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Core Topics in General & Emergency Surgery E-Book

Core Topics in General & Emergency Surgery E-Book

Simon Paterson-Brown | Hugh M. Paterson

(2018)

Additional Information

Abstract

Core Topics in General and Emergency Surgery meets the needs of surgeons in higher training and practising consultants for a contemporary and evidence-based account of general surgery in both elective and emergency situations. It is a practical reference source incorporating the most current information on recent developments, management issues and operative procedures. The text is thoroughly referenced and supported by evidence-based recommendations wherever possible, distinguishing between strong evidence to support a conclusion, and evidence suggesting that a recommendation can be reached on the balance of probabilities.

For this Sixth Edition the authorship team across the series has been expanded to include additional European and World experts, with an increased emphasis on global practice. Throughout all six volumes the contents have been extensively revised in line with recently published evidence. Detailed supportive key references are provided and are also included within the comprehensive list of references in the accompanying ebook. Links to recommended online videos have been added where appropriate.

  • The Companion to Specialist Surgical Practice series provides a current and concise summary of the key topics within the major sub-specialties of general surgery.
  • Each volume highlights evidence-based practice both in the text and within the extensive list of references at the end of every chapter.

The extensive revisions to this edition of Core Topics in General and Emergency Surgery are intended to maximize its appeal to all those in general surgical practice. There are several entirely new chapters on subjects previously covered in other volumes of the series, while the remaining chapters have been revised, updated or re-written by new authors where appropriate. The new chapters include those on the Evaluation of surgical literature; Enhanced recovery; Organ donation and general surgery in transplant patients; and Principles of neck surgery for the general surgeon. For the first time this volume includes a chapter on Patient safety and human factors in surgery, which distills the core knowledge that is fundamental to achieving good outcomes (and avoiding bad ones) in practice for all grades of surgeon.


Table of Contents

Section Title Page Action Price
Front Cover Cover
Inside Front Cover ES2
Core Topics in General and Emergency Surgery i
Copyright ii
Contents iii
Series Editors' preface v
Editors' preface vii
Evidence-based practice in surgery ix
Contributors xi
Chapter 1: Evaluation of surgical evidence 1
Introduction to surgical evidence 1
Changing the world with evidence 2
Formulating a clinical question 2
Study population or target condition 2
Intervention or exposure 2
Comparison 3
Outcome 3
Study designs 4
Systematic reviews and meta-analyses 4
Randomised controlled trials 6
Randomisation 7
Simple randomisation 7
Block randomisation 8
Blinding 8
Open-label studies 9
Cluster randomisation 9
Allocation concealment 9
Phases of trials 9
Phase 0 trials 9
Phase I trials 10
Phase II trials 10
Phase III trials 10
Post-marketing studies 10
IDEAL framework 10
Cohort studies 10
Case-control studies 11
Cross-sectional studies 12
Case series and case reports 12
Single-centre or multicentre research 12
Finding the evidence 12
Journals 12
Books 12
Conferences 12
Social media 12
Medical literature databases 13
MEDLINE 13
EMBASE 13
Clinical trials databases 13
Search clients 13
PubMed 13
OvidSP 13
Google Scholar 13
Evidence-based medicine organisations 13
The Cochrane Library 13
Specialist registers 13
Constructing a systematic search 14
Defining search terms using PICOS 14
Population 14
Intervention or exposure 14
Comparison 14
Outcomes 14
Study design 14
Combining terms 14
Boolean operators 14
Wildcards 15
Critical appraisal 15
Systematic approaches for critical appraisal 15
Bias 16
Types of bias 16
Selection bias 16
Responder bias 17
Reporting bias 17
Attrition bias 19
Performance bias 19
Recall bias 20
Observer bias 20
Publication bias 20
Judging the risk of bias 20
Simple statistics 21
Summarising data 21
Summarising ordinal or categorical data 21
Summarising continuous data 21
Measuring dispersion 22
Standard deviation (SD or σ) 22
Confidence interval (CI) 22
Interquartile range (IQR) 22
Range 22
Missing data 22
Treatment effect 23
Risk 23
Odds 23
The 2 x 2 table, risk ratios and odds ratios 23
Risk ratio versus odds ratio 24
Hypothesis testing 24
Association and causation 24
Statistical significance 25
Adjusting for confounding factors 25
Example studies 25
MRC-CLASICC 25
EVAR-1 25
ProtecT 25
Appendix 26
Further reading 26
Books 26
Websites 26
Journals 27
Databases 27
Sources of guidelines and integrated care pathways 27
Chapter 2: Perioperative care and enhanced recovery 28
Introduction 28
Before the operation 28
Patient counselling 28
Preoperative nutrition and immunonutrition 29
Cessation of smoking 29
Prehabilitation 29
Antithromboembolic drugs in the perioperative period 29
Vitamin-K antagonists (VKA) 30
Direct oral anticoagulants (DOAC) 30
Anti-platelet drugs 30
Immediate preoperative period 30
Preoperative bowel preparation 30
Prevention of thromboembolic events 31
Preoperative fasting 31
Preoperative carbohydrate loading 31
Antibiotic prophylaxis 32
Intraoperative care 32
Preventing postoperative nausea and vomiting (PONV) 32
Postoperative analgesia 32
Thoracic epidural 32
Transverse abdominal plane blocks 32
Intravenous analgesia 32
Oral non-opioid analgesics 33
Access and incision 33
Perioperative fluid balance, blood pressure, oedema and diuresis 33
Intraoperative fluid balance 33
Postoperative fluid balance 34
Postoperative care 34
Nasogastric drainage 34
Glycaemic control 34
Abdominal drains 35
Stimulation of bowel movement 35
Postoperative artificial nutrition 36
Early and scheduled mobilisation 36
Key references 37
Chapter 3: Organisation of emergency general surgical services 38
Introduction 38
Separation of elective and emergency surgery 39
Subspecialisation in emergency general surgery 40
Process and facilities 41
Emergency general surgery 'Hot Clinics' 43
Summary 43
Key references 44
Chapter 4: Patient assessment and surgical risk 45
Introduction 45
Why assess surgical risk? 45
How can we assess surgical risk? 45
Estimation of surgical risk 46
Clinical assessment 46
Risk prediction models and scoring systems 46
POSSUM 47
CR-POSSUM (colorectal) 48
O-POSSUM (oesophagogastric) 48
V-POSSUM (vascular) 48
ASA 49
Surgical Mortality Probability Model and Surgical Risk Scale 49
Surgical Risk Calculator 50
Surgical Outcome Risk Tool 50
Surgical Risk Preoperative Assessment System (SURPAS) 50
Other risk prediction models 51
Functional assessment 51
Cardiopulmonary exercise testing (CPEX) 52
Other objective measures of exercise capacity 53
Frailty 53
Sarcopenia and body composition analysis 54
Biomarkers 54
Communicating risk 55
Key references 56
Chapter 5: Perioperative and intensive care management of the surgical patient 58
Introduction 58
How big is the problem? 58
Why do patients die after surgery? 59
What is a high-risk surgical patient? 59
Variables associated with postoperative complications and death 59
The role of the splanchnic circulation 60
Strategies to improve outcomes 60
Oxygen delivery 60
Measurement and monitoring of cardiac output 61
Fluid resuscitation 61
Delirium as a postoperative complication 61
Conclusions 61
Key references 63
Chapter 6: Surgical nutrition 64
Introduction 64
Metabolic response to feeding, trauma and sepsis 64
Trauma 65
Protein metabolism 65
Carbohydrate metabolism 66
Fat metabolism 67
Mineral and micronutrient metabolism 67
Sepsis 67
Nutritional requirements 67
Proteins and amino acids 67
Energy requirements 68
Minerals and micronutrients 68
Identification of patients who are malnourished 69
Anthropometric measures 69
Height and weight 69
Body composition 69
Subcutaneous fat thickness 69
Bioelectrical impedance 69
Biochemical measures 69
Serum proteins 69
Nitrogen balance 70
Tests of function 70
Immune competence 70
Muscle function 70
Skeletal muscle 70
Respiratory muscle 70
How should nutritional status be assessed in clinical practice? 70
The Malnutrition Universal Screening Tool (MUST) 70
Significance of the resultant score and clinical management 70
Re-feeding syndrome 71
Nutritional support in surgical practice 71
Route of nutritional support 71
Enteral nutritional support 71
The importance of enteral nutrition 71
Routes of access for enteral nutritional support 71
Nasoenteric tubes 71
Gastrostomy tubes 72
Jejunostomy tubes 72
Nutrient solutions available for enteral nutrition 72
Polymeric diets 72
Elemental diets 72
Special formulations 72
Modular diets 72
Enteral nutrition delivery and complications 72
Parenteral nutritional support 73
Parenteral routes of access 73
Central venous access 73
Technical aspects of feeding lines 73
Catheter care 73
Peripheral venous access 74
Nutrients used in parenteral feeding solutions 74
Nitrogen sources 74
Energy sources 74
Other nutrients 75
Delivery and administration of PN 75
Complications of parenteral nutritional support 75
Monitoring patients receiving nutritional support 75
Nutritional support teams 76
Nutritional support in defined clinical situations 76
Nutritional support in the perioperative period 76
Parenteral nutrition 76
Nutritional support in patients with acute pancreatitis (see also Chapter 14) 77
Nutritional supplementation in inflammatory bowel disease 77
Nutritional support in enterocutaneous fistulas 77
Nutritional support in patients with burns 77
Nutritional supplementation with key nutrients: application to clinical practice 77
Combinations of these nutrients and their place in practice 78
Key references 80
Chapter 7: Abdominal hernias 81
Introduction 81
Aetiology 81
Classification of hernias 82
Mesh 82
Epigastric hernia 84
Aetiology 84
Clinical presentation 84
Management 84
Operative details 84
Complications 85
Umbilical and para-umbilical hernias 85
Congenital umbilical hernias 85
Para-umbilical hernias 85
Clinical presentation 85
Management 85
Operative details 85
Complications 86
Adult umbilical hernias 86
Spigelian, lumbar and other primary ventral hernias 86
Inguinal hernias 86
Anatomy 86
Definition 87
Inguinal hernia in infants and children (see also Chapter 18) 87
Clinical presentation 87
Management 87
Operative details 88
Complications 88
Adult inguinal hernias 89
Aetiology 89
Diagnosis 89
Management 89
Tension-free' open mesh repair 89
Laparoscopic repair 91
Intraperitoneal prosthetic repair 91
Transabdominal pre-peritoneal prosthetic (TAPP) repair 91
Totally extraperitoneal prosthetic (TEP) repair 91
Single incision laparoscopic surgery (SILS) and robotic surgery 92
Complications 92
Open suture, open mesh or laparoscopic repair? 92
Contralateral repair 93
Recurrent inguinal hernias 93
Open mesh repair of recurrent inguinal hernias 93
Laparoscopic repair of recurrent inguinal hernias 93
The asymptomatic hernia 93
Femoral hernia 94
Anatomy 94
Aetiology 94
Management 94
Operative details 94
The low approach (Lockwood) 94
Transinguinal approach (Lothiessen) 94
High approach (McEvedy) 94
Laparoscopic approach 95
Incisional hernia 95
Aetiology 95
Management 95
Mesh repair 96
Open sublay repair 97
Laparoscopic repair 97
Parastomal hernia 99
Emergency hernia surgery 99
Port-site hernia 99
Antibiotic prophylaxis in hernia surgery 99
Prophylactic' hernia surgery 100
Management of an infected mesh 100
Key references 101
Chapter 8: Neck surgery for the general surgeon 102
Introduction 102
Diagnostic approach to neck masses 102
Initial assessment (Table 8.1) 102
Imaging 103
Biopsy 103
Thyroid mass 104
Surgery for malignancy 105
Surgery for pressure symptoms 107
Surgery for hyperthyroidism 107
Postoperative management following thyroidectomy 108
Congenital masses 108
Parathyroid disease 109
Conclusion 111
Key references 112
Chapter 9: Human factors and patient safety in surgery 114
The scale of medical error 114
Adverse events in surgery 114
Human factors 115
Non-technical skills in surgery 116
Situation Awareness (SA) 116
Decision-making 118
Teamwork and communication 118
Leadership 119
Conclusion 120
Key references 120
Chapter 10: Principles of organ donation and general surgery in the transplant patient 122
Introduction 122
Principles of organ donation 122
Ethical and legal aspects of organ donation 122
Types of organ donation 123
Living donation 123
Living kidney donation 124
Living liver donation 126
Deceased organ donation 126
Donor identification and referral 126
Donation after brain death 126
Donation after circulatory death 128
Contraindications to deceased donation 130
General surgery in the transplant patient 131
Immunosuppression 131
Specific general surgical problems 132
Peptic ulceration 132
Colonic perforation 132
Cholelithiasis 132
Appendicitis 132
Key references 133
Chapter 11: Early assessment of the acute abdomen 135
Conditions associated with abdominal pain 135
Initial assessment: history, examination and simple tests 136
Initial investigations 137
Blood tests 137
Diagnostic imaging 138
Plain radiography 138
Contrast radiography 138
Ultrasonography 139
Computed tomography 140
Magnetic resonance imaging 143
Diagnostic laparoscopy 143
Special populations 144
Pathways/guidelines for assessment 144
Key references 145
Chapter 12: Perforations of the upper gastrointestinal tract 146
Introduction 146
Key principles of treatment 146
Anatomical consideration 146
Pathological considerations 146
Diagnosis 147
Advanced imaging 147
Perforated peptic ulceration 148
Cause 148
H. pylori 148
Non-steroidal anti-inflammatory drugs (NSAIDs) 148
Indications for surgery 148
Open or laparoscopic surgery? 150
New options 151
Giant duodenal ulcer 151
Perforated gastric ulcers 151
Antimicrobial therapy 152
Postoperative care 152
Oesophageal perforation 152
Causes 153
Iatrogenic 153
Spontaneous rupture (Boerhaave’s syndrome) 153
Caustic injury 153
Diagnosis of oesophageal perforation78 153
Treatment 153
Drainage 155
Control of the perforation 156
Endoscopic therapy 156
Surgical repair 157
Resection and/or oesophageal exclusion 157
Nutrition 158
Perforation after endoscopic retrograde cholangiopancreatography 158
Intraperitoneal perforation 158
Duodenal wall injury 158
Retroperitoneal perforations 158
Chapter 13: Acute non-variceal upper gastrointestinal bleeding 160
Introduction 160
Aetiology 160
Initial assessment and triage 160
Scoring systems 161
Initial management 162
Massive haemorrhage 162
Use of blood and blood products 162
Management of patients on antiplatelet agents and anticoagulants 163
Early pharmacological treatment 163
Endoscopy 164
Endoscopic technique 164
Management of bleeding due to causes other than peptic ulceration 164
Gastritis/duodenitis 164
Mallory–Weiss syndrome 164
Oesophagitis 165
Neoplastic disease 165
Dieulafoy's lesion 165
Endoscopic management of bleeding peptic ulcers 165
Endoscopic stigmata of bleeding 165
Endoscopic treatment 166
Injection 166
Thermal methods 167
Mechanical methods 167
Hemospray® 167
Over-the-scope clip (OTSC)’ 167
Single versus combined methods 167
Limit of endoscopic therapy 168
Second-look endoscopy 168
Pharmacological management of bleeding peptic ulcers 168
Acid suppression 168
Surgical management of bleeding peptic ulcers 169
Choice of surgical procedure for bleeding peptic ulcers 169
Management of recurrent bleeding 170
The role of angiographic embolisation 171
Helicobacter pylori eradication 171
Use of NSAIDs 172
Summary 172
Key references 173
Chapter 14: Pancreatico-biliary emergencies 174
Introduction 174
Gallstones 174
Cholecystolithiasis and associated complications 174
Clinical presentation and diagnosis 174
Management of acute cholecystitis 177
Patient-specific factors for consideration in acute cholecystitis 180
Investigation for suspected choledocholithiasis in acute cholecystitis 180
Acalculous acute cholecystitis 181
Choledocholithiasis and associated complications 181
Management of choledocholithiasis 182
Acute bacterial cholangitis 183
Acute pancreatitis 184
Initial assessment, investigations and management 184
Early management of severe disease 185
Fluid management 185
Nutrition 186
Preventing secondary infectious complications 187
Management of mild biliary pancreatitis 187
When should a patient with severe acute pancreatitis be transferred? 188
Follow-up for non-biliary, non-ETOH-induced pancreatitis 188
Implementation and compliance with the evidence base 188
Technical considerations of cholecystectomy, laparoscopic bile duct exploration and ERCP 188
Key references 191
Chapter 15: Acute conditions of the small bowel and appendix 193
Introduction 193
Small-bowel obstruction 193
Mechanism 193
Presentation 194
Initial management 194
Investigations 195
Non-operative management 195
Surgical management 196
Operative principles 196
Laparoscopy 197
Reducing adhesion formation 197
Difficult closure 197
Special conditions 197
Radiation enteritis 197
Malignant obstruction 198
Abdominal wall hernia 199
Enterolith obstruction 199
Intussusception 200
Connective tissue disorders 200
Chronic intestinal pseudo-obstruction 200
Intestinal obstruction in the early postoperative period 200
Laparoscopy 200
Peritonitis 201
Crohn's disease 201
Presentation 201
Investigation 201
Surgery for acute Crohn's disease presenting de novo 201
Mesenteric ischaemia 202
Meckel's diverticulum 203
Haemorrhage 203
Appendicitis 205
Aetiology and pathology 205
Clinical features 205
Investigations 206
Differential diagnosis 207
Management 207
Surgical Treatment 207
Open appendicectomy 207
Laparoscopic appendicectomy 208
The normal appendix at open surgery 209
The normal appendix at laparoscopy 209
Non-surgical treatment 209
Treatment of atypical presentation of acute appendicitis 210
Appendix mass 210
Appendix abscess 210
Chronic appendicitis 211
Appendicitis in pregnancy 211
Postoperative complications and outcome 211
Hospital stay 211
Wound infection 211
Other septic complications 212
Prognosis 212
Appendiceal tumours 212
Neuroendocrine neoplasm 212
Mucinous tumours 213
Adenocarcinoma 213
Acknowledgement 214
Key references 214
Chapter 16: Colonic emergencies 216
Introduction 216
Colonic obstruction 216
Neoplastic obstruction 216
Intervention: colonic stents 217
Intervention: operative 218
Diverticular 219
Sigmoid volvulus 219
Caecal volvulus 220
Caecal bascule 221
Acute colonic pseudo-obstruction 221
Inflammation/infection 222
Toxic colitis/megacolon 222
Neutropenic enterocolitis 225
Perforation 225
Complicated colonic diverticulitis 225
Stercoral 226
Colonoscopic 226
Anastomotic leak/dehiscence 227
Haemorrhage 228
Ischaemia 229
Key references 232
Chapter 17: Anorectal emergencies 234
Introduction 234
Anorectal anatomy 234
Anorectal abscesses 234
Clinical features 235
Radiological imaging 235
Treatment 236
Technical tips 237
Fistula-in-ano 237
Management of secondary perianal sepsis 238
Malignant disease 238
Inflammatory bowel disease 238
Necrotising infection 239
Anorectal sepsis in neutropenic patients 239
Anorectal sepsis in HIV patients 239
Pilonidal abscess 239
Acute anal fissure 239
Haemorrhoids 240
Thrombosed haemorrhoids 240
Anorectal haemorrhage 241
Anorectal trauma 241
Anal sphincter injuries 241
Obstetric anal sphincter injuries 241
Non-obstetric trauma 242
Rectal injuries 242
Foreign bodies 242
Irreducible rectal prolapse 242
Key references 243
Chapter 18: Paediatric surgical emergencies 245
Introduction 245
Neonatal period 245
Prenatal diagnosis 245
Intestinal obstruction 245
Assessment 245
Specific forms of intestinal obstruction 248
Oesophageal atresia 248
Meconium ileus 248
Intestinal atresia/stenosis 249
Hirschsprung disease 249
Anorectal malformations 249
Malrotation 250
Inflammatory conditions 251
Assessment 251
Specific forms of abdominal inflammation 251
Meconium peritonitis 251
Necrotising enterocolitis 251
Isolated ileal perforation 252
Other neonatal conditions 253
Incarcerated inguinal hernia 253
Abdominal wall defects 253
Infancy 253
Hypertrophic pyloric stenosis 253
Intussusception 254
Children 255
Appendicitis 255
Fluid resuscitation of the child with a surgical emergency 256
Paediatric trauma 256
Chapter 19: Management of trauma for the general surgeon 258
Introduction 258
Evaluation of the injured patient 259
Primary and secondary survey, damage control surgery, transfer 259
Damage control surgery 259
Referral patterns 260
Regional injuries 260
Injury scoring scales 260
Blunt and penetrating abdominal trauma 260
Special investigations 261
Focused assessment with sonography in trauma (FAST) 261
Computed tomography (CT) 262
Diagnostic and therapeutic laparoscopy 262
Blunt trauma 262
Spleen 262
Liver 263
Kidneys 263
Abdominal stab and low-velocity gunshot wounds 264
Stab wounds 264
Gunshot wounds (GSW) 264
Small bowel, colon and rectum 265
Kidneys 266
Duodenum and pancreas 267
Abdominal vena cava 268
Complications 268
Pelvic fractures 268
A step-by-step guide to trauma laparotomy 269
Blunt and penetrating chest injuries 270
Rib fractures, pneumothorax, haemothorax and pulmonary contusions 270
Rib fracture 270
Pneumothorax and haemothorax 270
Pulmonary contusions 271
Intrathoracic complications 271
Cardiac injuries 271
Aortic injuries 273
Oesophageal injuries 274
Transmediastinal gunshot wounds 274
Emergency department thoracotomy 274
Emergency department thoracotomy technique99 275
Retained knife blade 275
Thoraco-abdominal trauma 276
Diaphragmatic injuries 276
Neck trauma 277
Penetrating neck injuries 277
Vascular injuries 278
Oesophageal injuries 279
Pharyngeal injuries 279
Future developments 279
Resuscitative endovascular balloon occlusion of the aorta (REBOA) 279
Enhanced recovery after surgery (ERAS) 279
Key references 280
Chapter 20: Abdominal sepsis and abdominal compartment syndrome 281
Introduction 281
Definition of sepsis 281
Pathophysiology of sepsis 282
The slippery slope of sepsis 283
The Surviving Sepsis Campaign (SSC) 283
Systematic assessment 283
Lactate measurement 285
Antimicrobial therapy in abdominal sepsis 285
Imaging in abdominal sepsis 285
Early source control in abdominal sepsis 286
Aims of treatment in abdominal sepsis 286
Abdominal sepsis on the ICU 287
Assessment on the ICU 288
Re-operating in abdominal sepsis 288
Damage control laparotomy 289
Second-look (planned) re-laparotomy 289
Leaving the abdomen open (laparostomy) 290
The National Emergency Laparotomy Audit (NELA) 291
Abdominal compartment syndrome 291
Enterocutaneous fistulas (ECF) 292
Key references 294
Chapter 21: Complications of bariatric surgery presenting to the general surgeon and considerations for the general surgeon ... 295
Introduction 295
Causes of obesity 295
Mechanisms of weight loss surgery 296
Bariatric operations 296
Gastric band 296
Roux-en-Y gastric bypass 297
Mini-gastric bypass 297
Sleeve gastrectomy 297
Duodenal switch 298
Intragastric balloon 298
Older, more obsolete operations 298
Jejuno-ileal bypass (JIB) 298
Vertical banded gastroplasty (VBG) 298
Newer procedures 299
Endoscopic duodenojejunal sleeve 299
Gastric plication 299
Implantable neuroregulators (gastric ‘pacemakers’) 299
Complications of bariatric surgery 299
General complications 299
Specific complications 300
Clinical presentation 301
Gastric band patients 301
Vomiting and/or dysphagia 301
Band too tight 301
Acute band 'slippage' 301
Band erosion 302
Abdominal pain 302
Chest pain 302
Mega-oesophagus 302
Port problems 303
Migration 303
Leakage 303
Infection 303
Skin erosion 303
Sleeve gastrectomy patients 303
Staple-line leak or bleed 303
Splenic infarction 303
Omental necrosis 303
Sleeve stenosis 303
Gastric bypass/duodenal switch patients 304
Staple-line leak 304
Staple-line bleed 304
Small-bowel enterotomy 304
Early small-bowel obstruction 304
Late small-bowel obstruction 304
Gastro-gastric fistula 305
Dumping syndrome 305
Mini-gastric bypass patients 305
Gastric balloon patients 305
Gastric plication patients 305
Patients with older, now obsolete operations 306
Other postoperative problems 306
Gallstones 306
Nutritional deficiencies 306
Failure to lose weight 306
Considerations when operating on the obese patient 306
Preoperative measures 306
Anaesthesia 306
Surgery 307
Postoperative care 307
Patient optimisation 307
Intraoperative measures 307
Postoperative measures 308
Key references 309
Index 311