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Colorectal Surgery E-Book

Colorectal Surgery E-Book

Sue Clark

(2018)

Additional Information

Abstract

Colorectal Surgery meets the needs of surgeons in higher training and practising consultants for a contemporary and evidence-based account of this sub-specialty that is relevant to their general surgical practice. It is a practical reference source incorporating the most current information on recent developments, management issues and operative procedures. The text is thoroughly referenced and supported by evidence-based recommendations wherever possible, distinguishing between strong evidence to support a conclusion, and evidence suggesting that a recommendation can be reached on the balance of probabilities.

For this Sixth Edition the authorship team across the series has been expanded to include additional European and World experts, with an increased emphasis on global practice. Throughout all six volumes the contents have been extensively revised in line with recently published evidence. Detailed supportive key references are provided and are also included within the comprehensive list of references in the accompanying ebook. Links to recommended online videos have been added where appropriate.

  • The Companion to Specialist Surgical Practice series provides a current and concise summary of the key topics within the major sub-specialties of general surgery.
  • Each volume highlights evidence-based practice both in the text and within the extensive list of references at the end of every chapter.

This edition of Colorectal Surgery includes new chapters on surgery for colon cancer, and on the management of advanced and recurrent colorectal cancer. New techniques for the minimally invasive treatment of rectal cancer are included for the first time, as are a number of new procedures for fistula. The latest evidence for total mesocolic excision is included for the first time, together with clear descriptions of the technique.


Table of Contents

Section Title Page Action Price
Front Cover Cover
Inside Front Cover ES2
Colorectal Surgery iii
Copyright iv
Contents v
Series Editors’ preface vii
Editors’ preface ix
Evidence-based practice in surgery xi
Contributors xiii
Chapter 1: Anorectal investigation 1
Introduction 1
Anatomy and physiology of the anal canal 1
Rectoanal inhibitory reflex 2
Manometry 2
Ambulatory manometry 4
Anal and rectal sensation 5
Rectal compliance 5
Pelvic floor descent 6
Electrophysiology 6
Electromyography 6
Pudendal nerve terminal motor latency 7
Spinal motor latency 7
Defecography/evacuation proctography 7
Dynamic pelvic MRI 7
Dynamic transperineal and three-dimensional pelvic floor ultrasound 8
Scintigraphy 8
Imaging the rectum and anal sphincters 8
Anal endosonography/endorectal ultrasound 8
Endocoil receiver MRI 9
Imaging in rectal cancer 9
Imaging in anal sepsis and anal fistulas 10
Imaging in faecal incontinence 11
Summary 12
Key references 12
Chapter 2: Colonoscopy and flexible sigmoidoscopy 14
Introduction 14
Indications and contraindications 14
Flexible sigmoidoscopy vs colonoscopy 14
Contraindications 14
Sedation 14
Insertion technique 15
Handling and scope control 15
Insertion and steering 15
Tips for insertion and steering 15
Patient position change 15
Abdominal hand pressure 16
Three-dimensional imager 16
Withdrawal technique 16
Withdrawal time 16
Optimal examination technique 16
Bowel preparation 17
Position change 17
Antispasmodics 18
Rectal and caecal retroflexion 18
Quality assurance 18
Endoscopy training 18
New techniques in endoscopic mucosal visualisation 19
Assisted-viewing devices 19
Chromoendoscopy 19
High-magnification endoscopy 20
Endoscopic therapy 20
Basic therapy 20
Polypectomy 20
Endoscopic mucosal resection (EMR) 21
Investigation of acute lower gastrointestinal (GI) bleeding 22
Colonic decompression 22
Advanced therapy 23
Endoscopic submucosal dissection (ESD) 23
Stricture dilatation and stenting 23
Novel therapies 23
Competing technologies 23
Computed tomography colonography (or virtual colonoscopy) 23
Self-propelling colonoscopes 24
Colon capsule 24
Conclusions 24
Key references 24
Chapter 3: Colorectal cancer 26
Introduction 26
Natural history 26
Direct spread 27
Lymphatic spread 27
Blood-borne spread 27
Transcoelomic spread 27
Aetiology 27
Genetic factors 27
Diet and lifestyle 28
Predisposing conditions 28
Presentation 28
Investigation 29
Screening 29
Surveillance after adenoma detection 30
The malignant polyp 30
Surgery 32
Adjuvant therapy 32
Management of advanced disease 33
Operable metastases 33
Advanced local disease 33
Inoperable disseminated disease 34
Pathological staging 34
Summary recommendations for best practice 34
Key references 36
Chapter 4: Colorectal cancer and genetics 37
Introduction 37
Assessment of risk 37
Chapter 5: Surgery for colon cancer 51
Preparation of the patient for elective surgery 51
General issues 51
Bowel preparation 51
Venous thromboembolism prophylaxis 51
Blood transfusion 52
Antibiotic prophylaxis 52
The principles of surgery 52
The evidence for CME 52
Dissection in the mesocolic plane 52
Central vascular ligation 52
The extent of longitudinal resection 54
Practical guidance on the extent of resection 55
Laparoscopic or open surgery? 56
Vascular variations of the colon 57
Obesity and difficulties in laparoscopic surgery 57
Anastomotic leakage 57
Diagnosis 59
Management 60
Defunctioning stoma 60
Emergency management 60
Obstruction 60
Management of obstruction 60
Perforation 61
Future developments 61
Acknowledgements 62
Key references 62
Chapter 6: Surgery for rectal cancer 63
Introduction 63
Objectives of surgery 63
In-hospital mortality 63
Local recurrence 64
Circumferential resection margin and the role of preoperative radiotherapy 64
Complications of preoperative radiotherapy 65
Downstaging rectal cancer with preoperative radiotherapy 65
MRI can predict T stage and CRM status 66
Considerations for decision-making 66
Tumour disruption 66
Extent of excision – TME versus mesorectal transection, pelvic lymphadenectomy and level of vascular ligation 67
TME 67
Lateral pelvic lymph nodal involvement 68
High versus low inferior mesenteric artery ligation 68
Implantation of viable cells 68
Quality of life 68
Preservation of continence by restorative resection 68
Distal clearance margin 69
Tumour height – the importance of rectal palpation (PR) 70
Aspects of anal and neo-rectal function 70
Low rectal cancer and the English National Low Rectal Cancer Programme (LOREC) 70
Abdominoperineal excision (APE) 70
Reconstruction (colonic pouch, end-to-side or end-to-end anastomosis) 71
Sexual and urinary disturbance 71
Temporary defunctioning stomas 71
Alternative approaches to standard surgery for rectal cancer 71
Papillon/contact radiotherapy 71
Transanal endoscopic microsurgery (TEMS) and transanal minimally invasive surgery (TAMIS) 72
Laparoscopic surgery for rectal cancer 72
Robotic rectal cancer surgery 72
Transanal TME (TA-TME) for rectal cancer 72
Non-operative approach for rectal cancer by'watch and wait' after chemoradiotherapy 73
Alternative non-surgical options in rectal cancer 73
Follow-up 73
Synchronous tumours 73
Metachronous tumours 73
Surveillance for local and distant recurrence 73
The way forward 74
Key references 74
Chapter 7: Perioperative chemotherapy and radiotherapy for colorectal cancer 75
Introduction 75
Adjuvant chemotherapy for colorectal cancer 75
Acute and long-term toxicity 76
The elderly 77
Stage II disease 77
Addition of ‘targeted’ therapy to chemotherapy 77
Timing and duration of adjuvant chemotherapy 77
Adjuvant chemotherapy in rectal cancer 77
Radiotherapy 78
Evidence base for the use of adjuvant radiotherapy in resectable rectal cancer 79
Short-course radiotherapy and TME 79
Preoperative concurrent chemoradiotherapy 79
Short-course radiotherapy versus preoperative CRT 80
Short-course radiotherapy and delay to surgery 80
Late toxicity and second malignancy 81
Patient selection 81
Sphincter preservation 82
Organ preservation 83
Future directions: intensification of neoadjuvant treatment 83
Addition of a second concurrent chemotherapy agent during LCCRT 83
Neoadjuvant chemotherapy 84
Key references 85
Chapter 8: Advanced and recurrent colorectal cancer 86
Introduction 86
Incidence 86
Diagnosis and staging of advanced and recurrent CRC 87
Histological confirmation and biomarkers 87
Radiology 87
Computed tomography 87
Magnetic resonance imaging 87
Positron emission tomography 87
Ultrasonography 87
The advanced colorectal cancer MDT 88
Locally advanced primary and recurrent rectal cancer 88
Radiotherapy 88
Perineal excision 89
Pelvic multivisceral exenteration 89
Patterns of rectal cancer recurrence 89
Types of pelvic clearance 90
Sacrectomy 91
Perineal reconstruction 91
Colorectal peritoneal metastases (CRPM) 91
CRS/HIPEC 92
Scoring systems 92
Patient Selection 93
Colorectal liver metastases 93
Key references 95
Chapter 9: Anal cancer 96
Introduction 96
Epidermoid tumours 96
Aetiology and pathogenesis 96
Premalignant lesions 97
Histological types 98
Patterns of spread 98
Clinical presentation 98
Investigation 99
Clinical staging 99
Treatment 99
Historical 99
Current 99
Radiation-alone therapy 99
Chemo-irradiation therapy (combined modality therapy) 100
Role of surgery today 101
Initial diagnosis 101
Lesions at the anal margin 101
Treatment complications and disease relapse 101
Inguinal metastases 102
Long-term outcomes 102
Treatment of intraepithelial neoplasia 102
Rarer tumours 103
Adenocarcinoma 103
Malignant melanoma 103
Key references 103
Chapter 10: Diverticular disease 105
Historical perspectives 105
Terminology 105
Anatomical and physiological perspectives 105
Incidence and geographical differences 105
Race and geography 105
Age and gender 106
Diet 106
Aetiology and pathogenesis 106
Lifestyle 107
Smoking 107
NSAIDs 107
Diverticulitis 107
The extent of the problem 107
Classification 107
Segmental colitis-associated diverticulosis 108
Diagnosis and imaging 108
Treatment 110
Conservative and medical options 110
Emergency surgery 111
Historical perspectives 111
Laparoscopic peritoneal lavage for generalised purulent peritonitis 112
Resection with primary anastomosis 114
Elective resection – facts, fiction and functional outcome 115
Diverticular haemorrhage 115
Key references 116
Chapter 11: Ulcerative colitis 117
Introduction 117
Epidemiology 117
Aetiopathogenesis 117
Clinical presentation 118
Extraintestinal manifestations 118
Musculoskeletal 118
Hepatopancreatobiliary 118
Dermatological 119
Thromboembolic 119
Ophthalmological 119
Diagnosis and evaluation 119
Microbiology 119
Endoscopy 120
Histopathology 120
Imaging 120
Serology and microbiome 121
Colorectal cancer and surveillance 121
Severity assessment 122
Medical management 122
Proctitis 123
Mild to moderate distal colitis 123
Mild to moderate extensive colitis 123
Severe colitis 124
Surgical management 124
Emergency/urgent 124
Elective 125
Proctocolectomy with end ileostomy 125
Proctocolectomy with continent ileostomy 126
Ileorectal anastomosis 126
Restorative proctocolectomy/ileal pouch–anal anastomosis (IPAA) 126
Double-stapled technique 127
Hand-sewn technique 127
Outcomes in stapled versus hand-sewn anastomosis 128
Complications following pouch surgery 130
Functional outcomes 133
Key references 134
Chapter 12: Crohn’s disease 135
Introduction 135
Epidemiology 135
Aetiology 135
Smoking and oral contraception 135
Infection 135
Genes and the microbiome 136
Pathogenesis 136
Pathology 136
Distribution 136
Macroscopic appearance 137
Microscopy 137
Pitfalls in differentiating Crohn’s colitis from ulcerative colitis 137
Clinical 138
Gastrointestinal symptoms 138
Systemic symptoms 138
Extraintestinal manifestations 138
Physical signs 139
Paediatric age group 139
Pregnancy 139
Investigations 139
Laboratory 139
Radiology 140
Endoscopy 141
Disease activity assessment and quality of life 142
Phenotyping 142
Differential diagnosis 142
Small-bowel Crohn’s disease 142
Large-bowel Crohn’s disease 143
Medical treatment 143
Multidisciplinary care 143
Aminosalicylates 143
Steroids 144
Antibiotics 144
Nutrition for therapy 144
Immunomodulatory therapy 144
Biological agents’ 145
Surgery and immunosuppression 146
Prophylaxis against recurrent disease after surgery 146
Other drugs 146
Surgery 146
Development of surgery 146
Risk of operation and re-operation 147
Risk factors for recurrence 147
Principles of surgery for Crohn’s disease 148
Perioperative considerations 148
Technique 148
Surgery for small-bowel and ileocolic Crohn’s disease 148
Indications 148
Gastroduodenal disease 148
Ileocolic disease 149
Ileal and jejunal multisite disease 149
Fistulas and abscesses 149
Enterocutaneous fistulas and intra-abdominal abscess 150
Management principles 150
Spontaneous enterocutaneous fistulas 150
Postoperative fistulas 150
Intra-abdominal fistulas 151
Spontaneous free perforation in the small bowel or colon 151
Surgery for colonic and rectal Crohn’s disease 151
Indications 151
Emergency colectomy and colectomy and ileostomy 151
Segmental colectomy 151
Total colectomy and ileorectal anastomosis 151
Panproctocolectomy 152
Restorative proctocolectomy 152
Crohn’s colitis and cancer 153
Perianal disease 153
Investigation 153
Medical treatment 153
Anal fissure 154
Abscesses 154
Anal fistulas 154
Rectovaginal fistulas 154
Defunctioning ileostomy for perianal disease 155
Long-term complications of perianal disease 155
Prognosis 155
Key references 155
Chapter 13: Intestinal failure 157
Introduction 157
Intestinal failure: criteria for referral 157
Epidemiology 158
Causes 158
Loss of intestinal length 158
Loss of functional absorptive capacity 158
Loss of intestinal absorptive capacity 159
Loss of intestinal function 159
Pathophysiology 159
The three stages of intestinal failure 159
Stage I: hypersecretory phase 159
Stage II: adaptation phase 159
Stage III: stabilisation phase 159
Fluid and electrolytes 159
Nutrients 160
Carbohydrates, proteins and water-soluble vitamins 160
Fat, bile salts and fat-soluble vitamins 160
Adaptation 160
Role of the colon in short-bowel syndrome 160
Surgical catastrophe and management 161
Resuscitation 161
Restitution 161
Sepsis 161
Nutrition 161
Fluid and electrolytes 161
Nutritional support 162
Reduction of output 162
Dietary modification 163
Outcome aims and monitoring 163
Parenteral nutrition 163
Fistuloclysis 163
Anatomy (mapping) 164
Protection of skin 165
Planned surgery 165
Reconstruction 166
Enterocutaneous fistula 166
Rehabilitation 167
Transplantation 167
Supporting organisations 168
Summary 168
Key references 169
Chapter 14: Incontinence 170
Introduction 170
Aetiology 170
Sphincter injury 170
Rectal compliance 172
Idiopathic’ faecal incontinence 172
Presentation 172
History 172
Examination 173
Investigations 173
Management of faecal incontinence in adults 174
Conservative measures 174
Dietary modification and medications 174
Biofeedback and pelvic floor muscle retraining 175
Anal plug 176
Surgery 176
Sphincteroplasty 176
Pelvic floor repair (postanal, preanal or total) 177
Sphincter reconstruction – muscle transposition 177
Artificial sphincters 178
Artificial bowel sphincter 178
Magnetic anal sphincter 178
Sacral nerve stimulation 178
Percutaneous and transcutaneous tibial nerve stimulation 181
Injection therapy 182
Stoma formation 182
Antegrade continence enema 182
End stoma 182
Conclusion 183
Key references 183
Chapter 15: Functional problems and their surgical management 184
Introduction 184
Rectal prolapse 184
Mucosal prolapse 184
Full-thickness rectal prolapse (see Table 15.1) 184
Choice of abdominal or perineal surgical approaches 186
Perineal approaches 187
Abdominal approaches 188
Laparoscopic approaches 189
Recurrent rectal prolapse 190
Obstructive defaecation, rectocele and rectal intussusception 190
Rectocele 190
Rectal intussusception 191
Laparoscopic ventral rectopexy 193
Stapled transanal rectal resection (STARR) 193
Solitary rectal ulcer syndrome (SRUS) 195
Key references 196
Chapter 16: Functional problems and their medical management 198
Introduction 198
Irritable bowel syndrome 198
Investigation 199
Treatment 199
Lifestyle modification 199
Pharmacological treatments 199
Psychological treatments 200
Surgery 200
Functional constipation 200
Investigation 201
Treatment 201
Dietary fibre supplementation 201
Laxatives, suppositories, enemas and novel prokinetics 201
Behavioural therapy (biofeedback) 202
Surgical treatment for constipation 202
Putative treatments for constipation 203
Idiopathic megarectum and megacolon 203
Key references 204
Chapter 17: Anal fistula: evaluation and management 206
Introduction 206
Aetiology 206
Management of acute sepsis 208
Classification of anal fistula 209
Assessment 211
Clinical 211
Imaging 212
Physiological 213
Principles of fistula surgery 214
Surgical treatment – general principles and interpreting the evidence 214
Track preparation 215
Fistulotomy 216
Fistulotomy and immediate reconstitution 216
Fistulectomy 216
Setons 217
The loose seton 217
The tight seton 217
The chemical seton 218
Advancement flaps 218
Intersphincteric approaches 219
Infill materials – glues and plugs (Table 17.1) 219
Fibrin glue 219
Bioprosthetic plugs 220
Newer techniques 220
VAAFT (video assisted anal fistula treatment) 220
FiLaC (fistula tract laser closure) 220
OTSC (over the scope clip) 220
Stem cells 221
Management of the recurrent fistula 221
Key references 222
Chapter 18: Minor anorectal conditions 223
Haemorrhoids 223
Anatomy and physiology 223
Aetiology and pathogenesis 223
Classification 224
Symptoms and diagnosis 224
Management 224
First-degree 225
Dietary changes 225
Phlebotonics 225
Second-degree 225
Rubber-band ligation 225
Sclerotherapy 226
Other treatments 226
Third-degree 226
Stapled haemorrhoidopexy 226
Haemorrhoidal arterial ligation/transanal haemorrhoidal dearterialisation 227
Fourth-degree 227
Postoperative problems 227
Postoperative pain 227
Postoperative haemorrhage 227
Anal stenosis 228
Thrombosed haemorrhoids 228
Conclusions 228
Anal fissure 228
Aetiology 228
Classification 229
Symptoms and diagnosis 229
Management 230
Initial treatment – conservative measures 230
Glyceryl trinitrate 230
Diltiazem 230
Botulinum toxin 230
Surgical treatments 231
Anal dilatation 231
Lateral anal sphincterotomy 231
Fissurectomy 231
Anal advancement flap 231
Conclusion 231
Pruritus ani 231
Aetiology and pathogenesis 232
Diagnosis 232
Treatment 232
Conclusion 233
Pilonidal sinus 233
Aetiology 233
Clinical manifestation 233
Treatment 233
Pilonidal abscess 233
Chronic pilonidal sinus 233
Outpatient options 233
Surgical options 234
Recurrent pilonidal sinus 234
Conclusion 235
Anal stenosis 235
Aetiology 235
Clinical presentation 236
Treatment 236
Prevention 236
Anal dilatation 236
Sphincterotomy 236
Stricturoplasty 236
Flap procedures 237
Mucosal advancement flap (above to down) 237
Y–V advancement flap (outside to in) 237
V–Y advancement flap (outside to in) 237
Island advancement flap (outside to in) 237
Conclusion 237
Sexually transmitted diseases 237
Human papillomavirus and anal warts 238
Treatment 239
Buschke–Lowenstein tumour: giant anal condyloma 240
Other STDs affecting the anorectum 240
Key references 242
Index 245