Additional Information
Book Details
Abstract
Confidently diagnose, treat, and manage patient conditions with the only comprehensive book on the market devoted solely to equine internal medicine. Filled with fully updated content on principles of treatment and contributions from internationally known equine experts, Equine Internal Medicine, 4th Edition focuses on the basic pathophysiologic mechanisms that underlie the development of various equine diseases. A problem-based approach outlines how to apply the latest clinical evidence directly to the conditions you will encounter in practice. A new companion website with over 120 video clips presents diseases and disorders that cannot be explained as well through words
- Updated information throughout , including the most recent drug information. Current and well-referenced content on equine diseases and treatment techniques cites the latest books and journals.
- Internationally known equine experts present information on problems affecting horses throughout the world — and provide contributions that enable practitioners and students to approach disease and treatment of equine patients with more authority and understanding.
- User-friendly exterior and interior design makes the book appealing to both the equine internal medicine practitioner and the veterinary student. Easy-to-find information facilitates a more thorough understanding with minimal frustration.
- Organized and consistent coverage among chapters allows you to easily find information on a specific topic.
- NEW! Fully updated and revised sections on disorders and principles of treatment.
- NEW! Problem-based approach outlines how to apply the latest clinical evidence directly to the conditions you will encounter in practice.
- NEW! Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow.
- NEW! Body systems chapters begin with a thorough discussion of the diagnostic method appropriate to the system, including physical examination, clinical pathology, radiography, endoscopy, and ultrasonography.
- NEW and UNIQUE! Companion website includes more than 120 video clips linked to content from chapters on cardiovascular and neurologic system disorders.
- NEW! Flow charts, diagrams, and algorithms clarify complex material.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| EQUINE INTERNAL MEDICINE | i | ||
| EQUINE INTERNAL MEDICINE | iii | ||
| Copyright | iv | ||
| Contributors | v | ||
| Preface | ix | ||
| Contents | xi | ||
| 1 - Mechanisms of Disease and Principles of Treatment | 1 | ||
| 1 - Mechanisms of Disease and Immunity | 3 | ||
| The Microbiome | 3 | ||
| Skin Microbiome | 3 | ||
| Oral Microbiome | 3 | ||
| Pharyngeal and Respiratory Microbiome | 4 | ||
| Intestinal Microbiome | 4 | ||
| Urogenital Microbiome | 4 | ||
| Fungal Microbiome | 5 | ||
| Nosocomial Infections | 5 | ||
| Pathogenesis of Bacterial Infections | 5 | ||
| Pathogenesis of Fungal Infections | 7 | ||
| Pathogenesis of Viral Infections | 8 | ||
| Pathogenesis of Parasitic Infections | 14 | ||
| ?GASTROINTESTINAL TRACT | 14 | ||
| ?RESPIRATORY SYSTEM | 16 | ||
| ?SKIN | 16 | ||
| ?PROTECTIVE RESISTANCE | 17 | ||
| ?PARASITE-INDUCED REGULATORY RESPONSES | 18 | ||
| Infection and Immunity | 19 | ||
| ?BASIC PRINCIPLES OF INFECTIOUS DISEASE | 19 | ||
| ?EQUINE IMMUNOLOGY | 19 | ||
| Adaptive Immunity | 23 | ||
| Immunoglobulin: Antigen-Specific Receptor of B Lymphocytes | 24 | ||
| T-Cell Receptor and CD3 Complex: Antigen-Specific Receptor of T Cells | 27 | ||
| T-Lymphocyte Subsets | 27 | ||
| Major Histocompatibility Complex Molecules and Antigen Presentation | 28 | ||
| Signaling through Antigen-Specific Receptors | 30 | ||
| Costimulatory Signals | 31 | ||
| Cytokines and Cell-Mediated Immunity | 32 | ||
| TH1 CD4+ Effector T Cells | 33 | ||
| TH2 CD4+ Effector T Cells | 33 | ||
| T-Helper Paradigms | 34 | ||
| TH17 CD4+ Effector T Cells | 35 | ||
| Regulatory T Cells | 35 | ||
| Lymphocyte Trafficking Pathways | 35 | ||
| Mucosal Immunity | 36 | ||
| Ontogeny of the Equine Immune System | 38 | ||
| Immunocompetence in Foals | 38 | ||
| Innate Immune Responses in Foals | 38 | ||
| Adaptive Cell-Mediated Immunity in Foals | 39 | ||
| De Novo Antibody Production in Foals. Few studies of de novo antibody production have been conducted in foals without the effect... | 40 | ||
| Implications for Immunocompetence in Foals | 41 | ||
| ?HYPERSENSITIVITY AND AUTOIMMUNITY | 41 | ||
| Classical Types of Hypersensitivity Reactions | 42 | ||
| Type I Hypersensitivity | 42 | ||
| Type II Hypersensitivity | 43 | ||
| Type III Hypersensitivity | 43 | ||
| Type IV Hypersensitivity | 44 | ||
| Systemic Anaphylaxis | 44 | ||
| Insect Bite Hypersensitivity | 45 | ||
| Recurrent Airway Obstruction | 45 | ||
| Neonatal Isoerythrolysis and Alloimmune Thrombocytopenia | 45 | ||
| Purpura Hemorrhagica | 46 | ||
| Equine Recurrent Uveitis | 46 | ||
| Autoimmunity | 47 | ||
| ?IMMUNODEFICIENCY | 47 | ||
| Tests of Equine Immune Function | 48 | ||
| Tests of Antibody-Mediated Immunity | 48 | ||
| Tests of Cellular Immunity | 49 | ||
| Tests of Innate Immunity | 52 | ||
| Primary Immunodeficiencies | 52 | ||
| Severe Combined Immunodeficiency | 52 | ||
| Foal Immunodeficiency Syndrome | 53 | ||
| Common Variable Immunodeficiency | 54 | ||
| Selective IgM deficiency | 54 | ||
| Other Primary Immunodeficiencies | 55 | ||
| Secondary Immunodeficiencies | 55 | ||
| Failure of Transfer of Passive Immunity | 55 | ||
| Exercise | 57 | ||
| Age | 57 | ||
| Leukoproliferative Disease–Associated Immunodeficiency | 58 | ||
| Drug-Induced Immunodeficiency | 58 | ||
| Infectious Disease | 58 | ||
| Undifferentiated Immunodeficiencies | 59 | ||
| ?IMMUNOMODULATORS | 59 | ||
| Immunosuppressors | 59 | ||
| Corticosteroids | 59 | ||
| Cytotoxic Drugs | 60 | ||
| Bacterial and Fungal Derivatives | 60 | ||
| ?IMMUNOSTIMULANTS | 60 | ||
| Cytokines | 60 | ||
| Bacterial, Viral, and Plant Products | 61 | ||
| Mycobacterial Products | 61 | ||
| Propionibacterium acnes | 61 | ||
| Parapoxvirus ovis | 61 | ||
| Imiquimod | 61 | ||
| Cytosine-Phosphate-Guanosine-Oligodeoxynucleotides | 62 | ||
| Chemically Defined Agents | 62 | ||
| Levamisole | 62 | ||
| Antigen-Specific Immunomodulation | 62 | ||
| Vaccination and Adjuvants | 62 | ||
| Hyposensitization | 62 | ||
| REFERENCES | 63 | ||
| 2 - Pharmacologic Principles | 79 | ||
| ?PHARMACOKINETICS | 79 | ||
| ?PLASMA DRUG CONCENTRATIONS AS THERAPEUTIC GUIDELINES | 79 | ||
| ?VARIATION BETWEEN DRUG DOSE AND PLASMA DRUG CONCENTRATION | 79 | ||
| ?DEFINITIONS IN PHARMACOKINETICS | 79 | ||
| ?RATES AND ORDERS OF REACTIONS | 80 | ||
| ?CLINICAL APPLICATION OF COMPARTMENTAL MODELING, RATES, AND ORDERS OF REACTIONS | 81 | ||
| ?DISTRIBUTION OF DRUGS IN THE BODY | 82 | ||
| Conditions That Affect Volume of Distribution | 83 | ||
| Bioavailability | 84 | ||
| Drug Protein Binding | 85 | ||
| ?DRUG ELIMINATION FROM THE BODY | 85 | ||
| ?ELIMINATION RATE CONSTANT AND ELIMINATION HALF-LIFE | 85 | ||
| Flip-Flop Kinetics | 86 | ||
| Clearance | 86 | ||
| Renal Clearance of Drugs | 87 | ||
| Hepatic Clearance of Drugs | 87 | ||
| Induction and Inhibition of Metabolism | 88 | ||
| Kinetics of Drug Metabolism | 88 | ||
| ?DRUG ACCUMULATION | 89 | ||
| ?DESIGNING DRUG DOSAGE REGIMENS | 89 | ||
| Pharmacokinetic-Based Dosage Regimens | 90 | ||
| Single-Dose Regimen | 90 | ||
| Continuous Rate Infusion | 91 | ||
| Multiple-Dose Regimen | 91 | ||
| Loading Dose Followed by Maintenance Dose Regimen | 91 | ||
| ?THERAPEUTIC DRUG MONITORING | 91 | ||
| Performing Therapeutic Drug Monitoring | 91 | ||
| Adjustment of Dosage Regimens | 91 | ||
| ?DOSAGE ADJUSTMENTS IN RENAL FAILURE | 92 | ||
| Dose-Reduction Method | 93 | ||
| Interval-Extension Method | 93 | ||
| Antimicrobial Therapy | 94 | ||
| ?RATIONAL USE OF ANTIMICROBIAL AGENTS | 94 | ||
| Documenting the Infection | 95 | ||
| Antimicrobial Dosage Regimen Design | 95 | ||
| Interpreting Minimum Inhibitory Concentrations | 95 | ||
| Bactericidal Versus Bacteriostatic Antimicrobials | 96 | ||
| Postantibiotic Effect | 97 | ||
| ?DESIGNING THE DRUG DOSAGE REGIMEN | 97 | ||
| ?CONCURRENT USE OF ADDITIONAL ANTIMICROBIALS | 99 | ||
| ?PROPHYLACTIC USE OF ANTIMICROBIALS | 99 | ||
| ?Β-LACTAMS: PENICILLINS AND CEPHALOSPORINS | 99 | ||
| Mechanism of Action | 99 | ||
| Resistance Mechanisms | 99 | ||
| ?PENICILLIN G (BENZYLPENICILLIN ) | 100 | ||
| Spectrum of Activity | 100 | ||
| Pharmacokinetics | 100 | ||
| Absorption | 100 | ||
| Distribution | 100 | ||
| Elimination | 100 | ||
| Adverse Effects and Drug Interactions | 100 | ||
| Immune-Mediated Reactions | 100 | ||
| Procaine Reactions and Use in Performance Horses | 100 | ||
| Electrolyte Imbalances | 101 | ||
| Phenylbutazone | 101 | ||
| Formulations | 101 | ||
| Clinical Use | 101 | ||
| ?AMINOPENICILLINS | 101 | ||
| Spectrum of Activity | 101 | ||
| Pharmacokinetics | 101 | ||
| Absorption | 101 | ||
| Distribution | 101 | ||
| Elimination | 101 | ||
| Adverse Effects and Drug Interactions | 101 | ||
| 2 - Disorders of SpecificBody Systems | 311 | ||
| 8 - Disorders of the Respiratory System | 313 | ||
| ?PATIENT ASSESSMENT | 314 | ||
| Signalment | 314 | ||
| Diagnostic Considerations | 314 | ||
| Physical Examination | 315 | ||
| ?EXAMINATION OF THE LOWER RESPIRATORY TRACT | 316 | ||
| Endoscopy | 316 | ||
| Radiography | 317 | ||
| ?LOWER RESPIRATORY TRACT DIAGNOSTIC SAMPLING | 318 | ||
| Tracheobronchial Aspiration | 318 | ||
| Bronchoalveolar Lavage Sampling | 318 | ||
| Thoracocentesis | 319 | ||
| Thoracic Ultrasonographic Examination | 320 | ||
| Thoracic Radiography | 320 | ||
| Pulmonary Function Testing | 322 | ||
| Lung Biopsy | 322 | ||
| Thoracoscopy | 323 | ||
| ?DISEASES OF THE UPPER RESPIRATORY TRACT | 323 | ||
| Sinusitis | 323 | ||
| ?PROGRESSIVE ETHMOIDAL HEMATOMA | 324 | ||
| Definition and Epidemiology | 324 | ||
| Clinical Signs | 324 | ||
| Diagnosis | 324 | ||
| Treatment | 324 | ||
| ?GUTTURAL POUCH ANATOMY | 324 | ||
| Guttural Pouch Tympany | 325 | ||
| I - ASPECTS OF CLINICAL RELEVANCE IN DONKEYS | 1513 | ||
| ?DISORDERS | 1513 | ||
| Cardiovascular System | 1513 | ||
| Respiratory Tract | 1513 | ||
| Alimentary Tract | 1514 | ||
| Endocrine and Metabolic Disorders | 1514 | ||
| Nutritional Requirements | 1514 | ||
| Endocrine Disorders | 1514 | ||
| ?CLINICAL PATHOLOGY | 1516 | ||
| Hematology | 1516 | ||
| Biochemistry | 1516 | ||
| ?PHARMACOLOGY | 1516 | ||
| Antiinflammatory Drugs | 1516 | ||
| Antibiotics | 1516 | ||
| Antiparasitic Drugs | 1516 | ||
| Index | 1525 | ||
| A | 1525 | ||
| B | 1528 | ||
| C | 1529 | ||
| D | 1533 | ||
| E | 1535 | ||
| F | 1538 | ||
| G | 1540 | ||
| H | 1542 | ||
| I | 1544 | ||
| J | 1546 | ||
| K | 1546 | ||
| L | 1547 | ||
| M | 1548 | ||
| N | 1550 | ||
| O | 1552 | ||
| P | 1552 | ||
| Q | 1557 | ||
| R | 1557 | ||
| S | 1559 | ||
| T | 1562 | ||
| U | 1563 | ||
| V | 1565 | ||
| W | 1566 | ||
| X | 1566 | ||
| Y | 1566 | ||
| Z | 1566 |