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Pathophysiology for the Health Professions - E- Book

Pathophysiology for the Health Professions - E- Book

Karin C. VanMeter | Robert J Hubert

(2017)

Additional Information

Book Details

Abstract

Learn the essential concepts of major diseases/disorders and disease processes. Gouldā€™s Pathophysiology for the Health Professions, 6th Edition is a concise, easy-to-understand introduction to the fundamentals of pathophysiology. Continuing in its well-known tradition of readability and vivid, full-color illustrations, the text is updated with the latest research and trends in human disease. Disorders are described by body system, with coverage of the interactions between systems, and special features help you to apply the material to real-life situations. No matter which healthcare field you may enter, this book provides solid preparation for the conditions you may encounter in clinical practice.

  • Updated graphics help you recognize and identify various concepts and specific disorders through enhanced flowcharts, photos, and illustrations.
  • Concise and readable approach includes the information you need without overwhelming you, even if you have a limited scientific background.
  • Format for individual disorder discussions includes 1) background, 2) pathophysiology, 3) etiology, 4) signs and symptoms, 5) diagnoses, 6) possible related complications/disorders, and 7) treatments/research.
  • UNIQUE! Apply Your Knowledge questions ask you to use what youā€™ve learned to predict What can go wrong with this structure or system, transitioning you from normal anatomy and physiology into pathophysiology.
  • UNIQUE! Think About questions alert you to important points and help with self-evaluation, test preparation, and review.
  • Warning Signs boxes help in identifying the pre-emptive signs of physiologic events such as strokes.
  • Emergency Treatment boxes give step-by-step instructions to follow for emergencies such as shock, cardiac arrest, and pneumothorax.
  • Research boxes discuss new developments, problem areas of pathophysiology, and complications associated with research.
  • Key terms, learning objectives, and bulleted chapter summaries help you focus on key concepts and information.
  • NEW! All chapters updated to include new data on major diseases and other changes in guidelines and the literature, reflecting latest developments in pathophysiology including, updated drug therapy content, expanded coverage of viruses, new cancer treatments, new research on the links between mental health and biochemical/physiologic factors, and much more!
  • NEW! Streamlined narrative content enhances the readability of imperative information.

Table of Contents

Section Title Page Action Price
Front Cover cover
Inside Front Cover ifc1
Half title page i
Evolve page ii
Gould's Pathophysiology for the Health Professions iii
Copyright Page iv
Dedication v
Reviewers vii
Preface viii
Organization viii
Section Iā€”Basic Concepts of Disease Processes viii
Section IIā€”Defense/Protective Mechanisms viii
Section IIIā€”Pathophysiology of Body Systems viii
Section IV: Factors Contributing to Pathophysiology viii
Section V: Environmental Factors and Pathophysiology viii
Appendicesā€”additional information: viii
Format and Features viii
Whatā€™s New? ix
Guidelines for Users ix
Resources x
Acknowledgments xii
Table Of Contents xiii
I Pathophysiology: Background and Overview 1
1 Introduction to Pathophysiology 1
Chapter Outline 1
Learning Objectives 1
Key Terms 1
What Is Pathophysiology and Why Study It? 1
Understanding Health and Disease 2
Concept and Scope of Pathophysiology 2
Beginning the Process: A Medical History 4
New Developments and Trends 4
Basic Terminology of Pathophysiology 5
The Disease Process 5
Etiology-Causes of Disease 6
Characteristics of Disease 6
Disease Prognosis 7
Introduction to Cellular Changes 8
Terms Used for Common Cellular Adaptations 8
Cell Damage and Necrosis 9
Chapter Summary 12
Study Questions 13
2 Fluid, Electrolyte, and Acid-Base Imbalances 14
Chapter Outline 14
Learning Objectives 14
Key Terms 14
Fluid Imbalance 15
Review of Concepts and Processes 15
Fluid Compartments 15
Movement of Water 15
Fluid Excess: Edema 16
Causes of Edema 18
Effects of Edema 19
Fluid Deficit: Dehydration 20
Causes of Dehydration 21
Effects of Dehydration 21
Third-Spacing: Fluid Deficit and Fluid Excess 21
Electrolyte Imbalances 21
Sodium Imbalance 21
Review of Sodium 21
Hyponatremia 22
Causes of Hyponatremia 22
Effects of Hyponatremia 23
Hypernatremia 23
Causes of Hypernatremia 23
Effects of Hypernatremia 24
Potassium Imbalance 24
Review of Potassium 24
Hypokalemia 24
Causes of Hypokalemia 24
Effects of Hypokalemia 24
Hyperkalemia 25
Causes of Hyperkalemia 25
Effects of Hyperkalemia 26
Calcium Imbalance 26
Review of Calcium 26
Hypocalcemia 27
Causes of Hypocalcemia 27
Effects of Hypocalcemia 27
Hypercalcemia 27
Causes of Hypercalcemia 27
Effects of Hypercalcemia 27
Other Electrolytes 28
Magnesium 28
Hypomagnesemia 28
Causes of Hypomagnesemia 28
Effects of Hypomagnesemia 28
Hypermagnesemia 28
Cause of Hypermagnesemia 28
Effects of Hypermagnesemia 28
Phosphate 28
Causes of Hypophosphatemia 28
Effects of Hypophosphatemia 28
Causes of Hyperphosphatemia 28
Effects of Hyperphosphatemia 28
Chloride 28
Causes of Hypochloremia 28
Effects of Hypochloremia 29
Causes of Hyperchloremia 29
Effects of Hyperchloremia 29
Acid-Base Imbalance 29
Review of Concepts and Processes 29
Control of Serum pH 30
Buffer Systems 30
Bicarbonateā€“Carbonic Acid Buffer System and Maintenance of Serum pH 30
Respiratory System 31
Renal System 31
Acid-Base Imbalance 32
Compensation 32
Decompensation 32
Acidosis 33
Causes of Acidosis 33
Effects of Acidosis 35
Alkalosis 35
Effects of Alkalosis 36
Treatment of Imbalances 36
Chapter Summary 38
Study Questions 39
3 Introduction to Basic Pharmacology and Other Common Therapies 40
Chapter Outline 40
Learning Objectives 40
Key Terms 40
Pharmacology 40
Basic Principles 40
Drug Effects 41
Administration and Distribution of Drugs 42
Drug Mechanisms and Receptors 45
Responses 46
Dose Effects 46
Time Effects 46
Variability 46
Toxicity 46
Drug Classifications and Prescriptions 46
Traditional Forms of Therapy 48
Physiotherapy 48
Occupational Therapy 48
Speech/Language Therapy 48
Nutrition/Diet 48
Registered Massage Therapy 48
Osteopathy 48
Chiropractic 49
Complementary or Alternative Therapies 49
Noncontact Therapeutic Touch 49
Naturopathy 49
Homeopathy 49
Herbal Medicine 49
Aromatherapy 49
Asian Concepts of Disease and Healing 49
Acupuncture 50
Shiatsu 50
Yoga 50
Reflexology 50
Craniosacral Therapy 51
Ayurveda 51
Chapter Summary 51
Study Questions 52
4 Pain 53
Chapter Outline 53
Learning Objectives 53
Key Terms 53
Etiology and Sources of Pain 53
Structures and Pain Pathways 54
Physiology of Pain and Pain Control 55
Characteristics of Pain 57
Signs and Symptoms 57
Young Children and Pain 57
Referred Pain 57
Phantom Pain 57
Pain Perception and Response 57
Basic Classifications of Pain 59
Acute Pain 59
Chronic Pain 59
Headache 59
Central Pain 60
Neuropathic Pain 60
Ischemic Pain 61
Cancer-Related Pain 61
Pain Control 61
Methods of Managing Pain 61
Anesthesia 62
Chapter Summary 63
Study Questions 64
II Defense/Protective Mechanisms 65
5 Inflammation and Healing 65
Chapter Outline 65
Learning Objectives 65
Key Terms 66
Review of Body Defenses 66
Review of Normal Capillary Exchange 67
Physiology of Inflammation 67
Definition 67
Causes 67
Steps of Inflammation 67
Acute Inflammation 69
Pathophysiology and General Characteristics 69
Local Effects 70
Systemic Effects 71
Diagnostic Tests 71
Potential Complications 72
Chronic Inflammation 72
Pathophysiology and General Characteristics 72
Potential Complications 73
Treatment of Inflammation 73
Drugs 73
First Aid Measures 75
Other Therapies 75
Healing 75
Types of Healing 75
Healing Process 76
Factors Affecting Healing 76
Complications Due to Scar Formation 78
Loss of Function 78
Contractures and Obstructions 78
Adhesions 78
Hypertrophic Scar Tissue 78
Ulceration 78
Example of Inflammation and Healing 78
Burns 78
Classifications of Burns 79
Effects of Burn Injury 82
Shock 82
Respiratory Problems 82
Pain 83
Infection 83
Metabolic Needs 83
Healing of Burns 84
Children and Burns 86
Chapter Summary 86
Study Questions 87
Inflammation 87
Healing 87
Burns 87
6 Infection 88
Chapter Outline 88
Learning Objectives 88
Key Terms 88
Review of Microbiology 89
Microorganisms 89
Types of Microorganisms 90
Bacteria 90
Viruses 93
Chlamydiae, Rickettsiae, and Mycoplasmas 94
Fungi 94
Protozoa 97
Other Agents of Disease 99
Helminths 99
Prions 99
Algae 99
Resident Flora (Indigenous Normal Flora, Resident Microbiota) 99
Principles of Infection 100
Transmission of Infectious Agents 100
Host Resistance 101
Virulence and Pathogenicity of Microorganisms 102
New Issues Affecting Infections and Transmission 102
Control of Transmission and Infection 103
Physiology of Infection 105
Onset and Development 105
Patterns of Infection 106
Signs and Symptoms of Infection 106
Local Signs 106
Systemic Signs 106
Methods of Diagnosis 107
Treatment and Antimicrobial Drugs 107
Guidelines for Use 107
Classification 108
Mode of Action 108
Example of Infection: Influenza (Flu) 110
Chapter Summary 112
Study Questions 113
7 Immunity 114
Chapter Outline 114
Learning Objectives 114
Key Terms 114
Review of the Immune System 115
Components of the Immune System 115
Elements of the Immune System 115
Antigens 115
Cells 115
Antibodies or Immunoglobulins 118
Complement System 118
Chemical Mediators 118
Immune Response 118
Diagnostic Tests 119
Process of Acquiring Immunity 120
Outcome of Infectious Disease 121
Emerging and Reemerging Infectious Diseases and Immunity 121
Bioterrorism 121
Tissue and Organ Transplant Rejection 121
Rejection Process 122
Treatment and Prevention 122
Hypersensitivity Reactions 122
Type I: Allergic Reactions 123
Causative Mechanism 123
Clinical Signs and Symptoms 123
Hay Fever or Allergic Rhinitis 123
Food Allergies 123
Atopic Dermatitis or Eczema 124
Asthma 124
Anaphylaxis or Anaphylactic Shock 125
ā–  Pathophysiology 125
ā–  Signs and Symptoms 125
ā–  Treatment 125
Type II: Cytotoxic Hypersensitivity 126
Type III: Immune Complex Hypersensitivity 127
Type IV: Cell-Mediated or Delayed Hypersensitivity 127
Autoimmune Disorders 128
Mechanism 128
Example: Systemic Lupus Erythematosus 128
ā–  Pathophysiology 129
ā–  Clinical Signs and Symptoms 129
ā–  Diagnostic Tests 129
ā–  Treatment 129
Immunodeficiency 131
Causes of Immunodeficiency 131
Effects of Immunodeficiency 132
ā–  Treatment 132
Acquired Immunodeficiency Syndrome 132
History 132
Agent 134
Transmission 135
ā–  Diagnostic Tests 136
ā–  Clinical Signs and Symptoms 136
Women With AIDS 137
Children With AIDS 137
People Over 50 With HIV/AIDS 137
ā–  Treatment 137
Chapter Summary 140
Study Questions 141
III Pathophysiology of Body Systems 142
8 Skin Disorders 142
Chapter Outline 142
Learning Objectives 142
Key Terms 142
Review of the Skin 143
Resident Microbial Flora 144
Skin Lesions 144
ā–  Diagnostic Tests 145
ā–  General Treatment Measures 146
Skin Inflammatory Disorders 146
Contact Dermatitis 146
ā–  Pathophysiology 146
ā–  Signs and Symptoms 146
IV Factors Contributing to Pathophysiology 545
20 Neoplasms and Cancer 545
Chapter Outline 545
Learning Objectives 545
Key Terms 545
Review of Normal Cells 546
Benign and Malignant Tumors 546
Nomenclature 547
Characteristics of Benign and Malignant Tumors 547
Malignant Tumors: Cancer 547
Pathophysiology 547
Effects of Malignant Tumors 549
Local Effects of Tumors 549
Systemic Effects of Malignant Tumors 549
Diagnostic Tests 550
Spread of Malignant Tumors 550
Staging of Cancer 552
Etiology 553
Carcinogenesis 553
Risk Factors and Prevention 555
Host Defenses 555
Treatment 555
Surgery 557
Radiation Therapy 557
Chemotherapy 558
Other Drugs 559
Gene Therapy 560
Nutrition 560
Complementary Therapies 560
Prognosis 560
Examples of Malignant Tumors 561
Skin Cancer 561
Ovarian Cancer 561
Brain Cancer 561
Cancer Incidences 563
Chapter Summary 564
Study Questions 564
21 Congenital and Genetic Disorders 565
Chapter Outline 565
Learning Objectives 565
Key Terms 565
Review of Genetic Control 565
Congenital Anomalies 567
Genetic Disorders 570
Single-Gene Disorders 570
Autosomal-Recessive Disorders 571
Autosomal-Dominant Disorders 571
X-Linked Dominant Disorders 571
X-Linked Recessive Disorders 571
Chromosomal Disorders 572
Multifactorial Disorders 572
Developmental Disorders 573
Diagnostic Tools 574
Genetic Technology 575
Genetic Engineering and Gene Therapy 575
Genetic Diagnosis and DNA Testing 575
Proteomic Research and Designer Drugs 576
Down Syndrome 576
Chapter Summary 577
Study Questions 578
22 Complications of Pregnancy 579
Chapter Outline 579
Learning Objectives 579
Key Terms 579
Embryonic and Fetal Development 579
Physiologic Changes During Pregnancy 580
Diagnosis of Pregnancy 580
Physiologic Changes and Their Implications 581
Hormonal Changes 581
Reproductive System Changes 581
Weight Gain and Nutrition 582
Digestive System Changes 582
Musculoskeletal Changes 582
Cardiovascular Changes 582
Potential Complications of Pregnancy 583
Ectopic Pregnancy 583
Preeclampsia and Eclampsia: Pregnancy-Induced Hypertension 583
Gestational Diabetes Mellitus 583
Placental Disorders 584
Blood Clotting Disorders 584
Thrombophlebitis and Thromboembolism 584
Disseminated Intravascular Coagulation 584
Rh Incompatibility 584
Infection 585
Adolescent Pregnancy 586
Chapter Summary 586
Study Questions 587
23 Complications of Adolescence 588
Chapter Outline 588
Learning Objectives 588
Key Terms 588
Review of Changes During Adolescence 588
Obesity and Metabolic Syndrome 589
Musculoskeletal Abnormalities 590
Kyphosis and Lordosis 590
Scoliosis 590
Osteomyelitis 591
Juvenile Rheumatoid Arthritis 591
Eating Disorders 593
Anorexia Nervosa 593
Bulimia Nervosa 593
Skin Disorders 593
Acne Vulgaris 593
Infection 594
Infectious Mononucleosis 594
Disorders Affecting Sexual Development 595
Chromosomal Disorders 595
Tumors 595
Menstrual Abnormalities 595
Chapter Summary 595
Study Questions 596
24 Complications of Aging 597
Chapter Outline 597
Learning Objectives 597
Key Terms 597
The Aging Process 597
Physiological Changes With Aging 598
Hormonal Changes 598
Reproductive System Changes 598
Changes in the Skin and Mucosa 599
Cardiovascular System Changes 599
Musculoskeletal System Changes 600
Osteoporosis 600
Osteoarthritis 600
Herniated Intervertebral Disc 601
Other Changes 601
Respiratory System Changes 601
Nervous System Changes 602
Digestive System Changes and Nutrition 602
Urinary System Changes 603
Other Factors 603
Multiple Disorders 603
Chapter Summary 604
Study Questions 605
V Environmental Factors and Pathophysiology 606
25 Immobility and Associated Problems 606
Chapter Outline 606
Learning Objectives 606
Key Terms 606
Factors Involving Immobility 606
Musculoskeletal System Effects 607
Cutaneous Effects 607
Cardiovascular System Effects 608
Respiratory System Effects 608
Digestive System Effects 609
Urinary System Effects 609
Neurologic/Psychological Effects 609
Effects of Immobility on Children 610
Chapter Summary 610
Study Questions 610
26 Stress and Associated Problems 611
Chapter Outline 611
Learning Objectives 611
Key Terms 611
Review of the Stress Response 611
Stress and Disease 612
Potential Effects of Prolonged or Severe Stress 614
Coping With Stress 615
Chapter Summary 616
Study Questions 616
27 Substance Abuse and Associated Problems 617
Chapter Outline 617
Learning Objectives 617
Key Terms 617
Terminology 618
Predisposing Factors 619
Environmental/Behavioral Risk Factors 619
Indications/Recognition of Abuse 620
Potential Complications of Substance Abuse 620
Overdose 620
Withdrawal 621
Effects on Pregnancy 621
Cardiovascular Problems 621
Infection 621
Neurologic/Psychological Effects 621
Alcohol 621
Cirrhosis (Laƫnnec Cirrhosis) 621
Nervous System Damage 622
Treatment for Substance Abuse 622
Chapter Summary 622
Study Questions 623
28 Environmental Hazards and Associated Problems 624
Chapter Outline 624
Learning Objectives 624
Key Terms 624
Chemicals 625
Heavy Metals 626
Acids/Bases 626
Inhalants 626
Asbestos 627
Pesticides 627
Physical Agents 627
Temperature Hazards 627
Hyperthermia 627
Hypothermia 628
Radiation Hazards 628
Ionizing Radiation 628
Light Energy 628
Noise Hazards 629
Food and Waterborne Hazards 629
Biologic Agents 629
Bites and Stings 629
Chapter Summary 630
Study Questions 630
Appendices 631
Ready Reference 1 631
Body Planes, Cavities, Regions, and Fluid Compartments 631
Body Planes (Fig. RR1.1) 631
Body Cavities (Fig. RR1.2) 631
Body Regions (Figs. RR1.3 and RR1.4) 631
Body Fluid Compartments (Fig. RR1.5) 631
Common Body Movements 633
Ready Reference 2 633
Anatomic Terms 633
Prefix or Root (Combining Form) Used in Anatomic Terms 633
Directional Terms 633
Ready Reference 3 635
Conversion Tables 635
Ready Reference 4 635
Common Abbreviations and Acronyms 635
Common Pharmaceutical Abbreviations 637
Ready Reference 5 637
Common Diagnostic Studies and Tests 637
Endoscopic Examination 637
Imaging Studies 637
Radiograph or X-Ray Film 637
Computed Tomography (Ct Scan, Formerly Computerized Axial Tomography or Cat Scan) 637
Ultrasonography (Ultrasound) 637
Magnetic Resonance Imaging (MRI) 637
Nuclear Scanning 639
Positron Emission Tomography (PET) 639
Determinations of Electrical Activity 639
Electrocardiogram (ECG, EKG) 639
Stress Test (Exercise Electrocardiography) 639
Electroencephalogram (EEG) 639
Pulmonary Function Tests 640
Blood Tests 640
Hematology Testing 640
Blood Chemistry Tests 640
Immunodiagnostic Tests 640
Chromosomal and Genetic Analysis 641
Therapeutic Drug Monitoring 641
Urine Tests 641
Cerebrospinal Fluid Tests 641
Fecal Tests or Stool Analysis 641
Microbiologic Tests 641
Ready Reference 6 641
Example of a Medical History 641
Ready Reference 7 645
Disease Index 645
Ready Reference 8 650
Drug Index 650
Ready Reference 9 652
Additional Resources 652
Textbooks 652
Anatomy and Physiology 652
Pathophysiology 652
Medicine 652
Pharmacology 652
Other Topics 652
Dictionaries and Medical Terminology 652
Journals 652
Journals Published by Professional Groups 653
Web Sites 653
Glossary 654
Index 663
A 663
B 665
C 666
D 668
E 669
F 670
G 670
H 671
I 672
J 673
K 673
L 673
M 674
N 674
O 675
P 675
Q 677
R 677
S 678
T 679
U 680
V 680
W 680
X 681
Y 681
Z 681
Handy Tables 682