS 558
DEFINITION AND ETIOLOGY 558
PATHOLOGY AND PATHOPHYSIOLOGY 559
CLINICAL PRESENTATION AND TREATMENT 559
ECHOCARDIOGRAPHIC DIAGNOSIS 560
Abnormal Ventricular Septal Motion: Ventricular Septal Shift and Shudder 560
Ventricular Septal Shift 560
Ventricular Septal Shudder 560
Respiratory Variation in the Hepatic Vein Doppler Profile: Prominent Diastolic Flow Reversals in Expiration 560
Annulus Reversus 562
Annulus Paradoxus 563
Respiratory Variation in Mitral Inflow Velocity 563
Other Doppler Findings 564
Strain Imaging 564
DIFFERENTIATION FROM RESTRICTIVE CARDIOMYOPATHY 565
EFFUSIVE-CONSTRICTIVE PERICARDITIS AND TRANSIENT CONSTRICTIVE PERICARDITIS 566
PERICARDIAL EFFUSION 567
ECHOCARDIOGRAPHIC DIAGNOSIS 567
PERICARDIAL TAMPONADE 568
DEFINITION AND ETIOLOGY 568
PATHOPHYSIOLOGY 568
ECHOCARDIOGRAPHIC DIAGNOSIS 568
Characterization of the Pericardial Effusion 569
Cardiac Chamber Collapse 569
Right Atrial Compression, Inversion, or Collapse 569
Right Ventricular Compression, Inversion, or Collapse 569
Left Heart Chamber Collapse 570
Plethora of the Inferior Vena Cava 570
Respiratory Variation in Right- and Left-Heart Filling 570
Combining Chamber Collapse with Abnormal Hepatic Venous Flow: Test Performance Characteristics 570
REGIONAL TAMPONADE 571
ECHOCARDIOGRAPHICALLY GUIDED PERICARDIOCENTESIS 571
Contraindications 572
Procedural Steps 572
ACUTE PERICARDITIS 572
CONGENITAL ABSENCE OF THE PERICARDIUM 573
PERICARDIAL CYSTS 573
ACKNOWLEDGMENTS 573
REFERENCES 575
29 - Cardiac Transplantation: Pretransplant and Posttransplant Evaluation 577
EVALUATION BEFORE CARDIAC TRANSPLANTATION 577
RISK ASSESSMENT IN HEART FAILURE 577
STRUCTURE AND FUNCTION OF THE CARDIAC ALLOGRAFT 579
TRANSPLANT OPERATIVE TECHNIQUE 579
LEFT VENTRICULAR WALL THICKNESS AND SYSTOLIC AND DIASTOLIC FUNCTION 580
RIGHT HEART STRUCTURE AND FUNCTION 581
STRUCTURE AND FUNCTION OF THE CARDIAC ALLOGRAFT DURING ACUTE REJECTION 581
POSTTRANSPLANT MONITORING 582
ROUTINE FOLLOW-UP 582
PERICARDIAL EFFUSION 582
ECHOCARDIOGRAPHIC GUIDANCE FOR ENDOMYOCARDIAL BIOPSY 582
DIAGNOSIS OF CARDIAC ALLOGRAFT VASCULOPATHY 583
CORONARY ANGIOGRAPHY WITH INTRAVASCULAR ULTRASOUND 586
STRESS ECHOCARDIOGRAPHY 587
MYOCARDIAL PERFUSION IMAGING 587
REFERENCES 593
30 - Echocardiography in Mechanical Circulatory Support: Normal Findings, Complications, and Speed Changes 596
BASIC PRINCIPLES OF MECHANICAL CIRCULATORY SUPPORT AND THE ECHOCARDIOGRAPHIC APPROACH 596
Implanted Ventricular Assist Devices 596
Percutaneous Mechanical Circulatory Support Devices 597
PREIMPLANT ASSESSMENT 599
PERIPROCEDURAL GUIDANCE 600
POSTIMPLANT SURVEILLANCE AND COMPLICATIONS 601
OVERFILLING 601
UNDERFILLING 601
VALVULAR DYSFUNCTION 602
SPEED CHANGE STUDIES 603
Optimization of Device Settings 603
Optimization of Percutaneous Mechanical Circulatory Support Position 603
Ramp Studies 603
Ventricular Recovery 603
LEFT VENTRICULAR END-DIASTOLIC DIAMETER AND SEPTAL ORIENTATION 604
VENTRICULAR FUNCTION 605
AORTIC VALVE OPENING 605
PERICARDIUM 605
CANNULAE 605
OPTIMIZATION STUDIES 607
RAMP STUDIES 607
WEANING AND TURNDOWN STUDIES 608
POTENTIAL LIMITATIONS AND FUTURE DIRECTIONS 609
ALTERNATE APPROACHES 610
REFERENCES 614
VI - The Right Heart 617
31 - Right Ventricular Anatomy, Function, and Echocardiographic Evaluation 619
BASIC PRINCIPLES AND ECHOCARDIOGRAPHIC APPROACH 619
RIGHT VENTRICULAR ANATOMY 619
TECHNICAL DETAILS, QUANTITATION, AND DATA ANALYSIS 621
TRANSTHORACIC ECHOCARDIOGRAPHIC VIEWS 621
TRANSESOPHAGEAL ECHOCARDIOGRAPHIC VIEWS 623
INTRACARDIAC ECHOCARDIOGRAPHIC VIEWS 623
QUANTITATIVE EVALUATION 623
RIGHT VENTRICULAR WALL THICKNESS AND SIZE 623
RIGHT VENTRICULAR SYSTOLIC FUNCTION 624
RIGHT VENTRICULAR DIASTOLIC FUNCTION 625
CLINICAL UTILITY AND OUTCOME DATA 626
RESEARCH APPLICATIONS 627
POTENTIAL LIMITATIONS AND FUTURE DIRECTIONS 628
ALTERNATE APPROACHES 629
ACKNOWLEDGMENTS 629
REFERENCES 631
32 - Pulmonary Hypertension: Role of Echocardiography in Diagnosis and Patient Management 633
GENERAL PRINCIPLES 633
ESTIMATING RIGHT ATRIAL PRESSURE 634
ESTIMATING THE RIGHT VENTRICULAR–TO–RIGHT ATRIAL PRESSURE DIFFERENCE FROM THE TRICUSPID REGURGITATION PROFILE 634
PULMONARY REGURGITATION PROFILE 634
PULMONARY ACCELERATION TIME 634
MIDSYSTOLIC NOTCHING OF THE RIGHT VENTRICULAR OUTFLOW DOPPLER 636
FACTORS THAT AFFECT PULMONARY ARTERY PRESSURE IN NORMAL INDIVIDUALS 636
IDENTIFYING THE CAUSE FOR PULMONARY HYPERTENSION 636
GENERAL CLASSIFICATION 636
PULMONARY ARTERIAL HYPERTENSION 636
PULMONARY HYPERTENSION DUE TO CONGENITAL HEART DISEASE 637
PULMONARY HYPERTENSION DUE TO LEFT HEART DISEASE 639
PULMONARY HYPERTENSION DUE TO LUNG DISEASE 640
PULMONARY HYPERTENSION DUE TO CHRONIC PULMONARY THROMBOEMBOLIC DISEASE 640
ACUTE PULMONARY HYPERTENSION 640
EFFECT OF PULMONARY HYPERTENSION ON THE RIGHT HEART 641
MEASUREMENT OF RIGHT VENTRICULAR FUNCTION IN THE SETTING OF PRESSURE LOADING 641
RIGHT VENTRICULAR DIMENSIONS 642
RIGHT VENTRICULAR WALL THICKNESS 642
RIGHT VENTRICULAR SYSTOLIC FUNCTION 642
THREE-DIMENSIONAL ANALYSIS OF RIGHT VENTRICULAR SYSTOLIC FUNCTION 643
RIGHT VENTRICULAR DIASTOLIC FUNCTION 645
VENTRICULAR SEPTAL MOTION 645
ESTIMATING PULMONARY VASCULAR RESISTANCE 645
EXERCISE STRESS ECHOCARDIOGRAPHY AND PULMONARY HYPERTENSION 646
DIAGNOSTIC APPROACH FOR A PATIENT WITH SUSPECTED PULMONARY HYPERTENSION 646
REFERENCES 650
33 - RIGHT-SIDED VALVE DISEASE IN ADULTS 651
TRICUSPID VALVE DISEASE 651
TRICUSPID REGURGITATION 651
BACKGROUND 651
BASIC PRINCIPLES AND ECHOCARDIOGRAPHIC APPROACH TO DIAGNOSIS 651
TECHNICAL DETAILS, QUANTITATION, AND DATA ANALYSIS 651
Determining the Cause of Tricuspid Regurgitation 651
Determining the Severity of Tricuspid Regurgitation 654
CLINICAL UTILITY AND OUTCOMES DATA 658
POTENTIAL LIMITATIONS 662
TRICUSPID STENOSIS 662
BACKGROUND 662
BASIC PRINCIPLES AND ECHOCARDIOGRAPHIC APPROACH 662
TECHNICAL DETAILS, QUANTITATION, AND DATA ANALYSIS 662
CLINICAL UTILITY AND OUTCOMES DATA 663
ALTERNATE APPROACHES 663
PULMONIC VALVE STENOSIS 663
BACKGROUND 663
BASIC PRINCIPLES AND ECHOCARDIOGRAPHIC APPROACH 663
TECHNICAL DETAILS, QUANTITATION, AND DATA ANALYSIS 663
CLINICAL UTILITY AND OUTCOMES DATA 664
ALTERNATE APPROACHES 666
PULMONIC VALVE REGURGITATION 666
BACKGROUND 666
BASIC PRINCIPLES AND ECHOCARDIOGRAPHIC APPROACH 666
TECHNICAL DETAILS, QUANTITATION, AND DATA ANALYSIS 667
CLINICAL UTILITY AND OUTCOMES DATA 668
ALTERNATE APPROACHES 669
REFERENCES 671
VII - Vascular and Systemic Diseases 675
34 - AORTIC DISSECTION AND TRAUMA: VALUE AND LIMITATIONS OF ECHOCARDIOGRAPHY 677
PATHOPHYSIOLOGY OF AORTIC DISSECTION 677
ANATOMY AND HISTOLOGY 677
MECHANICAL AND SHEAR STRESSES 677
SPECTRUM OF ACUTE AORTIC SYNDROMES 679
AORTIC DISSECTION 679
Classification 679
Time Course 680
Sequelae 680
INTRAMURAL HEMATOMA 680
PENETRATING AORTIC ULCER 680
AORTIC TRAUMA 680
IMAGING ACUTE AORTIC SYNDROMES 680
COMPUTED TOMOGRAPHY 681
MAGNETIC RESONANCE IMAGING 682
TRANSTHORACIC ECHOCARDIOGRAPHY 682
TRANSESOPHAGEAL ECHOCARDIOGRAPHY 683
Safety of Transesophageal Echocardiography 684
Complications of Dissection 685
Intramural Hematoma 686
Penetrating Aortic Ulcer 686
Aortic Trauma 686
INCONCLUSIVE TRANSESOPHAGEAL ECHOCARDIOGRAPHIC RESULTS 686
SURGICAL CONSIDERATIONS 687
AORTIC REGURGITATION 688
MITRAL REGURGITATION 689
PERFUSION OF DISTAL VASCULAR BEDS 689
ENDOVASCULAR REPAIR CONSIDERATIONS 689
FOLLOW-UP OF PATIENTS AFTER AORTIC DISSECTION 689
CONCLUSIONS 690
REFERENCES 690
35 - ECHOCARDIOGRAPHIC FINDINGS IN SYSTEMIC DISEASES CHARACTERIZED BY IMMUNE-MEDIATED INJURY 692
SYSTEMIC LUPUS ERYTHEMATOSUS 692
BACKGROUND 692
CARDIOVASCULAR INVOLVEMENT 692
Valve Disease, Intracardiac Thrombosis, and Thromboembolism 692
Atherosclerosis 694
Myocardial Disease 695
Pericardial Disease 697
Pulmonary Hypertension 699
PRIMARY ANTIPHOSPHOLIPID SYNDROME 699
BACKGROUND 699
CARDIOVASCULAR INVOLVEMENT 700
Valve Disease, Intracardiac Thrombosis, and Thromboembolism 700
Pulmonary Hypertension 701
VIII - Adult Congenital Heart Disease and the Pregnant Patient 859
43 - Heart Disease in Pregnancy 861
PHYSIOLOGIC CHANGES DURING PREGNANCY 861
SYSTEMIC VASCULAR RESISTANCE 861
CARDIAC OUTPUT 861
ECHOCARDIOGRAPHIC FINDINGS IN NORMAL PREGNANCY 862
CARDIAC CHAMBER SIZE 862
DOPPLER FLOWS 862
SYSTOLIC AND DIASTOLIC FUNCTION 862
INTERPRETATION OF ECHOCARDIOGRAPHIC FINDINGS DURING PREGNANCY 862
PREGNANCY RISKS 862
CARDIAC SHUNTS 864
TETRALOGY OF FALLOT 865
COARCTATION OF THE AORTA 866
EBSTEIN ANOMALY 866
TRANSPOSITION OF THE GREAT ARTERIES 867
FONTAN CIRCULATION 867
CYANOTIC HEART DISEASE 868
AORTIC VALVE DISEASE 868
MITRAL VALVE DISEASE 869
PROSTHETIC HEART VALVES 870
AORTOPATHIES 870
CARDIOMYOPATHIES 871
FETAL AND NEONATAL RISK 872
MANAGEMENT PRINCIPLES 873
ANTEPARTUM 873
LABOR AND DELIVERY 874
POSTPARTUM 874
MANAGEMENT OF COMPLICATIONS 874
REFERENCES 877
44 - Congenital Shunts 879
PATENT FORAMEN OVALE 880
ANATOMY AND PATHOPHYSIOLOGY 880
IMAGING 880
INDEX 990
A 990
B 991
C 992
D 993
E 994
F 994
G 994
H 994
I 995
K 995
L 995
M 996
N 997
O 997
P 998
Q 999
R 999
S 999
T 1000
U 1002
V 1002
W 1002
Z 1002
IBC ES2