Menu Expand
Bariatric and Metabolic Endoscopy, An Issue of Gastrointestinal Endoscopy Clinics, E-Book

Bariatric and Metabolic Endoscopy, An Issue of Gastrointestinal Endoscopy Clinics, E-Book

Richard I. Rothstein

(2017)

Additional Information

Abstract

Dr. Rothstein has assembled top experts to present the current status of the role of endoscopy in managing the obese patient. Authors present current clinical information on the following topics: Small Bowel Target Devices and Techniques; Reimbursement Issues for Endoscopic Devices Used for Metabolic Endoscopy; the Physiologic Alteractions of Bariatric Surgery; Non-Balloon Gastric and Pyloric Therapies for Obesity; Aspiration Therapy for Obesity; Endoscopic Therapies after Surgery; Duodenal Mucosal Resurfacing: Role for Diabetes Treatment; Gastric Plication; and Gastric Balloons. Readers should come away with the information they need to utilize endoscopic techniques to improve outcomes in their patients.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Bariatric and MetabolicEndoscopy i
Copyright\r ii
Contributors iii
CONSULTING EDITOR iii
EDITOR iii
AUTHORS iii
Contents vii
Foreword: Bariatric and Metabolic Endoscopy: New Approaches to Obesity and Diabetes vii
Preface: Bariatric and Metabolic Endoscopy vii
Current and Future Medical Treatment of Obesity vii
Surgical Treatment of Obesity and Diabetes vii
What Bariatric Surgery Can Teach Us About Endoluminal Treatment of Obesity and Metabolic Disorders vii
Endoscopic Treatments Following Bariatric Surgery viii
Intragastric Balloons in Clinical Practice viii
Gastric Plication viii
Selected Endoscopic Gastric Devices for Obesity viii
Aspiration Therapy for Obesity ix
Small Bowel Target Devices and Techniques ix
Hydrothermal Duodenal Mucosal Resurfacing: Role in the Treatment of Metabolic Disease ix
Therapeutic Options to Treat Pediatric Obesity ix
The Regulatory Perspectives on Endoscopic Devices for Obesity x
Reimbursement for Endoscopic Bariatric Therapies x
GASTROINTESTINAL ENDOSCOPY CLINICS\rOF NORTH AMERICA\r xi
FORTHCOMING ISSUES xi
July 2017 xi
October 2017 xi
January 2018 xi
RECENT ISSUES xi
January 2017 xi
October 2016 xi
July 2016 xi
Foreword: Bariatric and Metabolic Endoscopy: New Approaches to Obesity and Diabetes\r xiii
Preface:\rBariatric and Metabolic Endoscopy xv
Current and Future Medical Treatment of Obesity 181
Key points 181
INTRODUCTION 181
PHENTERMINE 182
ORLISTAT (XENICAL) 183
LORCASERIN (BELVIQ) 183
PHENTERMINE/TOPIRAMATE ER (QSYMIA) 184
LIRAGLUTIDE 3.0 (SAXENDA) 184
NALTREXONE ER/BUPROPION ER (CONTRAVE) 185
Antidiabetic Medications That Promote Weight Loss 186
Sodium glucose transporter 2 inhibitors 186
Glucagon-like Polypeptide-1 agonists 187
Pramlintide (Symlin) 187
Future Option for Obesity Pharmacotherapy 188
Gelesis 100 188
SUMMARY 188
REFERENCES 188
Surgical Treatment of Obesity and Diabetes 191
Key points 191
INTRODUCTION 191
PATIENT SELECTION FOR METABOLIC SURGERY 192
TECHNIQUE OF THE PROCEDURES 194
Approach 194
Liver retraction 194
Operative Procedures 195
Sleeve gastrectomy 195
Adjustable gastric band 196
Roux-en-Y gastric bypass 197
Other Gastrojejunal Anastomosis Options 197
Gastric Pouch Ring Placement 199
Biliopancreatic diversion/duodenal switch 200
Complications and Management 201
POSTOPERATIVE CARE 204
OUTCOMES 205
Weight Loss 205
Type 2 Diabetes Remission and Improvement 205
Cardiovascular Risk Reduction 207
Current Controversies and Future Considerations 207
Cirrhosis improvement after metabolic surgery 207
Metabolic surgery in patients with diabetes and mild obesity (body mass index 30–34) 208
SUMMARY 208
REFERENCES 209
What Bariatric Surgery Can Teach Us About Endoluminal Treatment of Obesity and Metabolic Disorders 213
Key points 213
INTRODUCTION 213
REGULATION OF ENERGY BALANCE 215
WHAT CAUSES OBESITY? 216
BARIATRIC SURGICAL PROCEDURES 217
Roux-en-Y Gastric Bypass 217
Biliopancreatic Diversion 218
Vertical Sleeve Gastrectomy 219
Adjustable Gastric Banding 219
MECHANISMS OF WEIGHT LOSS AFTER BARIATRIC SURGERY 219
ANATOMIC DETERMINANTS OF RESPONSE 220
EFFECT OF SURGERY ON METABOLIC DISEASES 221
PHYSIOLOGIC MECHANISMS OF SURGICAL ACTION 223
Appetitive Drives and Appetite-Regulating Hormones 223
Energy Expenditure 224
Regulation of Circadian Rhythms 224
Bile Acids 225
Microbiota 225
Integrated Responses to Bariatric Surgery 226
IMPLICATIONS FOR ENDOSCOPIC TREATMENT OF OBESITY AND RELATED METABOLIC DISORDERS 226
REFERENCES 228
Endoscopic Treatments Following Bariatric Surgery 233
Key points 233
INTRODUCTION 233
PATIENT EVALUATION FOR WEIGHT REGAIN AFTER BARIATRIC SURGERY 234
ENDOSCOPIC BARIATRIC REVISION PROCEDURES 235
Argon Plasma Coagulation 235
The Transoral Outlet Reduction and Purse String 236
Weight Regain after Sleeve Gastrectomy 239
ENDOSCOPIC MANAGEMENT OF OTHER COMPLICATIONS OF BARIATRIC SURGERY 239
Gastro-Gastric Fistula 240
Marginal Ulceration and Bleeding 241
SUMMARY/DISCUSSION 242
REFERENCES 243
Intragastric Balloons in Clinical Practice 245
Key points 245
INTRAGASTRIC BALLOONS 246
MECHANISM OF ACTION 246
TYPES OF INTRAGASTRIC BALLOONS APPROVED FOR USE IN THE UNITED STATES 247
WEIGHT LOSS AND METABOLIC OUTCOMES IN INTRAGASTRIC BALLOON TRIALS 247
ADVERSE EVENTS 248
INTRAGASTRIC BALLOONS IN CLINICAL PRACTICE 250
THE FUTURE OF INTRAGASTRIC BALLOONS 254
REFERENCES 255
Gastric Plication 257
Key points 257
INTRODUCTION 257
ENDOLUMINAL VERTICAL GASTROPLASTY 258
ENDOSCOPIC SLEEVE GASTROPLASTY 258
Superficial Thickness Suturing 258
Full-Thickness Suturing 258
Procedure Development 259
Procedure Technique 260
Clinical Results 260
Mechanism 261
OTHER GASTRIC RESTRICTIVE PROCEDURES 261
Primary Obesity Surgery Endolumenal 261
Transoral Gastroplasty 262
Articulating Endoscopic Circular Stapler 262
SUMMARY 263
REFERENCES 264
Selected Endoscopic Gastric Devices for Obesity 267
Key points 267
SELECTED STOMACH TARGET DEVICES 268
Introduction 268
Devices/Techniques Affecting Gastric Emptying 268
Gastric botulinum toxin A injection 268
Transpyloric shuttle 269
Devices/Techniques Affecting Gastric Wall or Postbypass Stomal Compliance 270
Endoscopic sclerotherapy 270
Endoscopic radiofrequency ablation 271
Gastric Volume Restriction Devices 271
Transoral endoscopic restrictive implant system device 271
Articulating circular endoscopic stapler 272
FullSense device 272
Gelesis100 hydrogel capsule 273
Magnetically weight loss capsule 273
SUMMARY 274
REFERENCES 274
Aspiration Therapy for Obesity 277
Key points 277
INTRODUCTION 277
ASPIRATION AND THE COMPONENTS OF THE ASPIREASSIST SYSTEM 278
Permanent Components 278
Components Only Attached During Aspiration 278
PATIENT EVALUATION OVERVIEW 279
OUTCOMES 280
Weight Loss 280
Cardiometabolic Risk Factors 282
Eating Behaviors 282
Psychological Evaluations 283
COMPLICATIONS 283
ELECTROLYTES 285
MECHANISMS OF ACTION FOR WEIGHT LOSS 285
SUMMARY 286
REFERENCES 286
Small Bowel Target Devices and Techniques 289
Key points 289
INTRODUCTION 289
ENDOLUMINAL SLEEVES 290
Duodenal Jejunal Bypass Liner 290
Gastroduodenojejunal Bypass Sleeve 293
DUAL-PATH ENTERAL BYPASS 293
DUODENAL MUCOSAL RESURFACING 295
SUMMARY 295
REFERENCES 295
Hydrothermal Duodenal Mucosal Resurfacing 299
Key points 299
INTRODUCTION 300
INSULIN-RESISTANT STATES: BACKGROUND AND CURRENT MANAGEMENT 300
Background 300
Lifestyle/Behavior Modification 300
Pharmacologic Treatment 301
Bariatric Surgery 301
METABOLIC ROLE OF THE DUODENUM 302
Evidence from Animal Models 302
Evidence from Humans 303
DUODENAL MUCOSAL RESURFACING: METHOD FOR CORRECTING DUODENAL METABOLIC SIGNALING 303
Rationale for Targeting Duodenal Mucosa 303
Targeting Duodenal Mucosa in Animal Models: Proof of Concept 303
Duodenal Mucosal Resurfacing Catheter (Revita) and Procedure 305
First-in-Human Study of Revita Duodenal Mucosal Resurfacing in Type 2 Diabetes 305
Safety Profile of Duodenal Mucosal Resurfacing in Early Human Use 305
Glycemic Improvement in Subjects with Type 2 Diabetes in the First-in-Human Study 306
Wider Metabolic Effects of Duodenal Mucosal Resurfacing Observed in Human Subjects 307
SUMMARY 307
REFERENCES 308
Therapeutic Options to Treat Pediatric Obesity 313
Key points 313
INTRODUCTION 313
GOALS OF THERAPY 314
DIET, ACTIVITY, AND BEHAVIOR: HEALTHY LIVING 315
BARIATRIC SURGICAL PROCEDURES 317
WEIGHT LOSS MEDICATIONS 319
WEIGHT LOSS DEVICES 320
ENDOSCOPIC WEIGHT LOSS PROCEDURES 322
OTHER TECHNIQUES 323
SUMMARY 323
REFERENCES 324
The Regulatory Perspectives on Endoscopic Devices for Obesity 327
Key points 327
INTRODUCTION 327
DISCUSSION 329
Regulatory Pathways for Obesity Devices 329
Premarket notification (510[k]) 329
The de novo classification process 329
The premarket approval process 329
Clinical Studies to Support Safety and Effectiveness of Obesity Treatment Devices 330
Nonclinical testing 330
Pediatric patients 330
Benefit-risk paradigm 331
Benefit-Risk of US Food and Drug Administration–Approved Endoscopic Weight-Loss Devices 332
ReShape intragastric balloon 333
ORBERA intragastric balloon 333
Obalon intragastric balloon (balloon system) 334
AspireAssist gastric emptying device 335
Patient-reported outcomes 335
Patient Preference for Endoscopic Weight-Loss Devices 336
Summary 338
ACKNOWLEDGMENTS 338
REFERENCES 338
Reimbursement for Endoscopic Bariatric Therapies 343
Key points 343
CODING ENDOSCOPIC PLACEMENT AND REMOVAL OF GASTRIC DEVICES FOR THE MANAGEMENT OF OBESITY 344
COMPLICATIONS RELATED TO GASTRIC DEVICES FOR THE MANAGEMENT OF OBESITY 345
DATA COLLECTION 348
INTERNATIONAL STATISTICAL CLASSIFICATION OF DISEASES AND RELATED HEALTH PROBLEMS, 10TH REVISION, CODES FOR OBESITY 349
SUMMARY 350
REFERENCES 350