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Examination Obstetrics & Gynaecology

Examination Obstetrics & Gynaecology

Judith Goh | Michael Flynn

(2016)

Additional Information

Book Details

Abstract

Examination Obstetrics & Gynaecology is an accessible rapid reference appropriate for daily use in a busy ward, clinic or surgery. Fully revised and updated, this practical guide is a definitive resource for medical trainees undertaking speciality training.

Building on resources developed during the authors' specialist training in Obstetrics & Gynaecology, and refined by practical clinical experience, it provides a summary of important and essential information needed in women's health. Organised in a note and checklist format, it utilises a step-by-step guide to diagnosis, investigations and suggested treatments appropriate to primary consultation prior to specialist referral.

  • Sample Objective Structured Clinical Examination OSCE cases from O&G examiner's perspectives to assist with examination preparation
  • 24 chapters dedicated to gynaecology, and 32 chapters to obstetrics

Table of Contents

Section Title Page Action Price
Front Cover cover
IFC_Expert Consult IFC-1
Examination Obstetrics & Gynaecology i
Copyright Page iv
Dedication v
Table Of Contents vii
Preface to the 4th edition ix
Contributors xi
Reviewers xiii
Gynaecology 1
1 Gynaecological history and examination 2
History 2
Examination 3
General 3
Genital examination 3
Conclusion 3
2 Amenorrhoea 4
Puberty 4
Endocrinology of puberty 4
Secondary sexual characteristics 4
Major physical changes during puberty 4
Secondary female characteristics 4
Primary amenorrhoea 5
Management of primary amenorrhoea 5
When to investigate 5
History 5
Examination 5
Investigations 6
Classification of primary amenorrhoea 6
Sexually infantile 6
Feminising secondary sexual characteristics 6
Masculinising secondary sexual characteristics 6
Causes of primary amenorrhoea 6
Hypogonadotrophic hypogonadism 6
Hypergonadotrophic hypogonadism (gonadal dysgenesis) 6
Androgen insensitivity syndrome (testicular feminisation) 7
Müllerian anomalies 7
Other causes of primary amenorrhoea 7
Constitutional delay in puberty 7
Principles of management of primary amenorrhoea 8
Fertility 8
Physical/emotional development 8
Secondary amenorrhoea 8
Causes of secondary amenorrhoea 8
Oestrogen deficiency 8
Unopposed oestrogen 8
Other causes 8
History 8
Examination 9
Investigations 9
Management and further investigations of secondary amenorrhoea 9
Premature ovarian failure 9
Hypothalamic amenorrhoea 9
Polycystic ovarian syndrome 9
Asherman’s syndrome 9
Medical problems 9
Tumours 10
Further reading 10
3 Abnormal uterine bleeding 11
Terminology for disorders of menstruation 11
Disturbances of regularity 11
Disturbances of frequency 11
Disturbances of flow 11
Disturbance of the duration of flow 11
Irregular non-menstrual bleeding 12
Bleeding outside of the reproductive age 12
Acute AUB 12
Chronic AUB 12
Causes of AUB: the PALM-COEIN classification system 12
Anatomical and structural (PALM) 12
Polyps (AUB-P) 12
Adenomyosis (AUB-A) 13
Leiomyomas (AUB-Lsm or AUB-Lo) 13
Malignancy (AUB-M) 13
Unrelated to structural anomalies (COEI) 13
Coagulopathies (AUB-C) 13
Ovulatory dysfunction (AUB-O) 13
Endometrial causes (AUB-E) 13
Iatrogenic (AUB-I) 13
Not yet classified (AUB-N) 13
Assessment of AUB 13
History 13
Examination 14
Investigations 14
Management of AUB: HMB 14
Prostaglandin inhibitors 14
Antifibrinolytics and haemostatics 14
Hormonal therapy 14
Combined oral contraceptive pill 14
Progesterone 15
Surgical management of menorrhagia 15
Hysteroscopic removal of polyps and fibroids 15
Endometrial ablation/resection 15
Hysterectomy 15
Uterine artery embolisation 15
4 Endometriosis 16
Risk factors 16
Aetiology 17
Genetics 17
Pathology 17
Pathogenesis 18
Clinical presentation 18
Diagnosis 18
Staging 19
Treatments 19
Medical treatment 19
Contraceptive 19
Options 19
Surgical treatment 19
Alternative treatment 20
Prognosis 20
Special areas 20
Endometriosis in adolescence 20
Endometriosis and fertility 20
Impact on fertility 20
Medical therapies contraceptive 21
Impact on and role of assisted reproductive technology (ART) 21
Deep infiltrating endometriosis 21
Extrapelvic disease 21
References and further reading 21
5 Polycystic ovarian syndrome 23
Clinical presentation 23
Aetiology 24
Pathophysiology 24
Ovaries 24
Hypothalamus–pituitary 24
Peripheral compartment 24
Adrenal compartment 24
Consequences of PCOS 25
Reproductive consequences 25
Metabolic consequences 25
Neoplasia 25
Cardiovascular disease 25
Other 25
Differential diagnosis 26
Assessment 26
History 26
Examination 26
Investigations 26
Management 27
Supportive 27
Not wanting to conceive 27
COCP 27
Progesterone (cyclical oral or depot medroxyprogesterone acetate, DMPA) 27
Insulin-sensitising drugs 27
Wanting to conceive 28
Medical 28
Metformin 28
Other medical treatment 28
References and further reading 30
6 Hirsutism 31
Physiology of hair growth 31
Hair growth and hirsutism 31
Causes of hirsutism 32
Common 32
Uncommon 32
Non-androgenic 32
Androgenic 32
Adrenals 32
Ovarian 33
Drugs 33
Investigation and diagnosis 34
History 34
Examination 34
Investigations 34
Management 34
Principles 34
Counselling 34
Hair therapy 34
Permanent hair reduction 35
Topical treatment 35
Pharmacological 35
Oral contraceptives 35
Spironolactone 35
Cyproterone acetate 35
Finasteride 35
Flutamide 35
Insulin-lowering medications 35
Glucocorticoids 36
Gonadotropin-releasing hormone agonist (GnRH) agonist 36
7 Contraception 37
Natural methods 37
Barrier methods 37
Diaphragm 37
Function 37
Effectiveness 38
Cervical/vault caps 38
Advantages 38
Sponge 38
Condoms 38
Female condoms 38
Spermicides 38
Intrauterine contraceptive devices 38
Types 38
Mechanisms of action 39
Effectiveness 39
Counselling 39
Before insertion 39
Insertion 39
Change of the contraceptive device 39
Risks 39
Oral contraceptives 40
Combined oral contraceptive pill (COCP) 40
Two formulations 40
Mechanisms of action 40
Effectiveness 40
Assessment before commencing COCP 40
Side effects and risks 40
Missed pills 41
Problems and solutions 41
Progestogen-only pills 41
Contraceptive implants 41
Depot medroxyprogesterone acetate (DMPA) 41
Mechanisms of action 41
Side effects 41
Subcutaneous progestogen implants 42
Combined vaginal ring 42
Assessment 42
Side effects and risks 42
Pregnancy interception (emergency contraception) 42
Hormonal methods 42
Non-hormonal methods 43
Male contraception 43
Gonadotropin-releasing hormone (GnRH) analogues 43
Steroids 43
Antiandrogen (cyproterone acetate) 43
Gossypol 43
Sterilisation 43
Female sterilisation 43
Abdominal/laparoscopic 43
Hysteroscopic 43
Male sterilisation 43
Further reading 43
8 Miscarriage and abortion 44
Aetiology of spontaneous miscarriage 44
Presentation and management 45
Presentation (spontaneous miscarriage) 45
Examination 45
Investigations 45
Management 45
Recurrent pregnancy loss 45
Risk of miscarriage 46
Investigations for recurrent pregnancy loss 46
Management of recurrent pregnancy loss 46
Abortions due to uterine abnormalities 46
Abortions due to endocrine abnormalities 46
Support and counselling 46
Induced abortion 46
Surgical abortion 46
Medical abortion 46
Support and counselling 47
References 47
9 Ectopic pregnancy 48
Tubal ectopic pregnancy 48
Aetiology and risk factors 48
Presentation 49
Investigations 49
Quantitative serum human chorionic gonadotrophin (hCG) 49
Ultrasound 49
Laparoscopy 49
Management 49
Surgical 49
Salpingectomy and salpingostomy 49
Local injection of ectopic pregnancy 50
Medical 50
Systemic methotrexate 50
Expectant management 50
Anti-D 50
Contraception and future pregnancies 50
Abdominal pregnancy 50
Management 50
Reference 51
10 Infertility 52
Conception 52
Probability of conception 52
Aetiology 53
History 53
Female 53
Obstetrics 157
25 Antenatal care 158
Prepregnancy care 158
Aims of counselling before conception 158
Antenatal care 158
Aims of antenatal care 158
Booking assessment 159
Examination 159
Investigations 159
First visit 159
Discussion of antenatal screening 159
Obstetric ultrasound scan at 18–20 weeks gestation 160
At the end of the second trimester: 160
Group B streptococcus disease (GBS) 160
Continuing antenatal visits 160
Indications for ultrasound scan in antenatal care 160
26 Antenatal diagnosis of fetal and chromosomal abnormalities 161
Genetic counselling 161
Aims of genetic counselling 161
Indications for prenatal diagnosis 162
Preimplantation genetic diagnosis (PGD) 162
Tests available for antenatal diagnosis 162
Screening 162
Diagnostic 163
Distribution of chromosomal abnormalities 163
Screening 164
Maternal age 164
Combined nuchal translucency and biochemical screening 164
Non-invasive prenatal testing (NIPT) 165
Second-trimester screening 165
Ultrasound screening 166
Morphology ultrasound assessment 166
Trisomy 21 166
Trisomy 18 166
Trisomy 13 166
Definitive diagnostic tests 166
Amniocentesis 167
Chorionic villus sampling 167
Cordocentesis/fetal blood sampling 167
Chromosomal abnormalities 167
Trisomies 167
Translocations 168
Reciprocal translocation 168
Robertsonian translocation 168
Sex chromosome abnormalities 168
Turner’s syndrome 168
Klinefelter’s syndrome 168
Other genetic syndromes 168
Fragile X syndrome 168
Cystic fibrosis 169
Muscular dystrophies 169
Phenylketonuria 169
Marfan’s syndrome 169
Neurofibromatosis 169
Thalassaemia 169
Incidence in ethnic and racial groups 170
Neural tube defects 170
Gastrointestinal anomalies 170
Renal tract anomalies 170
Cardiac abnormalities 170
Dwarfism 171
Cleft lip/palate 171
References and further reading 171
27 Assessing fetal wellbeing 172
Tests available for assessing fetal wellbeing 172
Fetal movement 172
Fetal movement in late pregnancy 172
Cardiotocography (CTG) 173
Fetal scalp pH or lactate 173
Fetal pulse oximetry 173
Biophysical assessment 173
Amniotic fluid volume assessment 174
Growth 174
Doppler flow studies 174
Biochemical markers of placental function 175
Further reading 175
28 Drugs and drugs of abuse in pregnancy 176
Teratogens 176
Drug pharmacokinetics and pregnancy 177
Drug absorption 177
Drug distribution 178
Protein binding 178
Drug elimination 178
Placental–fetal compartment 178
Specific drugs in pregnancy 178
Anticonvulsants 178
Carbamazepine 178
Phenytoin 178
Valproic acid 179
Antibiotics 179
Penicillins/cephalosporins 179
Tetracycline 179
Nitrofurantoin 179
Sulfonamides 179
Doxycycline 179
Metronidazole 179
Azithromycin 179
Methotrexate 179
Warfarin 179
Lithium 179
Retinoids 180
Angiotensin-converting enzyme (ACE) inhibitors 180
Selective serotonin reuptake inhibitors (SSRIs) 180
Drugs of abuse in pregnancy 180
Alcohol 180
Cigarette smoking 180
Cocaine 180
Cannabis 180
Amphetamines 181
Lysergic acid diethylamide (LSD) 181
Glue/petrol 181
Opiates 181
Management of opiate abuse in pregnancy 181
References 181
29 Infections in pregnancy 182
Urinary tract infection 182
Asymptomatic bacteriuria 182
Acute symptomatic urinary tract infection 182
Management 182
Relapses and reinfection 183
Management 183
Syphilis 183
Screening 183
Clinical syndromes 183
Primary syphilis 183
Secondary syphilis 183
Latent syphilis 183
Tertiary syphilis 183
Management of syphilis 184
Toxoplasmosis 184
Rubella 184
Possible outcomes of maternal rubella infection 184
Risk to fetus of maternal infection 185
Diagnosis of maternal rubella 185
Diagnosis of intrauterine/congenital rubella 185
Vaccination 185
Hepatitis B 185
Hepatitis B virus (HBV) 185
Factors in perinatal transmission 186
Prevention of hepatitis B 186
Hepatitis C 186
Human immunodeficiency virus (HIV) and pregnancy 186
Maternal to child transmission (MTCT) 186
Managing HIV in pregnancy 187
Cytomegalovirus 187
Fetal complications 187
Diagnosis 187
Pathogenesis of fetal complications 187
Antenatal advice 188
Listeriosis 188
Complications of listeriosis in pregnancy 188
Varicella zoster 188
Infection in late pregnancy 188
Management 188
Exposure in pregnancy 189
Group B streptococcus 189
Management 189
Herpes simplex 189
Risk factors for intrapartum infection 190
Management 190
Further reading 190
30 Red blood cell and platelet alloimmunisation in pregnancy 191
Red blood cell isoimmunisation 191
Background and pathophysiology 191
Prevention of HDFN 192
Prepregnancy management of RBC alloimmunisation 192
Antenatal management of RBC alloimmunisation 192
Determination of fetal Rh type 193
Antibody quantification 193
Non-invasive assessment of fetal anaemia 193
Intrauterine transfusion 193
RBCs for intrauterine transfusion should be: 194
Platelet isoimmunisation 194
Pathophysiology 194
Diagnosis 194
Parental and fetal/neonatal platelet antigen typing 195
Management of pregnancies at risk of FNAIT 195
Further reading 195
31 Antepartum haemorrhage 197
Aetiology 197
Placenta praevia 197
Classification 197
Risk factors 198
Management 198
Placenta accreta 198
Placental abruption 199
Risk factors 199
Differential diagnosis 199
Complications of placental abruption 199
Management 199
Vasa praevia 200
Diagnosis 200
Local causes 200
Further reading 200
32 Fetal complications in later pregnancy 201
Intrauterine fetal death (IUFD) 201
Aetiology 201
Complications 201
Coagulopathy and disseminated intravascular coagulopathy 201
Investigations 202
Delivery of the dead fetus 202
Prostaglandins 202
Prostaglandin pessaries or gel 202
Vaginal 202
Misoprostol (prostaglandin E1 analogue) 202
Oxytocin 202
Caesarean section 202
Fetal growth restriction (FGR) 202
Causes 203
Screening 203
Diagnosis 203
Management 203
Disorders of amniotic fluid volume 203
Screening 204
Diagnosis 204
Polyhydramnios 204
Risk factors 204
Complications of polyhydramnios 204
Management 204
Oligohydramnios 204
Factors associated with reduced amniotic fluid volume 204
Complications of oligohydramnios 204
Management 205
Further reading 205
33 Breech presentation 206
Types 206
Risk factors 206
External cephalic version 206
Management of breech presentation 207
Diagnosis 207
Term breech trial 207
Delivery of the breech presentation diagnosed in late labour 207
Breech born by maternal expulsive efforts up to the umbilicus 207
Lövset’s manoeuvre 208
Possible hazards in vaginal delivery 208
Preterm breech presentation 208
Further reading 208
34 Multiple pregnancy 209
Mechanism of twinning 209
Dizygotic twins 209
Monozygotic twins 209
Diagnosis of chorionicity and amnionicity 210
Prenatal diagnosis 210
Complications of twin pregnancy 210
General 210
Specific: monochorionic twinning 211
Twin-to-twin transfusion syndrome (TTTS) 211
Staging (Quintero) 211
Management 211
Selective intrauterine growth restriction (sIUGR) 211
Twin reversed arterial perfusion sequence (TRAP) or acardiac twinning 211
Antenatal management of twin pregnancy 211
Diagnosis 211
Antenatal care 212
Ultrasound role 212
Prevention of premature labour 212
Delivery of twins 212
Indications for elective caesarean section 212
Vaginal delivery 212
Twin with single intrauterine fetal death 212
Triplet pregnancy 213
Complications of triplet pregnancy 213
Delivery 213
Further reading 213
35 Preterm prelabour rupture of membranes 214
Aetiology of PPROM 214
Risk factors of PPROM 214
Clinical significance of PPROM 215
Maternal risks 215
Fetal risks 215
Diagnosis 215
Management of PPROM 216
Initial management 216
PPROM: 34–37 weeks 216
PPROM: 24–33 weeks 217
PPROM: < 23 completed weeks 217
Antenatal corticosteroids 217
Adjuvant antibiotics 218
Magnesium sulfate 218
Progesterone 218
Tocolysis 218
Emerging therapies 218
Further reading 218
36 Preterm labour 220
Significance 220
Aetiology 220
Spontaneous preterm labour 220
Indicated preterm labour 221
Prevention of preterm labour 221
Diagnosis of preterm labour 222
Cervical length and morphology 222
Fetal fibronectin (fFN) 222
Management of preterm labour 222
Further reading 223
37 Induction of labour 225
Mechanism of labour 225
Induction of labour 225
Indications 225
Contraindications 226
Likelihood of successful induction 226
Pre-induction cervical assessment 226
Techniques of induction 227
Mechanical 227
‘Sweeping’ of the membranes 227
Balloon catheters 227
Amniotomy 227
Medical 228
Prostaglandin 228
Types of prostaglandin agents 228
Actions of prostaglandins 228
Other effects 228
Contraindications to prostaglandin E2 228
Side effects of prostaglandins 228
Oxytocin 228
Augmentation of labour 229
Aims 229
Methods 229
Considerations in augmentation 229
Further reading 229
38 Malpresentation and malposition 230
Stages of labour 230
Occipito-posterior position 230
Risk factors for persistent occipito-posterior position 231
Appendix MRANZCOG oral examination (sample questions) 341
Case 1 341
Encounter 1 341
Encounter 2 341
Encounter 3 342
Model answer for case 1 342
Encounter 1 342
Encounter 2 342
Encounter 3 343
Case 2 344
Encounter 1 344
Encounter 2 344
Encounter 3 344
Model answer for case 2 345
Encounter 1 345
Encounter 2 345
Encounter 3 345
Credit 346
Disclaimer: 346
Index 347
A 347
B 348
C 348
D 349
E 350
F 350
G 351
H 351
I 352
K 353
L 353
M 353
N 354
O 354
P 355
R 357
S 357
T 358
U 358
V 359
W 359
X 359
Y 359
Z 359