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Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas E-Book

Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas E-Book

L. Jeffrey Medeiros | Roberto N. Miranda

(2017)

Additional Information

Book Details

Abstract

Part of the highly regarded Diagnostic Pathology series, this updated volume is a visually stunning, easy-to-use reference covering all aspects of benign and malignant lesions of lymph node, spleen, and extranodal lymphomas. Outstanding images make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice.

  • Unsurpassed visual coverage with carefully annotated gross and microscopic pathology, stains, ancillary tests, and detailed medical illustrations that provide clinically and diagnostically important information on typical and variant disease features
  • Designed to help the reader identify crucial elements of each diagnosis, along with associated differential diagnoses and pitfalls, to more quickly resolve problems during routine signout of cases
  • Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index
  • Thoroughly updated content throughout, reflecting the 2016 revision of the WHO classification of lymphoid neoplasms, the latest nomenclature of diseases, and a current review of the literature of each disease
  • New coverage of classification of B-cell lymphomas, subtypes of diffuse large B-cell lymphoma, and gray zone lymphoma; classification of T-cell lymphomas, recent genomic discoveries, and their effect in classification; and an updated review of provisional entities such as breast implant-associated anaplastic large cell lymphoma, cutaneous lymphomas, and lymphomas derived of cytotoxic lymphocytes

Table of Contents

Section Title Page Action Price
Front Cover Cover
Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas iii
Copyright Page iv
Dedications v
Additional Contributors vii
Preface ix
Acknowledgments xi
Sections xiii
Table of Contents xiv
SECTION 1:\rReactive Nonspecific Changes 3
Chapter 1.\rReactive Follicular Hyperplasia 4
TERMINOLOGY 5
ETIOLOGY/PATHOGENESIS 5
CLINICAL ISSUES 5
MICROSCOPIC 5
ANCILLARY TESTS 6
DIFFERENTIAL DIAGNOSIS 6
SELECTED REFERENCES 6
Chapter\r2. Reactive Paracortical Hyperplasia 10
TERMINOLOGY 11
ETIOLOGY/PATHOGENESIS 11
CLINICAL ISSUES 11
IMAGING 11
MACROSCOPIC 11
MICROSCOPIC 11
ANCILLARY TESTS 11
DIFFERENTIAL DIAGNOSIS 12
DIAGNOSTIC CHECKLIST 12
SELECTED REFERENCES 12
SECTION 2:\rInfectious Causes of Lymphadenitis 19
Chapter\r3. Chronic Granulomatous Lymphadenitis 20
TERMINOLOGY 21
ETIOLOGY/PATHOGENESIS 21
CLINICAL ISSUES 21
IMAGING 21
MACROSCOPIC 21
MICROSCOPIC 22
ANCILLARY TESTS 22
DIFFERENTIAL DIAGNOSIS 22
DIAGNOSTIC CHECKLIST 23
SELECTED REFERENCES 23
Chapter\r4. Suppurative Lymphadenitis 28
TERMINOLOGY 29
ETIOLOGY/PATHOGENESIS 29
CLINICAL ISSUES 29
MICROSCOPIC 29
ANCILLARY TESTS 29
DIFFERENTIAL DIAGNOSIS 29
SELECTED REFERENCES 29
Chapter\r5. Mycobacterium tuberculosis Lymphadenitis 32
TERMINOLOGY 33
ETIOLOGY/PATHOGENESIS 33
CLINICAL ISSUES 33
IMAGING 34
MACROSCOPIC 35
MICROSCOPIC 35
DIFFERENTIAL DIAGNOSIS 35
SELECTED REFERENCES 35
Chapter\r6. Atypical Mycobacterial Lymphadenitis 40
TERMINOLOGY 41
ETIOLOGY/PATHOGENESIS 41
CLINICAL ISSUES 41
MACROSCOPIC 43
MICROSCOPIC 43
DIFFERENTIAL DIAGNOSIS 43
DIAGNOSTIC CHECKLIST 44
SELECTED REFERENCES 44
Chapter\r7. Mycobacterial Spindle Cell Pseudotumor 48
TERMINOLOGY 49
ETIOLOGY/PATHOGENESIS 49
CLINICAL ISSUES 49
MICROSCOPIC 49
ANCILLARY TESTS 49
DIFFERENTIAL DIAGNOSIS 49
SELECTED REFERENCES 49
Chapter\r8. Cat-Scratch Disease 52
TERMINOLOGY 53
ETIOLOGY/PATHOGENESIS 53
CLINICAL ISSUES 53
MACROSCOPIC 53
MICROSCOPIC 53
ANCILLARY TESTS 54
DIFFERENTIAL DIAGNOSIS 54
DIAGNOSTIC CHECKLIST 54
SELECTED REFERENCES 54
Chapter\r9. Bacillary Angiomatosis 58
TERMINOLOGY 59
ETIOLOGY/PATHOGENESIS 59
CLINICAL ISSUES 59
MICROSCOPIC 59
ANCILLARY TESTS 60
DIFFERENTIAL DIAGNOSIS 60
DIAGNOSTIC CHECKLIST 60
SELECTED REFERENCES 61
Chapter\r10. Lymphogranuloma Venereum Lymphadenitis 64
TERMINOLOGY 65
ETIOLOGY/PATHOGENESIS 65
CLINICAL ISSUES 65
MICROSCOPIC 65
ANCILLARY TESTS 66
DIFFERENTIAL DIAGNOSIS 66
DIAGNOSTIC CHECKLIST 66
SELECTED REFERENCES 66
Chapter\r11. Whipple Disease 68
TERMINOLOGY 69
ETIOLOGY/PATHOGENESIS 69
CLINICAL ISSUES 69
IMAGING 69
MICROSCOPIC 70
ANCILLARY TESTS 70
DIFFERENTIAL DIAGNOSIS 70
DIAGNOSTIC CHECKLIST 70
SELECTED REFERENCES 70
Chapter\r12. Syphilitic Lymphadenitis 72
TERMINOLOGY 73
ETIOLOGY/PATHOGENESIS 73
CLINICAL ISSUES 73
MICROSCOPIC 73
ANCILLARY TESTS 74
DIFFERENTIAL DIAGNOSIS 74
SELECTED REFERENCES 74
Chapter\r13. Infectious Mononucleosis 78
TERMINOLOGY 79
ETIOLOGY/PATHOGENESIS 79
CLINICAL ISSUES 79
MICROSCOPIC 79
ANCILLARY TESTS 80
DIFFERENTIAL DIAGNOSIS 80
DIAGNOSTIC CHECKLIST 80
SELECTED REFERENCES 80
Chapter\r14. Histoplasma Lymphadenitis 84
TERMINOLOGY 85
ETIOLOGY/PATHOGENESIS 85
CLINICAL ISSUES 85
IMAGING 86
MICROSCOPIC 86
ANCILLARY TESTS 86
DIFFERENTIAL DIAGNOSIS 86
DIAGNOSTIC CHECKLIST 86
SELECTED REFERENCES 86
Chapter\r15. Cryptococcus Lymphadenitis 90
TERMINOLOGY 91
ETIOLOGY/PATHOGENESIS 91
CLINICAL ISSUES 91
IMAGING 91
MICROSCOPIC 91
DIFFERENTIAL DIAGNOSIS 91
SELECTED REFERENCES 91
Chapter\r16. Toxoplasma Lymphadenitis 94
TERMINOLOGY 95
ETIOLOGY/PATHOGENESIS 95
CLINICAL ISSUES 95
MICROSCOPIC 95
ANCILLARY TESTS 96
DIFFERENTIAL DIAGNOSIS 96
DIAGNOSTIC CHECKLIST 96
SELECTED REFERENCES 96
Chapter\r17. Coccidioides Lymphadenitis 100
TERMINOLOGY 101
ETIOLOGY/PATHOGENESIS 101
CLINICAL ISSUES 101
IMAGING 103
MICROSCOPIC 103
DIFFERENTIAL DIAGNOSIS 103
DIAGNOSTIC CHECKLIST 103
SELECTED REFERENCES 103
Chapter\r18. Herpes Simplex Lymphadenitis 108
TERMINOLOGY 109
ETIOLOGY/PATHOGENESIS 109
CLINICAL ISSUES 109
MICROSCOPIC 109
ANCILLARY TESTS 110
DIFFERENTIAL DIAGNOSIS 110
DIAGNOSTIC CHECKLIST 110
SELECTED REFERENCES 110
Chapter\r19. Cytomegalovirus Lymphadenitis 114
TERMINOLOGY 115
ETIOLOGY/PATHOGENESIS 115
CLINICAL ISSUES 115
IMAGING 116
MICROSCOPIC 116
ANCILLARY TESTS 117
DIFFERENTIAL DIAGNOSIS 117
DIAGNOSTIC CHECKLIST 118
SELECTED REFERENCES 118
Chapter\r20. Human Immunodeficiency Virus Lymphadenitis 122
TERMINOLOGY 123
ETIOLOGY/PATHOGENESIS 123
CLINICAL ISSUES 123
MACROSCOPIC 124
MICROSCOPIC 124
ANCILLARY TESTS 125
DIFFERENTIAL DIAGNOSIS 125
DIAGNOSTIC CHECKLIST 125
SELECTED REFERENCES 125
SECTION 3:\rReactive Lymphadenopathies 133
Chapter\r21. Inflammatory Pseudotumor of Lymph Node 134
TERMINOLOGY 135
ETIOLOGY/PATHOGENESIS 135
CLINICAL ISSUES 135
MACROSCOPIC 135
MICROSCOPIC 135
ANCILLARY TESTS 135
DIFFERENTIAL DIAGNOSIS 135
SELECTED REFERENCES 136
Chapter\r22. Progressive Transformation of Germinal Centers 142
TERMINOLOGY 143
ETIOLOGY/PATHOGENESIS 143
CLINICAL ISSUES 143
IMAGING 143
MICROSCOPIC 143
ANCILLARY TESTS 143
DIFFERENTIAL DIAGNOSIS 144
DIAGNOSTIC CHECKLIST 144
SELECTED REFERENCES 144
Chapter\r23. Kikuchi-Fujimoto Disease 148
TERMINOLOGY 149
ETIOLOGY/PATHOGENESIS 149
CLINICAL ISSUES 149
IMAGING 149
MACROSCOPIC 149
MICROSCOPIC 149
ANCILLARY TESTS 150
DIFFERENTIAL DIAGNOSIS 150
DIAGNOSTIC CHECKLIST 151
SELECTED REFERENCES 151
Chapter\r24. Rosai-Dorfman Disease 158
TERMINOLOGY 159
ETIOLOGY/PATHOGENESIS 159
CLINICAL ISSUES 159
IMAGING 160
MACROSCOPIC 160
MICROSCOPIC 160
ANCILLARY TESTS 160
DIFFERENTIAL DIAGNOSIS 161
DIAGNOSTIC CHECKLIST 161
SELECTED REFERENCES 161
Chapter\r25. Kimura Disease 166
TERMINOLOGY 167
ETIOLOGY/PATHOGENESIS 167
CLINICAL ISSUES 167
IMAGING 167
MICROSCOPIC 167
ANCILLARY TESTS 168
DIFFERENTIAL DIAGNOSIS 168
DIAGNOSTIC CHECKLIST 169
SELECTED REFERENCES 169
Chapter\r26. Unicentric Hyaline Vascular Variant Castleman Disease 174
TERMINOLOGY 175
ETIOLOGY/PATHOGENESIS 175
CLINICAL ISSUES 175
IMAGING 175
MICROSCOPIC 175
ANCILLARY TESTS 175
DIFFERENTIAL DIAGNOSIS 176
DIAGNOSTIC CHECKLIST 176
SELECTED REFERENCES 176
Chapter\r27. Unicentric Plasma Cell Variant Castleman Disease 180
TERMINOLOGY 181
ETIOLOGY/PATHOGENESIS 181
CLINICAL ISSUES 181
IMAGING 181
MACROSCOPIC 181
MICROSCOPIC 181
ANCILLARY TESTS 181
DIFFERENTIAL DIAGNOSIS 182
DIAGNOSTIC CHECKLIST 182
SELECTED REFERENCES 182
Chapter\r28. Multicentric Castleman Disease 186
TERMINOLOGY 187
ETIOLOGY/PATHOGENESIS 187
CLINICAL ISSUES 187
IMAGING 188
MICROSCOPIC 188
ANCILLARY TESTS 188
DIFFERENTIAL DIAGNOSIS 188
DIAGNOSTIC CHECKLIST 189
SELECTED REFERENCES 189
Chapter\r29. Rheumatoid Arthritis-Related Lymphadenopathy 194
TERMINOLOGY 195
ETIOLOGY/PATHOGENESIS 195
CLINICAL ISSUES 195
IMAGING 196
MICROSCOPIC 196
ANCILLARY TESTS 196
DIFFERENTIAL DIAGNOSIS 196
DIAGNOSTIC CHECKLIST 197
SELECTED REFERENCES 197
Chapter\r30. Sarcoid Lymphadenopathy 202
TERMINOLOGY 203
ETIOLOGY/PATHOGENESIS 203
CLINICAL ISSUES 203
IMAGING 204
MACROSCOPIC 204
MICROSCOPIC 204
ANCILLARY TESTS 204
DIFFERENTIAL DIAGNOSIS 204
DIAGNOSTIC CHECKLIST 205
SELECTED REFERENCES 205
Chapter\r31. Dermatopathic Lymphadenopathy 208
TERMINOLOGY 209
ETIOLOGY/PATHOGENESIS 209
CLINICAL ISSUES 209
MACROSCOPIC 209
MICROSCOPIC 209
ANCILLARY TESTS 210
DIFFERENTIAL DIAGNOSIS 210
DIAGNOSTIC CHECKLIST 210
SELECTED REFERENCES 210
Chapter\r32. Hemophagocytic Lymphohistiocytosis 214
TERMINOLOGY 215
ETIOLOGY/PATHOGENESIS 215
CLINICAL ISSUES 215
IMAGING 216
MICROSCOPIC 216
ANCILLARY TESTS 217
DIFFERENTIAL DIAGNOSIS 217
DIAGNOSTIC CHECKLIST 218
SELECTED REFERENCES 218
Chapter\r33. Lymphadenopathy Associated With Joint Prostheses 224
TERMINOLOGY 225
ETIOLOGY/PATHOGENESIS 225
CLINICAL ISSUES 225
MACROSCOPIC 225
MICROSCOPIC 225
ANCILLARY TESTS 225
DIFFERENTIAL DIAGNOSIS 225
DIAGNOSTIC CHECKLIST 226
SELECTED REFERENCES 226
Chapter\r34. Lipid-Associated Lymphadenopathy 230
TERMINOLOGY 231
ETIOLOGY/PATHOGENESIS 231
CLINICAL ISSUES 231
IMAGING 231
MICROSCOPIC 231
DIFFERENTIAL DIAGNOSIS 231
SELECTED REFERENCES 231
Chapter\r35. Lymphadenopathy Secondary to Drug-Induced Hypersensitivity Syndrome 234
TERMINOLOGY 235
ETIOLOGY/PATHOGENESIS 235
CLINICAL ISSUES 235
MICROSCOPIC 236
ANCILLARY TESTS 237
DIFFERENTIAL DIAGNOSIS 237
SELECTED REFERENCES 238
Chapter\r36. IgG4-Related Disease 242
TERMINOLOGY 243
ETIOLOGY/PATHOGENESIS 243
CLINICAL ISSUES 243
IMAGING 244
MACROSCOPIC 244
MICROSCOPIC 244
ANCILLARY TESTS 244
DIFFERENTIAL DIAGNOSIS 244
DIAGNOSTIC CHECKLIST 245
SELECTED REFERENCES 245
SECTION 4:\rHodgkin Lymphomas 253
Chapter\r37. Nodular Lymphocyte-Predominant Hodgkin Lymphoma 254
TERMINOLOGY 255
ETIOLOGY/PATHOGENESIS 255
CLINICAL ISSUES 255
IMAGING 256
MACROSCOPIC 256
MICROSCOPIC 256
ANCILLARY TESTS 257
DIFFERENTIAL DIAGNOSIS 257
DIAGNOSTIC CHECKLIST 258
SELECTED REFERENCES 258
Chapter\r38. Lymphocyte-Rich Classic Hodgkin Lymphoma 266
TERMINOLOGY 267
ETIOLOGY/PATHOGENESIS 267
CLINICAL ISSUES 267
IMAGING 267
MICROSCOPIC 267
ANCILLARY TESTS 268
DIFFERENTIAL DIAGNOSIS 268
SELECTED REFERENCES 268
Chapter\r39. Nodular Sclerosis Hodgkin Lymphoma 274
TERMINOLOGY 275
ETIOLOGY/PATHOGENESIS 275
CLINICAL ISSUES 275
IMAGING 276
MACROSCOPIC 276
MICROSCOPIC 276
ANCILLARY TESTS 277
DIFFERENTIAL DIAGNOSIS 277
SELECTED REFERENCES 278
Chapter\r40. Mixed Cellularity Hodgkin Lymphoma 284
TERMINOLOGY 285
ETIOLOGY/PATHOGENESIS 285
CLINICAL ISSUES 285
IMAGING 285
MICROSCOPIC 285
ANCILLARY TESTS 286
DIFFERENTIAL DIAGNOSIS 286
SELECTED REFERENCES 286
Chapter\r41. Lymphocyte-Depleted Hodgkin Lymphoma 290
TERMINOLOGY 291
ETIOLOGY/PATHOGENESIS 291
CLINICAL ISSUES 291
MICROSCOPIC 291
ANCILLARY TESTS 292
DIFFERENTIAL DIAGNOSIS 292
SELECTED REFERENCES 292
SECTION 5: Leukemia/Lymphoma of Immature B- or T-Cell Lineage 297
Chapter\r42. B-Lymphoblastic Leukemia/Lymphoma 298
TERMINOLOGY 299
ETIOLOGY/PATHOGENESIS 299
CLINICAL ISSUES 299
MICROSCOPIC 300
ANCILLARY TESTS 300
DIFFERENTIAL DIAGNOSIS 301
DIAGNOSTIC CHECKLIST 301
SELECTED REFERENCES 301
Chapter\r43. T-Lymphoblastic Lymphoma/Leukemia 308
TERMINOLOGY 309
ETIOLOGY/PATHOGENESIS 309
CLINICAL ISSUES 309
IMAGING 309
MICROSCOPIC 309
ANCILLARY TESTS 310
DIFFERENTIAL DIAGNOSIS 311
SELECTED REFERENCES 312
SECTION 6:\rNodal B-Cell Lymphomas 317
Chapter\r44. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 318
TERMINOLOGY 319
CLINICAL ISSUES 319
MACROSCOPIC 319
MICROSCOPIC 319
ANCILLARY TESTS 319
DIFFERENTIAL DIAGNOSIS 320
DIAGNOSTIC CHECKLIST 320
SELECTED REFERENCES 320
Chapter\r45. Richter Syndrome 324
TERMINOLOGY 325
ETIOLOGY/PATHOGENESIS 325
CLINICAL ISSUES 325
IMAGING 325
MICROSCOPIC 325
ANCILLARY TESTS 325
DIFFERENTIAL DIAGNOSIS 326
SELECTED REFERENCES 326
Chapter\r46. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia 330
TERMINOLOGY 331
ETIOLOGY/PATHOGENESIS 331
CLINICAL ISSUES 331
MACROSCOPIC 332
MICROSCOPIC 332
ANCILLARY TESTS 333
DIFFERENTIAL DIAGNOSIS 333
DIAGNOSTIC CHECKLIST 334
SELECTED REFERENCES 334
Chapter\r47. Nodal Marginal Zone B-Cell Lymphoma 340
TERMINOLOGY 341
ETIOLOGY/PATHOGENESIS 341
CLINICAL ISSUES 341
MICROSCOPIC 341
ANCILLARY TESTS 341
DIFFERENTIAL DIAGNOSIS 342
DIAGNOSTIC CHECKLIST 342
SELECTED REFERENCES 342
Chapter\r48. Nodal Follicular Lymphoma 346
TERMINOLOGY 347
ETIOLOGY/PATHOGENESIS 347
CLINICAL ISSUES 347
IMAGING 347
MICROSCOPIC 347
ANCILLARY TESTS 349
DIFFERENTIAL DIAGNOSIS 349
SELECTED REFERENCES 350
Chapter\r49. Mantle Cell Lymphoma 358
TERMINOLOGY 359
ETIOLOGY/PATHOGENESIS 359
CLINICAL ISSUES 359
MICROSCOPIC 359
ANCILLARY TESTS 359
DIFFERENTIAL DIAGNOSIS 360
SELECTED REFERENCES 360
Chapter\r50. Mantle Cell Lymphoma, Blastoid and Pleomorphic Variants 364
TERMINOLOGY 365
ETIOLOGY/PATHOGENESIS 365
CLINICAL ISSUES 365
IMAGING 365
MICROSCOPIC 365
ANCILLARY TESTS 365
DIFFERENTIAL DIAGNOSIS 366
SELECTED REFERENCES 366
Chapter\r51. Diffuse Large B-Cell Lymphoma, Not Otherwise Specified 370
TERMINOLOGY 371
ETIOLOGY/PATHOGENESIS 371
CLINICAL ISSUES 371
IMAGING 371
MACROSCOPIC 372
MICROSCOPIC 372
ANCILLARY TESTS 372
DIFFERENTIAL DIAGNOSIS 372
DIAGNOSTIC CHECKLIST 373
SELECTED REFERENCES 373
Chapter\r52. Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Immunoblastic 378
TERMINOLOGY 379
ETIOLOGY/PATHOGENESIS 379
CLINICAL ISSUES 379
MACROSCOPIC 379
MICROSCOPIC 379
ANCILLARY TESTS 379
DIFFERENTIAL DIAGNOSIS 379
SELECTED REFERENCES 380
Chapter\r53. T-Cell/Histiocyte-Rich Large B-Cell Lymphoma 384
TERMINOLOGY 385
CLINICAL ISSUES 385
MICROSCOPIC 385
ANCILLARY TESTS 385
DIFFERENTIAL DIAGNOSIS 385
SELECTED REFERENCES 385
Chapter\r54. ALK(+) Large B-Cell Lymphoma 388
TERMINOLOGY 389
ETIOLOGY/PATHOGENESIS 389
CLINICAL ISSUES 389
MICROSCOPIC 389
ANCILLARY TESTS 389
DIFFERENTIAL DIAGNOSIS 390
SELECTED REFERENCES 390
Chapter\r55. EBV(+) Diffuse Large B-Cell Lymphoma 394
TERMINOLOGY 395
ETIOLOGY/PATHOGENESIS 395
CLINICAL ISSUES 395
MICROSCOPIC 395
ANCILLARY TESTS 396
DIFFERENTIAL DIAGNOSIS 396
SELECTED REFERENCES 397
Chapter\r56. HHV-8(+) Large B-Cell Lym 400
TERMINOLOGY 401
ETIOLOGY/PATHOGENESIS 401
CLINICAL ISSUES 401
IMAGING 402
MICROSCOPIC 402
ANCILLARY TESTS 402
DIFFERENTIAL DIAGNOSIS 402
SELECTED REFERENCES 403
Chapter\r57. Burkitt Lymphoma 408
TERMINOLOGY 409
ETIOLOGY/PATHOGENESIS 409
CLINICAL ISSUES 409
IMAGING 410
MACROSCOPIC 410
MICROSCOPIC 410
ANCILLARY TESTS 410
DIFFERENTIAL DIAGNOSIS 411
DIAGNOSTIC CHECKLIST 412
SELECTED REFERENCES 412
Chapter\r58. High-Grade B-Cell Lymphoma 416
TERMINOLOGY 417
CLINICAL ISSUES 417
IMAGING 417
MICROSCOPIC 417
ANCILLARY TESTS 418
DIFFERENTIAL DIAGNOSIS 418
SELECTED REFERENCES 418
Chapter\r59. B-Cell Lymphoma, Unclassifiable, Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma 422
TERMINOLOGY 423
CLINICAL ISSUES 423
MICROSCOPIC 423
ANCILLARY TESTS 423
DIFFERENTIAL DIAGNOSIS 423
DIAGNOSTIC CHECKLIST 425
SELECTED REFERENCES 425
SECTION 7:\rExtranodal B-Cell Lymphomas 433
Chapter\r60. Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma) 434
TERMINOLOGY 435
ETIOLOGY/PATHOGENESIS 435
CLINICAL ISSUES 435
IMAGING 435
MICROSCOPIC 435
ANCILLARY TESTS 436
DIFFERENTIAL DIAGNOSIS 437
SELECTED REFERENCES 437
Chapter\r61. Extranodal Follicular Lymphoma 444
TERMINOLOGY 445
ETIOLOGY/PATHOGENESIS 445
CLINICAL ISSUES 445
MACROSCOPIC 446
MICROSCOPIC 446
ANCILLARY TESTS 447
DIFFERENTIAL DIAGNOSIS 447
DIAGNOSTIC CHECKLIST 448
SELECTED REFERENCES 448
Chapter\r62. Primary Cutaneous Follicle Center Lymphoma 456
TERMINOLOGY 457
ETIOLOGY/PATHOGENESIS 457
CLINICAL ISSUES 457
MICROSCOPIC 457
ANCILLARY TESTS 457
DIFFERENTIAL DIAGNOSIS 458
DIAGNOSTIC CHECKLIST 458
SELECTED REFERENCES 459
Chapter\r63. Primary Mediastinal (Thymic) Large B-Cell Lymphoma 466
TERMINOLOGY 467
ETIOLOGY/PATHOGENESIS 467
CLINICAL ISSUES 467
IMAGING 467
MACROSCOPIC 467
MICROSCOPIC 467
ANCILLARY TESTS 467
DIFFERENTIAL DIAGNOSIS 468
DIAGNOSTIC CHECKLIST 469
SELECTED REFERENCES 469
Chapter\r64. Primary Diffuse Large B-Cell Lymphoma of Central Nervous System 476
TERMINOLOGY 477
ETIOLOGY/PATHOGENESIS 477
CLINICAL ISSUES 477
IMAGING 478
MACROSCOPIC 478
MICROSCOPIC 479
ANCILLARY TESTS 479
DIFFERENTIAL DIAGNOSIS 480
SELECTED REFERENCES 480
Chapter\r65. Pyothorax-Associated Lymphoma 486
TERMINOLOGY 487
ETIOLOGY/PATHOGENESIS 487
CLINICAL ISSUES 487
IMAGING 488
MACROSCOPIC 488
MICROSCOPIC 488
ANCILLARY TESTS 488
DIFFERENTIAL DIAGNOSIS 488
DIAGNOSTIC CHECKLIST 489
SELECTED REFERENCES 489
Chapter\r66. Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type 492
TERMINOLOGY 493
ETIOLOGY/PATHOGENESIS 493
CLINICAL ISSUES 493
MICROSCOPIC 493
ANCILLARY TESTS 493
DIFFERENTIAL DIAGNOSIS 493
DIAGNOSTIC CHECKLIST 494
SELECTED REFERENCES 494
Chapter\r67. Plasmablastic Lymphoma 500
TERMINOLOGY 501
ETIOLOGY/PATHOGENESIS 501
CLINICAL ISSUES 501
IMAGING 501
MICROSCOPIC 501
ANCILLARY TESTS 502
DIFFERENTIAL DIAGNOSIS 502
SELECTED REFERENCES 503
Chapter\r68. Primary Effusion Lymphoma and Solid Variant of Primary Effusion Lymphoma 510
TERMINOLOGY 511
ETIOLOGY/PATHOGENESIS 511
CLINICAL ISSUES 511
IMAGING 511
MICROSCOPIC 512
ANCILLARY TESTS 512
DIFFERENTIAL DIAGNOSIS 512
SELECTED REFERENCES 513
Chapter\r69. Lymphomatoid Granulomatosis 518
TERMINOLOGY 519
ETIOLOGY/PATHOGENESIS 519
CLINICAL ISSUES 519
MACROSCOPIC 519
MICROSCOPIC 519
ANCILLARY TESTS 519
DIFFERENTIAL DIAGNOSIS 520
SELECTED REFERENCES 520
Chapter\r70. Intravascular Large B-Cell Lymphoma 528
TERMINOLOGY 529
ETIOLOGY/PATHOGENESIS 529
CLINICAL ISSUES 529
MICROSCOPIC 529
ANCILLARY TESTS 530
DIFFERENTIAL DIAGNOSIS 530
DIAGNOSTIC CHECKLIST 530
SELECTED REFERENCES 530
Chapter\r71. Plasmacytoma 534
TERMINOLOGY 535
ETIOLOGY/PATHOGENESIS 535
CLINICAL ISSUES 535
IMAGING 535
MICROSCOPIC 535
ANCILLARY TESTS 535
DIFFERENTIAL DIAGNOSIS 536
DIAGNOSTIC CHECKLIST 536
SELECTED REFERENCES 536
Chapter\r72. Diffuse Large B-Cell Lymphoma of Testis 542
TERMINOLOGY 543
ETIOLOGY/PATHOGENESIS 543
CLINICAL ISSUES 543
IMAGING 543
MACROSCOPIC 543
MICROSCOPIC 543
ANCILLARY TESTS 543
DIFFERENTIAL DIAGNOSIS 543
DIAGNOSTIC CHECKLIST 544
SELECTED REFERENCES 544
Chapter\r73. Splenic Marginal Zone Lymphoma 548
TERMINOLOGY 549
ETIOLOGY/PATHOGENESIS 549
CLINICAL ISSUES 549
MACROSCOPIC 549
MICROSCOPIC 549
ANCILLARY TESTS 550
DIFFERENTIAL DIAGNOSIS 550
SELECTED REFERENCES 551
Chapter\r74. Hairy Cell Leukemia 556
TERMINOLOGY 557
ETIOLOGY/PATHOGENESIS 557
CLINICAL ISSUES 557
MACROSCOPIC 558
MICROSCOPIC 558
ANCILLARY TESTS 558
DIFFERENTIAL DIAGNOSIS 558
DIAGNOSTIC CHECKLIST 559
SELECTED REFERENCES 559
Chapter\r75. Hairy Cell Leukemia Variant 566
TERMINOLOGY 567
ETIOLOGY/PATHOGENESIS 567
CLINICAL ISSUES 567
MACROSCOPIC 567
MICROSCOPIC 567
ANCILLARY TESTS 567
DIFFERENTIAL DIAGNOSIS 568
DIAGNOSTIC CHECKLIST 568
SELECTED REFERENCES 568
Chapter\r76. Splenic Diffuse Red Pulp Small B-Cell Lymphoma 574
TERMINOLOGY 575
ETIOLOGY/PATHOGENESIS 575
CLINICAL ISSUES 575
MACROSCOPIC 575
MICROSCOPIC 575
ANCILLARY TESTS 575
DIFFERENTIAL DIAGNOSIS 576
DIAGNOSTIC CHECKLIST 576
SELECTED REFERENCES 576
Chapter\r77. Diffuse Large B-Cell Lymphoma Arising in the Spleen 582
TERMINOLOGY 583
ETIOLOGY/PATHOGENESIS 583
CLINICAL ISSUES 583
MACROSCOPIC 583
MICROSCOPIC 583
ANCILLARY TESTS 583
DIFFERENTIAL DIAGNOSIS 584
SELECTED REFERENCES 584
SECTION 8:\rNodal T-Cell Lymphomas 589
Chapter\r78. Peripheral T-Cell Lymphoma, Not Otherwise Specified 590
TERMINOLOGY 591
ETIOLOGY/PATHOGENESIS 591
CLINICAL ISSUES 591
IMAGING 591
MICROSCOPIC 591
ANCILLARY TESTS 592
DIFFERENTIAL DIAGNOSIS 593
DIAGNOSTIC CHECKLIST 594
SELECTED REFERENCES 594
Chapter\r79. Angioimmunoblastic T-Cell Lymphoma 600
TERMINOLOGY 601
ETIOLOGY/PATHOGENESIS 601
CLINICAL ISSUES 601
IMAGING 601
MICROSCOPIC 601
ANCILLARY TESTS 602
DIFFERENTIAL DIAGNOSIS 603
SELECTED REFERENCES 603
Chapter\r80. Adult T-Cell Leukemia/Lymphoma, HTLV-1(+) 610
TERMINOLOGY 611
ETIOLOGY/PATHOGENESIS 611
CLINICAL ISSUES 611
IMAGING 612
MICROSCOPIC 612
ANCILLARY TESTS 613
DIFFERENTIAL DIAGNOSIS 613
SELECTED REFERENCES 613
Chapter\r81. ALK(+) Anaplastic Large Cell Lymphoma 620
TERMINOLOGY 621
CLINICAL ISSUES 621
MICROSCOPIC 621
ANCILLARY TESTS 621
DIFFERENTIAL DIAGNOSIS 621
SELECTED REFERENCES 622
Chapter\r82. ALK(-) Anaplastic Large Cell Lymphoma 626
TERMINOLOGY 627
CLINICAL ISSUES 627
MICROSCOPIC 627
ANCILLARY TESTS 627
DIFFERENTIAL DIAGNOSIS 627
DIAGNOSTIC CHECKLIST 628
SELECTED REFERENCES 628
SECTION 9:\rExtranodal NK-/T-Cell Lymphomas 633
Chapter\r83. Breast Implant-Associated Anaplastic Large Cell Lymphoma 634
TERMINOLOGY 635
ETIOLOGY/PATHOGENESIS 635
CLINICAL ISSUES 635
IMAGING 636
MACROSCOPIC 636
MICROSCOPIC 636
ANCILLARY TESTS 636
DIFFERENTIAL DIAGNOSIS 637
SELECTED REFERENCES 637
Chapter\r84. Extranodal NK-/T-Cell Lymphoma, Nasal Type 644
TERMINOLOGY 645
ETIOLOGY/PATHOGENESIS 645
CLINICAL ISSUES 645
IMAGING 645
MICROSCOPIC 645
ANCILLARY TESTS 645
DIFFERENTIAL DIAGNOSIS 646
STAGING 646
SELECTED REFERENCES 646
Chapter\r85. Hepatosplenic T-Cell Lymphoma 652
TERMINOLOGY 653
ETIOLOGY/PATHOGENESIS 653
CLINICAL ISSUES 653
MACROSCOPIC 653
MICROSCOPIC 653
ANCILLARY TESTS 653
DIFFERENTIAL DIAGNOSIS 654
SELECTED REFERENCES 654
Chapter\r86. Enteropathy-Associated T-Cell Lymphoma 662
TERMINOLOGY 663
ETIOLOGY/PATHOGENESIS 663
CLINICAL ISSUES 663
IMAGING 664
MACROSCOPIC 664
MICROSCOPIC 664
ANCILLARY TESTS 664
DIFFERENTIAL DIAGNOSIS 665
DIAGNOSTIC CHECKLIST 665
SELECTED REFERENCES 665
Chapter\r87. Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma 670
TERMINOLOGY 671
ETIOLOGY/PATHOGENESIS 671
CLINICAL ISSUES 671
IMAGING 671
MACROSCOPIC 671
MICROSCOPIC 671
ANCILLARY TESTS 671
DIFFERENTIAL DIAGNOSIS 672
DIAGNOSTIC CHECKLIST 672
SELECTED REFERENCES 672
Chapter\r88. Subcutaneous Panniculitis-Like T-Cell Lymphoma 678
TERMINOLOGY 679
ETIOLOGY/PATHOGENESIS 679
CLINICAL ISSUES 679
IMAGING 680
MICROSCOPIC 680
ANCILLARY TESTS 680
DIFFERENTIAL DIAGNOSIS 680
DIAGNOSTIC CHECKLIST 681
SELECTED REFERENCES 681
Chapter\r89. Primary Cutaneous γ/δ T-Cell Lymphoma 686
TERMINOLOGY 687
ETIOLOGY/PATHOGENESIS 687
CLINICAL ISSUES 687
MICROSCOPIC 687
ANCILLARY TESTS 687
DIFFERENTIAL DIAGNOSIS 687
SELECTED REFERENCES 687
Chapter\r90. Mycosis Fungoides 692
TERMINOLOGY 693
ETIOLOGY/PATHOGENESIS 693
CLINICAL ISSUES 693
MACROSCOPIC 693
MICROSCOPIC 694
ANCILLARY TESTS 694
DIFFERENTIAL DIAGNOSIS 695
STAGING 695
SELECTED REFERENCES 695
Chapter\r91. Sézary Syndrome 706
TERMINOLOGY 707
ETIOLOGY/PATHOGENESIS 707
CLINICAL ISSUES 707
IMAGING 707
MICROSCOPIC 707
ANCILLARY TESTS 708
DIFFERENTIAL DIAGNOSIS 708
DIAGNOSTIC CHECKLIST 709
SELECTED REFERENCES 709
Chapter\r92. Primary Cutaneous Anaplastic Large Cell Lymphoma 716
TERMINOLOGY 717
ETIOLOGY/PATHOGENESIS 717
CLINICAL ISSUES 717
MICROSCOPIC 717
ANCILLARY TESTS 717
DIFFERENTIAL DIAGNOSIS 717
SELECTED REFERENCES 718
Chapter\r93. Lymphomatoid Papulosis 722
TERMINOLOGY 723
ETIOLOGY/PATHOGENESIS 723
CLINICAL ISSUES 723
MICROSCOPIC 723
ANCILLARY TESTS 723
DIFFERENTIAL DIAGNOSIS 724
SELECTED REFERENCES 724
Chapter\r94. T-Cell Prolymphocytic Leukemia Involving Lymph Node and Other Tissues 728
TERMINOLOGY 729
ETIOLOGY/PATHOGENESIS 729
CLINICAL ISSUES 729
MICROSCOPIC 730
ANCILLARY TESTS 731
DIFFERENTIAL DIAGNOSIS 732
DIAGNOSTIC CHECKLIST 732
SELECTED REFERENCES 732
SECTION 10:\rImmunodeficiency-Associated\rLymphoproliferations 737
Chapter\r95. Overview of Primary Immunodeficiency-Associated Lymphoproliferative Disorders 738
TERMINOLOGY 738
EPIDEMIOLOGY 738
ETIOLOGY/PATHOGENESIS 738
CLINICAL IMPLICATIONS 739
MICROSCOPIC 739
DIAGNOSTIC TESTS 740
DIFFERENTIAL DIAGNOSIS FOR NONNEOPLASTIC LESIONS 740
DIFFERENTIAL DIAGNOSIS FOR NEOPLASTIC\rLESIONS 740
SELECTED REFERENCES 740
Chapter\r96. Autoimmune Lymphoproliferative Syndrome 744
TERMINOLOGY 745
ETIOLOGY/PATHOGENESIS 745
CLINICAL ISSUES 745
IMAGING 746
MICROSCOPIC 746
ANCILLARY TESTS 747
DIFFERENTIAL DIAGNOSIS 747
DIAGNOSTIC CHECKLIST 748
SELECTED REFERENCES 748
Chapter\r97. Immunomodulating Agent-Associated Lymphoproliferative Disorders 756
TERMINOLOGY 757
ETIOLOGY/PATHOGENESIS 757
CLINICAL ISSUES 758
IMAGING 758
MICROSCOPIC 759
ANCILLARY TESTS 759
DIFFERENTIAL DIAGNOSIS 759
SELECTED REFERENCES 759
Chapter\r98. Posttransplant Lymphoproliferative Disorder, Early Lesions and Polymorphic 764
TERMINOLOGY 765
ETIOLOGY/PATHOGENESIS 765
CLINICAL ISSUES 765
MICROSCOPIC 766
ANCILLARY TESTS 766
DIFFERENTIAL DIAGNOSIS 767
SELECTED REFERENCES 767
Chapter\r99. Posttransplant Lymphoproliferative Disorder, Monomorphic 774
TERMINOLOGY 775
ETIOLOGY/PATHOGENESIS 775
CLINICAL ISSUES 775
MICROSCOPIC 776
ANCILLARY TESTS 776
DIFFERENTIAL DIAGNOSIS 777
DIAGNOSTIC CHECKLIST 777
REPORTING 777
SELECTED REFERENCES 777
SECTION 11:\rGranulocytic/Histiocytic Tumors 785
Chapter\r100. Myeloid/Monocytic Sarcoma 786
TERMINOLOGY 787
ETIOLOGY/PATHOGENESIS 787
CLINICAL ISSUES 787
IMAGING 787
MACROSCOPIC 787
MICROSCOPIC 787
ANCILLARY TESTS 788
DIFFERENTIAL DIAGNOSIS 789
DIAGNOSTIC CHECKLIST 789
SELECTED REFERENCES 789
Chapter\r101. Blastic Plasmacytoid Dendritic Cell Neoplasm 794
TERMINOLOGY 795
ETIOLOGY/PATHOGENESIS 795
CLINICAL ISSUES 795
IMAGING 795
MACROSCOPIC 795
MICROSCOPIC 796
ANCILLARY TESTS 796
DIFFERENTIAL DIAGNOSIS 796
DIAGNOSTIC CHECKLIST 797
SELECTED REFERENCES 797
Chapter\r102. Blastic T/Myeloid Neoplasm Associated With ZMYM2-FGFR1 802
TERMINOLOGY 803
ETIOLOGY/PATHOGENESIS 803
CLINICAL ISSUES 803
MICROSCOPIC 803
ANCILLARY TESTS 803
DIFFERENTIAL DIAGNOSIS 804
DIAGNOSTIC CHECKLIST 805
REPORTING 805
SELECTED REFERENCES 805
Chapter\r103. Histiocytic Sarcoma 812
TERMINOLOGY 813
ETIOLOGY/PATHOGENESIS 813
CLINICAL ISSUES 813
MACROSCOPIC 814
MICROSCOPIC 814
ANCILLARY TESTS 814
DIFFERENTIAL DIAGNOSIS 815
DIAGNOSTIC CHECKLIST 815
SELECTED REFERENCES 816
Chapter\r104. Follicular Dendritic Cell Sarcoma 822
TERMINOLOGY 823
ETIOLOGY/PATHOGENESIS 823
CLINICAL ISSUES 823
IMAGING 823
MACROSCOPIC 824
MICROSCOPIC 824
ANCILLARY TESTS 824
DIFFERENTIAL DIAGNOSIS 824
DIAGNOSTIC CHECKLIST 825
SELECTED REFERENCES 825
Chapter\r105. Interdigitating Dendritic Cell Sarcoma 830
TERMINOLOGY 831
ETIOLOGY/PATHOGENESIS 831
CLINICAL ISSUES 831
IMAGING 831
MACROSCOPIC 831
MICROSCOPIC 831
ANCILLARY TESTS 832
DIFFERENTIAL DIAGNOSIS 832
SELECTED REFERENCES 832
Chapter\r106. Langerhans Cell Histiocytosis 836
TERMINOLOGY 837
ETIOLOGY/PATHOGENESIS 837
CLINICAL ISSUES 837
IMAGING 838
MICROSCOPIC 838
ANCILLARY TESTS 839
DIFFERENTIAL DIAGNOSIS 839
DIAGNOSTIC CHECKLIST 839
SELECTED REFERENCES 839
Chapter\r107. Langerhans Cell Sarcoma 848
TERMINOLOGY 849
CLINICAL ISSUES 849
IMAGING 849
MICROSCOPIC 849
ANCILLARY TESTS 849
DIFFERENTIAL DIAGNOSIS 850
DIAGNOSTIC CHECKLIST 851
SELECTED REFERENCES 851
Chapter\r108. Cutaneous Mastocytosis 856
TERMINOLOGY 857
ETIOLOGY/PATHOGENESIS 857
CLINICAL ISSUES 857
MACROSCOPIC 858
MICROSCOPIC 858
ANCILLARY TESTS 858
DIFFERENTIAL DIAGNOSIS 858
DIAGNOSTIC CHECKLIST 858
SELECTED REFERENCES 858
Chapter\r109. Systemic Mastocytosis 860
TERMINOLOGY 861
CLINICAL ISSUES 861
IMAGING 863
MACROSCOPIC 863
MICROSCOPIC 863
ANCILLARY TESTS 863
DIFFERENTIAL DIAGNOSIS 864
DIAGNOSTIC CHECKLIST 864
SELECTED REFERENCES 864
SECTION 12:\rNonhematopoietic\rProliferations in Lymph Node 873
Chapter\r110. Epithelial Inclusions in Lymph Node 874
TERMINOLOGY 875
ETIOLOGY/PATHOGENESIS 875
CLINICAL ISSUES 875
IMAGING 876
MACROSCOPIC 876
MICROSCOPIC 876
ANCILLARY TESTS 876
DIFFERENTIAL DIAGNOSIS 876
DIAGNOSTIC CHECKLIST 876
SELECTED REFERENCES 876
Chapter\r111. Nevus Cell Inclusions in Lymph Node 880
TERMINOLOGY 881
ETIOLOGY/PATHOGENESIS 881
CLINICAL ISSUES 881
MICROSCOPIC 881
ANCILLARY TESTS 882
DIFFERENTIAL DIAGNOSIS 882
DIAGNOSTIC CHECKLIST 882
SELECTED REFERENCES 882
Chapter\r112. Vascular Transformation of Lymph Node Sinuses 884
TERMINOLOGY 885
ETIOLOGY/PATHOGENESIS 885
CLINICAL ISSUES 885
MICROSCOPIC 885
ANCILLARY TESTS 885
DIFFERENTIAL DIAGNOSIS 885
SELECTED REFERENCES 885
Chapter\r113. Angiomyomatous Hamartoma 888
TERMINOLOGY 889
ETIOLOGY/PATHOGENESIS 889
CLINICAL ISSUES 889
IMAGING 889
MACROSCOPIC 889
MICROSCOPIC 889
ANCILLARY TESTS 889
DIFFERENTIAL DIAGNOSIS 889
SELECTED REFERENCES 889
Chapter\r114. Palisaded Myofibroblastoma 892
TERMINOLOGY 893
ETIOLOGY/PATHOGENESIS 893
CLINICAL ISSUES 893
IMAGING 893
MACROSCOPIC 893
MICROSCOPIC 893
ANCILLARY TESTS 893
DIFFERENTIAL DIAGNOSIS 894
SELECTED REFERENCES 894
Chapter\r115. Metastatic Kaposi Sarcoma 896
TERMINOLOGY 897
ETIOLOGY/PATHOGENESIS 897
CLINICAL ISSUES 897
MACROSCOPIC 898
MICROSCOPIC 898
ANCILLARY TESTS 898
DIFFERENTIAL DIAGNOSIS 898
DIAGNOSTIC CHECKLIST 898
SELECTED REFERENCES 898
INDEX I-i