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Book Details
Abstract
Amino Acids, Peptides and Proteins comprises a comprehensive and critical review of significant developments at the biology and chemistry interface. Compiled by leading researchers in their subject, this volume incorporates current trends and emerging areas in topics such as magnetic resonance studies of membrane active peptides, proteins and peptides for the diagnosis and therapy of Leishmania donovani parasite infections and advances in the design of ligands interacting with proteases causing infectious respiratory syndrome. Appealing broadly to researchers in academia and industry, it will be of great benefit to any researcher wanting a succinct reference on developments in this area now and looking to the future.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Cover | Cover | ||
| Contents | vii | ||
| Preface | v | ||
| Amino acids: chemistry, diversity and physical properties | 1 | ||
| 1 Naturally occurring amino acids | 1 | ||
| 2 Chemical synthesis and resolution of amino acids | 12 | ||
| 3 Analytical methods | 51 | ||
| Abbreviations | 66 | ||
| References | 67 | ||
| Amino acid and peptide bioconjugates | 85 | ||
| 1 Introduction | 85 | ||
| 2 Synthesis | 85 | ||
| 3 Selected applications of peptide-bioconjugates | 112 | ||
| Abbreviations | 129 | ||
| Acknowledgments | 131 | ||
| References | 131 | ||
| Magnetic resonance studies of antimicrobial peptides in membranes | 146 | ||
| 1 Introduction: peptide-lipid interactions | 146 | ||
| 2 Electron paramagnetic resonance (EPR) | 152 | ||
| 3 Solid-state nuclear magnetic resonance (NMR) | 166 | ||
| 4 Discussion | 179 | ||
| Acknowledgments | 181 | ||
| References | 181 | ||
| Emerging therapeutic agents on the basis of naturally occurring antimicrobial peptides | 190 | ||
| 1 Introduction | 190 | ||
| 2 AMPs origin and classification | 193 | ||
| 3 Mechanism of action | 195 | ||
| 4 SAR of AMPs | 199 | ||
| 5 Design of novel AMPS with improved activity | 203 | ||
| 6 Nano-Antimicrobials: delivery systems for AMPs | 208 | ||
| 7 AMPs with other activities | 211 | ||
| 8 AMPs in clinical applications | 212 | ||
| 9 Conclusion | 218 | ||
| References | 219 | ||
| Advances in the design of ligands interacting with 3CL protease of novel coronaviruses causing infectious respiratory syndrome | 228 | ||
| 1 Introduction | 228 | ||
| 2 Coronavirus 3CL protease | 230 | ||
| 3 Inhibitors of 3CL protease | 238 | ||
| 4 Conclusions | 274 | ||
| References | 275 | ||
| Targeting peptides, a Swiss-Army Knife against cancer | 280 | ||
| 1 Introduction | 280 | ||
| 2 The phage display technology: screening and characterisation of tumour targeting peptides | 281 | ||
| 3 Targeting peptides for cancer imaging and therapy | 292 | ||
| 4 Concluding remarks | 307 | ||
| List of abbreviations | 307 | ||
| References | 309 |