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Lookingbill and Marks' Principles of Dermatology E-Book

Lookingbill and Marks' Principles of Dermatology E-Book

James G. Marks | Jeffrey J. Miller

(2017)

Additional Information

Book Details

Abstract

Intuitively organized by appearance rather than etiology, Lookingbill and Marks’ Principles of Dermatology, 6th Edition, by Drs. James G. Marks, Jr. and Jeffrey J. Miller, is a concise, abundantly illustrated everyday reference for dermatologic diagnosis and therapy. It offers expert guidance and overviews of essential information in dermatology, including key points, clinical pearls, differential diagnosis, and tables of first- and second-line treatments. Superb clinical photographs, full-color histopathology images, and corresponding cross-sectional line diagrams provide details on cause and condition.

  • Features new and expanded evidence-based treatment tables to keep you up to date with fast-changing treatments in dermatology and guide you toward the best treatments for your patients.
  • Offers new coverage of common drug eruptions, as well as the latest therapies for common, difficult-to-treat skin disorders, such as acne, psoriasis, and eczema.
  • Includes a more diverse range of skin color patient images throughout.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Inside Front Cover ES2
Lookingbill and Marks' Principles of Dermatology iii
Copyright iv
Contents v
Preface vii
Preface to the First Edition viii
Acknowledgements ix
Dedication x
Section 1: Principles of dermatology 1
Chapter 1: Introduction 1
Chapter 2: Structure and Function of the Skin 2
Epidermis 2
Structure 3
Basal Cell Layer 3
Stratum Spinosum 3
Stratum Granulosum 3
Stratum Corneum 4
Other Cellular Components 4
Melanocytes 4
Langerhans Cells 4
Merkel Cells 5
Dermal–Epidermal Junction – The Basement Membrane Zone 5
Dermis 5
Nerves 6
Blood Vessels 7
Skin Appendages 7
Eccrine Sweat Glands 7
Apocrine Sweat Glands 7
Hair Follicle 8
Sebaceous Glands 8
Nails 9
Subcutaneous Fat 10
Chapter 3: Principles of Diagnosis 11
History 11
Preliminary History 12
Chief Complaint 12
History of the Present Illness 12
Onset and Evolution 12
Symptoms 12
Treatment to Date 12
Follow-Up History 12
Past Medical History 12
Review of Systems 13
Family History 13
Social History 13
Physical Examination 13
Terminology of Skin Lesions 15
Clinicopathologic Correlations 15
Growths 22
Rashes 23
Miscellaneous Conditions 25
Configuration of Skin Lesions 25
Distribution of Skin Lesions 26
Chapter 4: Dermatologic Therapy and Procedures 29
Principles of Topical Therapy 29
Writing a Dermatologic Prescription 30
Dressings and Baths 31
Topical Steroids (Glucocorticosteroids) 31
Potency 31
Side-Effects 32
Guidelines for Topical Steroid Usage 32
Phototherapy 33
Photobiology and Therapy 33
Sun Protection 33
Diagnostic Tests 34
Potassium Hydroxide Mount for Dermatophytic Infections 34
Potassium Hydroxide Preparation for Candidal Infection 35
Tzanck Preparation 35
Scabies Scraping 36
Culture 36
Skin Biopsy 36
Immunofluorescence Test 37
Patch Testing 38
Dermatologic Surgery 38
Excision 39
Curettage and Electrodesiccation 39
Cryosurgery 40
Patient Education 40
Section 2: Growths 41
Chapter 5: Epidermal Growths 41
Actinic Keratosis 41
Definition 41
Incidence 41
History 41
Physical examination 43
Differential diagnosis 43
Laboratory and biopsy 43
Therapy 43
Course and complications 44
Pathogenesis 44
Basal Cell Carcinoma 44
Definition 44
Incidence 44
History 44
Physical Examination 45
Differential Diagnosis 45
Laboratory and Biopsy 46
Therapy 47
Course and Complications 48
Pathogenesis 48
Corns 48
Definition 48
Incidence 48
History 48
Physical Examination 48
Differential Diagnosis 48
Laboratory and Biopsy 49
Therapy 49
Course and Complications 49
Pathogenesis 49
Molluscum Contagiosum 49
Definition 49
Incidence 49
History 49
Physical Examination 49
Differential Diagnosis 50
Laboratory and Biopsy 50
Therapy 50
Course and Complications 50
Pathogenesis 50
Seborrheic Keratosis 50
Definition 50
Incidence 50
History 50
Physical Examination 51
Differential Diagnosis 51
Laboratory and Biopsy 51
Therapy 51
Course and Complications 52
Skin Tag 52
Definition 52
Incidence 52
History 52
Physical Examination 52
Differential Diagnosis 52
Laboratory and Biopsy 53
Therapy 53
Course and Complications 53
Squamous Cell Carcinoma 53
Definition 53
Incidence 53
History 53
Physical Examination 54
Differential Diagnosis 54
Laboratory and Biopsy 55
Therapy 55
Course and Complications 55
Pathogenesis 55
Wart 56
Definition 56
Incidence 56
History 56
Physical Examination 56
Differential Diagnosis 57
Laboratory and Biopsy 58
Therapy 58
Course and Complications 59
Pathogenesis 59
Birt-Hogg-Dube Syndrome 60
Merkel Cell Carcinoma 60
Nevus Sebaceous 60
Trichoepithelioma 60
Chapter 6: Pigmented Growths 62
Freckle 62
Definition 62
Incidence 62
History 62
Physical Examination 62
Differential Diagnosis 62
Laboratory and Biopsy 63
Therapy 63
Pathogenesis 63
Lentigo 63
Definition 63
Incidence 64
History 64
Physical Examination 64
Differential Diagnosis 64
Laboratory and Biopsy 65
Therapy 65
Course and Complications 65
Malignant Melanoma 65
Definition 65
Incidence 65
History 65
Physical Examination 65
Differential Diagnosis 66
Biopsy 67
Therapy 68
Course and Complications 68
Pathogenesis 69
Melasma 69
Definition 69
Incidence 69
History 69
Physical Examination 70
Differential Diagnosis 70
Laboratory and Biopsy 70
Therapy 70
Course and Complications 70
Pathogenesis 70
Nevus 70
Definition 70
Incidence 70
History 70
Physical Examination 71
Differential Diagnosis 71
Laboratory and Biopsy 72
Therapy 73
Course and Complications 73
Pathogenesis 74
Uncommon Pigmented Growths 74
Becker’s Nevus 74
Nevus of Ota 74
Chapter 7: Dermal and Subcutaneous Growths 75
Angioma 75
Definition 75
Incidence 75
History 75
Physical Examination 76
Differential Diagnosis 76
Laboratory and Biopsy 76
Therapy 76
Course and Complications 77
Dermatofibroma 77
Definition 77
Incidence 77
History 77
Physical Examination 77
Differential Diagnosis 77
Laboratory and Biopsy 78
Therapy 78
Course and Complications 78
Pathogenesis 78
Epidermal Inclusion Cyst 78
Definition 78
Incidence 79
History 79
Physical Examination 79
Differential Diagnosis 79
Laboratory and Biopsy 79
Therapy 79
Course and Complications 80
Pathogenesis 80
Infantile Hemangioma 80
Definition 80
Incidence 80
History 81
Physical Examination 81
Differential Diagnosis 81
Laboratory and Biopsy 81
Therapy 81
Course and Complications 81
Pathogenesis 81
Kaposi’s Sarcoma 82
Definition 82
Incidence 82
History 82
Physical Examination 82
Differential Diagnosis 82
Laboratory and Biopsy 83
Therapy 83
Course and Complications 83
Pathogenesis 83
Keloid 83
Definition 83
Incidence 83
History 83
Physical Examination 84
Differential Diagnosis 84
Laboratory and Biopsy 84
Therapy 84
Course and Complications 84
Pathogenesis 85
Lipoma 85
Definition 85
Incidence 85
History 85
Physical Examination 85
Differential Diagnosis 85
Laboratory and Biopsy 86
Therapy 86
Course and Complications 86
Neurofibroma 86
Definition 86
Incidence 86
History 86
Physical Examination 87
Differential Diagnosis 87
Laboratory and Biopsy 87
Therapy 87
Course and Complications 88
Pathogenesis 88
Xanthoma 88
Definition 88
Incidence 88
History 88
Physical Examination 88
Differential Diagnosis 89
Laboratory and Biopsy 90
Therapy 90
Course and Complications 90
Pathogenesis 90
Malignant Dermal Tumors 90
Definition 90
Incidence 90
History 91
Physical Examination 91
Differential Diagnosis 92
Laboratory and Biopsy 92
Therapy 92
Course and Complications 92
Pathogenesis 92
Uncommon Dermal and Subcutaneous Growths 92
Glomus Tumor 92
Granular Cell Tumor 92
Infantile Digital Fibromatosis 93
Leiomyoma 93
Lymphangioma Circumscriptum 93
Myxoid Cyst 94
Section 3: Rashes with epidermal involvement 95
Chapter 8: Eczematous Rashes 95
Atopic Dermatitis 95
Definition 95
Incidence 95
History 95
Physical Examination 96
Differential Diagnosis 96
Laboratory and Biopsy 98
Therapy 98
Course and Complications 98
Pathogenesis 99
Contact Dermatitis 99
Definition 99
Incidence 100
History 100
Physical Examination 101
Differential Diagnosis 101
Laboratory and Biopsy 101
Therapy 102
Course and Complications 102
Pathogenesis 102
Essential Dermatitis 102
Definition 102
Incidence 103
History 103
Physical Examination 103
Differential Diagnosis 104
Biopsy 104
Therapy 105
Pathogenesis 106
Lichen Simplex Chronicus 106
Definition 106
Incidence 106
History 106
Physical Examination 106
Differential Diagnosis 106
Laboratory and Biopsy 107
Therapy 107
Course and Complications 107
Seborrheic Dermatitis 107
Definition 107
Incidence 107
History 107
Physical Examination 108
Differential Diagnosis 108
Laboratory and Biopsy 109
Therapy 109
Course and Complications 109
Pathogenesis 109
Stasis Dermatitis 109
Definition 109
Incidence 109
History 109
Physical Examination 109
Differential Diagnosis 109
Laboratory and Biopsy 110
Therapy 110
Course and Complications 110
Pathogenesis 110
Uncommon Eczematous Appearing Diseases 111
Darier’s Disease 111
Glucagonoma Syndrome 111
Langerhans Cell Histiocytosis 111
Lichen Sclerosus 112
Pemphigus Foliaceus 112
Wiskott–Aldrich Syndrome 112
Zinc Deficiency 112
Chapter 9: Scaling Papules, Plaques, and Patches 113
Discoid Lupus Erythematosus 113
Definition 113
Incidence 114
History 114
Physical Examination 114
Differential Diagnosis 115
Laboratory and Biopsy 115
Therapy 115
Course and Complications 116
Pathogenesis 116
Fungal Infections 116
Definition 116
History 116
Section 4: Dermal rashes 197
Chapter 14: Generalized Erythema 197
Drug Eruptions 197
Definition 197
Incidence 197
History 197
Physical Examination 198
Differential Diagnosis 199
Laboratory and Biopsy 201
Therapy 201
Course and Complications 201
Pathogenesis 202
Viral Exanthems 202
Definition 202
Incidence 202
History 202
Physical Examination 202
Differential Diagnosis 203
Laboratory and Biopsy 204
Therapy 204
Course and Complications 204
Pathogenesis 204
Uncommon Causes of Generalized Erythema 204
Systemic Lupus Erythematosus 204
Definition 204
Incidence 204
History 205
Physical Examination 205
Differential Diagnosis 205
Laboratory and Biopsy 206
Therapy 206
Course and Complications 207
Pathogenesis 207
Toxic Erythema 207
Definition 207
Incidence 208
History 208
Physical Examination 208
Differential Diagnosis 209
Laboratory and Biopsy 209
Therapy 210
Course and Complications 210
Pathogenesis 210
Other Uncommon Causes – Generalized Erythema 210
Erythroderma 210
Sézary Syndrome 211
Chapter 15: Localized Erythema 212
Abscess and Furuncle 212
Definition 212
Incidence 212
History 212
Physical Examination 212
Differential Diagnosis 212
Laboratory and Biopsy 213
Therapy 214
Course and Complications 214
Pathogenesis 214
Cellulitis 215
Definition 215
Incidence 215
History 216
Physical Examination 216
Differential Diagnosis 216
Laboratory and Biopsy 217
Therapy 217
Course and Complications 218
Pathogenesis 218
Erythema Nodosum 218
Definition 218
Incidence 219
History 219
Physical Examination 219
Differential Diagnosis 219
Laboratory and Biopsy 219
Therapy 219
Course and Complications 220
Pathogenesis 220
Uncommon Causes of Localized Erythema 220
Carcinoid Syndrome 220
Carcinoma Erysipeloids 220
Fixed Drug Eruption 221
Chapter 16: Specialized Erythema 222
Erythema Migrans 222
Definition 222
Incidence 222
History 222
Physical Findings 223
Differential Diagnosis 223
Laboratory and Biopsy 224
Therapy 225
Course and Complications 225
Pathogenesis 225
Erythema Multiforme 225
Definition 226
Incidence 226
History 226
Physical Findings 227
Differential Diagnosis 227
Laboratory and Biopsy 228
Therapy 228
Course and Complications 229
Pathogenesis 229
Urticaria (Hives) 229
Definition 229
Incidence 229
History 230
Physical Findings 230
Differential Diagnosis 230
Laboratory and Biopsy 231
Therapy 231
Course and Complications 232
Pathogenesis 232
Uncommon Causes of Specialized Erythema 232
Erythema Ab Igne 232
Erythema Annulare Centrifugum 233
Erythema Gyratum Repens 233
Chapter 17: Purpura 234
Actinic Purpura 234
Definition 234
Incidence 234
History 234
Physical Findings 235
Differential Diagnosis 236
Laboratory and Biopsy 236
Therapy 236
Course and Complications 236
Pathogenesis 236
Disseminated Intravascular Coagulation 237
Definition 237
Incidence 237
History 237
Physical Findings 237
Differential Diagnosis 238
Laboratory and Biopsy 238
Therapy 238
Course and Complications 238
Pathogenesis 239
Thrombocytopenic Purpura 239
Definition 239
Incidence 239
History 239
Physical Findings 239
Differential Diagnosis 239
Laboratory and Biopsy 240
Therapy 240
Course and Complications 241
Pathogenesis 241
Vasculitis 241
Definition 241
Incidence 242
History 242
Physical Examination 242
Differential Diagnosis 243
Laboratory and Biopsy 243
Therapy 244
Course and Complications 244
Pathogenesis 245
Chapter 18: Dermal Induration 246
Granuloma Annulare 246
Definition 246
Incidence 246
History 246
Physical Examination 246
Differential diagnosis 246
Laboratory and Biopsy 247
Therapy 247
Course and Complications 248
Pathogenesis 248
Lichen Sclerosus 248
Definition 248
Incidence 248
History 248
Physical Examination 248
Differential Diagnosis 249
Laboratory and Biopsy 249
Therapy 249
Necrobiosis Lipoidica 250
Definition 250
Incidence 250
History 250
Physical Examination 250
Differential Diagnosis 250
Laboratory and Biopsy 250
Therapy 251
Scleroderma/Morphea 251
Definition 251
Incidence 251
History 251
Physical Examination 252
Differential Diagnosis 252
Laboratory and Biopsy 254
Therapy 254
Course and Complications 254
Pathogenesis 255
Uncommon Causes of Dermal Induration 255
En Coup De Sabre 255
Sarcoidosis 255
Section 5: Ulcers 257
Chapter 19: Ulcers 257
Definition 257
Incidence 257
History 257
Physical Examination 257
Laboratory and Biopsy 259
Therapy 260
Course and Complications 261
Pathogenesis 261
Section 6: Hair and nails 263
Chapter 20: Hair Disorders 263
Alopecia Areata 263
Definition 263
Incidence 263
History 263
Physical Examination 263
Differential Diagnosis 264
Laboratory and Biopsy 265
Therapy 265
Course and Complications 266
Pathogenesis 266
Lupus Erythematosus 266
Definition 266
Physical Examination 266
Differential Diagnosis 266
Laboratory and Biopsy 267
Therapy 267
Course and Complications 268
Pathogenesis 268
Male and Female Pattern Hair Loss (Androgenetic Alopecia) 268
Definition 268
Incidence 268
History 269
Physical Examination 269
Differential Diagnosis 269
Laboratory and Biopsy 269
Therapy 269
Course and Complications 270
Pathogenesis 270
Telogen Effluvium (Stress-Induced Alopecia) 270
Definition 270
Incidence 270
History 270
Physical Examination 270
Differential Diagnosis 270
Laboratory and Biopsy 271
Therapy 271
Course and Complications 271
Pathogenesis 271
Tinea Capitis 271
Definition 272
Incidence 272
History 272
Physical Examination 272
Differential Diagnosis 272
Laboratory and Biopsy 272
Therapy 272
Course and Complications 273
Pathogenesis 273
Trichotillomania 273
Definition 273
Incidence 273
History 273
Physical Examination 273
Differential Diagnosis 274
Laboratory and Biopsy 274
Therapy 274
Course and complications 274
Pathogenesis 274
Uncommon Hair Disorders 275
Acne Keloidalis Nuchae 275
Folliculitis Decalvans 275
Lichen Planopilaris 275
Loose Anagen Syndrome 276
Chapter 21: Nail Disorders 277
Fungal Infection 277
Definition 277
Incidence 277
History 277
Physical Examination 277
Differential Diagnosis 277
Laboratory and Biopsy 278
Therapy 278
Section 7: Mucous membrane disorders 283
Chapter 22: Mucous Membrane Disorders 283
Aphthous Stomatitis 283
Definition 283
Incidence 283
History 283
Physical Examination 283
Differential Diagnosis 284
Laboratory and Biopsy 285
Therapy 285
Course and Complications 285
Pathogenesis 286
Leukoplakia 286
Definition 286
Incidence 286
History 286
Physical Findings 286
Differential Diagnosis 286
Laboratory and Biopsy 287
Therapy 287
Course and Complications 287
Pathogenesis 288
Lichen Planus 288
Definition 288
Incidence 288
History 288
Physical Examination 288
Differential Diagnosis 288
Laboratory and Biopsy 289
Therapy 289
Course and Complications 289
Pathogenesis 289
Thrush (Oral Candidiasis) 289
Definition 290
Incidence 290
History 290
Physical Examination 290
Differential Diagnosis 290
Laboratory and Biopsy 291
Therapy 291
Course and Complications 291
Pathogenesis 291
Uncommon Causes of Oral Ulcers 291
Autoimmune Diseases 291
Cancer 292
Infections 292
Section 8: Diagnosis by symptom 295
Chapter 23: Skin Signs of Systemic Disease 295
Fever and Rash 295
Itching Patient 295
Skin Signs of AIDS 296
Skin Signs of Cancer 298
Sun Sensitivity 299
Chapter 24: Self-Assessment 301
Index 315
Inside Back Cover ES3