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Fundamentals of General, Organic and Biological Chemistry in SI Units

Fundamentals of General, Organic and Biological Chemistry in SI Units

John E. McMurry | David S. Ballantine | Carl A. Hoeger | Virginia E. Peterson

(2017)

Additional Information

Book Details

Abstract

For courses in General, Organic, and Biological Chemistry (2 - Semester)

 

A Clear, Flexible Approach to Chemistry for the Modern Classroom

Active learning, an increased focus on clinical examples, updates based on current teaching and research findings, and digital innovations designed to engage and personalize students’ experience make Fundamentals of General, Organic, and Biological Chemistry simply the best choice for students with a future in allied health. With the Eighth Edition, the authors make learning chemistry a more active experience through features designed to get students doing chemistry. Every chapter features Hands on Chemistry sections that deepen students’ understanding of chemistry by having them perform elementary experiments with everyday household items. Group Problemsat the end of every chapter are designed for in-class use and motivate students toward higher level thinking, such as how concepts fit together and how to apply these concepts in a clinical application. All of the chapter openers, including many of the Chemistry in Action boxes and end-of-chapter problems, have been rewritten for a stronger clinical focus that provides more relevance to allied health majors.

 

All content has been updated for the modern classroom with special attention to the biochemistry chapters, making the Eighth Edition of Fundamentals of General, Organic and Biological Chemistry the best choice for future allied health students.

 

MasteringChemistry not included. Students, if MasteringChemistry is a recommended/mandatory component of the course, please ask your instructor for the correct ISBN and course ID. MasteringChemistry should only be purchased when required by an instructor. Instructors, contact your Pearson representative for more information.


MasteringChemistry is an online homework, tutorial, and assessment system, designed to improve results by engaging students before, during, and after class with powerful content. Instructors ensure students arrive ready to learn by assigning educationally effective content before class, and they encourage critical thinking and retention with in-class resources such as Learning Catalytics.


Table of Contents

Section Title Page Action Price
Cover Cover
Title Page 5
Copyright Page 6
About the Authors 7
Brief Contents 9
Contents 10
Features 16
Preface 18
Acknowledgments 25
Chapter 1: Matter and Measurements 34
1.1 Chemistry: The Central Science 35
HANDS-ON CHEMISTRY 1.1 37
1.2 States of Matter 38
1.3 Classification of Matter 39
CHEMISTRY IN ACTION: Aspirin—A Case Study 41
1.4 Chemical Elements and Symbols 41
1.5 Chemical Reactions: Examples of Chemical Change 44
1.6 Physical Quantities: Units and Scientific Notation 45
CHEMISTRY IN ACTION: Mercury and Mercury Poisoning 46
1.7 Measuring Mass, Length, and Volume 49
HANDS-ON CHEMISTRY 1.2 51
1.8 Measurement and Significant Figures 52
1.9 Rounding Off Numbers 55
1.10 Problem Solving: Unit Conversions and Estimating Answers 57
1.11 Temperature, Heat, and Energy 61
CHEMISTRY IN ACTION: Temperature-Sensitive Materials 63
1.12 Density and Specific Gravity 65
CHEMISTRY IN ACTION: A Measurement Example: Obesity and Body Fat 67
Chapter 2: Atoms and the Periodic Table 76
2.1 Atomic Theory and the Structure of Atoms 77
CHEMISTRY IN ACTION: Are Atoms Real 78
2.2 Elements and Atomic Number 79
2.3 Isotopes and Atomic Mass 80
HANDS-ON CHEMISTRY 2.1 83
2.4 The Periodic Table 83
2.5 Some Characteristics of Different Groups 86
CHEMISTRY IN ACTION: Essential Elements and Group Chemistry 88
2.6 Electronic Structure of Atoms 89
HANDS-ON CHEMISTRY 2.2 92
2.7 Electron Configurations 92
2.8 Electron Configurations and the Periodic Table 96
2.9 Electron-Dot Symbols 99
CHEMISTRY IN ACTION: Atoms and Light 100
Chapter 3: Ionic Compounds 106
3.1 Ions 107
3.2 Ions and the Octet Rule 108
3.3 Ions of Some Common Elements 110
3.4 Periodic Properties and Ion Formation 112
3.5 Naming Monoatomic Ions 114
CHEMISTRY IN ACTION: Salt 115
3.6 Polyatomic Ions 116
CHEMISTRY IN ACTION: Biologically Important Ions 117
3.7 Ionic Bonds 118
3.8 Formulas of Ionic Compounds 119
HANDS-ON CHEMISTRY 3.1 122
3.9 Naming Ionic Compounds 122
HANDS-ON CHEMISTRY 3.2 124
3.10 Some Properties of Ionic Compounds 125
CHEMISTRY IN ACTION: Ionic Liquids 125
3.11 H+ and OH- Ions: An Introduction to Acids and Bases 126
CHEMISTRY IN ACTION: Osteoporosis 127
Chapter 4: Molecular Compounds 134
4.1 Covalent Bonds 135
4.2 Covalent Bonds and the Periodic Table 137
4.3 Multiple Covalent\r Bonds 140
4.4 Coordinate Covalent\r Bonds 142
4.5 Characteristics of Molecular Compounds 143
4.6 Molecular Formulas and Lewis Structures 144
4.7 Drawing Lewis Structures 145
CHEMISTRY IN ACTION: CO and NO: Pollutants or Miracle Molecules? 150
4.8 The Shapes of Molecules 150
CHEMISTRY IN ACTION: VERY Big Molecules 155
4.9 Polar Covalent Bonds and Electronegativity 156
4.10 Polar Molecules 158
HANDS-ON CHEMISTRY 4.1 160
4.11 Naming Binary Molecular Compounds 161
CHEMISTRY IN ACTION: Damascenone by Any Other Name Would Smell as Sweet 162
Chapter 5: Classification and Balancing of Chemical Reactions 170
5.1 Chemical\r Equations 171
5.2 Balancing Chemical\r Equations 172
HANDS-ON\r CHEMISTRY 5.1 175
5.3 Precipitation\r Reactions and Solubility Guidelines 175
CHEMISTRY IN ACTION: Kidney Stones: A Problem in Solubility 176
5.4 Acids, Bases, and Neutralization Reactions 177
HANDS-ON CHEMISTRY 5.2 178
5.5 Redox Reactions 179
CHEMISTRY IN ACTION: Batteries 184
5.6 Recognizing Redox Reactions 184
5.7 Net Ionic Equations 187
Chapter 6: Chemical Reactions: Mole and Mass Relationships 196
6.1 The Mole and Avogadro’s Number 197
6.2 Gram–Mole Conversions 201
6.3 Mole Relationships and Chemical Equations 203
6.4 Mass Relationships and Chemical Equations 204
6.5 Limiting Reagent and Percent Yield 207
HANDS-ON CHEMISTRY 6.1 211
CHEMISTRY IN ACTION: Anemia—A Limiting Reagent Problem? 211
Chapter 7: Chemical Reactions: Energy, Rates, and Equilibrium 218
7.1 Energy and Chemical Bonds 219
7.2 Heat Changes during Chemical Reactions 219
7.3 Exothermic and Endothermic Reactions 221
CHEMISTRY IN ACTION: Energy from Food 225
HANDS-ON CHEMISTRY 7.1 226
7.4 Why Do Chemical Reactions Occur? Free Energy 226
7.5 How Do Chemical Reactions Occur? Reaction\r Rates 229
7.6 Effects of Temperature, Concentration, and Catalysts on Reaction Rates 231
7.7 Reversible Reactions and Chemical Equilibrium 234
7.8 Equilibrium Equations and Equilibrium Constants 235
7.9 Le Châtelier’s Principle: The Effect of Changing Conditions on Equilibria 239
CHEMISTRY IN ACTION: Regulation of Body Temperature 242
Chapter 8: Gases, Liquids, and Solids 250
8.1 States of Matter and Their Changes 251
8.2 Intermolecular Forces 252
8.3 Gases and the Kinetic–Molecular Theory 257
8.4 Pressure 257
CHEMISTRY IN ACTION: Greenhouse Gases and Global\r Warming 260
8.5 Boyle’s Law: The Relation between Volume and Pressure 261
CHEMISTRY IN ACTION: Blood Pressure 263
8.6 Charles’s Law: The Relation between Volume and Temperature 264
HANDS-ON CHEMISTRY 8.1 265
8.7 Gay-Lussac’s Law: The Relation between Pressure and Temperature 265
8.8 The Combined Gas Law 267
8.9 Avogadro’s Law: The Relation between Volume and Molar Amount 268
8.10 The Ideal Gas Law 270
8.11 Partial Pressure and Dalton’s Law 272
8.12 Liquids 273
8.13 Solids 275
8.14 Changes of State Calculations 277
CHEMISTRY IN ACTION: CO2 as an Environmentally Friendly Solvent 280
Chapter 9: Solutions 288
9.1 Mixtures and Solutions 289
9.2 The Solution Process 290
CHEMISTRY IN ACTION: Solid Hydrates—Salt + Water 292
9.3 Solubility 292
9.4 The Effect of Temperature on Solubility 293
9.5 The Effect of Pressure on Solubility: Henry’s Law 295
9.6 Units of Concentration 297
CHEMISTRY IN ACTION: Breathing and Oxygen Transport 298
9.7 Dilution 304
9.8 Ions in Solution: Electrolytes 306
CHEMISTRY IN ACTION: Electrolytes, Fluid Replacement, and Sports Drinks 308
9.9 Properties of Solutions 309
HANDS-ON CHEMISTRY 9.1 312
9.10 Osmosis and Osmotic Pressure 313
HANDS-ON CHEMISTRY 9.2 316
9.11 Dialysis 316
CHEMISTRY IN ACTION: Timed-Release Drug Delivery Systems 317
Chapter 10: Acids and Bases 324
10.1 Acids and Bases: Definitions 325
10.2 Acid and Base Strength 329
CHEMISTRY IN ACTION: GERD—Too Much Acid or Not Enough? 333
10.3 Acid Dissociation Constants 334
10.4 Water as Both an Acid and a ase 335
10.5 Measuring Acidity in Aqueous Solution: The pH Scale 337
10.6 Working with pH 340
CHEMISTRY IN ACTION: Acid Rain 342
10.7 Acid and Base Equivalents 344
10.8 Some Common Acid-Base Reactions 345
HANDS-ON CHEMISTRY 10.1 347
10.9 Acidity and Basicity of Salt Solutions 347
10.10 Buffer Solutions 348
10.11 Titration 352
CHEMISTRY IN ACTION: Buffers in the Body: Acidosis and Alkalosis 355
Chapter 11: Nuclear Chemistry 362
11.1 Nuclear Reactions 363
11.2 The Discovery and Nature of Radioactivity 364
11.3 Stable and Unstable Isotopes 365
11.4 Nuclear Decay 366
11.5 Radioactive Half-Life 370
CHEMISTRY IN ACTION: Medical Uses of Radioactivity 372
11.6 Ionizing Radiation 375
11.7 Detecting and Measuring Radiation 377
CHEMISTRY IN ACTION: Irradiated Food 379
11.8 Artificial Transmutation 380
CHEMISTRY IN ACTION: Body Imaging 381
11.9 Nuclear Fission and Nuclear Fusion 382
HANDS-ON CHEMISTRY 11.1 385
Chapter 12: Introduction to Organic Chemistry: Alkanes 390
12.1 The Nature of Organic Molecules 391
12.2 Families of Organic Molecules: Functional Groups 393
HANDS-ON CHEMISTRY 12.1 399
12.3 The Structure of Organic Molecules: Alkanes and Their Isomers 399
12.4 Drawing Organic Structures 402
12.5 The Shapes of Organic Molecules 407
12.6 Naming Alkanes 410
CHEMISTRY IN ACTION: How Important Can a Methyl Group Really Be 417
12.7 Properties of Alkanes 418
12.8 Reactions of Alkanes 419
MASTERING REACTIONS: Organic Chemistry and the Curved Arrow Formalism 420
12.9 Cycloalkanes 424
12.10 Drawing and Naming Cycloalkanes 426
CHEMISTRY IN ACTION: Surprising Uses of Petroleum 428
Chapter 13: Alkenes, Alkynes, and Aromatic Compounds 436
13.1 Alkenes and Alkynes 437
13.2 Naming Alkenes and Alkynes 438
13.3 The Structure of Alkenes: Cis–Trans Isomerism 441
HANDS-ON CHEMISTRY\r 13.1 444
13.4 Properties of Alkenes and Alkynes 445
13.5 Types of Organic Reactions 445
CHEMISTRY IN ACTION: The Chemistry of Vision and Color 448
13.6 Addition Reactions of Alkenes 449
MASTERING REACTIONS: How Addition Reactions Occur 456
13.7 Alkene Polymers 458
13.8 Aromatic Compounds and the Structure of Benzene 460
13.9 Naming Aromatic Compounds 462
13.10 Reactions of Aromatic Compounds 464
CHEMISTRY IN ACTION: Enediyne Antibiotics: A Newly Emerging Class of Antitumor Agents 466
Chapter 14: Some Compounds with Oxygen, Sulfur, or a Halogen 474
14.1 Alcohols, Phenols, and Ethers 475
14.2 Naming Alcohols 476
14.3 Properties of Alcohols 480
14.4 Reactions of Alcohols 481
MASTERING REACTIONS: How Eliminations Occur 483
14.5 Phenols 488
14.6 Acidity of Alcohols and Phenols 490
14.7 Ethers 490
CHEMISTRY IN ACTION: Inhaled Anesthetics 492
14.8 Thiols and Disulfides 493
14.9 Halogen-Containing Compounds 494
14.10 Stereochemistry and Chirality 496
HANDS-ON CHEMISTRY 14.1 498
CHEMISTRY IN ACTION: Fetal Alcohol Syndrome: Ethanol as a Toxin 501
Chapter 15: Aldehydes and Ketones 508
15.1 The Carbonyl Group 509
15.2 Naming Simple Aldehydes and Ketones 511
CHEMISTRY IN ACTION: Chemical Warfare among the Insects 512
15.3 Properties of Aldehydes and Ketones 513
15.4 Some Common Aldehydes and Ketones 514
15.5 Oxidation of Aldehydes 515
15.6 Reduction of Aldehydes and Ketones 517
15.7 Addition of Alcohols: Hemiacetals and Acetals 519
HANDS-ON CHEMISTRY 15.1 526
MASTERING REACTIONS: Carbonyl Additions 527
CHEMISTRY IN ACTION: When Is Toxicity Beneficial? 529
Chapter 16: Amines 536
16.1 Classifying Amines 537
16.2 Naming and Drawing Amines 538
16.3 Properties of Amines 540
HANDS-ON CHEMISTRY 16.1 542
16.4 Heterocyclic Nitrogen Compounds 543
16.5 Basicity of Amines 544
16.6 Amine Salts 547
16.7 Amines in Plants: Alkaloids 549
CHEMISTRY IN ACTION: Calming a Stormy Mind: Amines as Anti-Anxiety Medications 551
Chapter 17: Carboxylic Acids and Their Derivatives 556
17.1 Carboxylic Acids and Their Derivatives: Properties and Names 557
HANDS-ON CHEMISTRY 17.1 565
17.2 Acidity of Carboxylic Acids 566
CHEMISTRY IN ACTION: Medicinally Important Carboxylic Acids and Derivatives 568
17.3 Reactions of Carboxylic Acids: Ester and Amide Formation 570
17.4 Hydrolysis of Esters and Amides 573
17.5 Polyamides and Polyesters 576
17.6 Phosphoric Acid Derivatives 577
CHEMISTRY IN ACTION: Medications, Body Fluids, and the “Solubility Switch 580
Chapter 18: Amino Acids and Proteins 588
18.1 An Introduction to Biochemistry 589
18.2 Proteins and Their Functions: An Overview 589
18.3 Amino Acids 591
18.4 Acid-Base Properties of Amino Acids 595
CHEMISTRY IN ACTION: Protein Analysis by Electrophoresis 596
18.5 Peptides 597
HANDS-ON CHEMISTRY 18.1 599
CHEMISTRY IN ACTION: Proteins in the Diet 600
18.6 Protein Structure: An Overview and Primary Protein Structure (1°) 600
CHEMISTRY IN ACTION: What Is Sickle-Cell Anemia 602
18.7 Secondary Protein Structure (2°) 603
18.8 Tertiary Protein Structure (3°) 607
18.9 Quaternary Protein Structure (4°) 612
18.10 Chemical Properties of Proteins 614
HANDS-ON CHEMISTRY 18.2 616
CHEMISTRY IN ACTION: Imperfect Collagen—An Unfortunate Event 617
Chapter 19: Enzymes and Vitamins 624
19.1 Catalysis by Enzymes 625
HANDS-ON CHEMISTRY\r 19.1 626
19.2 Enzyme\r Cofactors 627
HANDS-ON CHEMISTRY\r 19.2 629
19.3 Enzyme\r Classification 629
MASTERING REACTIONS: How to Read Biochemical Reactions 629
19.4 How Enzymes Work 633
19.5 Factors Affecting Enzyme Activity 636
19.6 Enzyme Regulation: Inhibition 639
19.7 Enzyme Regulation: Allosteric Control and Feedback Inhibition 642
19.8 Enzyme Regulation: Covalent Modification and Genetic Control 644
CHEMISTRY IN ACTION: Enzyme Inhibitors as Drugs 646
19.9 Vitamins, Antioxidants, and Minerals 647
CHEMISTRY IN ACTION: Vitamins, Minerals, and Food Labels 651
CHEMISTRY IN ACTION: Enzymes in Medical Diagnosis 653
Chapter 20: Carbohydrates 660
20.1 An Introduction to Carbohydrates 661
20.2 Handedness of Carbohydrates and Fischer Projections 663
20.3 Structure of Glucose and Other Monosaccharides 667
HANDS-ON CHEMISTRY 20.1 669
20.4 Some Important Monosaccharides 671
CHEMISTRY IN ACTION: Cell-Surface Carbohydrates and Blood Type 674
20.5 Reactions of Monosaccharides 674
20.6 Common Disaccharides 677
20.7 Some Important Polysaccharides Based on Glucose 680
CHEMISTRY IN ACTION: Bacterial Cell Walls: Rigid Defense Systems 682
HANDS-ON CHEMISTRY 20.2 684
CHEMISTRY IN ACTION: Carbohydrates and Fiber in the Diet 685
Chapter 21: The Generation of Biochemical Energy 692
21.1 Energy, Life, and Biochemical Reactions 693
CHEMISTRY IN ACTION: Plants and Photosynthesis 696
21.2 Cells and Their Structure 697
21.3 An Overview of Metabolism and Energy Production 698
21.4 Strategies of Metabolism: ATP and Energy Transfer 701
CHEMISTRY IN ACTION: Harmful Oxygen Species and Antioxidant Vitamins 703
21.5 Strategies of Metabolism: Metabolic Pathways and Coupled Reactions 703
CHEMISTRY IN ACTION: Basal Metabolism 705
HANDS-ON CHEMISTRY 21.1 706
21.6 Strategies of Metabolism: Oxidized and Reduced Coenzymes 706
21.7 The Citric Acid Cycle 709
21.8 The Electron-Transport Chain and ATP Production 713
CHEMISTRY IN ACTION: Metabolic Poisons 717
Chapter 22: Carbohydrate Metabolism 724
22.1 Digestion of Carbohydrates 725
22.2 Glucose Metabolism: An Overview 725
22.3 Glycolysis 726
22.4 Entry of Other Sugars into Glycolysis 730
CHEMISTRY IN ACTION: Tooth Decay 731
22.5 The Fate of Pyruvate 732
HANDS-ON CHEMISTRY 22.1 734
22.6 Energy Output in Complete Glucose Catabolism 734
22.7 Regulation of Glucose Metabolism and Metabolism during Stress 735
HANDS-ON CHEMISTRY 22.2 737
CHEMISTRY IN ACTION: The Biochemistry of Running 738
22.8 Glycogen Metabolism: Glycogenesis and Glycogenolysis 739
22.9 Gluconeogenesis: Glucose Synthesis from Noncarbohydrates 740
CHEMISTRY IN ACTION: Diagnosis and Monitoring of Diabetes 742
Chapter 23: Lipids 748
23.1 Structure and Classification of Lipids 749
23.2 Fatty Acids and Their Esters 751
23.3 Properties of Fats and Oils 754
CHEMISTRY IN ACTION: Lipids in the Diet 755
HANDS-ON CHEMISTRY 23.1 755
23.4 Chemical Reactions of Triacylglycerols 756
23.5 Phospholipids and Glycolipids 758
23.6 Sterols 763
23.7 Cell Membranes: Structure and Transport 765
CHEMISTRY IN ACTION: Eicosanoids: Prostaglandins and Leukotrienes 769
HANDS-ON CHEMISTRY 23.2 770
Chapter 24: Lipid Metabolism 774
24.1 Digestion of Triacylglycerols 775
24.2 Lipoproteins for Lipid Transport 777
24.3 Triacylglycerol Metabolism: An Overview 778
24.4 Storage and Mobilization of Triacylglycerols 780
24.5 Oxidation of Fatty Acids 782
24.6 Ketone Bodies and Ketoacidosis 785
CHEMISTRY IN ACTION: The Liver—Clearinghouse for Metabolism 787
24.7 Biosynthesis of Fatty Acids 788
CHEMISTRY IN ACTION: Fat Storage, Lipids, and Atherosclerosis 790
HANDS-ON CHEMISTRY 24.1 791
Chapter 25: Protein and Amino Acid Metabolism 796
25.1 Digestion of Proteins 797
HANDS-ON CHEMISTRY 25.1 798
25.2 Amino Acid Metabolism: An Overview 799
25.3 Amino Acid Catabolism: The Amino Group 800
25.4 The Urea Cycle 802
CHEMISTRY IN ACTION: Gout: When Biochemistry Goes Awry 804
25.5 Amino Acid Catabolism: The Carbon Atoms 805
25.6 Biosynthesis of Nonessential Amino Acids 806
CHEMISTRY IN ACTION: The Importance of Essential Amino Acids and Effects of Deficiencies 808
Chapter 26: Nucleic Acids and Protein Synthesis 814
26.1 DNA, Chromosomes, and Genes 815
26.2 Composition of Nucleic Acids 815
26.3 The Structure of Nucleic Acid Chains 820
26.4 Base Pairing in DNA: The Watson–Crick Model 821
26.5 Nucleic Acids and Heredity 824
26.6 Replication of DNA 824
26.7 Structure and Function of RNA 827
26.8 Transcription: RNA Synthesis 828
26.9 The Genetic Code 830
HANDS-ON CHEMISTRY 26.1 831
CHEMISTRY IN ACTION: Influenza: Variations on a Theme 832
26.10 Translation: tRNA and Protein Synthesis 833
Chapter 27: Genomics 840
27.1 Mapping the Human Genome 841
27.2 DNA and Chromosomes 843
27.3 Mutations and Polymorphisms 845
HANDS-ON CHEMISTRY 27.1 846
27.4 Recombinant DNA 849
CHEMISTRY IN ACTION: The Polymerase Chain Reaction 848
27.5 Genomics: Using What We Know 851
CHEMISTRY IN ACTION: DNA Fingerprinting 854
Chapter 28: Chemical Messengers: Hormones, Neurotransmitters, and Drugs 858
28.1 Messenger Molecules 859
28.2 Hormones and the Endocrine System 860
28.3 How Hormones Work: Epinephrine and Fight-or-Flight 863
28.4 Amino Acid Derivatives, Polypeptides, and Steroid Hormones 865
CHEMISTRY IN ACTION: Homeostasis 868
28.5 Neurotransmitters 869
28.6 How Neurotransmitters Work: Acetylcholine, Its Agonists and Antagonists 871
28.7 Histamines, Antihistamines, and Important Neurotransmitters 873
HANDS-ON CHEMISTRY 28.1 877
Chapter 29: Body Fluids 882
29.1 Body Water and Its Solutes 883
29.2 Fluid Balance 885
HANDS-ON CHEMISTRY\r 29.1 886
29.3 Blood 887
CHEMISTRY IN ACTION: The Blood–Brain Barrier 889
29.4 Plasma Proteins, White Blood Cells, and Immunity 890
29.5 Blood Clotting 893
29.6 Red Blood Cells and Blood Gases 894
29.7 The Kidney and Urine Formation 897
29.8 Urine Composition and Function 898
CHEMISTRY IN ACTION: What’s in Your Blood Test 899
Appendices 905
Answers to Selected Problems 911
Glossary 949
Credits 957
Index 959
A 959
B 960
C 961
D 962
E 963
F 963
G 964
H 964
I 965
J 965
K 965
L 965
M 966
N 967
O 967
P 967
Q 968
R 968
S 969
T 970
U 970
V 970
W 971
X 971
Z 971