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Equine Internal Medicine - E-Book

Equine Internal Medicine - E-Book

Stephen M. Reed | Warwick M. Bayly | Debra C. Sellon

(2017)

Additional Information

Book Details

Abstract

Confidently diagnose, treat, and manage patient conditions with the only comprehensive book on the market devoted solely to equine internal medicine. Filled with fully updated content on principles of treatment and contributions from internationally known equine experts, Equine Internal Medicine, 4th Edition focuses on the basic pathophysiologic mechanisms that underlie the development of various equine diseases. A problem-based approach outlines how to apply the latest clinical evidence directly to the conditions you will encounter in practice. A new companion website with over 120 video clips presents diseases and disorders that cannot be explained as well through words

  • Updated information throughout, including the most recent drug information. Current and well-referenced content on equine diseases and treatment techniques cites the latest books and journals.
  • Internationally known equine experts present information on problems affecting horses throughout the world — and provide contributions that enable practitioners and students to approach disease and treatment of equine patients with more authority and understanding.
  • User-friendly exterior and interior design makes the book appealing to both the equine internal medicine practitioner and the veterinary student. Easy-to-find information facilitates a more thorough understanding with minimal frustration.
  • Organized and consistent coverage among chapters allows you to easily find information on a specific topic.
  • NEW! Fully updated and revised sections on disorders and principles of treatment.
  • NEW! Problem-based approach outlines how to apply the latest clinical evidence directly to the conditions you will encounter in practice.
  • NEW! Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow.
  • NEW! Body systems chapters begin with a thorough discussion of the diagnostic method appropriate to the system, including physical examination, clinical pathology, radiography, endoscopy, and ultrasonography.
  • NEW and UNIQUE! Companion website includes more than 120 video clips linked to content from chapters on cardiovascular and neurologic system disorders.
  • NEW! Flow charts, diagrams, and algorithms clarify complex material.

Table of Contents

Section Title Page Action Price
Front Cover Cover
EQUINE INTERNAL MEDICINE i
EQUINE INTERNAL MEDICINE iii
Copyright iv
Contributors v
Preface ix
Contents xi
1 - Mechanisms of Disease and Principles of Treatment 1
1 - Mechanisms of Disease and Immunity 3
The Microbiome 3
Skin Microbiome 3
Oral Microbiome 3
Pharyngeal and Respiratory Microbiome 4
Intestinal Microbiome 4
Urogenital Microbiome 4
Fungal Microbiome 5
Nosocomial Infections 5
Pathogenesis of Bacterial Infections 5
Pathogenesis of Fungal Infections 7
Pathogenesis of Viral Infections 8
Pathogenesis of Parasitic Infections 14
?GASTROINTESTINAL TRACT 14
?RESPIRATORY SYSTEM 16
?SKIN 16
?PROTECTIVE RESISTANCE 17
?PARASITE-INDUCED REGULATORY RESPONSES 18
Infection and Immunity 19
?BASIC PRINCIPLES OF INFECTIOUS DISEASE 19
?EQUINE IMMUNOLOGY 19
Adaptive Immunity 23
Immunoglobulin: Antigen-Specific Receptor of B Lymphocytes 24
T-Cell Receptor and CD3 Complex: Antigen-Specific Receptor of T Cells 27
T-Lymphocyte Subsets 27
Major Histocompatibility Complex Molecules and Antigen Presentation 28
Signaling through Antigen-Specific Receptors 30
Costimulatory Signals 31
Cytokines and Cell-Mediated Immunity 32
TH1 CD4+ Effector T Cells 33
TH2 CD4+ Effector T Cells 33
T-Helper Paradigms 34
TH17 CD4+ Effector T Cells 35
Regulatory T Cells 35
Lymphocyte Trafficking Pathways 35
Mucosal Immunity 36
Ontogeny of the Equine Immune System 38
Immunocompetence in Foals 38
Innate Immune Responses in Foals 38
Adaptive Cell-Mediated Immunity in Foals 39
De Novo Antibody Production in Foals. Few studies of de novo antibody production have been conducted in foals without the effect... 40
Implications for Immunocompetence in Foals 41
?HYPERSENSITIVITY AND AUTOIMMUNITY 41
Classical Types of Hypersensitivity Reactions 42
Type I Hypersensitivity 42
Type II Hypersensitivity 43
Type III Hypersensitivity 43
Type IV Hypersensitivity 44
Systemic Anaphylaxis 44
Insect Bite Hypersensitivity 45
Recurrent Airway Obstruction 45
Neonatal Isoerythrolysis and Alloimmune Thrombocytopenia 45
Purpura Hemorrhagica 46
Equine Recurrent Uveitis 46
Autoimmunity 47
?IMMUNODEFICIENCY 47
Tests of Equine Immune Function 48
Tests of Antibody-Mediated Immunity 48
Tests of Cellular Immunity 49
Tests of Innate Immunity 52
Primary Immunodeficiencies 52
Severe Combined Immunodeficiency 52
Foal Immunodeficiency Syndrome 53
Common Variable Immunodeficiency 54
Selective IgM deficiency 54
Other Primary Immunodeficiencies 55
Secondary Immunodeficiencies 55
Failure of Transfer of Passive Immunity 55
Exercise 57
Age 57
Leukoproliferative Disease–Associated Immunodeficiency 58
Drug-Induced Immunodeficiency 58
Infectious Disease 58
Undifferentiated Immunodeficiencies 59
?IMMUNOMODULATORS 59
Immunosuppressors 59
Corticosteroids 59
Cytotoxic Drugs 60
Bacterial and Fungal Derivatives 60
?IMMUNOSTIMULANTS 60
Cytokines 60
Bacterial, Viral, and Plant Products 61
Mycobacterial Products 61
Propionibacterium acnes 61
Parapoxvirus ovis 61
Imiquimod 61
Cytosine-Phosphate-Guanosine-Oligodeoxynucleotides 62
Chemically Defined Agents 62
Levamisole 62
Antigen-Specific Immunomodulation 62
Vaccination and Adjuvants 62
Hyposensitization 62
REFERENCES 63
2 - Pharmacologic Principles 79
?PHARMACOKINETICS 79
?PLASMA DRUG CONCENTRATIONS AS THERAPEUTIC GUIDELINES 79
?VARIATION BETWEEN DRUG DOSE AND PLASMA DRUG CONCENTRATION 79
?DEFINITIONS IN PHARMACOKINETICS 79
?RATES AND ORDERS OF REACTIONS 80
?CLINICAL APPLICATION OF COMPARTMENTAL MODELING, RATES, AND ORDERS OF REACTIONS 81
?DISTRIBUTION OF DRUGS IN THE BODY 82
Conditions That Affect Volume of Distribution 83
Bioavailability 84
Drug Protein Binding 85
?DRUG ELIMINATION FROM THE BODY 85
?ELIMINATION RATE CONSTANT AND ELIMINATION HALF-LIFE 85
Flip-Flop Kinetics 86
Clearance 86
Renal Clearance of Drugs 87
Hepatic Clearance of Drugs 87
Induction and Inhibition of Metabolism 88
Kinetics of Drug Metabolism 88
?DRUG ACCUMULATION 89
?DESIGNING DRUG DOSAGE REGIMENS 89
Pharmacokinetic-Based Dosage Regimens 90
Single-Dose Regimen 90
Continuous Rate Infusion 91
Multiple-Dose Regimen 91
Loading Dose Followed by Maintenance Dose Regimen 91
?THERAPEUTIC DRUG MONITORING 91
Performing Therapeutic Drug Monitoring 91
Adjustment of Dosage Regimens 91
?DOSAGE ADJUSTMENTS IN RENAL FAILURE 92
Dose-Reduction Method 93
Interval-Extension Method 93
Antimicrobial Therapy 94
?RATIONAL USE OF ANTIMICROBIAL AGENTS 94
Documenting the Infection 95
Antimicrobial Dosage Regimen Design 95
Interpreting Minimum Inhibitory Concentrations 95
Bactericidal Versus Bacteriostatic Antimicrobials 96
Postantibiotic Effect 97
?DESIGNING THE DRUG DOSAGE REGIMEN 97
?CONCURRENT USE OF ADDITIONAL ANTIMICROBIALS 99
?PROPHYLACTIC USE OF ANTIMICROBIALS 99
?Β-LACTAMS: PENICILLINS AND CEPHALOSPORINS 99
Mechanism of Action 99
Resistance Mechanisms 99
?PENICILLIN G (BENZYLPENICILLIN ) 100
Spectrum of Activity 100
Pharmacokinetics 100
Absorption 100
Distribution 100
Elimination 100
Adverse Effects and Drug Interactions 100
Immune-Mediated Reactions 100
Procaine Reactions and Use in Performance Horses 100
Electrolyte Imbalances 101
Phenylbutazone 101
Formulations 101
Clinical Use 101
?AMINOPENICILLINS 101
Spectrum of Activity 101
Pharmacokinetics 101
Absorption 101
Distribution 101
Elimination 101
Adverse Effects and Drug Interactions 101
2 - Disorders of SpecificBody Systems 311
8 - Disorders of the Respiratory System 313
?PATIENT ASSESSMENT 314
Signalment 314
Diagnostic Considerations 314
Physical Examination 315
?EXAMINATION OF THE LOWER RESPIRATORY TRACT 316
Endoscopy 316
Radiography 317
?LOWER RESPIRATORY TRACT DIAGNOSTIC SAMPLING 318
Tracheobronchial Aspiration 318
Bronchoalveolar Lavage Sampling 318
Thoracocentesis 319
Thoracic Ultrasonographic Examination 320
Thoracic Radiography 320
Pulmonary Function Testing 322
Lung Biopsy 322
Thoracoscopy 323
?DISEASES OF THE UPPER RESPIRATORY TRACT 323
Sinusitis 323
?PROGRESSIVE ETHMOIDAL HEMATOMA 324
Definition and Epidemiology 324
Clinical Signs 324
Diagnosis 324
Treatment 324
?GUTTURAL POUCH ANATOMY 324
Guttural Pouch Tympany 325
I - ASPECTS OF CLINICAL RELEVANCE IN DONKEYS 1513
?DISORDERS 1513
Cardiovascular System 1513
Respiratory Tract 1513
Alimentary Tract 1514
Endocrine and Metabolic Disorders 1514
Nutritional Requirements 1514
Endocrine Disorders 1514
?CLINICAL PATHOLOGY 1516
Hematology 1516
Biochemistry 1516
?PHARMACOLOGY 1516
Antiinflammatory Drugs 1516
Antibiotics 1516
Antiparasitic Drugs 1516
Index 1525
A 1525
B 1528
C 1529
D 1533
E 1535
F 1538
G 1540
H 1542
I 1544
J 1546
K 1546
L 1547
M 1548
N 1550
O 1552
P 1552
Q 1557
R 1557
S 1559
T 1562
U 1563
V 1565
W 1566
X 1566
Y 1566
Z 1566