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Book Details
Abstract
Demonstrating the interdisciplinary nature of modern glycosciences, this volume covers research in the fields of polysaccharides and small carbohydrates from the synthetic and structural viewpoints, with applications ranging from biology to the bioeconomy. Key aspects of the synthesis and properties of imino disaccharides and regioselective glycosylation reactions are reviewed, glycosyltransferase inhibitors are shown to be potential future therapeutic agents, protein-carbohydrate interactions in plant cell-wall biodegradation are targeted by the use of glycan microarrays, biological properties of polysaccharidic microbial surface antigens are discussed with respect to their intimate structure, and contributions on carbohydrate-based hydrogelators, green/blue sugar-based surfactants and carbohydrate-based green solvents illustrate the modern design of tomorrow’s chemicals. With the increase in volume, velocity and variety of information, researchers can find it difficult to keep up to date with the literature in their field and this book remains a valuable addition to any researcher’s library.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Cover | Cover | ||
| Contents | ix | ||
| Preface | vii | ||
| Synthesis and biological properties of imino-disaccharides and -oligosaccharides | 1 | ||
| 1 Introduction | 1 | ||
| 2 Synthesis of imino-O-oligosaccharides | 3 | ||
| 3 Synthesis of imino-S-disaccharides | 30 | ||
| 4 Synthesis of imino-N-oligosaccharides | 31 | ||
| 5 Synthesis of imino-C-disaccharides | 36 | ||
| 6 Glycosidase inhibition properties | 60 | ||
| 7 Conclusions | 66 | ||
| References | 66 | ||
| Bacterial polysaccharides as major surface antigens: interest in O-acetyl substitutions | 71 | ||
| 1 Introduction | 71 | ||
| 2 PS O-acetylation: a widespread modification | 72 | ||
| 3 On the role of CPS O-acetylation on the host-pathogen crosstalk | 76 | ||
| 4 O-Acetylated CPSs from pathogenic bacteria: implication in vaccine development | 81 | ||
| 5 Conclusion | 97 | ||
| References | 97 | ||
| Regioselective glycosylation: What's new? | 104 | ||
| 1 Introduction | 104 | ||
| 2 Tackling the regioselectivity problem using biocatalysts | 105 | ||
| 3 Bioinspired chemical glycosylation | 118 | ||
| 4 Conclusion | 129 | ||
| References | 130 | ||
| Glycosyltransferase inhibitors: a promising strategy to pave a path from laboratory to therapy | 135 | ||
| 1 Glycan biosynthesis and glycan processing enzymes | 135 | ||
| 2 Small molecule inhibitors to modulate glycan processing enzymes | 137 | ||
| 3 Glycosyltransferase inhibitors | 138 | ||
| 4 Substrate analogs | 139 | ||
| 5 Transition state analogs | 143 | ||
| 6 Glycomimetics | 145 | ||
| 7 Alternate chemotype analogs | 147 | ||
| 8 Metabolic chain terminator | 151 | ||
| 9 Conclusion | 154 | ||
| References | 154 | ||
| Targeting protein-carbohydrate interactions in plant cell-wall biodegradation: the power of carbohydrate microarrays | 159 | ||
| 1 Structural diversity of plant cell-wall polysaccharides | 159 | ||
| 2 Cellulolytic microorganisms express proteomes highly efficient in plant cell-wall biodegradation | 162 | ||
| 3 Carbohydrate microarrays | 166 | ||
| 4 Conclusions | 172 | ||
| Acknowledgments | 173 | ||
| References | 173 | ||
| Low melting carbohydrate mixtures and aqueous carbohydrates - an effective green medium for organic synthesis | 177 | ||
| 1 Introduction | 177 | ||
| 2 Organic Transformations in carbohydrate-based low melt | 180 | ||
| 3 Organic Transformations in an aqueous Sugar | 185 | ||
| 4 Conclusions and Outlook | 193 | ||
| References | 193 | ||
| Surfactants based on green/blue sugars: towards new functionalities in formulations | 196 | ||
| 1 Introduction | 196 | ||
| 2 Sugar-based ionic surfactants | 199 | ||
| 3 Surfactants based on novel carbohydrate motifs | 204 | ||
| 4 Sugar-based surfactants including original linkers between polar and lipophilic domains | 214 | ||
| 5 Surfactant compositions resulting from the direct transformation of polysaccharides | 232 | ||
| 6 Conclusion | 240 | ||
| Abbreviations | 240 | ||
| References | 241 | ||
| Low molecular weight carbohydrate-based hydrogelators | 245 | ||
| 1 Introduction | 245 | ||
| 2 Monosaccharides | 246 | ||
| 3 Disaccharides | 255 | ||
| 4 Bipolar hydrogelators | 258 | ||
| 5 Rationalisation and structure/property relationships | 261 | ||
| 6 Conclusion | 261 | ||
| References | 261 |